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      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Executive Page

      Executive Page: Antonella Macerollo as Editor of EANpages

      April 1, 2021

      Executive Page

      Executive page: From Website editor to Co-Chair Communication Committee

      February 1, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Country of the Month

      Country of the Month: Lithuania

      March 1, 2021

      Country of the Month

      Country of the Month: Albania

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      Country of the Month: The Netherlands

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      October 1, 2020

      Paper of the Month

      Paper of the month: Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: A non-inflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

      March 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and Efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe Study)

      March 1, 2021

      EAN News

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EAN News

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      EAN News

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

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      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      EAN Congress news

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

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      December 15, 2020

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      December 15, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Cape Verde)

      March 3, 2021

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee interviews Prof. Raad Shakir, CBE

      March 1, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (South Africa)

      February 5, 2021

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      COVID-19

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

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      December 1, 2019

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      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      Breaking news

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      Breaking news

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Breaking news

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Neurology updates

      Neurology Update: Epilepsy

      March 19, 2021

      Neurology updates

      Neurology Update: Coordinating Panel on Rare Neurological Diseases

      March 12, 2021

      Neurology updates

      Neurology Update: Rare Diseases

      March 8, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      The Future of Brain Research: EU-Initiatives and Experts Together for a Shared European Brain Research Agenda

      March 1, 2021

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

  • Educational
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      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Educational

      Clinical Fellowship Reports 2020

      April 1, 2021

      Educational

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Educational

      Clinical Fellowship Reports 2020

      March 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Fellowship reports

      Clinical Fellowship Reports 2020

      April 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2020

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2019

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports III 2019

      February 1, 2021

      Education corner

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Education corner

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      Education corner

      New Scales & Scores on Dementia

      February 11, 2021

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

  • Miscellanea
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      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      General interest

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EBC

      The European Brain Council launches Brain Innovation Policy Roadmap on the occasion of Brain Awareness Week

      April 1, 2021

      Miscellanea

      Alzheimer Europe outlines state-of-play of dementia policy in Europe

      March 31, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

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      December 23, 2018

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      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      News from EMA: First oral treatment for spinal muscular atrophy (SMA) recommended for approval

      March 3, 2021

      News from EAN member societies

      EMA’s Webinar on ”COVID-19 vaccination – what you need to know as a health professional”

      February 5, 2021

      News from EAN member societies

      Personalized plans, blood biomarkers and early interventions: Think Brain Health conference highlights

      February 1, 2021

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      EBC

      The European Brain Council launches Brain Innovation Policy Roadmap on the occasion of Brain Awareness Week

      April 1, 2021

      EBC

      EBC launches statement on the impact of COVID-19 on brain health

      February 1, 2021

      EBC

      EBC launches new series of disease fact sheets!

      December 1, 2020

      EBC

      Present Your Business or Idea at the Brain Innovation Days Pitch Competition

      October 27, 2020

      EFNA

      EFNA launch eLearning Platform for neurology advocates

      February 1, 2021

      EFNA

      ‘Me and My Brain’ – Art Competition winners announced!

      February 1, 2021

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      EFNA

      EFNA Advocacy Awards 2021 – ‘Action Against Stigma’

      October 1, 2020

      News in general

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      News in general

      Alzheimer Europe outlines state-of-play of dementia policy in Europe

      March 31, 2021

      News in general

      EPA Forum 2021: Quality Indicators of Services and Care for Mental Health in Europe, from Clinician to Patient Perspective: A Paradigm Shift?

      March 31, 2021

      News in general

      ONE VOICE FOR NEUROLOGY

      March 31, 2021

      Topic of the Month/Week

      Brain Awareness Week (BAW) is the global campaign to increase public awareness of the progress and benefits of brain research

      March 13, 2018

      Topic of the Month/Week

      Dystonia Europe celebrates 25 years

      March 13, 2018

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Surveys

      SURVEY: Driving with an intracranial tumor

      June 25, 2020

      Surveys

      EAN SURVEY: Neurological Symptoms in COVID-19 Patients

      April 10, 2020

      Surveys

      EMA communication: ICH Good Clinical Practice Guidelines (ICH E6) – Open Comment Opportunity – Deadline: 1 November 2019

      October 7, 2019

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Uncategorized

      Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform

      December 2, 2020

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (New Zealand)

      November 24, 2020

      Uncategorized

      Report from the annual Pain Forum meeting

      November 2, 2020

  • EAN
  • Congress 2020
  • Congress 2021
  • EAN pages
  • Eur J Neurol
  • Virtual Congress

eanpages

  • General interest
    • All COVID-19 Executive Page Country of the Month Paper of the Month EAN News EAN Congress news Interviews
      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Executive Page

      Executive Page: Antonella Macerollo as Editor of EANpages

      April 1, 2021

      Executive Page

      Executive page: From Website editor to Co-Chair Communication Committee

      February 1, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Country of the Month

      Country of the Month: Lithuania

      March 1, 2021

      Country of the Month

      Country of the Month: Albania

      December 1, 2020

      Country of the Month

      Country of the Month: The Netherlands

      November 1, 2020

      Country of the Month

      Country of the Month: Serbia

      October 1, 2020

      Paper of the Month

      Paper of the month: Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: A non-inflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

      March 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and Efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe Study)

      March 1, 2021

      EAN News

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EAN News

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      EAN News

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      EAN Congress news

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      EAN Congress news

      Congress Registration is open

      December 15, 2020

      EAN Congress news

      Abstract Submission is open

      December 15, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Cape Verde)

      March 3, 2021

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee interviews Prof. Raad Shakir, CBE

      March 1, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (South Africa)

      February 5, 2021

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      COVID-19

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      Breaking news

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      Breaking news

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Breaking news

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Neurology updates

      Neurology Update: Epilepsy

      March 19, 2021

      Neurology updates

      Neurology Update: Coordinating Panel on Rare Neurological Diseases

      March 12, 2021

      Neurology updates

      Neurology Update: Rare Diseases

      March 8, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      The Future of Brain Research: EU-Initiatives and Experts Together for a Shared European Brain Research Agenda

      March 1, 2021

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

  • Educational
    • All E-Brain Grand Rounds Continuing medical education Resident and Research Fellows Fellowship reports Education corner
      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Educational

      Clinical Fellowship Reports 2020

      April 1, 2021

      Educational

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Educational

      Clinical Fellowship Reports 2020

      March 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Fellowship reports

      Clinical Fellowship Reports 2020

      April 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2020

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2019

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports III 2019

      February 1, 2021

      Education corner

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Education corner

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      Education corner

      New Scales & Scores on Dementia

      February 11, 2021

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

  • Miscellanea
    • All Holiday Calendar Grant opportunities News from EAN member societies EBC EFNA News in general Topic of the Month/Week Patients societies reports Surveys Forum Uncategorized
      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      General interest

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EBC

      The European Brain Council launches Brain Innovation Policy Roadmap on the occasion of Brain Awareness Week

      April 1, 2021

      Miscellanea

      Alzheimer Europe outlines state-of-play of dementia policy in Europe

      March 31, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

      Holiday Calendar

      23.12. Last-minute gift idea

      December 23, 2018

      Holiday Calendar

      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      News from EMA: First oral treatment for spinal muscular atrophy (SMA) recommended for approval

      March 3, 2021

      News from EAN member societies

      EMA’s Webinar on ”COVID-19 vaccination – what you need to know as a health professional”

      February 5, 2021

      News from EAN member societies

      Personalized plans, blood biomarkers and early interventions: Think Brain Health conference highlights

      February 1, 2021

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

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EAN News

News from ENS Barcelona: Stroke epidemic: new therapeutic strategies

August 1, 2013

At the Congress of the European Neurological Society held in Barcelona, researchers are discussing the advantages and disadvantages of OPs or catheter interventions to eliminate thrombi and arteriosclerotic plaque in acute cases. New insights into molecular processes could be the key to medications for combatting dangerous oedemas following a stroke.

Barcelona, June 2013 – Prof Guido Stoll (University Hospital Wurzburg, Germany) spoke on the subject of strokes at the 23rd Meeting of the European Neurological Society (ENS) in Barcelona: “Worldwide, one person dies every six seconds as the result of a stroke. Every year, 250 to 280 new cases are reported per 100,000 inhabitants in Europe, for a total of 600,000 strokes. It is a disease of epidemic proportions, which will continue to pose a host of problems for us.” About 3,000 experts are discussing current developments in their field at this congress right now. A special symposium is devoted to the subject of strokes. Participants critically explored the mechanical processes for reopening blocked arteries (recanalization) in the brain amongst other subjects.

Mechanical elimination of thrombi: innovation with two sides

An inadequate supply of blood to the brain due to thrombi (blood clots) accounts for 80 to 90% of strokes and the sudden neurological deficiency symptoms associated with them. The remaining 10 to 20% are attributable to cerebral haemorrhages. The only method that has thus far been proved effective is thrombolysis within 4.5 hours after the stroke. This IV-injected pharmacological treatment dissolves the clot. Additional mechanical interventions are the only chance for many patients, namely those who have thrombi over eight millimetres in diameter, which are usually resistant to dissolution. “Thrombectomy is a minimally invasive catheter-directed intervention to remove thrombi. In most cases, it restores the interrupted flow of blood immediately. It appears that specific conditions must be met for this type of intervention to be beneficial in the long term,” Prof Stoll explained.

Penumbra as a promising neurological area

Researchers at the University of Bern analysed 1,200 sets of data from acute stroke interventions and found that 90% of the mechanical interventions were above average in effectiveness if two criteria were met. First, the thrombus has to be completely removed and not fragmented in the process. Second, the collaterals, that is, the laterally running side branches of the arteries, are not sealed by the intervention. They form a natural bypass for the blocked artery and supply the tissue immediately adjoining the destroyed area and still containing nerve cells capable of surviving. This penumbra around the area of necrosis is a promising neurological area of decisive importance. If the collaterals continue supplying it adequately, the patients have a good chance. Experts at the University of Bern criticise that the techniques and instruments selected for many of the current studies sacrificed the collaterals and penumbra so the success of the treatment was quite poor.

Studies discussed in the New England Journal of Medicine (March 2013) show that the mechanical methods yield no results if they are used even an hour later than the thrombolysis. The time loss can no longer be offset although the recanalization rate would be much better (SYNTHESIS Expansion Trial). A further study (IMS III Trial) concludes that endovascular methods have advantages if they are combined with thrombolysis in accordance with a strict timetable; otherwise they are detrimental. A third study (MR RESCUE) concluded that patients who are not treated until after the critical time window of 4.5 hours and who have a specific type of penumbra pattern appear to benefit. “For actual clinical practice that means intravenous thrombolysis remains the treatment of choice. Further clinical studies are urgently needed to determine which patients profit from an additional mechanical removal of thrombi. Unfortunately, 90% of all stroke patients come too late to the hospital and thrombolysis cannot be used. We therefore have to do everything we can to prevent strokes from happening in the first place and to improve the therapeutic possibilities,” Prof Stoll emphasised.

Major advances have been made in the last two years in the prevention of strokes for patients with atrial fibrillation. Prof Diener from Essen, Germany, presented them at the stroke symposium. The inhibition of plasmatic blood clotting with new oral thrombin and factor Xa inhibitors prevents at least as many emboli from the heart into the brain as the heretofore usual treatment with vitamin K antagonists but involves a substantial reduction in the cerebral haemorrhaging feared in connection with “blood thinning”.

Pharmaceuticals against life-endangering cerebral oedemas

Dangerous oedemas that form after brain infarcts are still puzzling for scientists. Prof Stoll explained: “The brain tissue with neurons and glial cells may be dead but complex, largely unknown molecular processes continue to occur in the infarct region. The infarct region swells up and cannot escape because of the spatial restriction imposed by the bony skull. It presses against areas of the brain not even affected by the stroke.” If substantial swelling occurs, cerebral death follows unless part of the skullcap is surgically removed in time in a decompression operation. Until now, there have been no other reliable therapeutic options. Prof Stoll: “Cortisone has no decongestive effect with strokes the way it does with many other cerebral diseases. That is certainly one reason the mortality rate in people with brain oedemas is as high as 80%.”

Research findings are now offering new hope. In experimental studies, a working group from Wurzburg, Germany, was able to show for the first time that steroid receptors undergo premature degradation. These receptors are indispensable for the effectiveness of cortisone. Pharmacological inhibition of this degradation resulted in the cortisone counteracting the formation of cerebral oedemas. The very latest studies have also shown that factors in the plasmatic clotting system, such as factor XII (FXII), are not only involved in the formation of blood clots during a stroke but also play an instrumental part in oedema formation in the brain. FXII activates, inter alia, the kinin system, which is responsible for the formation of oedemas in the body. In experimental studies, researchers actually succeeded in suppressing the development of cerebral oedemas in the experiment by blocking a key molecule of this thrombotic oedematous activation path, C1 esterase. Prof Stoll: “That might possibly open up a new therapy option for the treatment of cerebral oedemas, especially since BerinertR, the C1 esterase inhibitor used, is already approved for another indication. Extensive tests will be needed, however, before it can be used for stroke patients.”

Sources: ENS Abstract 121: Thrombolysis and endovascular recanalization in acute stroke; ENS Abstract 124: Mechanisms and treatment of brain oedema formation; New England Journal of Medicine; March 7, 2013, Chimowitz MI: Endovascular Treatment for Acute Ischemic Stroke – Still Unproven

ENS Press Office:
B&K – Bettschart&Kofler Kommunikationsberatung
Dr Birgit Kofler

 

News from ENS Barcelona: Stroke epidemic: new therapeutic strategies was last modified: July 10th, 2013 by Editor
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