eanpages
  • General interest
    • All Executive Page Paper of the Month EAN News EAN Congress news COVID-19 Interviews
      Executive Page

      Executive Page: New President-Elect outlines aims for EAN’s future agenda

      August 1, 2022

      Paper of the Month

      Research Paper of the Month: Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke

      August 1, 2022

      EAN News

      Contribute to the EAN Neuro-Covid Registry (ENERGY) and be part of our growing global project

      July 29, 2022

      EAN Congress news

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajadiene

      July 28, 2022

      Executive Page

      Executive Page: New President-Elect outlines aims for EAN’s future agenda

      August 1, 2022

      Executive Page

      New EAN President, Prof. Paul Boon, identifies brain health, research agenda, and residents as key priorities

      July 8, 2022

      Executive Page

      Executive Page: packed programme for our happy reunion at EAN 2022 in Vienna

      June 3, 2022

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: Join the EAN Panels and reinforce our scientific backbone! (Plus ENERGY update, and our first Science School)

      May 1, 2022

      Paper of the Month

      Research Paper of the Month: Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke

      August 1, 2022

      Paper of the Month

      Research Paper of the Month: Association of intraventricular fibrinolysis with clinical outcomes in ICH: an individual participant data meta-analysis

      July 8, 2022

      Paper of the Month

      Covid-19 Paper of the month: Widespread white matter oedema in subacute COVID-19 patients with neurological symptoms

      July 8, 2022

      Paper of the Month

      Research Paper of the Month: Healthy lifestyle and life expectancy with and without Alzheimer’s dementia: population based cohort study

      June 3, 2022

      EAN News

      Executive Page: New President-Elect outlines aims for EAN’s future agenda

      August 1, 2022

      EAN News

      Research Paper of the Month: Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke

      August 1, 2022

      EAN News

      Contribute to the EAN Neuro-Covid Registry (ENERGY) and be part of our growing global project

      July 29, 2022

      EAN News

      Video: EAN supports World Brain Day

      July 19, 2022

      EAN Congress news

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajadiene

      July 28, 2022

      EAN Congress news

      Watch the full EAN 2022 Opening Session on our Vimeo channel!

      July 11, 2022

      EAN Congress news

      New EAN President, Prof. Paul Boon, identifies brain health, research agenda, and residents as key priorities

      July 8, 2022

      EAN Congress news

      Video Interview: WFN President, Prof. Wolfgang Grisold

      July 7, 2022

      COVID-19

      Contribute to the EAN Neuro-Covid Registry (ENERGY) and be part of our growing global project

      July 29, 2022

      COVID-19

      COVID-19 Breaking News: Case Series/Case Reports – July 2022

      July 18, 2022

      COVID-19

      COVID-19 Breaking News: Meta-analyses/systematic reviews – July 2022

      July 18, 2022

      COVID-19

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – July 2022

      July 18, 2022

      Interviews

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajadiene

      July 28, 2022

      Interviews

      Video: EAN supports World Brain Day

      July 19, 2022

      Interviews

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

      Interviews

      Video Interview: WFN President, Prof. Wolfgang Grisold

      July 7, 2022

  • Academic/Scientific
    • All Breaking news Neurology updates Scientific committee reports Scientific panels reports Eur J Neurol Top 10 Articles Scientific Corner
      EAN News

      Contribute to the EAN Neuro-Covid Registry (ENERGY) and be part of our growing global project

      July 29, 2022

      Academic/Scientific

      2nd EAN Science School, 18-20 March 2023

      July 20, 2022

      Breaking news

      COVID-19 Breaking News: Case Series/Case Reports – July 2022

      July 18, 2022

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – July 2022

      July 18, 2022

      Breaking news

      COVID-19 Breaking News: Case Series/Case Reports – July 2022

      July 18, 2022

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – July 2022

      July 18, 2022

      Breaking news

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – July 2022

      July 18, 2022

      Breaking news

      COVID-19 Breaking News: Observational studies – prospective longitudinal cohort – June 2022

      June 8, 2022

      Neurology updates

      Neurology Update: Palliative care

      July 6, 2021

      Neurology updates

      Neurology Update: Clinical Neurophysiology

      June 2, 2021

      Neurology updates Hannover Medical School

      Progressive multifocal leukoencephalopathy – promising therapeutic approach with allogeneic BK virus-specific T cells

      May 17, 2021

      Neurology updates

      Neurology Update: Neuroimmunology

      May 12, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Eur J Neurol

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

      Eur J Neurol

      EAN NeuroCOVID-19 Task Force position paper on COVID-19 vaccination hesitancy among people with chronic neurological disorders

      May 2, 2022

      Eur J Neurol

      European Journal of Neurology welcomes new associate editors

      December 13, 2021

      Eur J Neurol

      New European guideline and expert statements on the management of narcolepsy in adults and children

      June 30, 2021

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      Join the EAN Guideline Workshop on 24 June!

      May 13, 2022

      Scientific Corner

      First EAN Science School proves a hit in Salzburg

      April 1, 2022

      Scientific Corner

      Invitation to the EAN-EBRAINS Joint Workshop on ‘The Future of Medical Data Sharing in Clinical Neurosciences’

      July 2, 2021

      Scientific Corner

      1st EAN Science School, 26-29 March 2022: “Pathophysiology of disorders of the nervous system”

      June 18, 2021

  • Educational
    • All eLearning Student Corner E-Brain Grand Rounds Resident and Research Fellows Fellowship reports Education corner
      Fellowship reports

      Clinical Fellowship Reports 2022 – Oxford, Bern, London

      July 28, 2022

      Academic/Scientific

      2nd EAN Science School, 18-20 March 2023

      July 20, 2022

      Fellowship reports

      Clinical Fellowship Reports 2021 – Bucharest & Padova

      July 15, 2022

      Fellowship reports

      Research Fellowship Report 2021 – Inselspital Bern, Switzerland

      July 15, 2022

      eLearning

      Listen now to ‘eanCast: Weekly Neurology’ our latest eLearning resource

      July 14, 2022

      eLearning

      EAN Campus: Your source for online neurology education!

      June 24, 2022

      eLearning

      eanCast: Weekly Neurology

      June 24, 2022

      eLearning

      Meet our new eLearning Associate Editors

      August 12, 2021

      Student Corner

      EAN 2022 ‘Why Neurology?’ essay contest winners

      June 2, 2022

      Student Corner

      Students’ Corner: A day in the life of a medical student in your country

      May 20, 2022

      Student Corner

      Student Teaser Fellowship winners 2022

      May 11, 2022

      Student Corner

      ‘Why Neurology?’ student essay competition: win a travel grant for a future EAN Congress!

      March 14, 2022

      E-Brain

      ebrain May update: new website and podcast series

      May 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Resident and Research Fellows

      Workshop at EAN 2022 raises awareness of mentorship benefits

      July 5, 2022

      Resident and Research Fellows

      First ever UK Regional Teaching Course held in Liverpool, in person

      July 4, 2022

      Resident and Research Fellows

      RRFS Special Session – Unveiling research in Neurology: differences between basic, clinical and translational

      June 25, 2022

      Resident and Research Fellows

      23rd EAN Spring School – Report

      June 24, 2022

      Fellowship reports

      Clinical Fellowship Reports 2022 – Oxford, Bern, London

      July 28, 2022

      Fellowship reports

      Clinical Fellowship Reports 2021 – Bucharest & Padova

      July 15, 2022

      Fellowship reports

      Research Fellowship Report 2021 – Inselspital Bern, Switzerland

      July 15, 2022

      Fellowship reports

      Research Fellowship Report 2020 – Institut Necker Enfants Malades, Paris

      July 15, 2022

      Education corner

      Clinical Fellowship Reports 2022 – Oxford, Bern, London

      July 28, 2022

      Education corner

      Clinical Fellowship Reports 2021 – Bucharest & Padova

      July 15, 2022

      Education corner

      Research Fellowship Report 2021 – Inselspital Bern, Switzerland

      July 15, 2022

      Education corner

      Research Fellowship Report 2020 – Institut Necker Enfants Malades, Paris

      July 15, 2022

  • Other News
    • All EAN Staff Grant opportunities News from EAN member societies EBC EFNA News in general Patients societies reports Surveys Forum
      Other News

      The role of EAN in the European Medicine Agency

      August 2, 2022

      News from EAN member societies

      14 June: Special publication celebrates 10 years of the European Working Group of People with Dementia

      August 2, 2022

      News from EAN member societies

      14 June: Alzheimer Europe hosts European Parliament Lunch Debate examining EU and WHO policies on neurological conditions

      August 2, 2022

      News from EAN member societies

      22 June: Alzheimer Europe invites applications for its new Anti-Stigma Award

      August 2, 2022

      EAN Staff

      EAN Head Office Profiles: Patrycja & Martin

      July 28, 2022

      EAN Staff

      EAN Head Office Profiles: Anja S

      July 12, 2022

      EAN Staff

      EAN Head Office Profiles: Magda & Lindley

      June 7, 2022

      EAN Staff

      EAN Head Office Profiles: Julia & Maria

      April 4, 2022

      Grant opportunities

      1st EAN Science School, 26-29 March 2022: “Pathophysiology of disorders of the nervous system”

      June 18, 2021

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      14 June: Special publication celebrates 10 years of the European Working Group of People with Dementia

      August 2, 2022

      News from EAN member societies

      14 June: Alzheimer Europe hosts European Parliament Lunch Debate examining EU and WHO policies on neurological conditions

      August 2, 2022

      News from EAN member societies

      22 June: Alzheimer Europe invites applications for its new Anti-Stigma Award

      August 2, 2022

      News from EAN member societies

      Alzheimer Europe publishes new reports on ‘sex, gender and sexuality in the context of dementia’, and ‘dementia-inclusive initiatives and communities’

      April 5, 2022

      EBC

      Value of Treatment project releases results and calls to action

      March 29, 2022

      EBC

      Best practices for patient safety: An EU-wide view on the use of medicines off-label

      December 31, 2021

      EBC

      Creating synergies and showcasing innovation: Brain Innovation Days 2021

      November 30, 2021

      EBC

      Best practices for patient safety: Register now!

      October 28, 2021

      EFNA

      OneNeurology European Summit underlines urgent need to prioritise neurology and drive change

      December 31, 2021

      EFNA

      EFNA launch eLearning Platform for neurology advocates

      February 1, 2021

      EFNA

      ‘Me and My Brain’ – Art Competition winners announced!

      February 1, 2021

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      News in general

      EAN lecture at the International Neuro-Urology Society annual congress 2022

      May 25, 2022

      News in general

      EPA-EAN Joint Symposium: ‘Etiology and Treatment of the Long Covid-19 Syndrome’ and other highlights at the 30th European Congress of Psychiatry

      May 25, 2022

      News in general

      Organise an EAN-Day or EAN Regional Teaching Course in your Country!

      May 17, 2022

      News in general

      Value of Treatment project releases results and calls to action

      March 29, 2022

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      Survey: management of covert brain infarction

      October 29, 2021

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Surveys

      SURVEY: Driving with an intracranial tumor

      June 25, 2020

      Surveys

      EAN SURVEY: Neurological Symptoms in COVID-19 Patients

      April 10, 2020

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

  • EAN
  • Congress 2022
  • EAN pages
  • Eur J Neurol
  • Virtual Congress

eanpages

  • General interest
    • All Executive Page Paper of the Month EAN News EAN Congress news COVID-19 Interviews
      Executive Page

      Executive Page: New President-Elect outlines aims for EAN’s future agenda

      August 1, 2022

      Paper of the Month

      Research Paper of the Month: Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke

      August 1, 2022

      EAN News

      Contribute to the EAN Neuro-Covid Registry (ENERGY) and be part of our growing global project

      July 29, 2022

      EAN Congress news

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajadiene

      July 28, 2022

      Executive Page

      Executive Page: New President-Elect outlines aims for EAN’s future agenda

      August 1, 2022

      Executive Page

      New EAN President, Prof. Paul Boon, identifies brain health, research agenda, and residents as key priorities

      July 8, 2022

      Executive Page

      Executive Page: packed programme for our happy reunion at EAN 2022 in Vienna

      June 3, 2022

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: Join the EAN Panels and reinforce our scientific backbone! (Plus ENERGY update, and our first Science School)

      May 1, 2022

      Paper of the Month

      Research Paper of the Month: Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke

      August 1, 2022

      Paper of the Month

      Research Paper of the Month: Association of intraventricular fibrinolysis with clinical outcomes in ICH: an individual participant data meta-analysis

      July 8, 2022

      Paper of the Month

      Covid-19 Paper of the month: Widespread white matter oedema in subacute COVID-19 patients with neurological symptoms

      July 8, 2022

      Paper of the Month

      Research Paper of the Month: Healthy lifestyle and life expectancy with and without Alzheimer’s dementia: population based cohort study

      June 3, 2022

      EAN News

      Executive Page: New President-Elect outlines aims for EAN’s future agenda

      August 1, 2022

      EAN News

      Research Paper of the Month: Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke

      August 1, 2022

      EAN News

      Contribute to the EAN Neuro-Covid Registry (ENERGY) and be part of our growing global project

      July 29, 2022

      EAN News

      Video: EAN supports World Brain Day

      July 19, 2022

      EAN Congress news

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajadiene

      July 28, 2022

      EAN Congress news

      Watch the full EAN 2022 Opening Session on our Vimeo channel!

      July 11, 2022

      EAN Congress news

      New EAN President, Prof. Paul Boon, identifies brain health, research agenda, and residents as key priorities

      July 8, 2022

      EAN Congress news

      Video Interview: WFN President, Prof. Wolfgang Grisold

      July 7, 2022

      COVID-19

      Contribute to the EAN Neuro-Covid Registry (ENERGY) and be part of our growing global project

      July 29, 2022

      COVID-19

      COVID-19 Breaking News: Case Series/Case Reports – July 2022

      July 18, 2022

      COVID-19

      COVID-19 Breaking News: Meta-analyses/systematic reviews – July 2022

      July 18, 2022

      COVID-19

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – July 2022

      July 18, 2022

      Interviews

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajadiene

      July 28, 2022

      Interviews

      Video: EAN supports World Brain Day

      July 19, 2022

      Interviews

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

      Interviews

      Video Interview: WFN President, Prof. Wolfgang Grisold

      July 7, 2022

  • Academic/Scientific
    • All Breaking news Neurology updates Scientific committee reports Scientific panels reports Eur J Neurol Top 10 Articles Scientific Corner
      EAN News

      Contribute to the EAN Neuro-Covid Registry (ENERGY) and be part of our growing global project

      July 29, 2022

      Academic/Scientific

      2nd EAN Science School, 18-20 March 2023

      July 20, 2022

      Breaking news

      COVID-19 Breaking News: Case Series/Case Reports – July 2022

      July 18, 2022

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – July 2022

      July 18, 2022

      Breaking news

      COVID-19 Breaking News: Case Series/Case Reports – July 2022

      July 18, 2022

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – July 2022

      July 18, 2022

      Breaking news

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – July 2022

      July 18, 2022

      Breaking news

      COVID-19 Breaking News: Observational studies – prospective longitudinal cohort – June 2022

      June 8, 2022

      Neurology updates

      Neurology Update: Palliative care

      July 6, 2021

      Neurology updates

      Neurology Update: Clinical Neurophysiology

      June 2, 2021

      Neurology updates Hannover Medical School

      Progressive multifocal leukoencephalopathy – promising therapeutic approach with allogeneic BK virus-specific T cells

      May 17, 2021

      Neurology updates

      Neurology Update: Neuroimmunology

      May 12, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Eur J Neurol

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

      Eur J Neurol

      EAN NeuroCOVID-19 Task Force position paper on COVID-19 vaccination hesitancy among people with chronic neurological disorders

      May 2, 2022

      Eur J Neurol

      European Journal of Neurology welcomes new associate editors

      December 13, 2021

      Eur J Neurol

      New European guideline and expert statements on the management of narcolepsy in adults and children

      June 30, 2021

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

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Paper of the MonthTop ArticlesFeatured Slider

Paper of the month: Early diaphragm pacing should not be used in amyotrophic lateral sclerosis

December 1, 2016

Moro_Elena

 

 

 

by Elena Moro

 

 

 

For December 2016 we have selected: Gonzales-Bermejo J, Morélot-Panzini C, Tanguy M-L, et al.  Early diaphragm pacing in patients with amyotrophic lateral sclerosis (RespiStimALS): a randomized controlled triple-blind trial. Lancet Neurol 2016:15;1217-1227.

The main cause of death in patients with amyotrophic lateral sclerosis (ALS) is related to respiratory failure. It has been hypothesized that diaphragm pacing (a technique that induces diaphragm contraction through the stimulation of the phrenic nerve) could slow the progression of respiratory muscle weakness, and increase alveolar ventilation and lung compliance in ALS patients. Few previous uncontrolled studies had reported a probable benefit from diaphragm pacing in ALS. However, a more recent open controlled trial (the DiPALS study) has not only failed in showing any positive effects, but found a shorter survival in patients with diaphragm pacing and non-invasive ventilation compared to the group with only non-invasive ventilation.

The impact of diaphragm pacing on slowing diaphragm deterioration in ALS patients without non-invasive ventilation was assessed in this French multicenter, randomized, parallel group, triple-blind control trial (RespiStimALS). Between September 2012 and July 2015 twelve French centers included 74 patients with probable or definite ALS, sitting forced vital capacity (FVC) between 60% and 80% predicted (moderate respiratory involvement), and documented response to diagnostic phrenic nerve stimulation. All patients were laparoscopically implanted with intradiaphragmatic electrodes (NeuroRxRA/4, Synapse Biomedical, Cincinnati, OH), and randomly assigned to receive active or sham stimulation through an active or non-active cable, respectively, connected to an external stimulator. Patients, investigators, care-givers, and an independent treatment allocation committee for non-invasive ventilation were blinded to the study treatment. Phrenic stimulation was delivered following a standardized protocol and adapted according to the onset of side effects. During chronic stimulation patients were using diaphragm pacing within one session of 3 hours per day. Patients were regularly followed every 3 months, including assessments for possible indications for non-invasive ventilation. If non-invasive ventilation was started, treatment was unmasked and patients switched to active stimulation if previously with sham. The main outcome was the non-invasive ventilation-free survival time, calculated from the date of randomization to non-invasive ventilation introduction or death. All 74 patients were included in the intention-to-treat analysis. Survival estimates were calculated using the Kaplan-Meier method.

The negative results of the DiPALS study were published in July 2015. Since at that time the RespiStimALS was still ongoing, the study’s legal sponsor asked for a formal unplanned masked interim survival analysis. This analysis showed a significant difference for overall mortality between groups, and the study was stopped. The unmasked analysis confirmed higher mortality in the active stimulation group. The median non-invasive ventilation-free survival was 6.0 months (95% CI 3.6-8.7) in the active stimulation group, and 8.8 months (4.2 – not reached) in the sham group (HR 1.96; 95% CI 1.08-3.56; p=0.02). Twenty-three patients in the active group had non-invasive ventilation, whereas 20 in the sham group. In overall survival there was a significant difference between groups, with 18 deaths in the active group and seven in the sham group (HR 3.14, 95% CI 1.31-7.53). Serious adverse events (pneumothorax, acute respiratory failure, venous thromboembolism, gastrostomy) were frequent in both groups.

“The most important findings of this study are that not only early diaphragm pacing does not postpone the use of non-invasive ventilation in ALS patients but it also has negative effects on survival”, says Prof. Philippe Couratier, Division of Neurology, University of Limoges, France, who actively participated to the study. “Indeed, our results confirmed the open-label DiPALS findings, although their patients had a more advanced disease. Both studies’ results are in contrast with the previous findings that allowed the FDA to approve indication for diaphragm pacing in ALS patients (humanitarian device exemption), and thus support the need to re-examine this decision. Moreover, estimates of monthly changes of FVC and respiratory muscle strength variables during follow-up were significantly higher in the active stimulation group, further supporting the direct negative impact of the diaphragm pacing.”

“There was no accelerated deterioration after surgery in patients with sham stimulation. This finding rules out a putative accelerating effects of surgery in ALS patients, as suggested by some authors”, says Prof. Philippe Corcia, Centre de Ressources et de Compétences SLA, University of Tours, France. “While the negative effects of phrenic stimulation are clinically obvious, the mechanisms of its action are unknown. A better understanding of this kind of stimulation would not only avoid harmful consequences but help to find other more successful solutions.”

 

The other nominees for the December 2016 Paper of the month are:

 

  • Hanley DF, Thompson RE, Muschelli J, et al, for the MISTIE Investigators. Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomized, controlled, open-label, phase 2 trial. Lancet Neurol 2016;15:1228-1237. Ninety-six patients with a spontaneous intracerebral haemorrhage of 20ml or higher were randomized to receive standard medical care (54 patients) or image-guided minimally invasive surgery (MIS) followed by alteplase irrigation to remove clots (42 patients). There was no difference between groups in safety outcomes (30-day mortality, 7-day procedure-related mortality, 72-hour symptomatic bleeding, and 30-day brain infections). However, asymptomatic bleedings were more frequent in the MIS plus alteplase group.

 

  • Powers SW, Coffey CS, Chamberlin LA, et al., for the CHAMP Investigators. Trial of amitriptyline, topiramate, and placebo for pediatric migraine. N Engl J Med October 27, 2016. DOI: 10.1056/NEJMoa1610384. This randomized, double-blind, placebo-controlled trial was designed to investigate the effectiveness of amitriptyline and topiramate of preventing migraine in children and adolescents within a 24-week trial. The trial was closed early for futility since no difference in the primary outcome was found between groups. Patients receiving amitriptyline (132) and topiramate (130) had higher rate of adverse events compared to placebo (66).
Paper of the month: Early diaphragm pacing should not be used in amyotrophic lateral sclerosis was last modified: November 13th, 2018 by Editor
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