eanpages
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    • All COVID-19 Executive Page Country of the Month Paper of the Month EAN News EAN Congress news Interviews
      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      COVID-19

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      COVID-19

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Executive Page

      Executive Page: Recap of 2020 from Secretary-General

      December 1, 2020

      Executive Page

      Executive Page: Dafin Muresanu reelected as Chair of Communication Committee

      November 1, 2020

      Country of the Month

      Country of the Month: Albania

      December 1, 2020

      Country of the Month

      Country of the Month: The Netherlands

      November 1, 2020

      Country of the Month

      Country of the Month: Serbia

      October 1, 2020

      Country of the Month

      Country of the Month: Kazakhstan

      September 1, 2020

      Paper of the Month

      COVID-19 Paper of the month: Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

      January 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial

      January 1, 2021

      Paper of the Month

      Covid-19 Papers of the month: ”COVID-19 case fatality and Parkinson’s disease” and ”Multiple sclerosis and COVID-19: how many are at risk?”

      December 1, 2020

      Paper of the Month

      Research Paper of the Month: The burden of neurological diseases in Europe: an analysis for the Global Burden of Disease Study 2017

      December 1, 2020

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

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      Welcome to new year by Editor-in-Chief

      January 1, 2021

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      Congress Registration is open

      December 15, 2020

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      Abstract Submission is open

      December 15, 2020

      EAN Congress news

      Congress Registration is open

      December 15, 2020

      EAN Congress news

      Abstract Submission is open

      December 15, 2020

      EAN Congress news

      EAN announces Virtual Congress in 2021

      December 1, 2020

      EAN Congress news

      Investigator Award Winners 2020

      September 14, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Interviews

      Interview of the Month with Marco Medina, President of PAFNS

      January 1, 2021

      Interviews

      External Interview – Asian Oceanian Association of Neurology

      November 1, 2020

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee, interviews Prof. Jean-Antoine Girault, President of FENS – Federation of European Neuroscience Societies

      October 1, 2020

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      Academic/Scientific

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      COVID-19

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      Breaking news

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      Breaking news

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      Breaking news

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Neurology updates

      Neurology Update: Rare Diseases

      December 1, 2020

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

      Scientific Corner

      New Registrar’s Reading Lists from the Higher Cortical Functions Scientific Panel

      January 17, 2020

  • Educational
    • All E-Brain Grand Rounds Continuing medical education Resident and Research Fellows Fellowship reports Education corner
      General interest

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Educational

      Clinical Fellowship 2021 winners

      January 1, 2021

      Educational

      Clinical Fellowship Reports 2019 III

      December 21, 2020

      Educational

      Clinical Fellowship Reports 2019 II

      December 21, 2020

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Resident and Research Fellows

      EAN Virtual Congress: Round table Special Session: Unleash your potential with EAN!

      May 24, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019 III

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019 II

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019

      November 2, 2020

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Education corner

      EAN Spring School – Application Deadline is 31 January 2021

      December 21, 2020

      Education corner

      Research Fellowship winners 2021

      December 1, 2020

      Education corner

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

  • Miscellanea
    • All Holiday Calendar Grant opportunities News from EAN member societies EBC EFNA News in general Topic of the Month/Week Patients societies reports Surveys Forum Uncategorized
      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Miscellanea

      Alzheimer Europe launches new guide targeted at health and social care workers and a policy briefing on intercultural care and support

      January 1, 2021

      Miscellanea

      Alzheimer Europe Policy Report – Dementia as a European Priority

      January 1, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

      Holiday Calendar

      23.12. Last-minute gift idea

      December 23, 2018

      Holiday Calendar

      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      News from EAN member societies

      2020 – BioMed Alliance celebrates 10 years of existence

      January 1, 2021

      News from EAN member societies

      New BioMed Alliance Statement: Open Access Initiatives must not create inequality

      November 1, 2020

      News from EAN member societies

      Health partnership proposal paves the way for greater role for stakeholders

      October 1, 2020

      EBC

      EBC launches new series of disease fact sheets!

      December 1, 2020

      EBC

      Present Your Business or Idea at the Brain Innovation Days Pitch Competition

      October 27, 2020

      EBC

      Save the date for the Brain Innovation Days launch!

      October 1, 2020

      EBC

      The EBC releases its 2019 Annual Report

      September 1, 2020

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      EFNA

      EFNA Advocacy Awards 2021 – ‘Action Against Stigma’

      October 1, 2020

      EFNA

      EFNA Annual Report 2019 Published

      August 1, 2020

      EFNA

      Results of EFNA’s Survey on Stigma and Neurological Disorder

      July 22, 2020

      News in general

      Alzheimer Europe launches new guide targeted at health and social care workers and a policy briefing on intercultural care and support

      January 1, 2021

      News in general

      Joint strategy sets direction for EMA and EU medicines regulatory agencies to 2025

      January 1, 2021

      News in general

      Societal Impact of Pain Stakeholder Forum

      December 1, 2020

      News in general

      EAN participation in EMA and COVID-19

      December 1, 2020

      Topic of the Month/Week

      Brain Awareness Week (BAW) is the global campaign to increase public awareness of the progress and benefits of brain research

      March 13, 2018

      Topic of the Month/Week

      Dystonia Europe celebrates 25 years

      March 13, 2018

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Surveys

      SURVEY: Driving with an intracranial tumor

      June 25, 2020

      Surveys

      EAN SURVEY: Neurological Symptoms in COVID-19 Patients

      April 10, 2020

      Surveys

      EMA communication: ICH Good Clinical Practice Guidelines (ICH E6) – Open Comment Opportunity – Deadline: 1 November 2019

      October 7, 2019

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Uncategorized

      Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform

      December 2, 2020

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (New Zealand)

      November 24, 2020

      Uncategorized

      Report from the annual Pain Forum meeting

      November 2, 2020

  • EAN
  • Congress 2020
  • Congress 2021
  • EAN pages
  • Eur J Neurol
  • Virtual Congress

eanpages

  • General interest
    • All COVID-19 Executive Page Country of the Month Paper of the Month EAN News EAN Congress news Interviews
      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      COVID-19

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      COVID-19

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Executive Page

      Executive Page: Recap of 2020 from Secretary-General

      December 1, 2020

      Executive Page

      Executive Page: Dafin Muresanu reelected as Chair of Communication Committee

      November 1, 2020

      Country of the Month

      Country of the Month: Albania

      December 1, 2020

      Country of the Month

      Country of the Month: The Netherlands

      November 1, 2020

      Country of the Month

      Country of the Month: Serbia

      October 1, 2020

      Country of the Month

      Country of the Month: Kazakhstan

      September 1, 2020

      Paper of the Month

      COVID-19 Paper of the month: Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

      January 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial

      January 1, 2021

      Paper of the Month

      Covid-19 Papers of the month: ”COVID-19 case fatality and Parkinson’s disease” and ”Multiple sclerosis and COVID-19: how many are at risk?”

      December 1, 2020

      Paper of the Month

      Research Paper of the Month: The burden of neurological diseases in Europe: an analysis for the Global Burden of Disease Study 2017

      December 1, 2020

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      EAN News

      Welcome to new year by Editor-in-Chief

      January 1, 2021

      EAN News

      Congress Registration is open

      December 15, 2020

      EAN News

      Abstract Submission is open

      December 15, 2020

      EAN Congress news

      Congress Registration is open

      December 15, 2020

      EAN Congress news

      Abstract Submission is open

      December 15, 2020

      EAN Congress news

      EAN announces Virtual Congress in 2021

      December 1, 2020

      EAN Congress news

      Investigator Award Winners 2020

      September 14, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Interviews

      Interview of the Month with Marco Medina, President of PAFNS

      January 1, 2021

      Interviews

      External Interview – Asian Oceanian Association of Neurology

      November 1, 2020

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee, interviews Prof. Jean-Antoine Girault, President of FENS – Federation of European Neuroscience Societies

      October 1, 2020

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      Academic/Scientific

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      COVID-19

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      Breaking news

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      Breaking news

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      Breaking news

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Neurology updates

      Neurology Update: Rare Diseases

      December 1, 2020

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

      Scientific Corner

      New Registrar’s Reading Lists from the Higher Cortical Functions Scientific Panel

      January 17, 2020

  • Educational
    • All E-Brain Grand Rounds Continuing medical education Resident and Research Fellows Fellowship reports Education corner
      General interest

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Educational

      Clinical Fellowship 2021 winners

      January 1, 2021

      Educational

      Clinical Fellowship Reports 2019 III

      December 21, 2020

      Educational

      Clinical Fellowship Reports 2019 II

      December 21, 2020

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Resident and Research Fellows

      EAN Virtual Congress: Round table Special Session: Unleash your potential with EAN!

      May 24, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019 III

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019 II

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019

      November 2, 2020

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Education corner

      EAN Spring School – Application Deadline is 31 January 2021

      December 21, 2020

      Education corner

      Research Fellowship winners 2021

      December 1, 2020

      Education corner

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

  • Miscellanea
    • All Holiday Calendar Grant opportunities News from EAN member societies EBC EFNA News in general Topic of the Month/Week Patients societies reports Surveys Forum Uncategorized
      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Miscellanea

      Alzheimer Europe launches new guide targeted at health and social care workers and a policy briefing on intercultural care and support

      January 1, 2021

      Miscellanea

      Alzheimer Europe Policy Report – Dementia as a European Priority

      January 1, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

      Holiday Calendar

      23.12. Last-minute gift idea

      December 23, 2018

      Holiday Calendar

      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      News from EAN member societies

      2020 – BioMed Alliance celebrates 10 years of existence

      January 1, 2021

      News from EAN member societies

      New BioMed Alliance Statement: Open Access Initiatives must not create inequality

      November 1, 2020

      News from EAN member societies

      Health partnership proposal paves the way for greater role for stakeholders

      October 1, 2020

      EBC

      EBC launches new series of disease fact sheets!

      December 1, 2020

      EBC

      Present Your Business or Idea at the Brain Innovation Days Pitch Competition

      October 27, 2020

      EBC

      Save the date for the Brain Innovation Days launch!

      October 1, 2020

      EBC

      The EBC releases its 2019 Annual Report

      September 1, 2020

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      EFNA

      EFNA Advocacy Awards 2021 – ‘Action Against Stigma’

      October 1, 2020

      EFNA

      EFNA Annual Report 2019 Published

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General interestInterviewsTop Articles

Interview with Prof. Angela Vincent

March 1, 2018

 

 

Prof. Angela Vincent

Emeritus Professor, University of Oxford
Fellow of Somerville College, Oxford
Awardee of the Camillo Golgi Lecture at the 3rd EAN Congress in Amsterdam 2017

 

 

 

Elena Moro: Dear Prof. Vincent, you have recently been awarded with the WFN Medal for Scientific Achievement in Neurology. We congratulate with you for this well-deserved outstanding recognition!
In light of your longstanding experience in the world of neuro-immunology in particular, what do you think is it the most recent important discovery in your field?

Angela Vincent (AV): Well first of all thank you for the congratulations.  I am thrilled to receive the WFN Medal and it is much appreciated.

Neuroimmunology is a relatively recent discipline – probably only first defined in the 1980s.  It includes not only the work on antibody-mediated diseases, which is my interest, but also experimental and clinical work on multiple sclerosis and other disorders and, more recently, growing attempts to demonstrate a role of the immune system in neurodegenerative diseases.

In terms of direct clinical relevance to these diseases, there is no doubt that the development of drugs, mainly monoclonal antibodies, that target different cells or processes of the immune system has proved very important for the treatment of multiple sclerosis and increasingly other conditions.  On a smaller scale, but equally exciting, is the growing number of antibody-mediated disorders of the central nervous system (CNS) which often respond to other, more conventional, immunotherapies such as steroids, plasma exchange and intravenous immunoglobulins.

This field really started in the 1970s with the discovery of antibodies to the acetylcholine receptors in myasthenia gravis but until the 1990s, new discoveries were made essentially only in the peripheral nervous system.  The change to the central nervous system started almost 20 years ago when we first began to identify “voltage-gated potassium channel (VGKC)” antibodies in patients with peripheral hyperexcitability syndromes, some of whom had evident central nervous system symptoms.  The first patients with predominant CNS disease with highly raised VGKC-antibodies had limbic encephalitis and Morvan’s syndrome respectively (both published 2001).  Previously, limbic encephalitis had mostly been considered “paraneoplastic” with antibodies against intracellular proteins such as “Hu” and “Yo” and these antibodies were not associated with immunotherapy-responses, but one of our two patients with classical limbic encephalitis had no tumour and recovered spontaneously over-time, whilst the other had myasthenia gravis associated thymoma and recovered with immunotherapies. These case reports, and the Morvan’s syndrome patient who also responded very well to plasma exchange, provided the first strong clinical evidence that antibodies could cause CNS disease, and questioned the old dogma that antibodies could not get into the brain.  It was only later that we showed that the VGKC-antibodies targeted associated proteins, CASPR2 and LGI1, rather than the VGKC itself.  CASPR2 antibodies are frequently found in Morvan’s syndrome and LGI1 antibodies in limbic encephalitis.  A very interesting discovery by my former clinical fellow, Dr Sarosh Irani and his collaborators, is of a specific and previously unrecognised form of epilepsy – now known as faciobrachial dystonic seizures – that is strongly associated with LGI1 antibodies and often predates the development of limbic encephalitis.   Dr Irani now heads the Oxford group.

There is no doubt, however, that the discovery by Prof Josep Dalmau’s group of the NMDAR-antibody form of autoimmune encephalitis in 2007, which mostly presents in young female adults and in children of both sexes, is the most important, treatable antibody-mediated disease.  The movement disorder with loss of consciousness and autonomic instability that these patients develop, often means many weeks or months in intensive care, with the need for multiple immunotherapies and symptomatic treatments before they begin to recover.  Strikingly, recovery is often very good and even apparently complete.  Working as I have been doing with the paediatric neurologists in the UK and elsewhere to help diagnose and study this condition in children has been a privilege and very satisfying.

Scientifically, there is still much to be discovered.  We don’t really know fully the mechanisms by which the NMDAR and other antibodies cause disease.  There are lots of unanswered questions but there are limitations on experimental models for these disorders – and the number of laboratories with experience in their use – and the questions are not easy to answer in man.  However, one aspect that is definitely beginning to have an impact is the use of cutting edge imaging techniques to map the structural and functional changes in brain connectivity during and following treatments for the antibody-mediated conditions.  Up till now the results are partly confounded by heterogeneity in the patients, their treatments and duration of disease, but there are certainly some interesting observations being made, including changes in brain structure or function that may not only reflect the effects of the antibodies, but may also be secondary, compensatory changes that occur over time.

EM: What importance takes the study of neuro-immunology when considering clinical neurology?

AV: Because the recently discovered antibody-mediated diseases are immunotherapy responsive, their identification in patients usually leads to immunotherapies.  It is thought that prompt treatment leads to quicker results, and less time in intensive care, although it is difficult to be certain as patients are very variable in their severity and the natural progression of the disease.  In any case, the response to treatment, even if it requires patience and perseverance, means that the neurologists are very keen to identify the patients.  For this reason, although the individual antibody-mediated disorders are all rare compared with common disorders like Parkinson’s, their identification has made a real change in the manner in which clinicians approach patients with unexplained memory problems, seizures, psychiatric features and movement disorders.  Many now think “could this be an antibody-mediated disease?” This is a real change from former decades.

EM: Can you tell the readers of EAN Pages about your career? What brought you to the study of neuro-immunology and the worldwide character of your work?

AV: I usually describe my career as a mixture of “science and serendipity”!  I qualified as a doctor in the 1960s and enjoyed my first year of internship but I found clinical medicine at that time to be often lacking in scientific background – and also lacking in clinicians who wanted to investigate the mechanisms of disease.  I decided to study biochemistry which gave me the credentials to do laboratory work, and I planned to spend my time in the basic sciences which appealed to me intellectually.   By a series of lucky accidents I got involved with some of the early studies of acetylcholine receptors with Ricardo Miledi at University College in London, and this led to our first work on myasthenia gravis collaborating with the neurologist John Newsom-Davis.  It was not long before I joined John at the Royal Free Hospital in London, where together we set up the Neuroimmunology Group.  Ten years later 16 members of the Group moved to Oxford when John became Professor of Neurology there, and the Group has flourished since then.  We began to attract visiting clinical fellows from around the world and that meant that international collaborations were set up.  When I took over as leader, on Johns’ retirement in 1998, I was able to expand our interests from the periphery, where we had focused mostly on myasthenia gravis  and the Lambert Eaton syndrome, and begin to move cautiously towards the CNS.  At the same time, as our interests widened, so also did the need for the clinical diagnostic service that I had established, and this became a centre for the testing of antibodies in samples sent from around the globe, first from previous fellows and then increasingly from those who had read our publications.  Trying to help these doctors to diagnose their patients was gratifying both personally and also in helping to extend the clinical features encountered.  In rare cases it led to identification of new antibodies. I feel that the WFN Medal is at least partly justified by my efforts to harness our expertise to help others.

EM: Your outstanding work and teaching experiences stand as a role model for scientists and neurologists in training. What would be your advice to neurologists who start up their career?

AV: My advice is rather simple and is the same to everyone whatever their field.  Find out what you are good at and do it as well as you can.  For the clinical doctors, identify novel phenotypes and write them up – they often stimulate research and new ideas and may help you get a Fellowship to pursue them.  For those already in a laboratory, don’t ignore experimental results that don’t fit neatly into your expectations, but use them to stimulate new ideas.  Pursue these ideas first with simple experiments or collaborations, and then let them help shape your future career.

Good fortune and serendipity really has played a large part, but nothing would have been possible the without bright young people, both clinicians and basic scientists, who have spent time in our lab, and the wonderful, supportive and enthusiastic longer-term colleagues who have been the backbone of our Group over more than 30 years.

by Elena Moro, Editor-in-chief EAN Pages

Interview with Prof. Angela Vincent was last modified: November 12th, 2018 by Editor
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