Better understanding of RLS and narcolepsy neurobiology
Anectdotal evidence has pointed out clinical improvements narcolepsy-specific symptoms following treatment of painful conditions with opiates. Post-mortem findings in human brains revealed a significant increase of hypocretin neurons on patients abusing opiates. Thannickal et al. showed that 14-day administration of morphine led to a significant increase of hypocretin neurons in narcoleptic mice and, moreover, to a marked decrease of cataplexy.
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