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  • General interest
    • All COVID-19 Executive Page Country of the Month Paper of the Month EAN News EAN Congress news Interviews
      General interest

      Fellow of EAN awarded 2021 Brain Prize

      March 4, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Cape Verde)

      March 3, 2021

      General interest

      Brain Talks: Professor Günther Deuschl addresses burden of neurological diseases in Europe

      March 3, 2021

      COVID-19

      Serum and CSF alpha-synuclein levels do not change in COVID-19 patients with neurological symptoms

      March 3, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Cape Verde)

      March 3, 2021

      COVID-19

      Serum and CSF alpha-synuclein levels do not change in COVID-19 patients with neurological symptoms

      March 3, 2021

      COVID-19

      COVID-19 continuous-EEG case series: A Descriptive Study

      March 3, 2021

      COVID-19

      Acute ischemic stroke and COVID-19: An analysis of 27 676 Patients

      March 3, 2021

      Executive Page

      Executive page: From Website editor to Co-Chair Communication Committee

      February 1, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Executive Page

      Executive Page: Recap of 2020 from Secretary-General

      December 1, 2020

      Country of the Month

      Country of the Month: Lithuania

      March 1, 2021

      Country of the Month

      Country of the Month: Albania

      December 1, 2020

      Country of the Month

      Country of the Month: The Netherlands

      November 1, 2020

      Country of the Month

      Country of the Month: Serbia

      October 1, 2020

      Paper of the Month

      COVID-19 Paper of the month: A non-inflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

      March 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and Efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe Study)

      March 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine

      February 1, 2021

      Paper of the Month

      Research Paper of the month: Trial of dexamethasone for chronic subdural hematoma

      February 1, 2021

      EAN News

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      EAN News

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      EAN News

      Welcome to new year by Editor-in-Chief

      January 1, 2021

      EAN Congress news

      Congress Registration is open

      December 15, 2020

      EAN Congress news

      Abstract Submission is open

      December 15, 2020

      EAN Congress news

      EAN announces Virtual Congress in 2021

      December 1, 2020

      EAN Congress news

      Investigator Award Winners 2020

      September 14, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Cape Verde)

      March 3, 2021

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee interviews Prof. Raad Shakir, CBE

      March 1, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (South Africa)

      February 5, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Japan)

      February 1, 2021

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      General interest

      Brain Talks: Professor Günther Deuschl addresses burden of neurological diseases in Europe

      March 3, 2021

      COVID-19

      Serum and CSF alpha-synuclein levels do not change in COVID-19 patients with neurological symptoms

      March 3, 2021

      COVID-19

      COVID-19 continuous-EEG case series: A Descriptive Study

      March 3, 2021

      COVID-19

      Acute ischemic stroke and COVID-19: An analysis of 27 676 Patients

      March 3, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      Serum and CSF alpha-synuclein levels do not change in COVID-19 patients with neurological symptoms

      March 3, 2021

      Breaking news

      COVID-19 continuous-EEG case series: A Descriptive Study

      March 3, 2021

      Breaking news

      Acute ischemic stroke and COVID-19: An analysis of 27 676 Patients

      March 3, 2021

      Breaking news

      Inflammatory cytokine patterns associated with neurological diseases in COVID-19

      March 3, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Neurology updates

      Neurology Update: Dementia and cognitive disorders

      February 18, 2021

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      The Future of Brain Research: EU-Initiatives and Experts Together for a Shared European Brain Research Agenda

      March 1, 2021

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

  • Educational
    • All E-Brain Grand Rounds Continuing medical education Resident and Research Fellows Fellowship reports Education corner
      Educational

      Clinical Fellowship Reports 2020

      March 1, 2021

      Educational

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      Educational

      Clinical Fellowship Reports 2019

      March 1, 2021

      Academic/Scientific

      New Scales & Scores on Dementia

      February 11, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Resident and Research Fellows

      EAN Virtual Congress: Round table Special Session: Unleash your potential with EAN!

      May 24, 2020

      Fellowship reports

      Clinical Fellowship Reports 2020

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2019

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports III 2019

      February 1, 2021

      Fellowship reports

      Clinical Fellowship Reports II 2019

      February 1, 2021

      Education corner

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      Education corner

      New Scales & Scores on Dementia

      February 11, 2021

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Education corner

      EAN Spring School – Application Deadline is 5 February 2021

      December 21, 2020

  • Miscellanea
    • All Holiday Calendar Grant opportunities News from EAN member societies EBC EFNA News in general Topic of the Month/Week Patients societies reports Surveys Forum Uncategorized
      Miscellanea

      FLAG-ERA Calls

      March 4, 2021

      News from EAN member societies

      News from EMA: First oral treatment for spinal muscular atrophy (SMA) recommended for approval

      March 3, 2021

      General interest

      Brain Talks: Professor Günther Deuschl addresses burden of neurological diseases in Europe

      March 3, 2021

      Miscellanea

      Alzheimer Europe adds two new trials to its Clinical Trials Watch

      March 1, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

      Holiday Calendar

      23.12. Last-minute gift idea

      December 23, 2018

      Holiday Calendar

      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      News from EMA: First oral treatment for spinal muscular atrophy (SMA) recommended for approval

      March 3, 2021

      News from EAN member societies

      EMA’s Webinar on ”COVID-19 vaccination – what you need to know as a health professional”

      February 5, 2021

      News from EAN member societies

      Personalized plans, blood biomarkers and early interventions: Think Brain Health conference highlights

      February 1, 2021

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      EBC

      EBC launches statement on the impact of COVID-19 on brain health

      February 1, 2021

      EBC

      EBC launches new series of disease fact sheets!

      December 1, 2020

      EBC

      Present Your Business or Idea at the Brain Innovation Days Pitch Competition

      October 27, 2020

      EBC

      Save the date for the Brain Innovation Days launch!

      October 1, 2020

      EFNA

      EFNA launch eLearning Platform for neurology advocates

      February 1, 2021

      EFNA

      ‘Me and My Brain’ – Art Competition winners announced!

      February 1, 2021

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      EFNA

      EFNA Advocacy Awards 2021 – ‘Action Against Stigma’

      October 1, 2020

      News in general

      WFN Brain Health Awareness Public Webinar

      February 16, 2021

      News in general

      EBC launches statement on the impact of COVID-19 on brain health

      February 1, 2021

      News in general

      European Neuromuscular Centre (ENMC) – Mid-Career Mentoring Programme

      February 1, 2021

      News in general

      Alzheimer Europe launches new guide targeted at health and social care workers and a policy briefing on intercultural care and support

      January 1, 2021

      Topic of the Month/Week

      Brain Awareness Week (BAW) is the global campaign to increase public awareness of the progress and benefits of brain research

      March 13, 2018

      Topic of the Month/Week

      Dystonia Europe celebrates 25 years

      March 13, 2018

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Surveys

      SURVEY: Driving with an intracranial tumor

      June 25, 2020

      Surveys

      EAN SURVEY: Neurological Symptoms in COVID-19 Patients

      April 10, 2020

      Surveys

      EMA communication: ICH Good Clinical Practice Guidelines (ICH E6) – Open Comment Opportunity – Deadline: 1 November 2019

      October 7, 2019

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Uncategorized

      Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform

      December 2, 2020

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (New Zealand)

      November 24, 2020

      Uncategorized

      Report from the annual Pain Forum meeting

      November 2, 2020

  • EAN
  • Congress 2020
  • Congress 2021
  • EAN pages
  • Eur J Neurol
  • Virtual Congress

eanpages

  • General interest
    • All COVID-19 Executive Page Country of the Month Paper of the Month EAN News EAN Congress news Interviews
      General interest

      Fellow of EAN awarded 2021 Brain Prize

      March 4, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Cape Verde)

      March 3, 2021

      General interest

      Brain Talks: Professor Günther Deuschl addresses burden of neurological diseases in Europe

      March 3, 2021

      COVID-19

      Serum and CSF alpha-synuclein levels do not change in COVID-19 patients with neurological symptoms

      March 3, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Cape Verde)

      March 3, 2021

      COVID-19

      Serum and CSF alpha-synuclein levels do not change in COVID-19 patients with neurological symptoms

      March 3, 2021

      COVID-19

      COVID-19 continuous-EEG case series: A Descriptive Study

      March 3, 2021

      COVID-19

      Acute ischemic stroke and COVID-19: An analysis of 27 676 Patients

      March 3, 2021

      Executive Page

      Executive page: From Website editor to Co-Chair Communication Committee

      February 1, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Executive Page

      Executive Page: Recap of 2020 from Secretary-General

      December 1, 2020

      Country of the Month

      Country of the Month: Lithuania

      March 1, 2021

      Country of the Month

      Country of the Month: Albania

      December 1, 2020

      Country of the Month

      Country of the Month: The Netherlands

      November 1, 2020

      Country of the Month

      Country of the Month: Serbia

      October 1, 2020

      Paper of the Month

      COVID-19 Paper of the month: A non-inflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

      March 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and Efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe Study)

      March 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine

      February 1, 2021

      Paper of the Month

      Research Paper of the month: Trial of dexamethasone for chronic subdural hematoma

      February 1, 2021

      EAN News

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      EAN News

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      EAN News

      Welcome to new year by Editor-in-Chief

      January 1, 2021

      EAN Congress news

      Congress Registration is open

      December 15, 2020

      EAN Congress news

      Abstract Submission is open

      December 15, 2020

      EAN Congress news

      EAN announces Virtual Congress in 2021

      December 1, 2020

      EAN Congress news

      Investigator Award Winners 2020

      September 14, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Cape Verde)

      March 3, 2021

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee interviews Prof. Raad Shakir, CBE

      March 1, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (South Africa)

      February 5, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Japan)

      February 1, 2021

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      General interest

      Brain Talks: Professor Günther Deuschl addresses burden of neurological diseases in Europe

      March 3, 2021

      COVID-19

      Serum and CSF alpha-synuclein levels do not change in COVID-19 patients with neurological symptoms

      March 3, 2021

      COVID-19

      COVID-19 continuous-EEG case series: A Descriptive Study

      March 3, 2021

      COVID-19

      Acute ischemic stroke and COVID-19: An analysis of 27 676 Patients

      March 3, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      Serum and CSF alpha-synuclein levels do not change in COVID-19 patients with neurological symptoms

      March 3, 2021

      Breaking news

      COVID-19 continuous-EEG case series: A Descriptive Study

      March 3, 2021

      Breaking news

      Acute ischemic stroke and COVID-19: An analysis of 27 676 Patients

      March 3, 2021

      Breaking news

      Inflammatory cytokine patterns associated with neurological diseases in COVID-19

      March 3, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Neurology updates

      Neurology Update: Dementia and cognitive disorders

      February 18, 2021

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      The Future of Brain Research: EU-Initiatives and Experts Together for a Shared European Brain Research Agenda

      March 1, 2021

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

  • Educational
    • All E-Brain Grand Rounds Continuing medical education Resident and Research Fellows Fellowship reports Education corner
      Educational

      Clinical Fellowship Reports 2020

      March 1, 2021

      Educational

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      Educational

      Clinical Fellowship Reports 2019

      March 1, 2021

      Academic/Scientific

      New Scales & Scores on Dementia

      February 11, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Resident and Research Fellows

      EAN Virtual Congress: Round table Special Session: Unleash your potential with EAN!

      May 24, 2020

      Fellowship reports

      Clinical Fellowship Reports 2020

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2019

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports III 2019

      February 1, 2021

      Fellowship reports

      Clinical Fellowship Reports II 2019

      February 1, 2021

      Education corner

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      Education corner

      New Scales & Scores on Dementia

      February 11, 2021

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Education corner

      EAN Spring School – Application Deadline is 5 February 2021

      December 21, 2020

  • Miscellanea
    • All Holiday Calendar Grant opportunities News from EAN member societies EBC EFNA News in general Topic of the Month/Week Patients societies reports Surveys Forum Uncategorized
      Miscellanea

      FLAG-ERA Calls

      March 4, 2021

      News from EAN member societies

      News from EMA: First oral treatment for spinal muscular atrophy (SMA) recommended for approval

      March 3, 2021

      General interest

      Brain Talks: Professor Günther Deuschl addresses burden of neurological diseases in Europe

      March 3, 2021

      Miscellanea

      Alzheimer Europe adds two new trials to its Clinical Trials Watch

      March 1, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

      Holiday Calendar

      23.12. Last-minute gift idea

      December 23, 2018

      Holiday Calendar

      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      News from EMA: First oral treatment for spinal muscular atrophy (SMA) recommended for approval

      March 3, 2021

      News from EAN member societies

      EMA’s Webinar on ”COVID-19 vaccination – what you need to know as a health professional”

      February 5, 2021

      News from EAN member societies

      Personalized plans, blood biomarkers and early interventions: Think Brain Health conference highlights

      February 1, 2021

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      EBC

      EBC launches statement on the impact of COVID-19 on brain health

      February 1, 2021

      EBC

      EBC launches new series of disease fact sheets!

      December 1, 2020

      EBC

      Present Your Business or Idea at the Brain Innovation Days Pitch Competition

      October 27, 2020

      EBC

      Save the date for the Brain Innovation Days launch!

      October 1, 2020

      EFNA

      EFNA launch eLearning Platform for neurology advocates

      February 1, 2021

      EFNA

      ‘Me and My Brain’ – Art Competition winners announced!

      February 1, 2021

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      EFNA

      EFNA Advocacy Awards 2021 – ‘Action Against Stigma’

      October 1, 2020

      News in general

      WFN Brain Health Awareness Public Webinar

      February 16, 2021

      News in general

      EBC launches statement on the impact of COVID-19 on brain health

      February 1, 2021

      News in general

      European Neuromuscular Centre (ENMC) – Mid-Career Mentoring Programme

      February 1, 2021

      News in general

      Alzheimer Europe launches new guide targeted at health and social care workers and a policy briefing on intercultural care and support

      January 1, 2021

      Topic of the Month/Week

      Brain Awareness Week (BAW) is the global campaign to increase public awareness of the progress and benefits of brain research

      March 13, 2018

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EAN Congress newsTop Articles

Plenary Symposium 2: Presidential Symposium Report

July 1, 2019

Presidential Symposium Report

By Tom Jenkins and Tim Von Oertzen

 

The Brain Prize Lecture: The prodromal cellular phase of Alzheimer’s disease (AD): toward a novel understanding of the disorder

Charles Edouard Brown-Séquard Lecture: Do we need to reinvent translational cerebrovascular research?

The Moritz Romberg Lecture: Translational neuroscience to improve outcomes for MND: are we winning?

 

The Brain Prize Lecture was given by Prof Bart De Strooper, a world-leading expert on the pathogenesis of Alzheimer’s disease, who works both at the University of Leuven, Belgium and University College London, UK. His lecture was titled: “The prodromal cellular phase of Alzheimer’s disease (AD): toward a novel understanding of the disorder”. He started by pointing out the need for investment into this huge healthcare challenge, offering parallels with cancer research, then took us through familial AD. He described the three known genetic causes of AD: amyloid precursor protein and presenilin 1 and 2, and the role of secretases which cleave amyloid-beta. Destabilisation of presenilin causes release of longer amyloid-beta peptides, which are associated with younger onset AD. So, amyloid-beta and secretase cleavage appear central at a molecular mechanistic level, but unfortunately therapeutic trials- 234 to date- targeting these pathways have so far been unsuccessful. An example was the trial of semagacestat, which targets gamma secretase pathways, but Prof De Strooper pointed out that there may have been pharmacokinetic reasons for this: the compound has a very short half-life and, although beta amyloid levels were demonstrated to decrease in blood, no effect on cerebrospinal fluid levels was evident. Therefore, the dose may have been sub-therapeutic, by trying to minimise side effects. Further trials targeting this pathway and addressing methodological issues may be indicated.

The second reason for failure of clinical trials may be the time factor. Amyloid, and then tau, increase up to 30 years before brain structural changes and clinical features develop, so we may be treating too late; by analogy with cancer, perhaps we are treating during the metastatic phase.

Twins studies have shown that two thirds of the risk for sporadic disease is genetic. Genome-wide association studies have identified around 1000 risk genes, and polygenic risk scores can be calculated. Interestingly, there is good evidence that genetic risk is related to microglial responses to amyloid plaques (but not tangles). Transcriptomic work has demonstrated upregulation of microglial, astroglial and complement genes in response to amyloid, in linked patterns suggesting a regulatory network. This raises the possibility that amyloid plaques are the trigger but not the driver for AD. The driver may instead be the microglial response, which is dependent on polygenic risk. Neurodegeneration appears a downstream event from inflammation. Prof De Strooper advocated being more proactive to detect AD earlier in the future. A tailored approach is likely to be required, through a combination of individual genetic profiling, home cognitive tests, and early combination therapeutics which will probably need to address both triggers and drivers: anti-amyloid, anti-inflammatory and novel genetic approaches.

Prof. Ulrich Dirnagl started his lecture by interpreting the title slightly different: Increasing value and reducing waste in translational neuroscience.

At the beginning of the era of translational cerebrovascular research, it was the general opinion, that any change in stroke is down to lack of perfusion only. Since the 1990’s publications in the field of basic science in cerebrovascular translational research (CVTR) have started to increase and have continued to increase steadily to over 3000 per year. Even in the most recent time, several publication in Nature featured CVTR indicating involvement of capillary pericytes in regulating cerebral blood flow, transfer of mitochondria post stroke from astrocytes to neurons, and suppression of astrogliosis and potential recovery by brain regulating T-cells. All of this in mice, in models of cerebrovascular disease. He mentioned the frequently discussed article titled ‘Restoration of brain circulation and cellular function hours after post-mortem’ and added … in pigs. In summary, during the last decades CVTR identified the complex pathobiology of tissue damages in stroke involving not only neurons but astrocytes, oligodendrocytes, microglia, basal membrane, extracellular space, pericytes, endothelium, and last not least immune cells. The time course of the changes after the stroke onset identifies mechanisms of damage as well as endogenous brain protection as well as plasticity, regeneration and repair. Finally a pooled analysis of neuroprotection trials identified that all interventions reported showed a protective effect in the animal models.

Referring to movie title, the ‘trouble in paradise’ is that those results have been shown in rats and mice mostly, and similar trials for neuroprotection in humans failed to show positive or significant effect.

Prof Dirnagl did scrutinize the success of CVTR. Have been decades of hard work and investment of funding been wasted? Can you compare mice to man?

Indeed there is good data that time windows in acute stroke are comparable between mice and man. Although the developments of treatment progress in stroke came from clinical research, this might have been the low hanging fruits. In contrast, in (CV)TR many studies have had only 8 animals investigated. Clinical trial designs for neuroprotection had a mean inclusion time window of 16 hours, which well beyond the clinical applied time windows.   Changing the concept of studying animal models in larger numbers, in blinded study designs, developing more appropriate study designs and other changes will reduce bias and increase quality of results. Increasing internal validity, sample sizes, external validity, and report of neutral and negative results should define the new standard. Open data policies, collaboration in multicenter trials and preregistration of study protocols will support this development. All those measure will open the chance to develop new treatments based on results of translational neuroscience research.

The Moritz Romberg lecture was delivered by Professor Dame Pamela Shaw from the University of Sheffield, UK, an international expert in motor neuron disease (MND) research and clinical care. Her lecture was entitled “Translational neuroscience to improve outcomes for MND: are we winning?” She started by acknowledging several giants of European neurology from the past, and moved on to describe the anatomy of the motor neuron, and the burden of its dysfunction in motor neuron disease (MND). MND is a clinically, genetically, pathologically and prognostically heterogeneous condition. Advances in genetics and their contribution to understanding pathophysiological mechanisms were highlighted, including the most prevalent gene, C9ORF72, the basis of mouse models, SOD1, and a more recent discovery from Prof Shaw’s group, GLT8D1, which implicates ganglioside dysfunction. In terms of pathology, MND is a TDP-43 proteinopathy in most cases, characterised by protein mislocalisation from the nucleus to the cytoplasm. Importantly, SOD1 MND, unlike most other forms of MND lacks TDP-43 pathology. In C9ORF72 disease, there is TDP-43 proteinopathy but also additional dipeptide repeats, which are thought to contribute to toxicity. In addition to proteinopathy, at least 11 inter-connected molecular pathways and mechanisms have been implicated in pathophysiology, and this complexity has contributed towards difficulties in developing disease-modifying therapies.

Meanwhile, advances have been made in clinical care. Multidisciplinary care has been demonstrated to improve survival compared to care in general neurology clinics, independent of gastrostomy, non-invasive ventilation and riluzole. An important advance was the development of non-invasive ventilation, which was shown to improve not only survival, but also quality of life. The head-up collar was developed in Sheffield to address the troublesome symptom of neck weakness, in collaboration with engineers and utilising a patient-centred design process.

Prof Shaw described the fundamentals of a translational neuroscientific approach. Candidate genes are identified, give clues to mechanisms, which are then explored in fruit fly, zebra fish (and elegant model by which linkage to a heat-shock protein makes damaged motor neurons glow red in the transparent fish) and mouse models. Human biosamples are collected, including skin samples, which can be reprogrammed to develop motor neuron and astrocyte co-cultures. Astrocytes from MND patients are toxic to motor neurons in culture, and can be used for drug screening, first in vitro, then in vivo to determine influences on pathogenic mechanisms in animal models, and finally to proof of concept in human observational studies, effects on biomarkers and drug trials.

Promising new potential therapeutic targets were discussed. The nuclear factor erythroid-2-related factor 2 (NRF2) pathway is a response to oxidative stress, with links to multiple implicated mechanisms in MND. This protective system is downregulated in MND. Slow progressing strains of the SOD1 mouse activate this pathway, whereas fast-progressing mice do not. NRF2 is protective in human in vitro cell models, and in vivo mouse models, reducing levels of oxidised glutathione in the spinal cord. This has led to identification of new compounds to test through drug screening programmes.

A second exciting target is knockdown of nuclear export factors in C9ORF72-related genetic MND. Pathogenic mechanisms in C9ORF72 include haploinsufficiency, protein sequestration or production of toxic dipeptide repeat proteins. A puzzle has been how normal nuclear retention mechanisms are overridden in order for abnormal C9ORF72 messenger RNA to escape the nucleus and be translated into dipeptide repeat proteins. A nuclear export factor named SRSF1 is implicated and motor neuron loss is prevented in human cell cultures in which it is knocked down. This provides a target to treat C9ORF72-related MND.

Gene silencing is an exciting new research direction. Delivery is an issue in genetic therapeutics and viral vectors are generally used, for example, to enable retrograde transport of genes to spinal cord motor neurons. The development of adenoviruses was an important advance, and 60-80% knockdown of SOD1 in primate models via cerebrospinal fluid injection was shown using this technique. Recent approaches have utilised antisense oligonucleotides, such a tofersen, given in escalating doses to 50 SOD1 MND patients for 12 weeks in a phase 1 trial. The therapy appeared safe and, at the highest dose, encouraging results suggesting efficacy were even seen in a small group of 12 patients of rapid progressors, which has led to an ongoing phase III trial.

Exciting developments are occurring in MND therapeutics. While people living with MND wait, high quality symptomatic care improves outcomes and quality of life.

Plenary Symposium 2: Presidential Symposium Report was last modified: July 1st, 2019 by Editor
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