eanpages
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    • All COVID-19 Executive Page Country of the Month Paper of the Month EAN News EAN Congress news Interviews
      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      COVID-19

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      COVID-19

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Executive Page

      Executive Page: Recap of 2020 from Secretary-General

      December 1, 2020

      Executive Page

      Executive Page: Dafin Muresanu reelected as Chair of Communication Committee

      November 1, 2020

      Country of the Month

      Country of the Month: Albania

      December 1, 2020

      Country of the Month

      Country of the Month: The Netherlands

      November 1, 2020

      Country of the Month

      Country of the Month: Serbia

      October 1, 2020

      Country of the Month

      Country of the Month: Kazakhstan

      September 1, 2020

      Paper of the Month

      COVID-19 Paper of the month: Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

      January 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial

      January 1, 2021

      Paper of the Month

      Covid-19 Papers of the month: ”COVID-19 case fatality and Parkinson’s disease” and ”Multiple sclerosis and COVID-19: how many are at risk?”

      December 1, 2020

      Paper of the Month

      Research Paper of the Month: The burden of neurological diseases in Europe: an analysis for the Global Burden of Disease Study 2017

      December 1, 2020

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

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      Congress Registration is open

      December 15, 2020

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      Abstract Submission is open

      December 15, 2020

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      Congress Registration is open

      December 15, 2020

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      Abstract Submission is open

      December 15, 2020

      EAN Congress news

      EAN announces Virtual Congress in 2021

      December 1, 2020

      EAN Congress news

      Investigator Award Winners 2020

      September 14, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Interviews

      Interview of the Month with Marco Medina, President of PAFNS

      January 1, 2021

      Interviews

      External Interview – Asian Oceanian Association of Neurology

      November 1, 2020

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee, interviews Prof. Jean-Antoine Girault, President of FENS – Federation of European Neuroscience Societies

      October 1, 2020

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      COVID-19

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      COVID-19

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

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      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      Breaking news

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      Breaking news

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      Breaking news

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Neurology updates

      Neurology Update: Rare Diseases

      December 1, 2020

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

      Scientific Corner

      New Registrar’s Reading Lists from the Higher Cortical Functions Scientific Panel

      January 17, 2020

      Scientific Corner

      New Scales & Scores from the Higher Cortical Functions Scientific Panel

      January 17, 2020

  • Educational
    • All E-Brain Grand Rounds Continuing medical education Resident and Research Fellows Fellowship reports Education corner
      General interest

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Educational

      Clinical Fellowship 2021 winners

      January 1, 2021

      Educational

      Clinical Fellowship Reports 2019 III

      December 21, 2020

      Educational

      Clinical Fellowship Reports 2019 II

      December 21, 2020

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Resident and Research Fellows

      EAN Virtual Congress: Round table Special Session: Unleash your potential with EAN!

      May 24, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019 III

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019 II

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019

      November 2, 2020

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Education corner

      EAN Spring School – Application Deadline is 31 January 2021

      December 21, 2020

      Education corner

      Research Fellowship winners 2021

      December 1, 2020

      Education corner

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

  • Miscellanea
    • All Holiday Calendar Grant opportunities News from EAN member societies EBC EFNA News in general Topic of the Month/Week Patients societies reports Surveys Forum Uncategorized
      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Miscellanea

      Alzheimer Europe launches new guide targeted at health and social care workers and a policy briefing on intercultural care and support

      January 1, 2021

      Miscellanea

      Alzheimer Europe Policy Report – Dementia as a European Priority

      January 1, 2021

      News from EAN member societies

      2020 – BioMed Alliance celebrates 10 years of existence

      January 1, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

      Holiday Calendar

      23.12. Last-minute gift idea

      December 23, 2018

      Holiday Calendar

      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      2020 – BioMed Alliance celebrates 10 years of existence

      January 1, 2021

      News from EAN member societies

      New BioMed Alliance Statement: Open Access Initiatives must not create inequality

      November 1, 2020

      News from EAN member societies

      Health partnership proposal paves the way for greater role for stakeholders

      October 1, 2020

      News from EAN member societies

      21 September: On World Alzheimer’s Day, Alzheimer Europe calls for urgent action to support dementia research

      October 1, 2020

      EBC

      EBC launches new series of disease fact sheets!

      December 1, 2020

      EBC

      Present Your Business or Idea at the Brain Innovation Days Pitch Competition

      October 27, 2020

      EBC

      Save the date for the Brain Innovation Days launch!

      October 1, 2020

      EBC

      The EBC releases its 2019 Annual Report

      September 1, 2020

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      EFNA

      EFNA Advocacy Awards 2021 – ‘Action Against Stigma’

      October 1, 2020

      EFNA

      EFNA Annual Report 2019 Published

      August 1, 2020

      EFNA

      Results of EFNA’s Survey on Stigma and Neurological Disorder

      July 22, 2020

      News in general

      Alzheimer Europe launches new guide targeted at health and social care workers and a policy briefing on intercultural care and support

      January 1, 2021

      News in general

      Joint strategy sets direction for EMA and EU medicines regulatory agencies to 2025

      January 1, 2021

      News in general

      Societal Impact of Pain Stakeholder Forum

      December 1, 2020

      News in general

      EAN participation in EMA and COVID-19

      December 1, 2020

      Topic of the Month/Week

      Brain Awareness Week (BAW) is the global campaign to increase public awareness of the progress and benefits of brain research

      March 13, 2018

      Topic of the Month/Week

      Dystonia Europe celebrates 25 years

      March 13, 2018

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Surveys

      SURVEY: Driving with an intracranial tumor

      June 25, 2020

      Surveys

      EAN SURVEY: Neurological Symptoms in COVID-19 Patients

      April 10, 2020

      Surveys

      EMA communication: ICH Good Clinical Practice Guidelines (ICH E6) – Open Comment Opportunity – Deadline: 1 November 2019

      October 7, 2019

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Uncategorized

      Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform

      December 2, 2020

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (New Zealand)

      November 24, 2020

      Uncategorized

      Report from the annual Pain Forum meeting

      November 2, 2020

  • EAN
  • Congress 2020
  • Congress 2021
  • EAN pages
  • Eur J Neurol
  • Virtual Congress

eanpages

  • General interest
    • All COVID-19 Executive Page Country of the Month Paper of the Month EAN News EAN Congress news Interviews
      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      COVID-19

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      COVID-19

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Executive Page

      Executive Page: Recap of 2020 from Secretary-General

      December 1, 2020

      Executive Page

      Executive Page: Dafin Muresanu reelected as Chair of Communication Committee

      November 1, 2020

      Country of the Month

      Country of the Month: Albania

      December 1, 2020

      Country of the Month

      Country of the Month: The Netherlands

      November 1, 2020

      Country of the Month

      Country of the Month: Serbia

      October 1, 2020

      Country of the Month

      Country of the Month: Kazakhstan

      September 1, 2020

      Paper of the Month

      COVID-19 Paper of the month: Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

      January 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial

      January 1, 2021

      Paper of the Month

      Covid-19 Papers of the month: ”COVID-19 case fatality and Parkinson’s disease” and ”Multiple sclerosis and COVID-19: how many are at risk?”

      December 1, 2020

      Paper of the Month

      Research Paper of the Month: The burden of neurological diseases in Europe: an analysis for the Global Burden of Disease Study 2017

      December 1, 2020

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      EAN News

      Welcome to new year by Editor-in-Chief

      January 1, 2021

      EAN News

      Congress Registration is open

      December 15, 2020

      EAN News

      Abstract Submission is open

      December 15, 2020

      EAN Congress news

      Congress Registration is open

      December 15, 2020

      EAN Congress news

      Abstract Submission is open

      December 15, 2020

      EAN Congress news

      EAN announces Virtual Congress in 2021

      December 1, 2020

      EAN Congress news

      Investigator Award Winners 2020

      September 14, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Interviews

      Interview of the Month with Marco Medina, President of PAFNS

      January 1, 2021

      Interviews

      External Interview – Asian Oceanian Association of Neurology

      November 1, 2020

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee, interviews Prof. Jean-Antoine Girault, President of FENS – Federation of European Neuroscience Societies

      October 1, 2020

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      COVID-19

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      COVID-19

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      Breaking news

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      Breaking news

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      Breaking news

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Neurology updates

      Neurology Update: Rare Diseases

      December 1, 2020

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

      Scientific Corner

      New Registrar’s Reading Lists from the Higher Cortical Functions Scientific Panel

      January 17, 2020

      Scientific Corner

      New Scales & Scores from the Higher Cortical Functions Scientific Panel

      January 17, 2020

  • Educational
    • All E-Brain Grand Rounds Continuing medical education Resident and Research Fellows Fellowship reports Education corner
      General interest

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Educational

      Clinical Fellowship 2021 winners

      January 1, 2021

      Educational

      Clinical Fellowship Reports 2019 III

      December 21, 2020

      Educational

      Clinical Fellowship Reports 2019 II

      December 21, 2020

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Resident and Research Fellows

      EAN Virtual Congress: Round table Special Session: Unleash your potential with EAN!

      May 24, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019 III

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019 II

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019

      November 2, 2020

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Education corner

      EAN Spring School – Application Deadline is 31 January 2021

      December 21, 2020

      Education corner

      Research Fellowship winners 2021

      December 1, 2020

      Education corner

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

  • Miscellanea
    • All Holiday Calendar Grant opportunities News from EAN member societies EBC EFNA News in general Topic of the Month/Week Patients societies reports Surveys Forum Uncategorized
      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Miscellanea

      Alzheimer Europe launches new guide targeted at health and social care workers and a policy briefing on intercultural care and support

      January 1, 2021

      Miscellanea

      Alzheimer Europe Policy Report – Dementia as a European Priority

      January 1, 2021

      News from EAN member societies

      2020 – BioMed Alliance celebrates 10 years of existence

      January 1, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

      Holiday Calendar

      23.12. Last-minute gift idea

      December 23, 2018

      Holiday Calendar

      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      2020 – BioMed Alliance celebrates 10 years of existence

      January 1, 2021

      News from EAN member societies

      New BioMed Alliance Statement: Open Access Initiatives must not create inequality

      November 1, 2020

      News from EAN member societies

      Health partnership proposal paves the way for greater role for stakeholders

      October 1, 2020

      News from EAN member societies

      21 September: On World Alzheimer’s Day, Alzheimer Europe calls for urgent action to support dementia research

      October 1, 2020

      EBC

      EBC launches new series of disease fact sheets!

      December 1, 2020

      EBC

      Present Your Business or Idea at the Brain Innovation Days Pitch Competition

      October 27, 2020

      EBC

      Save the date for the Brain Innovation Days launch!

      October 1, 2020

      EBC

      The EBC releases its 2019 Annual Report

      September 1, 2020

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      EFNA

      EFNA Advocacy Awards 2021 – ‘Action Against Stigma’

      October 1, 2020

      EFNA

      EFNA Annual Report 2019 Published

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General interestPaper of the MonthFeatured Slider

Paper of the Month: Inebilizumab for the treatment of neuromyelitis optica (N-MOmentum): a double-blind, randomised placebo-controlled phase 2/3 trial

December 1, 2019

 

 

By Tom Jenkins

 

 

 

 

For December 2019, we have selected: Cree et al., Inebilizumab for the treatment of neuromyelitis optica (N-MOmentum): a double-blind, randomised placebo-controlled  phase 2/3 trial Lancet 2019 Epub ahead of print Sept 5.

Neuroinflammatory disease is the subject of this month’s selected paper, which reports a successful trial of an anti-CD19 B-cell depleting monoclonal antibody in neuromyelitis optica spectrum disorder (NMOSD), a severe disease in urgent need of evidence-based therapies.

NMOSD is an aggressive and disabling neuroinflammatory disease that commonly affects the optic nerves and spinal cord, and sometimes the diencephalon, brainstem and cerebral hemispheres. No approved therapies currently exist. Clinicians use immunosuppressants empirically to prevent attacks, and incomplete recovery is common. The authors tested inebilizumab, a humanised IgG1 kappa monoclonal antibody that binds to the CD19 B-cell surface antigen. Previous studies in multiple sclerosis had demonstrated safety. The aim of this phase 2/3 trial was to assess both safety and efficacy of inebilizumab to reduce attacks and disability in NMOSD.

This was a multi-centre international trial that recruited from 99 clinics in 25 countries, coordinated from San Francisco. Inclusion criteria were age 18 or older, a diagnosis of NMOSD, an Expanded Disability Status Score (EDSS) of 8 or less, and either a history of at least one attack in the last 12 months requiring rescue therapy (intravenous corticosteroids, intravenous immunoglobulins or plasma exchange, alone or in combination), or at least two attacks requiring rescue therapy in the last two years. Both aquaporin-4 seropositive and seronegative patients were included; Wingerchuk criteria had to be met.

Following screening, patients were randomised 3:1 to either 300mg intravenous inebilizumab or placebo with double blinding, and dosed twice on days 1 and 15. All participants also received oral steroids (prednisolone 20mg od or equivalent) between days 1 to 14, then tapered over a week to zero (because of concerns about triggering acute attacks at treatment initiation, which had previously been observed with rituximab therapy). No other immunosuppressants were permitted. Patients were followed for 197 days. An open-label extension of 12 months was offered. The primary outcome was occurrence of an NMOSD attack, determined by an adjudication committee, between day 1 and day 197. An attack was defined as the presence of a new symptom or worsening of existing symptoms related to NMOSD, according to predefined criteria, and MRI data were reviewed. Secondary outcomes were EDSS score, low-contrast visual acuity, active MRI lesion load, and number of hospitalisations. Circulating B cell levels were measured. Cox proportional hazards and regression models were applied and analysis was by intention to treat. The trial was funded by the pharmaceutical company that produced the medication, who played a role in the conduct of the study, in association with independent eligibility, adjudication and data monitoring committees.

Four hundred and sixty-seven patients were screened, 231 enrolled, 175 allocated to inebilizumab and 56 to placebo. One patient was omitted from analysis because they did not receive the study drug. Ninety-three percent of enrolled patients were aquaporin-4 seropositive. The data monitoring committee stopped the trial early because of clear evidence of efficacy of inebilizumab, before the original target of 252 participants was met. There was a significant reduction in NMOSD attacks: 12% of the inebilizumab group (21/174) experienced a relapse compared to 39% (22/56) of placebo-treated patients (hazard ratio 0.27 (95% confidence interval 0.15-0.50), p<0.0001). For the secondary outcome measures, fewer patients had EDSS worsening, and there were fewer MRI lesions and hospitalisations with inebilizumab, but no difference in visual acuity. There was a drop in circulating B cell levels to less than 10% of baseline in the inebilizumab group. Adverse event rates were similar between groups, most commonly mild to moderate infusion reactions. Two deaths occurred during open label extension on inebilizumab, one related to pneumonia and a relapse of NMOSD. The second patient developed weakness, dysphasia and seizures with large new lesions on MRI and a differential diagnosis of acute disseminated encephalomyelitis, atypical NMOSD or progressive multifocal leukoencephalopathy was considered. JC virus testing was inconclusive, and the diagnosis remained uncertain; it was not possible to exclude a relationship to treatment. Neutropenia was seen in 2% of patients on inebilizumab, and was generally transient and asymptomatic.

The authors concluded that inebilizumab was effective at preventing relapses and disability in NMOSD, and that this is the first randomised controlled trial to demonstrate efficacy in this disorder.

 

 

 

 

Paper of the Month: Inebilizumab for the treatment of neuromyelitis optica (N-MOmentum): a double-blind, randomised placebo-controlled phase 2/3 trial was last modified: December 4th, 2019 by Editor
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