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      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Executive Page

      Executive Page: Antonella Macerollo as Editor of EANpages

      April 1, 2021

      Executive Page

      Executive page: From Website editor to Co-Chair Communication Committee

      February 1, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Country of the Month

      Country of the Month: Lithuania

      March 1, 2021

      Country of the Month

      Country of the Month: Albania

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      Country of the Month: The Netherlands

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      October 1, 2020

      Paper of the Month

      Paper of the month: Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: A non-inflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

      March 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and Efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe Study)

      March 1, 2021

      EAN News

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EAN News

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      EAN News

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

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      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      EAN Congress news

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

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      December 15, 2020

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      December 15, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Cape Verde)

      March 3, 2021

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee interviews Prof. Raad Shakir, CBE

      March 1, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (South Africa)

      February 5, 2021

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      COVID-19

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

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      December 1, 2019

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      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      Breaking news

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      Breaking news

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Breaking news

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Neurology updates

      Neurology Update: Epilepsy

      March 19, 2021

      Neurology updates

      Neurology Update: Coordinating Panel on Rare Neurological Diseases

      March 12, 2021

      Neurology updates

      Neurology Update: Rare Diseases

      March 8, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      The Future of Brain Research: EU-Initiatives and Experts Together for a Shared European Brain Research Agenda

      March 1, 2021

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

  • Educational
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      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Educational

      Clinical Fellowship Reports 2020

      April 1, 2021

      Educational

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Educational

      Clinical Fellowship Reports 2020

      March 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Fellowship reports

      Clinical Fellowship Reports 2020

      April 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2020

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2019

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports III 2019

      February 1, 2021

      Education corner

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Education corner

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      Education corner

      New Scales & Scores on Dementia

      February 11, 2021

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

  • Miscellanea
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      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      General interest

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EBC

      The European Brain Council launches Brain Innovation Policy Roadmap on the occasion of Brain Awareness Week

      April 1, 2021

      Miscellanea

      Alzheimer Europe outlines state-of-play of dementia policy in Europe

      March 31, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

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      December 23, 2018

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      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      News from EMA: First oral treatment for spinal muscular atrophy (SMA) recommended for approval

      March 3, 2021

      News from EAN member societies

      EMA’s Webinar on ”COVID-19 vaccination – what you need to know as a health professional”

      February 5, 2021

      News from EAN member societies

      Personalized plans, blood biomarkers and early interventions: Think Brain Health conference highlights

      February 1, 2021

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      EBC

      The European Brain Council launches Brain Innovation Policy Roadmap on the occasion of Brain Awareness Week

      April 1, 2021

      EBC

      EBC launches statement on the impact of COVID-19 on brain health

      February 1, 2021

      EBC

      EBC launches new series of disease fact sheets!

      December 1, 2020

      EBC

      Present Your Business or Idea at the Brain Innovation Days Pitch Competition

      October 27, 2020

      EFNA

      EFNA launch eLearning Platform for neurology advocates

      February 1, 2021

      EFNA

      ‘Me and My Brain’ – Art Competition winners announced!

      February 1, 2021

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      EFNA

      EFNA Advocacy Awards 2021 – ‘Action Against Stigma’

      October 1, 2020

      News in general

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      News in general

      Alzheimer Europe outlines state-of-play of dementia policy in Europe

      March 31, 2021

      News in general

      EPA Forum 2021: Quality Indicators of Services and Care for Mental Health in Europe, from Clinician to Patient Perspective: A Paradigm Shift?

      March 31, 2021

      News in general

      ONE VOICE FOR NEUROLOGY

      March 31, 2021

      Topic of the Month/Week

      Brain Awareness Week (BAW) is the global campaign to increase public awareness of the progress and benefits of brain research

      March 13, 2018

      Topic of the Month/Week

      Dystonia Europe celebrates 25 years

      March 13, 2018

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Surveys

      SURVEY: Driving with an intracranial tumor

      June 25, 2020

      Surveys

      EAN SURVEY: Neurological Symptoms in COVID-19 Patients

      April 10, 2020

      Surveys

      EMA communication: ICH Good Clinical Practice Guidelines (ICH E6) – Open Comment Opportunity – Deadline: 1 November 2019

      October 7, 2019

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Uncategorized

      Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform

      December 2, 2020

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (New Zealand)

      November 24, 2020

      Uncategorized

      Report from the annual Pain Forum meeting

      November 2, 2020

  • EAN
  • Congress 2020
  • Congress 2021
  • EAN pages
  • Eur J Neurol
  • Virtual Congress

eanpages

  • General interest
    • All COVID-19 Executive Page Country of the Month Paper of the Month EAN News EAN Congress news Interviews
      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Executive Page

      Executive Page: Antonella Macerollo as Editor of EANpages

      April 1, 2021

      Executive Page

      Executive page: From Website editor to Co-Chair Communication Committee

      February 1, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Country of the Month

      Country of the Month: Lithuania

      March 1, 2021

      Country of the Month

      Country of the Month: Albania

      December 1, 2020

      Country of the Month

      Country of the Month: The Netherlands

      November 1, 2020

      Country of the Month

      Country of the Month: Serbia

      October 1, 2020

      Paper of the Month

      Paper of the month: Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: A non-inflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

      March 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and Efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe Study)

      March 1, 2021

      EAN News

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EAN News

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      EAN News

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      EAN Congress news

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      EAN Congress news

      Congress Registration is open

      December 15, 2020

      EAN Congress news

      Abstract Submission is open

      December 15, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Cape Verde)

      March 3, 2021

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee interviews Prof. Raad Shakir, CBE

      March 1, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (South Africa)

      February 5, 2021

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      COVID-19

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      Breaking news

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      Breaking news

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Breaking news

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Neurology updates

      Neurology Update: Epilepsy

      March 19, 2021

      Neurology updates

      Neurology Update: Coordinating Panel on Rare Neurological Diseases

      March 12, 2021

      Neurology updates

      Neurology Update: Rare Diseases

      March 8, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      The Future of Brain Research: EU-Initiatives and Experts Together for a Shared European Brain Research Agenda

      March 1, 2021

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

  • Educational
    • All E-Brain Grand Rounds Continuing medical education Resident and Research Fellows Fellowship reports Education corner
      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Educational

      Clinical Fellowship Reports 2020

      April 1, 2021

      Educational

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Educational

      Clinical Fellowship Reports 2020

      March 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Fellowship reports

      Clinical Fellowship Reports 2020

      April 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2020

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2019

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports III 2019

      February 1, 2021

      Education corner

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Education corner

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      Education corner

      New Scales & Scores on Dementia

      February 11, 2021

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

  • Miscellanea
    • All Holiday Calendar Grant opportunities News from EAN member societies EBC EFNA News in general Topic of the Month/Week Patients societies reports Surveys Forum Uncategorized
      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      General interest

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EBC

      The European Brain Council launches Brain Innovation Policy Roadmap on the occasion of Brain Awareness Week

      April 1, 2021

      Miscellanea

      Alzheimer Europe outlines state-of-play of dementia policy in Europe

      March 31, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

      Holiday Calendar

      23.12. Last-minute gift idea

      December 23, 2018

      Holiday Calendar

      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      News from EMA: First oral treatment for spinal muscular atrophy (SMA) recommended for approval

      March 3, 2021

      News from EAN member societies

      EMA’s Webinar on ”COVID-19 vaccination – what you need to know as a health professional”

      February 5, 2021

      News from EAN member societies

      Personalized plans, blood biomarkers and early interventions: Think Brain Health conference highlights

      February 1, 2021

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

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EAN Congress newsTop Articles

Symposium 3: EAN/IFCN-EMEAC: Neurophysiology and non- invasive brain stimulation (NIBS)

May 25, 2020

by Martin Rakusa

On the first day of the congress, more than 3000 participants joined the symposium organised by EAN and IFCN-EMEAC. In the first lecture prof. Walter Paulus from Germanypresented “Entrainment of brain function: bridging transcranial electric and magnetic stimulation”. At the beginning of his lecture, he explained some essentials of transcranial electric (tDCS) and transcranial magnetic (TMS) stimulation.

The key question is how to achieve the enduring effect of TMS. One of the possibilities would be to use higher voltage stimulation. As an alternative, we may use a longer stimulus. However, if the stimulus is too long, a reverse effect may occur, and cortex is inhibited. A possible solution is to give stimuli in approximately 13-minute long intervals.

Similarly, there is a window for optimal effect of intensity of the stimulus. If the stimulus is too strong, we will get the opposite effect. Current stimulation effect is dependent on the concentration of intracellular Ca2+, and neuroplasticity. Excitation is associated with a higher concentration of Ca2+ levels. In the end, Prof. Paulus presented possibilities for how we may improve the stimulation effect.

The second lecture was “NIBS in neuropathic pain syndromes”. The lecture was divided into two parts. In the first part, prof. Jean-Pascal Lefaucheur from France introduced the physiology of the non-invasive cortical stimulation for treatment of neuropathic pain.

Two non-invasive techniques are used (repetitive TMS (rTMS) and tDCS). With both, we target contralateral primary motor cortex in case of asymmetric pain and dominant hemisphere in case of symmetric pain. rTMS stimulates termination of long superficial cortical axons. Stimulated fibres are the same as in the case of epidural stimulation. Activation modulates cortical-cortical or cortical-thalamic networks.

The second part of the lecture was dedicated to the technical and practical part of stimulation. There are two types of rTMS techniques 1. Low frequency rTMS (inhibition), and 2. High frequency rTMS (excitation). Clinical effect of rTMS is moderate. However, it is different in comparison with placebo. The effect is also short, lasting up to two days. rTMS sessions have to be repeated, and then the pain could be relieved for several months. The effect can also be improved using a navigation system, robotic arm holding TMS coil and integrating neuroimaging or EEG data on neural circuits.

Both techniques are well-tolerated and safe, although the clinical effect of tDCS and rTMS are not equivalent. rTMS can be used for focal and diffused neuropathic pain, while tDCS can be used in non-neuropathic, e.g. fibromyalgia. rTMS has a higher level of evidence. Besides, there is a protocol of stimulation for clinical use. However, an advantage of the tDCS is that the patient can perform it at home and may become a method of choice for long-term therapy.

The third lecture presented Prof. Ulf Ziemann from Germany. He talked on “Brain-state-dependent NIBS: a new era for treating disordered brain networks”. Disorders of brain network are defined as discoordination of neuronal activity in space and time (e.g. stroke, Alzheimer’s disease, epilepsy, and chronic pain, among others).

The concept of the therapeutic effects of TMS is not entirely clear. There are several approaches to this problem. First is an ‘open-loop’ stimulation in which we consider the brain as a black box without knowing what is the actual state of the neurons inside. After we stimulate the brain, we hope that stimulus will induce necessary neuroplasticity, which will affect the network disorder. However, this is associated with high variability and low effect size.

Another possibility is ‘closed-loop’ stimulation which includes EEG and real-time analysis of the cortical activity. With this approach, we may stimulate the brain at the predefined network states and can monitor the effect of the stimulation.

Corticospinal excitability depends on the phase of sensorimotor µ rhythm. A negative µ peak measured at the C3 electrode reflects a state of high corticospinal excitability. On the other hand, the positive peak is a state of lower corticospinal excitability. If we provide a burst of rTMS at the high-excitability state, it will results in long–term potentiation(LTP). LTP is a persistent strengthening of synapses based on recent patterns of activity, and a single 100 Hz burst may induce plasticity in the corticospinal pathway. 

Prof. Ziemman concluded that the brain-state dependent therapeutic rTMS (closed-loop stimuli) would probably have a better effect than open-loop rTMS. However, we need more data from the randomised clinical trials.

Prof.  Simone Rossi from Italy presented a final lecture on “The safety of NIBS and its uses in neuropsychiatry”. In the first part of his talk, he explained different options for stimulation with rTMS and tDCS. He pointed to the new protocols which include stimulation of different cortical areas and using new technical abilities. E.g. newer TMS coils are designed to generate longer and deeper stimuli.

An essential part of his talk was on new guidelines on the safety of using TMS. TMS is safe, regardless if it is used in the routine or for experimental purposes. Crude estimation for provoking seizures in patients with epilepsy is less than 1.4 %, and it is below 1 % in healthy persons. The number of induced seizures is also low in patients who are treated with the drugs, which have an effect on central nervous system. When using a new protocol, it is also advised to use neurophysiology monitoring to reduce the possibility of seizures. Seizures are elicited during or immediately after the train of stimuli. tDCS is also very safe. It is unlikely that a stimulation lasting less than one hour will cause seizures. Most common adverse effects are skin burns at the position of the electrodes.

In the second part of the lecture, he explained the use of rTMS and tDCS in clinical practice. One of the possibilities to use rTMS is to induce a seizure for treating the psychiatric disorder, similar to the electroconvulsive therapy, however with fewer side effects. The International Federation of Clinical Neurophysiology assessed the evidence-based clinical efficacy of rTMS and tDCS.  Working group established a definitive efficacy (level 1A) for treating depression, targeting dorsolateral prefrontal cortex; neuropathic pain; and post-stroke motor hand recovery, targeting primary motor cortex in the acute phase of the disease. FDA also approved a protocol for treating obsessive-compulsive disorder. However, members of the working group did not find enough evidence from published literature. A possible efficacy (level 1B) could be for the treatment of lower limb spasticity in multiple sclerosis, depression and motor symptoms in Parkinson’s disease, post-stroke aphasia, and post-traumatic stress disorder. Using tDCS did not reach level 1A for any condition. A possible explanation for this is a lack of clinical trials.

In the end, he briefly touched current clinical experiments using transcranial stimulation for treating Alzheimer’s disease, reducing the amyloid load in the murine model. In another trial using tDCS, they were able to reduce perfusion of the cortical metastasis or glioblastoma. Further clinical trials will show if we may use tDCS in combination with pharmacotherapy.

We may conclude that symposium was well accepted and more than 50 comments and questions were raised during a lively discussion. All sessions are available online in the Virtual Congress, and all are welcome to listen to this exciting symposia on-demand

Symposium 3: EAN/IFCN-EMEAC: Neurophysiology and non- invasive brain stimulation (NIBS) was last modified: May 25th, 2020 by Editor
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