Case series/case reports
In this paper, the authors report a case of a previously healthy 58-year-old man who acutely developed hyposmia, generalised myoclonus, fluctuating and transient changes in level of consciousness, opsoclonus and an asymmetric hypokinetic-rigid syndrome with ocular abnormalities following severe SARS-CoV-2 infection.
DaT-SPECT confirmed a bilateral decrease in presynaptic dopamine uptake asymmetrically involving both putamina. Significant improvement in the parkinsonian symptoms was observed without any specific treatment. The authors concluded that this case study provides clinical and functional neuroimaging evidence to support that hypothesis that SARS-CoV-2 can gain access to the central nervous system, affecting midbrain structures and leading to neurological signs and symptoms.