Randomised double-blinded placebo-controlled trial (Orange)
LY-CoV555, a neutralising monoclonal antibody, has been associated with a decrease in viral load and frequency of hospitalisations or emergency department visits among outpatients with COVID-19. However, data are needed on the effect of this antibody in patients who are hospitalised with Covid-19.
In this platform trial of therapeutic agents, the authors randomly assigned hospitalised patients who had COVID-19 without end-organ failure in a 1:1 ratio to receive either LY-CoV555 or matching placebo. In addition, all patients received high-quality supportive care as background therapy, including the antiviral drug remdesivir and, when indicated, supplemental oxygen and glucocorticoids. LY-CoV555 (at a dose of 7000 mg) or placebo was administered as a single intravenous infusion over a 1-hour period. The primary outcome was sustained recovery during a 90-day period, as assessed in a time-to-event analysis. An interim futility assessment was performed on the basis of a seven-category ordinal scale for pulmonary function on day 5. On October 26, 2020, the data and safety monitoring board recommended stopping enrollment for futility after 314 patients (163 in the LY-CoV555 group and 151 in the placebo group) had undergone randomisation and infusion. The median interval since onset of symptoms was 7 days (interquartile range, 5 to 9). At day 5, a total of 81 patients (50%) in the LY-CoV555 group and 81 (54%) in the placebo group were in one of the two most favourable categories for pulmonary outcome. Across the seven categories, the odds ratio of being in a more favourable category in the LY-CoV555 group than in the placebo group was 0.85 (95% confidence interval [CI], 0.56 to 1.29; P=0.45). The percentage of patients meeting the primary safety outcome (a composite of death, serious adverse events, or clinical grade 3 or 4 adverse events through day 5) was similar in the LY-CoV555 group and the placebo group (19% and 14%, respectively; odds ratio, 1.56; 95% CI, 0.78 to 3.10; P=0.20). The rate ratio for a sustained recovery was 1.06 (95% CI, 0.77 to 1.47). The authors concluded that monoclonal antibody LY-CoV555, when coadministered with remdesivir, did not demonstrate efficacy among hospitalised patients who had COVID-19 without end-organ failure.