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      November 24, 2023

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      November 7, 2023

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      Executive Page: Join or renew your membership now and celebrate 10 years of the EAN

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      Executive Page: Join or renew your membership now and celebrate 10 years of the EAN

      November 6, 2023

      Executive Page

      Executive Page: Advocacy for brain health gaining momentum across the neurological landscape

      October 1, 2023

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: Management Group elections are coming – run for office and help shape our future!

      September 1, 2023

      Executive Page

      Executive Page: Thank you for making the EAN Congress 2023 a great success!

      July 24, 2023

      EAN News

      Swiss Brain Health Plan launches in Zurich

      November 24, 2023

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      July 24, 2023

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      July 3, 2023

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      Video Interview: Josep Dalmau, Camillo Golgi Lecturer at EAN 2023

      July 2, 2023

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      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

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      Research Paper of the Month: Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH)

      November 6, 2023

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      Research Paper of the Month: Soluble Nogo-Receptor-Fc decoy (AXER-204) in patients with chronic cervical spinal cord injury in the USA

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      Research Paper of the Month: Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma

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      November 7, 2023

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      October 13, 2023

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      Research Fellowship Report 2022 – Oxford Autoimmune Neurology Group

      September 16, 2023

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      September 15, 2023

      eLearning

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      November 7, 2023

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      October 13, 2023

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      World Brain Day with the European Academy of Neurology

      July 21, 2023

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      June 30, 2023

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      September 13, 2023

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      September 5, 2023

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      August 22, 2023

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      June 28, 2023

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      September 16, 2023

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      September 15, 2023

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      Research Fellowship Report 2022 – Department of Neuromuscular Diseases Institute, University College London

      September 14, 2023

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      Application deadline approaching for 2024 EAN Clinical Fellowships

      September 7, 2023

      Fellowship reports

      Research Fellowship Report 2022 – Oxford Autoimmune Neurology Group

      September 16, 2023

      Fellowship reports

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      September 15, 2023

      Fellowship reports

      Research Fellowship Report 2022 – Department of Neuromuscular Diseases Institute, University College London

      September 14, 2023

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      September 13, 2023

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      July 21, 2023

      News in general

      WHO’s Intersectoral Global Action Plan on epilepsy and other neurological disorders (IGAP) published in all six UN languages

      August 3, 2023

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      August 3, 2023

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      November 24, 2023

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      November 22, 2023

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      Call for Applications: e-Learning Platform Associate Editors

      November 7, 2023

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      Executive Page: Join or renew your membership now and celebrate 10 years of the EAN

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      Executive Page: Join or renew your membership now and celebrate 10 years of the EAN

      November 6, 2023

      Executive Page

      Executive Page: Advocacy for brain health gaining momentum across the neurological landscape

      October 1, 2023

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: Management Group elections are coming – run for office and help shape our future!

      September 1, 2023

      Executive Page

      Executive Page: Thank you for making the EAN Congress 2023 a great success!

      July 24, 2023

      EAN News

      Swiss Brain Health Plan launches in Zurich

      November 24, 2023

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      November 22, 2023

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      November 7, 2023

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      November 6, 2023

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      EAN 2024 – Abstract submission and registration OPEN!

      November 22, 2023

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      October 19, 2023

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      July 25, 2023

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      July 24, 2023

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      July 3, 2023

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      Video Interview: Josep Dalmau, Camillo Golgi Lecturer at EAN 2023

      July 2, 2023

      Interviews

      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

  • Research
    • All Paper of the Month Research Highlights
      Paper of the Month

      Research Paper of the Month: Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH)

      November 6, 2023

      Research Highlights One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – November 2023

      November 6, 2023

      Research

      EAN Guideline Production Group at the Guidelines International Network Conference 2023

      October 31, 2023

      EAN News

      Burden of Sleep/Wake Disorders Project at EAN Congress 2023

      October 19, 2023

      Paper of the Month

      Research Paper of the Month: Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH)

      November 6, 2023

      Paper of the Month

      Research Paper of the Month: Transdermal Nicotine Treatment and Progression of Early Parkinson’s Disease

      October 1, 2023

      Paper of the Month

      Research Paper of the Month: Soluble Nogo-Receptor-Fc decoy (AXER-204) in patients with chronic cervical spinal cord injury in the USA

      September 1, 2023

      Paper of the Month

      Research Paper of the Month: Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma

      July 24, 2023

      Research Highlights One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – November 2023

      November 6, 2023

      Research Highlights One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – October 2023

      October 1, 2023

      Research Highlights One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – September 2023

      September 1, 2023

      Research Highlights One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

  • Education
    • All eLearning Student Corner Resident and Research Fellows Fellowship reports
      eLearning

      Call for Applications: e-Learning Platform Associate Editors

      November 7, 2023

      eLearning

      Kick off the new season with highlights on the eanCampus

      October 13, 2023

      Resident and Research Fellows

      Research Fellowship Report 2022 – Oxford Autoimmune Neurology Group

      September 16, 2023

      Resident and Research Fellows

      Research Fellowship Report 2022 – Centre Hospitalier Universitaire Vaudois, Lausanne

      September 15, 2023

      eLearning

      Call for Applications: e-Learning Platform Associate Editors

      November 7, 2023

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      Kick off the new season with highlights on the eanCampus

      October 13, 2023

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      World Brain Day with the European Academy of Neurology

      July 21, 2023

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      New eanCampus content especially for EAN 2023

      June 30, 2023

      Student Corner

      Student Teaser Fellowship reports 2022 – Pisa, London, & Lausanne

      September 13, 2023

      Student Corner Illustration of a vertical pencil point on a blue background, with a yellow light bulb above it

      Student Corner: My EAN Congress experience

      September 5, 2023

      Student Corner

      Student Teaser Fellowship reports 2022 – Rotterdam, London, & Paris

      August 22, 2023

      Student Corner

      Student Teaser Fellowship winners 2023

      June 28, 2023

      Resident and Research Fellows

      Research Fellowship Report 2022 – Oxford Autoimmune Neurology Group

      September 16, 2023

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      September 15, 2023

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      Research Fellowship Report 2022 – Department of Neuromuscular Diseases Institute, University College London

      September 14, 2023

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      Application deadline approaching for 2024 EAN Clinical Fellowships

      September 7, 2023

      Fellowship reports

      Research Fellowship Report 2022 – Oxford Autoimmune Neurology Group

      September 16, 2023

      Fellowship reports

      Research Fellowship Report 2022 – Centre Hospitalier Universitaire Vaudois, Lausanne

      September 15, 2023

      Fellowship reports

      Research Fellowship Report 2022 – Department of Neuromuscular Diseases Institute, University College London

      September 14, 2023

      Fellowship reports

      Student Teaser Fellowship reports 2022 – Pisa, London, & Lausanne

      September 13, 2023

  • Other News
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      November 7, 2023

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      Brain Innovation Days 2023: Meet the speakers!

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      EAN Head Office Profiles: Kathrin & Sasha

      August 28, 2023

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      EAN Head Office Profiles: Kathrin & Sasha

      August 28, 2023

      EAN Staff Anja Sander receiving flowers at the end of EAN Congress 2023

      Celebrating 20 Years of Excellence: Anja Sander, EAN’s Executive Director!

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      Brain Innovation Days: Discover the early programme and register today!

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      Join the community’s calls for a European Brain Research and Innovation Plan

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      News in general

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      August 3, 2023

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      WHO recognises the public health need for effective and affordable treatments for multiple sclerosis

      August 3, 2023

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      July 14, 2023

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      ILAE survey on genetic testing in the epilepsies

      July 14, 2023

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      March 3, 2023

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      December 5, 2022

EAN Congress newsTop Articles

Neurological News from the Netherlands II – the land of the 3rd EAN Congress: Multiple sclerosis research in The Netherlands

February 1, 2017

By Brigit de Jong

Multiple sclerosis (MS) research has a longstanding history in the Netherlands with an impressive impact on global knowledge related to MS pathogenesis, diagnosis and treatment. During the time period where no disease modifying treatments options were available yet, and based on the hypothesis that MS is an autoimmune disease, Dutch researchers largely contributed in the 1970s and 1980s to pioneering, and later with evidence based studies to treat MS with immunosuppressive agents, i.e. cyclofosfamide, azathioprine. After the first large positive randomized-controlled trial (RCT) on treating relapsing remitting MS with a disease modifying therapy in 1993, several Dutch neurologists and neuroradiologists were leading in study design and monitoring of many following RCTs related to MS and therapeutic options.

Over the years the diagnostic criteria for MS have become more sensitive and specific. Since 2001 the diagnosis of MS is based on the so-called McDonald Criteria. The Dutch neurologist Prof. Chris Polman chaired the revised McDonald Criteria in 2005 and 2010. Since the introduction of the McDonald Criteria for MS, MRI of the central nervous system can support or replace clinical characteristics suggestive for MS to determine the diagnosis of MS. The radiological characteristics that support dissemination in space suggestive for MS are based on the Barkhof/Tintoré criteria.  Beside defining the radiological features that are suggestive for MS, the Dutch neuroradiologist Prof. Frederik Barkhof and his group have been internationally leading guidelines on how to use MRI for disease prognosis and monitoring during disease modifying therapies.

 

Inflammatory and neurodegenerative mechanisms determine the outcome of MS. Current disease modifying therapies target the inflammatory component of the disease. Unfortunately, the neurodegenerative features which are more pronounced during progressive stages of the disease are not directly affected by current therapeutic options. Today internationally, but also in the Netherlands, research groups are focusing on the etiology and treatment options of progressive MS.  Over the past two decades it has become more evident that besides inflammatory, demyelinating white matter lesions also gray matter pathology as determined by cortical demyelination and gray matter atrophy are involved in the pathogenesis of MS, even during the earliest stages of disease. Dutch histopathologic and radiologic studies on gray matter pathology and progressive MS contributed essentially to this knowledge.

During the last decade, there has been an impressive growth in awareness and knowledge on pediatric MS and other pediatric acquired demyelinating disorders. Dutch research has focused on etiology, clinical and radiological characteristics and treatment strategies of pediatric MS. These etiologic studies investigated the role of inflammatory, genetic and environmental features related to pediatric MS.

In summary, Dutch research contributed tremendously to the current knowledge on pathogenesis, diagnosis and treatment of MS. Our aim is to flourish at least as much in the future as we did in the past.

References:

  1. Hommes OR, Prick JJ, Lamers KJ. Treatment of the chronic progressive form of multiple sclerosis with a combination of cyclophosphamide and prednisone. Clin Neurol Neurosurg 1975;78:59-72
  2. Minderhoud JM, Prange AJ, Luyckx GJ. A long-term double-blind controlled study on the effect of azathioprine in the treatment of multiple sclerosis. Clin Neurol Neurosurg 1988;90:25-8
  3. Polman CH, O’Connor PW, Havrdova E, et al., A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 2006;354:899-910
  4. Kappos L, Polman C, Pozzilli C, et al. Final analysis of the European multicenter trial on IFNbeta-1b in secondary-progressive MS. Neurology 2001;57:1969-75
  5. Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011;69:292-302
  6. Barkhof F, Filippi M, Miller DH, et al. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain 1997;120:2059-69
  7. Wattjes MP, Rovira À, Miller D, et al. Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis–establishing disease prognosis and monitoring patients. Nat Rev Neurol 2015;11:597-606
  8. Geurts JJ, Calabrese M, Fisher E, Rudick RA. Measurement and clinical effect of grey matter pathology in multiple sclerosis. Lancet Neurol 2012;11:1082-92
  9. Waubant E, Ponsonby AL, Pugliatti M, Hanwell H, Mowry EM, Hintzen RQ. Environmental and genetic factors in pediatric inflammatory demyelinating diseases. Neurology 2016;87:S20-7
  10. Hintzen RQ, Dale RC, Neuteboom RF, Mar S, Banwell B. Pediatric acquired CNS demyelinating syndromes: Features associated with multiple sclerosis. Neurology 2016;87:S67-73

 

Dr. Birgit de Jong works at the VU University Medical Center Amsterdam –
Department of Neurology and VUmc MS Center Amsterdam, Amsterdam, The Netherlands

 

Neurological News from the Netherlands II – the land of the 3rd EAN Congress: Multiple sclerosis research in The Netherlands was last modified: February 2nd, 2017 by Editor
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20.12. Gingerbread cookies

December 20, 2018

BRAIN CHALLENGE 2021: Less is more!

June 19, 2021

Paper of the Month: Trial of galcanezumab in prevention of episodic cluster headache & Rimegepant, an oral calcitonin gene-related peptide receptor antagonist, for migraine

September 1, 2019

Amsterdam 2017 – visit the EAN Booth – Your home of Neurology

June 16, 2017

EAN Guidelines Workshop 2023: From questions to recommendations

July 21, 2023

COUNTRY OF THE MONTH: FRANCE

May 1, 2020

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17th European Headache Federation Congress
EHC 2023 17th European Headache Federation Congress 6-9 December 2023 | Barcelona/Spain Website: www.headache-congress.org/ As the European Headache Congress has always been a wide-ranging stage for scientists to present the latest…
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