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      EAN News

      Plans in progress for 30th Anniversary of the European Journal of Neurology (1994-2024)

      December 6, 2023

      Advocacy

      Executive Page: European neurology united as ever heading into milestone year

      December 6, 2023

      Paper of the Month

      Research Paper of the Month: Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation

      December 4, 2023

      Research Highlights One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – December 2023

      December 1, 2023

      Executive Page

      Executive Page: European neurology united as ever heading into milestone year

      December 6, 2023

      Executive Page

      Executive Page: Join or renew your membership now and celebrate 10 years of the EAN

      November 6, 2023

      Executive Page

      Executive Page: Advocacy for brain health gaining momentum across the neurological landscape

      October 1, 2023

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: Management Group elections are coming – run for office and help shape our future!

      September 1, 2023

      EAN News

      Plans in progress for 30th Anniversary of the European Journal of Neurology (1994-2024)

      December 6, 2023

      EAN News

      Executive Page: European neurology united as ever heading into milestone year

      December 6, 2023

      EAN News

      Research Paper of the Month: Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation

      December 4, 2023

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      December 1, 2023

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      July 25, 2023

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      July 24, 2023

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      September 8, 2022

  • Research
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      Research Paper of the Month: Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation

      December 4, 2023

      Research Highlights One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – December 2023

      December 1, 2023

      Paper of the Month

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      November 6, 2023

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      November 6, 2023

      Paper of the Month

      Research Paper of the Month: Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation

      December 4, 2023

      Paper of the Month

      Research Paper of the Month: Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH)

      November 6, 2023

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      Research Paper of the Month: Transdermal Nicotine Treatment and Progression of Early Parkinson’s Disease

      October 1, 2023

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      Research Paper of the Month: Soluble Nogo-Receptor-Fc decoy (AXER-204) in patients with chronic cervical spinal cord injury in the USA

      September 1, 2023

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      September 1, 2023

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      December 2, 2023

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      December 1, 2023

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      November 30, 2023

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      November 7, 2023

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      December 2, 2023

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      September 13, 2023

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      June 28, 2023

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      September 16, 2023

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      September 14, 2023

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      September 13, 2023

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      EAN News

      Plans in progress for 30th Anniversary of the European Journal of Neurology (1994-2024)

      December 6, 2023

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      Executive Page: European neurology united as ever heading into milestone year

      December 6, 2023

      Paper of the Month

      Research Paper of the Month: Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation

      December 4, 2023

      Research Highlights One glowing light bulb that stands out from unlit or dim lamps on a blue background

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      December 1, 2023

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      Executive Page: European neurology united as ever heading into milestone year

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      November 6, 2023

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      October 1, 2023

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: Management Group elections are coming – run for office and help shape our future!

      September 1, 2023

      EAN News

      Plans in progress for 30th Anniversary of the European Journal of Neurology (1994-2024)

      December 6, 2023

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      December 6, 2023

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      Research Highlights of the Month – November 2023

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      Research Paper of the Month: Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation

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EAN NewsEAN Congress newsFeatured Slider

Neurological news from Portugal III – Corina de Andrade and Paramyloidosis

March 1, 2018

Prof. Corino de Andrade graduated at Lisbon Medical School, Hospital of St Martha, in 1929.

He began his practice at the main hospital in Lisbon (Hospital S. José) and kept visiting his Alma Mater with a serious commitment to practice neurology at the department of Egas Moniz, the only one in Portugal. This passion was soon rewarded with the residency in neurology.

He was fascinated with the art of diagnosis in neurology, especially by collecting all subtle signs of the neurological examination. He was strongly influenced and supported by two senior neurologists: Miller Guerra, who had had a long fellowship with Barré in Strasbourg, and António Flores, who was in Berlin with the Vogt couple.

De Andreade was eager for more wide horizons. In 1931 he decided to move to the centers where his mentors had been, starting with Barré. The Laboratory of Neuropathology kept his attention above all the other areas, since he remained there for six years, living in a room at the hospital. In 1933 he was rewarded with the Déjerine Prize, received from the hands of the daughter of the renowned French neurologist Sorel-Déjerine, because of his work on meninges. He was the first non-French to receive such award. In 1936, he moved to Berlin for a short visit to the Vogt couple at the Charité. Since devastating times in Europe were about to come, he decided to stay at his neutral and peaceful homeland. First he tried to resume his place at the Department of Egas Moniz, still the only one in Portugal. But the future Portuguese Noble Prize did not accept him and suggested to try Porto. There, he might have the opportunity to found a Department of Neurology, he said. In Porto, initially, the life of Corino de Andrade was not easy, but he was able to create his own department by 1940.

A few months after arriving at Porto, he took care of a 37-year-old woman from Póvoa do Varzim, a small fishing village at north of Porto, who had a disease known popularly by the name of “Doença dos Pezinhos” (small feet disease). It is an autosomal dominant disease characterized by a distal loss of sensation markedly at the toes and a distal muscular atrophy progressively preventing from walking. Digestive disturbances with bouts of vomiting, diarrhea and subsequent consumption will lead to bedding and death in middle aged affected patients. Autonomic dysfunction and cardiac involvement were also recognized. Corino de Andrade devoted great deal of time to this unknown pathology.

He traveled regularly to Lisbon to attend the Saturday morning pathology rounds at the School Hospital, sometimes bringing cases for discussion. He was able to bring pathological samples from a case of this mysterious disease. Finally, a young pathologist, Jorge Horta, future chair of Pathology at University of Lisbon, was able to identify many extracellular fibrillary protein deposits stainable by Congo Red. He named it as “Paramyloidosis”. In September 1952, Corino de Andrade published in Brain: A Peculiar Form of Peripheral Polineuropathy – Familiar Atypical Generalized Amyloidosis with Special Involvement of the Peripheral Nerves (Brain, vol.75: 3, 408). Initially known as “Andrade Disease,” later on as Familiar Paramyloidosis (FAP) and more recently added – “Type I” and “Portuguese Form”. After this publication, some clusters of paramyloidosis where identified in different parts of the world, mainly in Japan, Sweden, and Mallorca, suggesting a “travel of genes” possibly exported from Portugal by the Portuguese navigators to Japan and Mallorca. Imported from Sweden, in the VIII – IX centuries, it had been propagated to Iberian Peninsula by the time of Vikings invasions. Also crusades movements have been suggested by some. Nowadays, four types of paramyloidosis have been described around the world. The locus of the Portuguese type is now well defined an abnormality of Transthyretin: (V30M ATTR). The remarkable progresses in therapy from plasmapheresis and liver transplantation in selected cases at the decade of 1980 to new pharmacological therapies, bring hope and relieve to the victims of this formerly devastating disease.

by Prof. Victor Oliveira

Dept Neurology, Faculty of Medicine, University of Lisboa

Ref:
Silva, Maria Augusta: Corino de Andrade. Excelência de uma vida e Obra, Lisboa (2002)
Polineuropatia amiloidótica familiar de tipo português: do artigo original ao futuro. Sinapse Sup 1, Vol 6 may (2006) Ed. Barros J, Carvalho M

Neurological news from Portugal III – Corina de Andrade and Paramyloidosis was last modified: November 13th, 2018 by Editor
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Paper of the month: Implementing early ALS diagnosis

February 1, 2018

Executive Page: Elena Moro elected as Secretary General

July 3, 2020

Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study

December 2, 2020

Welcome to new year by Editor-in-Chief

January 1, 2021

Impact of COVID-19 outbreak on ischemic stroke admissions and in-hospital mortality in north-west Spain

July 27, 2020

Research Paper of the Month: Headache attributed to SARS-CoV-2 infection, vaccination and the impact on primary headache disorders of the COVID-19 pandemic

February 9, 2023

Paper of the Month: Effects of open-label placebo on pain, functional disability, and spine mobility in patients with chronic back pain: a randomized controlled trial

February 1, 2020

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