eanpages
  • General interest
    • All Executive Page Paper of the Month EAN News EAN Congress news COVID-19 Interviews
      Executive Page

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      Paper of the Month

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      Paper of the Month One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      EAN News

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      Executive Page

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: EAN’s scientific activities provide opportunities to both learn and contribute

      May 1, 2023

      Executive Page

      Executive Page: EAN on a Mission to advocate for brain health & neurology in 2023

      April 11, 2023

      Executive Page Head and shoulders portrait photo of Irena Rektorova, in colourful dress

      Executive Page: Leadership, mentorship and many more EAN educational opportunities

      March 13, 2023

      Paper of the Month

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      Paper of the Month One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      Paper of the Month

      One hot topic, one expert, three questions: Kristian Steen Frederiksen on our May 2023 Paper of the Month

      May 16, 2023

      Paper of the Month

      Research Paper of the Month: Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease

      May 1, 2023

      EAN News

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      EAN News

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      EAN News One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      EAN News

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      EAN Congress news

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      EAN Congress news

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      EAN Congress news

      On sex and gender: the exciting new world of gender neurology at EAN 2023

      May 25, 2023

      EAN Congress news

      Join us for the movement disorders programme at EAN 2023

      May 24, 2023

      COVID-19

      COVID-19 Research Round-Up: Literature reviews – April 2023

      April 26, 2023

      COVID-19

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – April 2023

      April 26, 2023

      COVID-19

      COVID-19 Research Round-Up: Case Series/Case Reports – April 2023

      April 26, 2023

      COVID-19

      COVID-19 Research Round-Up: Literature reviews – March 2023

      March 16, 2023

      Interviews

      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

      Interviews

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajediene

      July 28, 2022

      Interviews

      Video: EAN supports World Brain Day

      July 19, 2022

      Interviews

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

  • Academic/Scientific
    • All Breaking news Neurology updates Scientific committee reports Scientific panels reports Eur J Neurol Top 10 Articles Scientific Corner
      Paper of the Month

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      Paper of the Month One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      EAN News

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      Paper of the Month

      One hot topic, one expert, three questions: Kristian Steen Frederiksen on our May 2023 Paper of the Month

      May 16, 2023

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Miscellaneous – November 2022

      November 7, 2022

      Breaking news

      COVID-19 Breaking News: Observational Studies – Prospective Longitudinal Cohort – November 2022

      November 7, 2022

      Neurology updates

      Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome – A MAGNIMS Study

      September 26, 2022

      Neurology updates

      Relapse-independent disability worsening plays a relevant role in every disease phase of MS

      September 26, 2022

      Neurology updates

      Epstein-Barr virus infection is a major risk factor for the development of multiple sclerosis

      September 26, 2022

      Neurology updates

      Glymphatic system impairment may contribute to multiple sclerosis pathology

      September 23, 2022

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Highlights from the World Muscle Society annual meeting, chosen by the Scientific Panel on Muscle and NMJ Disorders

      November 2, 2022

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Eur J Neurol

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

      Eur J Neurol

      EAN NeuroCOVID-19 Task Force position paper on COVID-19 vaccination hesitancy among people with chronic neurological disorders

      May 2, 2022

      Eur J Neurol

      European Journal of Neurology welcomes new associate editors

      December 13, 2021

      Eur J Neurol

      New European guideline and expert statements on the management of narcolepsy in adults and children

      June 30, 2021

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner graphic of a block staircase with text announcing the application deadline to the EAN's new Cost-Conscious Healthcare (CoCoCare) programme

      Training for the Future of European Guidelines: Cost-Conscious Healthcare 2023

      March 2, 2023

      Scientific Corner

      Join the EAN Guideline Workshop on 24 June!

      May 13, 2022

      Scientific Corner

      First EAN Science School proves a hit in Salzburg

      April 1, 2022

      Scientific Corner

      Invitation to the EAN-EBRAINS Joint Workshop on ‘The Future of Medical Data Sharing in Clinical Neurosciences’

      July 2, 2021

  • Educational
    • All eLearning Student Corner E-Brain Grand Rounds Resident and Research Fellows Fellowship reports Education corner
      Resident and Research Fellows

      24th EAN Spring School

      June 7, 2023

      Resident and Research Fellows

      Clinical Fellowship Reports 2022: London & Brussels

      June 5, 2023

      Student Corner Photo of a sheet of paper, pencil and crumpled paper on a desk.

      EAN 2023 ‘Why Neurology?’ essay contest winners

      May 24, 2023

      Resident and Research Fellows

      Activities for RRFS Members at EAN 2023

      May 4, 2023

      eLearning

      Brush up on your neuroimaging knowledge on the eanCampus!

      April 13, 2023

      eLearning

      Keep your mind sharp with free content on Brain Health through the eanCampus!

      March 13, 2023

      eLearning Illustration of two people holding an award between them and jumping in the air in a celebratory pose

      Learn with the eanCampus and win free EAN congress registration!

      January 12, 2023

      eLearning

      Kick off 2023 with highlights on the eanCampus

      January 10, 2023

      Student Corner Photo of a sheet of paper, pencil and crumpled paper on a desk.

      EAN 2023 ‘Why Neurology?’ essay contest winners

      May 24, 2023

      Student Corner Photo of a sheet of paper, pencil and crumpled paper on a desk.

      Win a travel grant for a future EAN congress with our ‘Why Neurology?’ student essay competition!

      March 10, 2023

      Student Corner Illustration of a vertical pencil point on a blue background, with a yellow light bulb above it

      Students’ Corner: What is it like to be a student on a neurology placement?

      March 10, 2023

      Student Corner

      Application for the Student Teaser Fellowship 2023 NOW OPEN

      February 1, 2023

      E-Brain

      ebrain May update: new website and podcast series

      May 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Resident and Research Fellows

      24th EAN Spring School

      June 7, 2023

      Resident and Research Fellows

      Clinical Fellowship Reports 2022: London & Brussels

      June 5, 2023

      Resident and Research Fellows

      Activities for RRFS Members at EAN 2023

      May 4, 2023

      Resident and Research Fellows

      Clinical Fellowship Reports 2022: Copenhagen & Dresden

      May 4, 2023

      Fellowship reports

      Clinical Fellowship Reports 2022: London & Brussels

      June 5, 2023

      Fellowship reports

      Clinical Fellowship Reports 2022: Copenhagen & Dresden

      May 4, 2023

      Fellowship reports

      Research Fellowship Report 2022 – Centre Hospitalier Universitaire de Lyon, France

      May 4, 2023

      Fellowship reports

      Research Fellowship Report 2022 – Department of Neuropathology, Amsterdam UMC

      May 4, 2023

      Education corner

      24th EAN Spring School

      June 7, 2023

      Education corner

      Clinical Fellowship Reports 2022: London & Brussels

      June 5, 2023

      Education corner

      Clinical Fellowship Reports 2022: Copenhagen & Dresden

      May 4, 2023

      Education corner

      Research Fellowship Report 2022 – Centre Hospitalier Universitaire de Lyon, France

      May 4, 2023

  • Other News
    • All EAN Staff Grant opportunities News from EAN member societies EBC EFNA News in general Patients societies reports Surveys Forum
      EAN Staff

      EAN Head Office Profiles: Dauren & Benita

      June 5, 2023

      EAN Staff

      EAN Head Office Profiles: Kristián & Anna

      May 2, 2023

      EAN Staff

      EAN Head Office Profiles: Antonia & Farah

      April 12, 2023

      Other News

      Alzheimer Europe supports the rights and dignity of people with dementia with three new publications

      April 10, 2023

      EAN Staff

      EAN Head Office Profiles: Dauren & Benita

      June 5, 2023

      EAN Staff

      EAN Head Office Profiles: Kristián & Anna

      May 2, 2023

      EAN Staff

      EAN Head Office Profiles: Antonia & Farah

      April 12, 2023

      EAN Staff Chest-height portrait photo of a woman,

      Never say never – or my 8,752 days with neurologists

      March 20, 2023

      Grant opportunities

      1st EAN Science School, 26-29 March 2022: “Pathophysiology of disorders of the nervous system”

      June 18, 2021

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies Black image titled "In Memoriam" in remembrance of the neurologists lost in the earthquake on 6 February 2023.

      Earthquake in Türkiye and Syria: Statement from President of Turkish Neurological Society

      February 20, 2023

      News from EAN member societies

      14 June: Special publication celebrates 10 years of the European Working Group of People with Dementia

      August 2, 2022

      News from EAN member societies

      14 June: Alzheimer Europe hosts European Parliament Lunch Debate examining EU and WHO policies on neurological conditions

      August 2, 2022

      News from EAN member societies

      22 June: Alzheimer Europe invites applications for its new Anti-Stigma Award

      August 2, 2022

      EBC

      EBC & EFPIA launch RETHINKING Alzheimer’s disease White Paper

      March 22, 2023

      EBC

      Registration and call for abstracts launched for 2023 Brain Innovation Days

      March 21, 2023

      EBC

      Connecting brains for the future: Brain Innovation Days 2022

      November 23, 2022

      EBC

      Final programme available for Brain Innovation Days – Register now!

      September 22, 2022

      EFNA

      OneNeurology European Summit underlines urgent need to prioritise neurology and drive change

      December 31, 2021

      EFNA

      EFNA launch eLearning Platform for neurology advocates

      February 1, 2021

      EFNA

      ‘Me and My Brain’ – Art Competition winners announced!

      February 1, 2021

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      News in general

      Registration now open for the launch event of the RETHINKING Alzheimer’s disease White Paper

      December 24, 2022

      News in general

      EAN lecture at the International Neuro-Urology Society annual congress 2022

      May 25, 2022

      News in general

      EPA-EAN Joint Symposium: ‘Etiology and Treatment of the Long Covid-19 Syndrome’ and other highlights at the 30th European Congress of Psychiatry

      May 25, 2022

      News in general

      Organise an EAN-Day or EAN Regional Teaching Course in your Country!

      May 17, 2022

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      COVID-19 and neurology: a survey of previous and continued restrictions on clinical practice, professional education and neuroeconomics

      March 3, 2023

      Surveys

      Help EAN contribute towards the development of a European Pain Research strategy

      December 5, 2022

      Surveys

      Survey: management of covert brain infarction

      October 29, 2021

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

  • EAN
  • Congress 2023
  • EANpages
  • EAN Campus
  • Eur J Neurol
  • Virtual Congress

eanpages

  • General interest
    • All Executive Page Paper of the Month EAN News EAN Congress news COVID-19 Interviews
      Executive Page

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      Paper of the Month

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      Paper of the Month One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      EAN News

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      Executive Page

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: EAN’s scientific activities provide opportunities to both learn and contribute

      May 1, 2023

      Executive Page

      Executive Page: EAN on a Mission to advocate for brain health & neurology in 2023

      April 11, 2023

      Executive Page Head and shoulders portrait photo of Irena Rektorova, in colourful dress

      Executive Page: Leadership, mentorship and many more EAN educational opportunities

      March 13, 2023

      Paper of the Month

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      Paper of the Month One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      Paper of the Month

      One hot topic, one expert, three questions: Kristian Steen Frederiksen on our May 2023 Paper of the Month

      May 16, 2023

      Paper of the Month

      Research Paper of the Month: Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease

      May 1, 2023

      EAN News

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      EAN News

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      EAN News One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      EAN News

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      EAN Congress news

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      EAN Congress news

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      EAN Congress news

      On sex and gender: the exciting new world of gender neurology at EAN 2023

      May 25, 2023

      EAN Congress news

      Join us for the movement disorders programme at EAN 2023

      May 24, 2023

      COVID-19

      COVID-19 Research Round-Up: Literature reviews – April 2023

      April 26, 2023

      COVID-19

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – April 2023

      April 26, 2023

      COVID-19

      COVID-19 Research Round-Up: Case Series/Case Reports – April 2023

      April 26, 2023

      COVID-19

      COVID-19 Research Round-Up: Literature reviews – March 2023

      March 16, 2023

      Interviews

      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

      Interviews

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajediene

      July 28, 2022

      Interviews

      Video: EAN supports World Brain Day

      July 19, 2022

      Interviews

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

  • Academic/Scientific
    • All Breaking news Neurology updates Scientific committee reports Scientific panels reports Eur J Neurol Top 10 Articles Scientific Corner
      Paper of the Month

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      Paper of the Month One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      EAN News

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      Paper of the Month

      One hot topic, one expert, three questions: Kristian Steen Frederiksen on our May 2023 Paper of the Month

      May 16, 2023

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Miscellaneous – November 2022

      November 7, 2022

      Breaking news

      COVID-19 Breaking News: Observational Studies – Prospective Longitudinal Cohort – November 2022

      November 7, 2022

      Neurology updates

      Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome – A MAGNIMS Study

      September 26, 2022

      Neurology updates

      Relapse-independent disability worsening plays a relevant role in every disease phase of MS

      September 26, 2022

      Neurology updates

      Epstein-Barr virus infection is a major risk factor for the development of multiple sclerosis

      September 26, 2022

      Neurology updates

      Glymphatic system impairment may contribute to multiple sclerosis pathology

      September 23, 2022

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

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Paper of the MonthGeneral interestFeatured Slider

Paper of the month: Improving neuropathy in hereditary transthyretin amyloidosis by targeting mRNA transcription

October 1, 2018

 

 

 

 

 

 

by Elena Moro

 

 

 

For October 2018, we have selected two papers. The first is: Adams D, Gonzales-Duarte A, O’Riordan WD, et al. Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis.(APOLLO trial). NEJM 2018;179:11-21. The second is: Benson MD, M Waddington-Cruz, JL Berk, et al. Inotersen treatment for patients with hereditary transthyretin amyloidosis. (NEURO-TTR trial) NEJM 2018;179:22-31.

 

Hereditary transthyretin amyloidosis is a rare autosomal dominant disorder in which mutations of the gene for transthyretin protein (TTR) induce systemic deposition of amyloid. This accumulation causes progressive peripheral polyneuropathy, cardiomyopathy, nephropathy, and dysfunction in other organs. Because the main production of systemic transthyretin protein is in the liver, liver transplantation has been the treatment goal standard. However, there are several limitations related to this therapy and to other treatments which became more recently available (tafamidis, diflunisal, small molecules that stabilize the circulating tetrameric form of transthyretin and slow disease progression).

Two new chemically modified oligonucleotides, patisiran and inotersen, have been tested in two double-blind, randomized, phase 3 multicenter trials.  These drugs reduce the amyloid deposition by similar mechanisms of action. Patisiran reduces the production of both the wild-type and mutant transthyretin RNA transcripts by binding the 3’ untranslated region of transthyretin mRNA (RNA interference therapeutic agent). Inotersen is an antisense oligonugleotide inhibitor that binding TTR mRNA activates its degradation by RNAase H thus reducing both the wild-type and mutant transthyretin RNA transcripts.

 

In the APOLLO study, Adams and colleagues investigated the effects of patisiran versus placebo in genetically confirmed hereditary transthyretin amyloidosis patients with peripheral neuropathy, and no liver transplant. Primary outcome was change in the modified Neuropathy Impairment Score+7 (mNIS+7) from baseline to 18 months. Among the secondary outcomes there were the  Norfolk Quality of Life-Diabetic Neuropathy (QOL-DN) questionnaire., motor strength, and gait speed. Treatment was given intravenously every 3 weeks. A total of 225 patients (148 randomized to patisiran, and 77 to placebo) were enrolled at 44 centers in 19 countries within about two years. Overall, at the end point, the patisiran group showed a significant improvement in the mNIS+7 compared to placebo (-6.0 ± 1.7 versus 28.0 ± 2.6; p<0.001). Quality of life and gait speed also improved significantly compared to placebo.

The overall incidence of adverse events did not differ between groups.

 

In the NEURO-TTR trial, Benson and colleagues studied the efficacy of inotersen versus placebo in patients coming from 24 centers in 10 countries. Included patients had genetically confirmed hereditary transthyretin amyloidosis with peripheral neuropathy, biopsy-confirmed amyloid deposits, no liver transplant or heart failure. Over three years, a total of 172 patients were randomized to receive inotersen (112) or placebo (60), administered subcutaneously once a week for 65 weeks. Primary outcomes were changes in a slightly different version of the mNIS+7 and the Norfolk QOL-DN questionnaire. About 22% of the patents with inotersen and 13% of the patents with placebo discontinued the study. At 15 months, both the mNIS+7 and the QOL-DN score (-19.7 points and -11.7 points difference, respectively; p<0.001) were improved compared to baseline for the inotersen group versus placebo. Concerning safety, one patient with inotersen died of intracranial hemorrhage due to thrombocytopenia. Fifty-four % of patients treated with inotersen had reduced platelets count. Moreover, glomerulonephritis occurred in three inotersen patients.

 

From the EAN Task Force for Rare Diseases and the EAN Neuropathy Panel, we have the pleasure to have comments from:

Prof. Dr. Davide Pareyson (Department of Clinical Neurosciences, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy) and Prof. Dr. Peter Van den Bergh (Neuromuscular Reference Centre, Department of Neurology, University Hospital Saint-Luc, Brussels, Belgium)

 

These two trials represent a major breakthrough in the treatment of this still lethal disorder, as liver transplantation has limited indications and the TTR stabilizers tafamidis and diflunisal are able to slow but not halt the disease progression. Instead, patisiran and inotersen had a major impact on disease course, resulting in stabilization/improvement (inotersen) or improvement (patisiran) of the disease scores according to the primary outcome measure mNIS+7 in 36 and 56% of patients and in quality of life in 50 and 51% of cases, respectively. Remarkably, both treatments proved effective irrespective of the TTR mutation (Val30Met and non-Val30Met), disease severity, age of onset (early and late onset forms), and presence of cardiomyopathy. Moreover, the difference with the placebo groups was significant for several secondary measures. The treatments were well tolerated, particularly for patisiran, which produced diarrhea, peripheral edema. and infusion-related reaction as the most frequent side effects, whereas more caution is needed with inotersen, which requires monitoring of platelet count and renal function to prevent and monitor adverse effects occurrence. There are still open questions about their use in the long-term treatment, including the consequences of low TTR levels, and those of the continuing TTR production in the eye and in the brain.

The EMA has started the procedures for marketing the compounds. It is fundamental that these drugs, which are life-saving, will soon be accessible throughout Europe to patients at an accessible cost.

 

The other nominees for the October 2018 Paper of the month are:

  • Tawbi HA, Forsyth PA, Algazi A, et al. Combined nivolumab and ipilimumab in melanoma metastatic to the brain. NEJM 2018; 379:722-730. Efficacy and safety of nivolumab abd ipilimumab were assessed in 94 patients with melanoma and at least one untreated brain metastasis without neurological symptoms. At a mean follow-up of 14 months, the majority (57%) of patients showed a clinical intracranial response, with 26% complete clinical benefit, 30% partial benefit, and 2% stable disease.
  • Peter I, Dubinsky M, Bressman S, et al. Anti-tumor necrosis factor therapy and incidence of Parkinson’s disease among patients with inflammatory bowel disease. JAMA Neurol 2018:75;939-946. In this retrospective study, the authors investigated the role of anti-tumor necrosis factor (anti-TNF) therapy as risk factor to develop Parkinson’s disease (PD) in patients with inflammatory bowel disease with or without anti-TNF treatment. Overall, a higher risk to develop PD was found in the 144,018 patients included. However, anti-TNF exposure was associated with decreased risk to develop PD.
  • Tsivgoulis G, Katsanos AH, Mavridis D, et al. Intravenous thrombolysis for ischemic stroke patients on dual antiplatelets. Ann Neurol 2018:84;89-97. The author investigated the effects of dual antiplatelets pre-stroke treatment or no treatment in patients who underwent intravenous thrombolysis for acute ischemic stroke. Data coming from prospectively collected data over a 7-year period of time showed that symptomatic intracerebral hemorrhage, 3-month mortality rate, and functional outcome did not differ between patients without antiplatelet treatment and dual platelet pretreatment history.
  • Vatzaki E, Straus S, Dogne J-M, Burgos JG, Girard T, Martelletti P. Latest clinical recommendation on valproate use for migraine prophylaxis in women of childbearing age: overview from European Medicines Agency and European Headache Federation. J Headache and Pain 2018;19:68. org/10.1186/s10194-018-0898-3. The adverse events induced by valproate to treat migraine in women of childbearing age are well known. For this reasons several recommendations have been implemented in Europe to limit valproate use. In this paper, the authors reviewed the effects of valproate in children exposed in utero, the effectiveness of measures and recommendations from 2014, the 2018 updates recommendations, and practical material for physicians.

 

 

Paper of the month: Improving neuropathy in hereditary transthyretin amyloidosis by targeting mRNA transcription was last modified: November 19th, 2018 by Editor
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