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      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Executive Page

      Executive Page: Antonella Macerollo as Editor of EANpages

      April 1, 2021

      Executive Page

      Executive page: From Website editor to Co-Chair Communication Committee

      February 1, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Country of the Month

      Country of the Month: Lithuania

      March 1, 2021

      Country of the Month

      Country of the Month: Albania

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      Country of the Month: The Netherlands

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      October 1, 2020

      Paper of the Month

      Paper of the month: Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: A non-inflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

      March 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and Efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe Study)

      March 1, 2021

      EAN News

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EAN News

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      EAN News

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

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      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      EAN Congress news

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

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      December 15, 2020

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      December 15, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Cape Verde)

      March 3, 2021

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee interviews Prof. Raad Shakir, CBE

      March 1, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (South Africa)

      February 5, 2021

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      COVID-19

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

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      December 1, 2019

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      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      Breaking news

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      Breaking news

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Breaking news

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Neurology updates

      Neurology Update: Epilepsy

      March 19, 2021

      Neurology updates

      Neurology Update: Coordinating Panel on Rare Neurological Diseases

      March 12, 2021

      Neurology updates

      Neurology Update: Rare Diseases

      March 8, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      The Future of Brain Research: EU-Initiatives and Experts Together for a Shared European Brain Research Agenda

      March 1, 2021

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

  • Educational
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      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Educational

      Clinical Fellowship Reports 2020

      April 1, 2021

      Educational

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Educational

      Clinical Fellowship Reports 2020

      March 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Fellowship reports

      Clinical Fellowship Reports 2020

      April 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2020

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2019

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports III 2019

      February 1, 2021

      Education corner

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Education corner

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      Education corner

      New Scales & Scores on Dementia

      February 11, 2021

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

  • Miscellanea
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      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      General interest

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EBC

      The European Brain Council launches Brain Innovation Policy Roadmap on the occasion of Brain Awareness Week

      April 1, 2021

      Miscellanea

      Alzheimer Europe outlines state-of-play of dementia policy in Europe

      March 31, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

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      December 23, 2018

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      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      News from EMA: First oral treatment for spinal muscular atrophy (SMA) recommended for approval

      March 3, 2021

      News from EAN member societies

      EMA’s Webinar on ”COVID-19 vaccination – what you need to know as a health professional”

      February 5, 2021

      News from EAN member societies

      Personalized plans, blood biomarkers and early interventions: Think Brain Health conference highlights

      February 1, 2021

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      EBC

      The European Brain Council launches Brain Innovation Policy Roadmap on the occasion of Brain Awareness Week

      April 1, 2021

      EBC

      EBC launches statement on the impact of COVID-19 on brain health

      February 1, 2021

      EBC

      EBC launches new series of disease fact sheets!

      December 1, 2020

      EBC

      Present Your Business or Idea at the Brain Innovation Days Pitch Competition

      October 27, 2020

      EFNA

      EFNA launch eLearning Platform for neurology advocates

      February 1, 2021

      EFNA

      ‘Me and My Brain’ – Art Competition winners announced!

      February 1, 2021

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      EFNA

      EFNA Advocacy Awards 2021 – ‘Action Against Stigma’

      October 1, 2020

      News in general

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      News in general

      Alzheimer Europe outlines state-of-play of dementia policy in Europe

      March 31, 2021

      News in general

      EPA Forum 2021: Quality Indicators of Services and Care for Mental Health in Europe, from Clinician to Patient Perspective: A Paradigm Shift?

      March 31, 2021

      News in general

      ONE VOICE FOR NEUROLOGY

      March 31, 2021

      Topic of the Month/Week

      Brain Awareness Week (BAW) is the global campaign to increase public awareness of the progress and benefits of brain research

      March 13, 2018

      Topic of the Month/Week

      Dystonia Europe celebrates 25 years

      March 13, 2018

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Surveys

      SURVEY: Driving with an intracranial tumor

      June 25, 2020

      Surveys

      EAN SURVEY: Neurological Symptoms in COVID-19 Patients

      April 10, 2020

      Surveys

      EMA communication: ICH Good Clinical Practice Guidelines (ICH E6) – Open Comment Opportunity – Deadline: 1 November 2019

      October 7, 2019

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Uncategorized

      Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform

      December 2, 2020

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (New Zealand)

      November 24, 2020

      Uncategorized

      Report from the annual Pain Forum meeting

      November 2, 2020

  • EAN
  • Congress 2020
  • Congress 2021
  • EAN pages
  • Eur J Neurol
  • Virtual Congress

eanpages

  • General interest
    • All COVID-19 Executive Page Country of the Month Paper of the Month EAN News EAN Congress news Interviews
      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Executive Page

      Executive Page: Antonella Macerollo as Editor of EANpages

      April 1, 2021

      Executive Page

      Executive page: From Website editor to Co-Chair Communication Committee

      February 1, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Country of the Month

      Country of the Month: Lithuania

      March 1, 2021

      Country of the Month

      Country of the Month: Albania

      December 1, 2020

      Country of the Month

      Country of the Month: The Netherlands

      November 1, 2020

      Country of the Month

      Country of the Month: Serbia

      October 1, 2020

      Paper of the Month

      Paper of the month: Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: A non-inflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

      March 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and Efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe Study)

      March 1, 2021

      EAN News

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EAN News

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      EAN News

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      EAN Congress news

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      EAN Congress news

      Congress Registration is open

      December 15, 2020

      EAN Congress news

      Abstract Submission is open

      December 15, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Cape Verde)

      March 3, 2021

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee interviews Prof. Raad Shakir, CBE

      March 1, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (South Africa)

      February 5, 2021

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      COVID-19

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      Breaking news

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      Breaking news

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Breaking news

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Neurology updates

      Neurology Update: Epilepsy

      March 19, 2021

      Neurology updates

      Neurology Update: Coordinating Panel on Rare Neurological Diseases

      March 12, 2021

      Neurology updates

      Neurology Update: Rare Diseases

      March 8, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      The Future of Brain Research: EU-Initiatives and Experts Together for a Shared European Brain Research Agenda

      March 1, 2021

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

  • Educational
    • All E-Brain Grand Rounds Continuing medical education Resident and Research Fellows Fellowship reports Education corner
      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Educational

      Clinical Fellowship Reports 2020

      April 1, 2021

      Educational

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Educational

      Clinical Fellowship Reports 2020

      March 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Fellowship reports

      Clinical Fellowship Reports 2020

      April 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2020

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2019

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports III 2019

      February 1, 2021

      Education corner

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Education corner

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      Education corner

      New Scales & Scores on Dementia

      February 11, 2021

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

  • Miscellanea
    • All Holiday Calendar Grant opportunities News from EAN member societies EBC EFNA News in general Topic of the Month/Week Patients societies reports Surveys Forum Uncategorized
      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      General interest

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EBC

      The European Brain Council launches Brain Innovation Policy Roadmap on the occasion of Brain Awareness Week

      April 1, 2021

      Miscellanea

      Alzheimer Europe outlines state-of-play of dementia policy in Europe

      March 31, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

      Holiday Calendar

      23.12. Last-minute gift idea

      December 23, 2018

      Holiday Calendar

      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      News from EMA: First oral treatment for spinal muscular atrophy (SMA) recommended for approval

      March 3, 2021

      News from EAN member societies

      EMA’s Webinar on ”COVID-19 vaccination – what you need to know as a health professional”

      February 5, 2021

      News from EAN member societies

      Personalized plans, blood biomarkers and early interventions: Think Brain Health conference highlights

      February 1, 2021

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

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General interestPaper of the MonthFeatured Slider

Paper of the month: Improving neuropathy in hereditary transthyretin amyloidosis by targeting mRNA transcription

October 1, 2018

 

 

 

 

 

 

by Elena Moro

 

 

 

For October 2018, we have selected two papers. The first is: Adams D, Gonzales-Duarte A, O’Riordan WD, et al. Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis.(APOLLO trial). NEJM 2018;179:11-21. The second is: Benson MD, M Waddington-Cruz, JL Berk, et al. Inotersen treatment for patients with hereditary transthyretin amyloidosis. (NEURO-TTR trial) NEJM 2018;179:22-31.

 

Hereditary transthyretin amyloidosis is a rare autosomal dominant disorder in which mutations of the gene for transthyretin protein (TTR) induce systemic deposition of amyloid. This accumulation causes progressive peripheral polyneuropathy, cardiomyopathy, nephropathy, and dysfunction in other organs. Because the main production of systemic transthyretin protein is in the liver, liver transplantation has been the treatment goal standard. However, there are several limitations related to this therapy and to other treatments which became more recently available (tafamidis, diflunisal, small molecules that stabilize the circulating tetrameric form of transthyretin and slow disease progression).

Two new chemically modified oligonucleotides, patisiran and inotersen, have been tested in two double-blind, randomized, phase 3 multicenter trials.  These drugs reduce the amyloid deposition by similar mechanisms of action. Patisiran reduces the production of both the wild-type and mutant transthyretin RNA transcripts by binding the 3’ untranslated region of transthyretin mRNA (RNA interference therapeutic agent). Inotersen is an antisense oligonugleotide inhibitor that binding TTR mRNA activates its degradation by RNAase H thus reducing both the wild-type and mutant transthyretin RNA transcripts.

 

In the APOLLO study, Adams and colleagues investigated the effects of patisiran versus placebo in genetically confirmed hereditary transthyretin amyloidosis patients with peripheral neuropathy, and no liver transplant. Primary outcome was change in the modified Neuropathy Impairment Score+7 (mNIS+7) from baseline to 18 months. Among the secondary outcomes there were the  Norfolk Quality of Life-Diabetic Neuropathy (QOL-DN) questionnaire., motor strength, and gait speed. Treatment was given intravenously every 3 weeks. A total of 225 patients (148 randomized to patisiran, and 77 to placebo) were enrolled at 44 centers in 19 countries within about two years. Overall, at the end point, the patisiran group showed a significant improvement in the mNIS+7 compared to placebo (-6.0 ± 1.7 versus 28.0 ± 2.6; p<0.001). Quality of life and gait speed also improved significantly compared to placebo.

The overall incidence of adverse events did not differ between groups.

 

In the NEURO-TTR trial, Benson and colleagues studied the efficacy of inotersen versus placebo in patients coming from 24 centers in 10 countries. Included patients had genetically confirmed hereditary transthyretin amyloidosis with peripheral neuropathy, biopsy-confirmed amyloid deposits, no liver transplant or heart failure. Over three years, a total of 172 patients were randomized to receive inotersen (112) or placebo (60), administered subcutaneously once a week for 65 weeks. Primary outcomes were changes in a slightly different version of the mNIS+7 and the Norfolk QOL-DN questionnaire. About 22% of the patents with inotersen and 13% of the patents with placebo discontinued the study. At 15 months, both the mNIS+7 and the QOL-DN score (-19.7 points and -11.7 points difference, respectively; p<0.001) were improved compared to baseline for the inotersen group versus placebo. Concerning safety, one patient with inotersen died of intracranial hemorrhage due to thrombocytopenia. Fifty-four % of patients treated with inotersen had reduced platelets count. Moreover, glomerulonephritis occurred in three inotersen patients.

 

From the EAN Task Force for Rare Diseases and the EAN Neuropathy Panel, we have the pleasure to have comments from:

Prof. Dr. Davide Pareyson (Department of Clinical Neurosciences, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy) and Prof. Dr. Peter Van den Bergh (Neuromuscular Reference Centre, Department of Neurology, University Hospital Saint-Luc, Brussels, Belgium)

 

These two trials represent a major breakthrough in the treatment of this still lethal disorder, as liver transplantation has limited indications and the TTR stabilizers tafamidis and diflunisal are able to slow but not halt the disease progression. Instead, patisiran and inotersen had a major impact on disease course, resulting in stabilization/improvement (inotersen) or improvement (patisiran) of the disease scores according to the primary outcome measure mNIS+7 in 36 and 56% of patients and in quality of life in 50 and 51% of cases, respectively. Remarkably, both treatments proved effective irrespective of the TTR mutation (Val30Met and non-Val30Met), disease severity, age of onset (early and late onset forms), and presence of cardiomyopathy. Moreover, the difference with the placebo groups was significant for several secondary measures. The treatments were well tolerated, particularly for patisiran, which produced diarrhea, peripheral edema. and infusion-related reaction as the most frequent side effects, whereas more caution is needed with inotersen, which requires monitoring of platelet count and renal function to prevent and monitor adverse effects occurrence. There are still open questions about their use in the long-term treatment, including the consequences of low TTR levels, and those of the continuing TTR production in the eye and in the brain.

The EMA has started the procedures for marketing the compounds. It is fundamental that these drugs, which are life-saving, will soon be accessible throughout Europe to patients at an accessible cost.

 

The other nominees for the October 2018 Paper of the month are:

  • Tawbi HA, Forsyth PA, Algazi A, et al. Combined nivolumab and ipilimumab in melanoma metastatic to the brain. NEJM 2018; 379:722-730. Efficacy and safety of nivolumab abd ipilimumab were assessed in 94 patients with melanoma and at least one untreated brain metastasis without neurological symptoms. At a mean follow-up of 14 months, the majority (57%) of patients showed a clinical intracranial response, with 26% complete clinical benefit, 30% partial benefit, and 2% stable disease.
  • Peter I, Dubinsky M, Bressman S, et al. Anti-tumor necrosis factor therapy and incidence of Parkinson’s disease among patients with inflammatory bowel disease. JAMA Neurol 2018:75;939-946. In this retrospective study, the authors investigated the role of anti-tumor necrosis factor (anti-TNF) therapy as risk factor to develop Parkinson’s disease (PD) in patients with inflammatory bowel disease with or without anti-TNF treatment. Overall, a higher risk to develop PD was found in the 144,018 patients included. However, anti-TNF exposure was associated with decreased risk to develop PD.
  • Tsivgoulis G, Katsanos AH, Mavridis D, et al. Intravenous thrombolysis for ischemic stroke patients on dual antiplatelets. Ann Neurol 2018:84;89-97. The author investigated the effects of dual antiplatelets pre-stroke treatment or no treatment in patients who underwent intravenous thrombolysis for acute ischemic stroke. Data coming from prospectively collected data over a 7-year period of time showed that symptomatic intracerebral hemorrhage, 3-month mortality rate, and functional outcome did not differ between patients without antiplatelet treatment and dual platelet pretreatment history.
  • Vatzaki E, Straus S, Dogne J-M, Burgos JG, Girard T, Martelletti P. Latest clinical recommendation on valproate use for migraine prophylaxis in women of childbearing age: overview from European Medicines Agency and European Headache Federation. J Headache and Pain 2018;19:68. org/10.1186/s10194-018-0898-3. The adverse events induced by valproate to treat migraine in women of childbearing age are well known. For this reasons several recommendations have been implemented in Europe to limit valproate use. In this paper, the authors reviewed the effects of valproate in children exposed in utero, the effectiveness of measures and recommendations from 2014, the 2018 updates recommendations, and practical material for physicians.

 

 

Paper of the month: Improving neuropathy in hereditary transthyretin amyloidosis by targeting mRNA transcription was last modified: November 19th, 2018 by Editor
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