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      COVID-19

      Assessing brain capillaries in coronavirus disease 2019

      February 25, 2021

      COVID-19

      Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US—December 14, 2020-January 18, 2021

      February 25, 2021

      COVID-19

      Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection. The COVID A to Z randomized clinical trial

      February 25, 2021

      COVID-19

      Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial

      February 25, 2021

      COVID-19

      Assessing brain capillaries in coronavirus disease 2019

      February 25, 2021

      COVID-19

      Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US—December 14, 2020-January 18, 2021

      February 25, 2021

      COVID-19

      Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection. The COVID A to Z randomized clinical trial

      February 25, 2021

      COVID-19

      Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial

      February 25, 2021

      Executive Page

      Executive page: From Website editor to Co-Chair Communication Committee

      February 1, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

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      Executive Page: Recap of 2020 from Secretary-General

      December 1, 2020

      Country of the Month

      Country of the Month: Albania

      December 1, 2020

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      Country of the Month: The Netherlands

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      Country of the Month: Serbia

      October 1, 2020

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      September 1, 2020

      Paper of the Month

      COVID-19 Paper of the month: Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine

      February 1, 2021

      Paper of the Month

      Research Paper of the month: Trial of dexamethasone for chronic subdural hematoma

      February 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

      January 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial

      January 1, 2021

      EAN News

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

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      Welcome to new year by Editor-in-Chief

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      Congress Registration is open

      December 15, 2020

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      Congress Registration is open

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      December 15, 2020

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      EAN announces Virtual Congress in 2021

      December 1, 2020

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      September 14, 2020

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      COVID-19 around the World: Clinician interviews on experience and impact of the virus (South Africa)

      February 5, 2021

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      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Japan)

      February 1, 2021

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      Interview with Professor Andrea Winkler

      February 1, 2021

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      Interview of the Month with Prof. Maged Abdel Naseer

      February 1, 2021

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      COVID-19

      Assessing brain capillaries in coronavirus disease 2019

      February 25, 2021

      COVID-19

      Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US—December 14, 2020-January 18, 2021

      February 25, 2021

      COVID-19

      Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection. The COVID A to Z randomized clinical trial

      February 25, 2021

      COVID-19

      Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial

      February 25, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

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      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

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      December 1, 2019

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      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      Assessing brain capillaries in coronavirus disease 2019

      February 25, 2021

      Breaking news

      Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US—December 14, 2020-January 18, 2021

      February 25, 2021

      Breaking news

      Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection. The COVID A to Z randomized clinical trial

      February 25, 2021

      Breaking news

      Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial

      February 25, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Neurology updates

      Neurology Update: Dementia and cognitive disorders

      February 18, 2021

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

      Scientific Corner

      New Registrar’s Reading Lists from the Higher Cortical Functions Scientific Panel

      January 17, 2020

  • Educational
    • All E-Brain Grand Rounds Continuing medical education Resident and Research Fellows Fellowship reports Education corner
      Academic/Scientific

      New Scales & Scores on Dementia

      February 11, 2021

      Educational

      Clinical Fellowship Reports III 2019

      February 1, 2021

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      Clinical Fellowship Reports II 2019

      February 1, 2021

      Educational

      Clinical Fellowship Reports I 2019

      February 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Resident and Research Fellows

      EAN Virtual Congress: Round table Special Session: Unleash your potential with EAN!

      May 24, 2020

      Fellowship reports

      Clinical Fellowship Reports III 2019

      February 1, 2021

      Fellowship reports

      Clinical Fellowship Reports II 2019

      February 1, 2021

      Fellowship reports

      Clinical Fellowship Reports I 2019

      February 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2019 III

      December 21, 2020

      Education corner

      New Scales & Scores on Dementia

      February 11, 2021

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Education corner

      EAN Spring School – Application Deadline is 5 February 2021

      December 21, 2020

      Education corner

      Research Fellowship winners 2021

      December 1, 2020

  • Miscellanea
    • All Holiday Calendar Grant opportunities News from EAN member societies EBC EFNA News in general Topic of the Month/Week Patients societies reports Surveys Forum Uncategorized
      Miscellanea

      WFN Brain Health Awareness Public Webinar

      February 16, 2021

      COVID-19

      EMA’s Webinar on ”COVID-19 vaccination – what you need to know as a health professional”

      February 5, 2021

      Miscellanea

      Invitation to ”Inspiring people in Neurosciences” event

      February 1, 2021

      Miscellanea

      EAN and ESRS Memorandum of Understanding signed

      February 1, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

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      December 23, 2018

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      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      EMA’s Webinar on ”COVID-19 vaccination – what you need to know as a health professional”

      February 5, 2021

      News from EAN member societies

      Personalized plans, blood biomarkers and early interventions: Think Brain Health conference highlights

      February 1, 2021

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      News from EAN member societies

      2020 – BioMed Alliance celebrates 10 years of existence

      January 1, 2021

      EBC

      EBC launches statement on the impact of COVID-19 on brain health

      February 1, 2021

      EBC

      EBC launches new series of disease fact sheets!

      December 1, 2020

      EBC

      Present Your Business or Idea at the Brain Innovation Days Pitch Competition

      October 27, 2020

      EBC

      Save the date for the Brain Innovation Days launch!

      October 1, 2020

      EFNA

      EFNA launch eLearning Platform for neurology advocates

      February 1, 2021

      EFNA

      ‘Me and My Brain’ – Art Competition winners announced!

      February 1, 2021

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      EFNA

      EFNA Advocacy Awards 2021 – ‘Action Against Stigma’

      October 1, 2020

      News in general

      WFN Brain Health Awareness Public Webinar

      February 16, 2021

      News in general

      EBC launches statement on the impact of COVID-19 on brain health

      February 1, 2021

      News in general

      European Neuromuscular Centre (ENMC) – Mid-Career Mentoring Programme

      February 1, 2021

      News in general

      Alzheimer Europe launches new guide targeted at health and social care workers and a policy briefing on intercultural care and support

      January 1, 2021

      Topic of the Month/Week

      Brain Awareness Week (BAW) is the global campaign to increase public awareness of the progress and benefits of brain research

      March 13, 2018

      Topic of the Month/Week

      Dystonia Europe celebrates 25 years

      March 13, 2018

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Surveys

      SURVEY: Driving with an intracranial tumor

      June 25, 2020

      Surveys

      EAN SURVEY: Neurological Symptoms in COVID-19 Patients

      April 10, 2020

      Surveys

      EMA communication: ICH Good Clinical Practice Guidelines (ICH E6) – Open Comment Opportunity – Deadline: 1 November 2019

      October 7, 2019

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Uncategorized

      Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform

      December 2, 2020

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (New Zealand)

      November 24, 2020

      Uncategorized

      Report from the annual Pain Forum meeting

      November 2, 2020

  • EAN
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  • Congress 2021
  • EAN pages
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eanpages

  • General interest
    • All COVID-19 Executive Page Country of the Month Paper of the Month EAN News EAN Congress news Interviews
      COVID-19

      Assessing brain capillaries in coronavirus disease 2019

      February 25, 2021

      COVID-19

      Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US—December 14, 2020-January 18, 2021

      February 25, 2021

      COVID-19

      Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection. The COVID A to Z randomized clinical trial

      February 25, 2021

      COVID-19

      Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial

      February 25, 2021

      COVID-19

      Assessing brain capillaries in coronavirus disease 2019

      February 25, 2021

      COVID-19

      Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US—December 14, 2020-January 18, 2021

      February 25, 2021

      COVID-19

      Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection. The COVID A to Z randomized clinical trial

      February 25, 2021

      COVID-19

      Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial

      February 25, 2021

      Executive Page

      Executive page: From Website editor to Co-Chair Communication Committee

      February 1, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Executive Page

      Executive Page: Recap of 2020 from Secretary-General

      December 1, 2020

      Country of the Month

      Country of the Month: Albania

      December 1, 2020

      Country of the Month

      Country of the Month: The Netherlands

      November 1, 2020

      Country of the Month

      Country of the Month: Serbia

      October 1, 2020

      Country of the Month

      Country of the Month: Kazakhstan

      September 1, 2020

      Paper of the Month

      COVID-19 Paper of the month: Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine

      February 1, 2021

      Paper of the Month

      Research Paper of the month: Trial of dexamethasone for chronic subdural hematoma

      February 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

      January 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial

      January 1, 2021

      EAN News

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      EAN News

      Welcome to new year by Editor-in-Chief

      January 1, 2021

      EAN News

      Congress Registration is open

      December 15, 2020

      EAN Congress news

      Congress Registration is open

      December 15, 2020

      EAN Congress news

      Abstract Submission is open

      December 15, 2020

      EAN Congress news

      EAN announces Virtual Congress in 2021

      December 1, 2020

      EAN Congress news

      Investigator Award Winners 2020

      September 14, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (South Africa)

      February 5, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Japan)

      February 1, 2021

      Interviews

      Interview with Professor Andrea Winkler

      February 1, 2021

      Interviews

      Interview of the Month with Prof. Maged Abdel Naseer

      February 1, 2021

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      COVID-19

      Assessing brain capillaries in coronavirus disease 2019

      February 25, 2021

      COVID-19

      Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US—December 14, 2020-January 18, 2021

      February 25, 2021

      COVID-19

      Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection. The COVID A to Z randomized clinical trial

      February 25, 2021

      COVID-19

      Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial

      February 25, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      Assessing brain capillaries in coronavirus disease 2019

      February 25, 2021

      Breaking news

      Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US—December 14, 2020-January 18, 2021

      February 25, 2021

      Breaking news

      Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection. The COVID A to Z randomized clinical trial

      February 25, 2021

      Breaking news

      Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial

      February 25, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Neurology updates

      Neurology Update: Dementia and cognitive disorders

      February 18, 2021

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

      Scientific Corner

      New Registrar’s Reading Lists from the Higher Cortical Functions Scientific Panel

      January 17, 2020

  • Educational
    • All E-Brain Grand Rounds Continuing medical education Resident and Research Fellows Fellowship reports Education corner
      Academic/Scientific

      New Scales & Scores on Dementia

      February 11, 2021

      Educational

      Clinical Fellowship Reports III 2019

      February 1, 2021

      Educational

      Clinical Fellowship Reports II 2019

      February 1, 2021

      Educational

      Clinical Fellowship Reports I 2019

      February 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Resident and Research Fellows

      EAN Virtual Congress: Round table Special Session: Unleash your potential with EAN!

      May 24, 2020

      Fellowship reports

      Clinical Fellowship Reports III 2019

      February 1, 2021

      Fellowship reports

      Clinical Fellowship Reports II 2019

      February 1, 2021

      Fellowship reports

      Clinical Fellowship Reports I 2019

      February 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2019 III

      December 21, 2020

      Education corner

      New Scales & Scores on Dementia

      February 11, 2021

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Education corner

      EAN Spring School – Application Deadline is 5 February 2021

      December 21, 2020

      Education corner

      Research Fellowship winners 2021

      December 1, 2020

  • Miscellanea
    • All Holiday Calendar Grant opportunities News from EAN member societies EBC EFNA News in general Topic of the Month/Week Patients societies reports Surveys Forum Uncategorized
      Miscellanea

      WFN Brain Health Awareness Public Webinar

      February 16, 2021

      COVID-19

      EMA’s Webinar on ”COVID-19 vaccination – what you need to know as a health professional”

      February 5, 2021

      Miscellanea

      Invitation to ”Inspiring people in Neurosciences” event

      February 1, 2021

      Miscellanea

      EAN and ESRS Memorandum of Understanding signed

      February 1, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

      Holiday Calendar

      23.12. Last-minute gift idea

      December 23, 2018

      Holiday Calendar

      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      EMA’s Webinar on ”COVID-19 vaccination – what you need to know as a health professional”

      February 5, 2021

      News from EAN member societies

      Personalized plans, blood biomarkers and early interventions: Think Brain Health conference highlights

      February 1, 2021

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      News from EAN member societies

      2020 – BioMed Alliance celebrates 10 years of existence

      January 1, 2021

      EBC

      EBC launches statement on the impact of COVID-19 on brain health

      February 1, 2021

      EBC

      EBC launches new series of disease fact sheets!

      December 1, 2020

      EBC

      Present Your Business or Idea at the Brain Innovation Days Pitch Competition

      October 27, 2020

      EBC

      Save the date for the Brain Innovation Days launch!

      October 1, 2020

      EFNA

      EFNA launch eLearning Platform for neurology advocates

      February 1, 2021

      EFNA

      ‘Me and My Brain’ – Art Competition winners announced!

      February 1, 2021

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

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Grand Rounds

Case report on non-paraneoplastic autoantibody-negative limbic encephalitis

January 1, 2012

A 69-year old previously healthy man presented in January 2011 with a two-week history of behavioural disturbances including anxiety, hypochondriac complaints and motor hyperactivity. Since the patient never had had any psychiatric symptoms his general practitioner chose to refer him to a neurologist rather than to a psychiatrist.

Neurological examination was unremarkable except for slight motor agitation. During the next days the patient had several episodes of sudden onset of unresponsiveness and orofacial automatisms. The episodes lasted for 30 to 60 seconds.

Magnetic resonance imaging (MRI) of the brain including T2-weighted and fluid attenuated inversion recovery (FLAIR) sequences was unremarkable (fig 1,2). However, EEG revealed epileptic activity in the left frontotemporal area (fig. 3). Fluorodeoxyglucose positron emission tomography (FDG PET) showed an area of increased metabolism in the left mesial temporal lobe (fig 4). Analysis of cerebrospinal fluid was notable for slightly increased protein (0.66 gram/litre) but was otherwise normal. A whole body PET computed tomography was without signs of systemic malignancy. An extensive search for infectious causes and anti-neuronal antibodies, including LGI1, CASPR2, NMDAR and anti-GAD65, was negative. We made a diagnosis of non-paraneoplastic limbic encephalitis without detectable anti-neuronal antibodies.

Treatment with steroids (1000mg prednisolone intravenously once daily during 3 days, followed by 1mg/kg oral prednisolone once daily), intravenous immunoglobulins (IVIG; 0.4g/kg once daily for 5 days) and levetiracetam (500mg twice daily) resulted in a return to baseline within the following months. Repeated neuroimaging in April and May 2011 revealed normal T2-weighted imaging (not shown), hyperintense signal change on MR diffusion weighted imaging (DWI; fig 5a,b) and FLAIR sequences (fig 6) but decreasing signal change on FDG PET (fig 7). The patient discontinued steroid treatment, which resulted a few weeks later in an episode of maniac mood disturbance and motor restlessness. IVIG and steroids were prescribed once again. Levetiracetam was replaced by lamotrigine (initially 25mg once daily, tapered gradually to 100mg once daily). Lamotrigine was chosen because of its mood-stabilizing effects. The patient made a near-complete recovery within the following two weeks. In August 2011 FDG PET showed further decrease of temporal lobe metabolism (fig 8). MR FLAIR and DWI in September revealed normalized signal in the left temporal lobe (fig. 9, 10). The patient is currently on low-dose prednisolone (12.5mg once daily) and lamotrigine. The last follow-up has been unremarkable except for minor irritability. A new MRI is scheduled for January 2012 in order to assess for possible temporal lobe atrophy.

*Legend figure 3: Electroencephalogram revealed epileptic spike and wave activity (red squares) bilaterally with predominance in the left prefrontal lead. This figure shows a 12 second long recording during which the patient was having a seizure with orofacial automatisms and unresponsiveness.

Case presented by:

Daniel Kondziella MD, PhD
Fellow of the European Board of Neurology
Staff neurologist
Department of Neurology
Rigshospitalet, Copenhagen University Hospital
DK-2100 Copenhagen

Comment by Massimo Filippi

Previous reports show that encephalitis frequently manifests as FDG-PET hypermetabolism (see below). Together with previous studies, this case suggests that hypermetabolism may be a sign of epileptic activity.

I have some questions regarding this interesting case:

1. Did the patient undergo a formal neuropsychological battery? It would be useful to see specific cognitive test performances (e.g., memory).

2. The authors should mention whether a Voltage-Gated Potassium Channel Antibodies titre has been performed.

3. Has hyponatraemia in the serum been excluded?

4. Thyroid function and autoantibodies tests should be reported.

5. How was the peripheral nervous system?

Fakhoury T, Abou-Khalil B, Kessler RM (1999) Limbic encephalitis and hyperactive foci on PET scan. Seizure 8(7):427-431.

Kassubek J, Juengling FD, Nitzsche EU, Lucking CH (2001). Limbic encephalitis investigated by 18FDG-PET and 3D MRI. J Neuroimaging 11:55-59.

Lee BY, Newberg AB, Liebeskind DS, Kung J, Alavi A (2004). FDG-PET findings in patients with suspected encephalitis. Clin Nucl Med 29(10):620-625.

Chatzikonstantinou A, Szabo K, Ottomeyer C, Kern R, Hennerici MG (2009). Successive affection of bilateral temporomesial structures in a case of non-paraneoplastic limbic encephalitis demonstrated by serial MRI and FDG-PET. J Neurol 256:1753-1755.

Massimo Filippi is Chair of the EFNS Scientist Panel on Neuroimaging and Director of the Neuroimaging Research Unit, INSPE, Division of Neuroscience, San Raffaele Scientific Institute and Viat-Salute San Raffaele University, Via Olgettina, 60; 20132 Milan, Italy

Comment by Angela Vincent and Christian Bien

This male patient presented with frequent focal seizures plus neuropsychiatric disturbance at the age of 69. Although there was no overt amnesia, and the MRI was negative initially, in the absence of any other identifiable cause (eg infection, tumours), these features in an otherwise healthy person of this age should raise suspicion of VGKC-Ab associated limbic encephalitis.

The lack of clear CSF abnormalities, merely a slightly raised protein, is typical of this syndrome. The authors did search for LGI1 and CASPR2 antibodies but they were negative. LGI1 and CASPR2 are antigens that are part of the VGKC-complex and major targets for the antibodies that immunoprecipitate VGKC-complexes from brain tissue extracts (as used in the radioactive “VGKC” antibody assay since the 1990s). However, these antigens alone do not cover the full spectrum of VGKC-complex Ab positivity. In our experience around 30% of patients with limbic encephalitis and VGKC-complex antibodies are not positive for LGI1 or CASPR2 (Irani et al Brain 2010), and it would have been better to request the VGKC-complex Abs first, and only do the LGI1 and CASPR2 antibodies if they were positive.

They also tested for NMDAR-Abs. These antibodies are often associated with seizures and behavioural disturbance initially but in many cases the patients progress to a much more complex encephalopathy which was not the case here. Moreover, they appear to be uncommon in older patients, particularly males.

The authors remark on the lack of a tumour; it is now clear that the majority of patients with limbic encephalitis, particularly presenting in this age range, are not tumour-associated.

Angela Vincent is Professor of Neurology at the Nuffield Department of Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9TH, United Kingdom

Christian Bien, PD Dr., Krankenhaus Mara, Epilepsie-Zentrum Bethel, Maraweg 21, 33617 Bielefeld, Germany

Case report on non-paraneoplastic autoantibody-negative limbic encephalitis was last modified: January 16th, 2012 by admin
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1 comment

Daniel Kondziella January 18, 2012 at 9:46 am

I thank Prof. Filipo, Prof. Vincent and Prof. Bien for their important comments.

A formal neuropsychology battery has been scheduled; indeed, on the last follow-up the patient’s wife has been complaining about her husband’s forgetfulness. Hyponatremia in the serum has been excluded. The peripheral nervous system and thyroid function were normal, thyroid autiantibodies were negative.

In the meantime we have ordered a second antineuronal antibody analysis from a different laboratory. As a matter of fact, whereas the first analysis for LGI1 antibodies was negative, for unknown reasons, the second analysis has been reported as positive. Thus, we now believe that the patient has LGI1 related limbic encephalitis. I apologize for the confusion, but at least we now have a final diagnosis.

Kind regards from Copenhagen,
Daniel Kondziella

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