I like to signal a couple of papers that could be worthwhile reading with a slightly more focused attention, since both are – to me – evidence of the growing impact of genetics in clinical studies.
a) Yates PA, Villemagne VL, Ellis KA et al; Cerebral microbleeds: a review of clinical, genetic , and neuroimaging associations. Front Neurol; 2014; Jan; 10.3389 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881231/
b) Zhou Q, Yang D, Ombrello AK, et al ; Early-onset stroke and vasculopathy associated with mutations in ADA2. NEJM; 2014; DOI 10.10.1056/NEJMoa1307361