Case series/case reports (Indigo)
In this multinational retrospective study, the authors presented a series of cerebral venous sinus thrombosis (CVST) cases with SARS-CoV-2 infection. In particular, they collected all cases of CVST in SARS-CoV-2 infected patients admitted to nine tertiary stroke centres from the beginning of the pandemic to June 30th, 2020. Moreover the authors compared demographics, clinical and radiological characteristics, risk factors, and outcomes of these patients with a control group of non-SARS-CoV-2 infected CVST patients in the same seasonal period between the years 2012-2016 from the country where the majority of cases were recruited. A total of 13 patients fulfilled inclusion criteria (62% women, mean age 50.9 ± 11.2 years). Six patients were discharged with good outcomes (mRS ≤ 2) and three patients died in hospital. Compared to the control group, the SARS-CoV-2 infected patients were significantly older (50.9 versus 36.7 years, p < 0.001), had a lower rate of identified CVST risk factors (23.1% versus 84.2%, p < 0.001), had more frequent cortical vein involvement (38.5% versus 10.5%, p: 0.025), and a non-significant higher rate of in-hospital mortality (23.1% versus 5.3%, p: 0.073). The authors concluded that CVST should be considered as potential comorbidity in SARS-CoV-2 infected patients presenting with neurological symptoms. Moreover, compared to non-SARS-CoV-2 infected patients, CVST occurs in older patients, with lower rates of known CVST risk factors and might lead to a poorer outcome in the SARS-CoV-2 infected group.