In this article the authors charted memory B cell receptor-encoded antibodies from 19 COVID-19 convalescent subjects against SARS-CoV-2 spike (S) and found 7 major antibody competition groups against epitopes recurrently targeted across individuals.
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Breaking newsCOVID-19
Myocarditis Following Immunization With mRNA COVID-19 Vaccines in Members of the US Military
July 29, 2021The objective of this study was to describe myocarditis presenting after COVID-19 vaccination within the Military Health System. -
Breaking newsCOVID-19
Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 A Meta-analysis
July 29, 2021The objective of this study was to estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes. -
Breaking newsCOVID-19
Effect of Oral Azithromycin vs Placebo on COVID-19 Symptoms in Outpatients With SARS-CoV-2 Infection A Randomized Clinical Trial
July 29, 2021The objective of this randomized clinical trial was to determine whether oral azithromycin in outpatients with SARS-CoV-2 infection leads to absence of self-reported COVID-19 symptoms at day 14. -
Breaking newsCOVID-19
Effect of Canakinumab vs Placebo on Survival Without Invasive Mechanical Ventilation in Patients Hospitalized With Severe COVID-19 A Randomized Clinical Trial
July 29, 2021This randomized, double-blind, placebo-controlled phase 3 trial was conducted at 39 hospitals in Europe and the United States. -
Breaking newsCOVID-19
Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants
July 29, 2021In this article the authors report cryo-EM structures of the full-length spike (S) trimers of the B.1.1.7 and B.1.351 variants, as well as their biochemical and antigenic properties. -
Breaking newsCOVID-19
Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity
July 29, 2021In this article the authors combine cryo-EM, binding and computational analyses to study variant spikes, including one that was involved in transmission between minks and humans, and others that originated and spread in human populations. -
Breaking newsCOVID-19
SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern
July 29, 2021A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), originally detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C in the N-terminal domain (NTD), and L452R in the receptor-binding domain (RBD). -
Breaking newsCOVID-19
Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants
July 28, 2021In this article the authors identify four receptor-binding domain targeting antibodies from three early-outbreak convalescent donors with potent neutralizing activity against 23 variants. -
Breaking newsCOVID-19
Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization
July 28, 2021In this article the authors isolated an infectious Delta strain from a traveller returning from India. -
Breaking newsCOVID-19
Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey
July 28, 2021In this double-blind, randomised, placebo-controlled phase 3 trial the authors present the interim efficacy and safety results of a phase 3 clinical trial of CoronaVac in Turkey. -
Breaking newsCOVID-19
Azithromycin versus standard care in patients with mild-to-moderate COVID-19 (ATOMIC2): an open-label, randomised trial
July 28, 2021In this article the authors assessed whether azithromycin is effective in reducing hospital admission in patients with mild-to-moderate COVID-19. -
Breaking newsCOVID-19
Mental disorders and risk of COVID-19-related mortality, hospitalisation, and intensive care unit admission: a systematic review and meta-analysis
July 28, 2021In this systematic review and meta-analysis, the authors searched various databases between Jan 1, 2020, and March 5, 2021, for original studies reporting data on COVID-19 outcomes in patients with psychiatric disorders compared with controls. -
Breaking newsCOVID-19
Characterizing long COVID in an international cohort: 7 months of symptoms and their impact
July 28, 2021In this article the authors conducted an online survey of people with suspected and confirmed COVID-19, distributed via COVID-19 support groups. -
Breaking newsCOVID-19
Safety and Immunogenicity of a DNA SARS-CoV-2 vaccine (ZyCoV-D): Results of an open-label, non-randomized phase I part of phase I/II clinical study by intradermal route in healthy subjects in India
July 28, 2021In this article the authors conducted a single-center, open-label, non-randomized, Phase 1 trial in India between July 2020 and October 2020.