It is unknown which of his many books James Parkinson (1755-1825) has considered the most important one. His 500 pages ‘Medical Admonitions’ for lay people, his ‘Chemical Pocket Book’ covering interesting facts on modern chemistry of the late 18th century, the ‘Hospital Pupil’ on the educational standards of physician education, his collection of minerals and fossils ‘Organic Remains of a Former World’ or any other of his many contributions. History has clearly shown that his most important contribution was his 1817 ‘Essay on the Shaking Palsy’ which celebrates its 200th birthday this year.
It is a dream of neurologists to cure degenerative diseases. The big brothers, Alzheimer’s and Parkinson’s disease have always been a huge burden of the population but are now, in the millennium of increasing population age becoming a scourge of humanity. While everybody is acknowledging this, both PD (1) and AD (2) communities of clinician researchers and basic researchers are preparing to attack the problem fundamentally frequently unnoticed by the general neurology community.