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  • General interest
    • All COVID-19 Executive Page Country of the Month Paper of the Month EAN News EAN Congress news Interviews
      COVID-19

      Breaking News from EMA

      January 27, 2021

      General interest

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Breaking News from EMA

      January 27, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Executive Page

      Executive Page: Recap of 2020 from Secretary-General

      December 1, 2020

      Executive Page

      Executive Page: Dafin Muresanu reelected as Chair of Communication Committee

      November 1, 2020

      Country of the Month

      Country of the Month: Albania

      December 1, 2020

      Country of the Month

      Country of the Month: The Netherlands

      November 1, 2020

      Country of the Month

      Country of the Month: Serbia

      October 1, 2020

      Country of the Month

      Country of the Month: Kazakhstan

      September 1, 2020

      Paper of the Month

      COVID-19 Paper of the month: Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

      January 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial

      January 1, 2021

      Paper of the Month

      Covid-19 Papers of the month: ”COVID-19 case fatality and Parkinson’s disease” and ”Multiple sclerosis and COVID-19: how many are at risk?”

      December 1, 2020

      Paper of the Month

      Research Paper of the Month: The burden of neurological diseases in Europe: an analysis for the Global Burden of Disease Study 2017

      December 1, 2020

      EAN News

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      EAN News

      Welcome to new year by Editor-in-Chief

      January 1, 2021

      EAN News

      Congress Registration is open

      December 15, 2020

      EAN Congress news

      Congress Registration is open

      December 15, 2020

      EAN Congress news

      Abstract Submission is open

      December 15, 2020

      EAN Congress news

      EAN announces Virtual Congress in 2021

      December 1, 2020

      EAN Congress news

      Investigator Award Winners 2020

      September 14, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Interviews

      Interview of the Month with Marco Medina, President of PAFNS

      January 1, 2021

      Interviews

      External Interview – Asian Oceanian Association of Neurology

      November 1, 2020

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee, interviews Prof. Jean-Antoine Girault, President of FENS – Federation of European Neuroscience Societies

      October 1, 2020

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      COVID-19

      Breaking News from EMA

      January 27, 2021

      Academic/Scientific

      Neurology Update: Pain

      January 27, 2021

      Academic/Scientific

      Neurology Update: Dementia and Cognitive Disorders

      January 27, 2021

      Academic/Scientific

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      Breaking News from EMA

      January 27, 2021

      Breaking news

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      Breaking news

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      Breaking news

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      Neurology updates

      Neurology Update: Pain

      January 27, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      January 27, 2021

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

      Scientific Corner

      New Registrar’s Reading Lists from the Higher Cortical Functions Scientific Panel

      January 17, 2020

  • Educational
    • All E-Brain Grand Rounds Continuing medical education Resident and Research Fellows Fellowship reports Education corner
      General interest

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Educational

      Clinical Fellowship 2021 winners

      January 1, 2021

      Educational

      Clinical Fellowship Reports 2019 III

      December 21, 2020

      Educational

      Clinical Fellowship Reports 2019 II

      December 21, 2020

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Resident and Research Fellows

      EAN Virtual Congress: Round table Special Session: Unleash your potential with EAN!

      May 24, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019 III

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019 II

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019

      November 2, 2020

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Education corner

      EAN Spring School – Application Deadline is 31 January 2021

      December 21, 2020

      Education corner

      Research Fellowship winners 2021

      December 1, 2020

      Education corner

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

  • Miscellanea
    • All Holiday Calendar Grant opportunities News from EAN member societies EBC EFNA News in general Topic of the Month/Week Patients societies reports Surveys Forum Uncategorized
      COVID-19

      Breaking News from EMA

      January 27, 2021

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Miscellanea

      Alzheimer Europe launches new guide targeted at health and social care workers and a policy briefing on intercultural care and support

      January 1, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

      Holiday Calendar

      23.12. Last-minute gift idea

      December 23, 2018

      Holiday Calendar

      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      News from EAN member societies

      2020 – BioMed Alliance celebrates 10 years of existence

      January 1, 2021

      News from EAN member societies

      New BioMed Alliance Statement: Open Access Initiatives must not create inequality

      November 1, 2020

      News from EAN member societies

      Health partnership proposal paves the way for greater role for stakeholders

      October 1, 2020

      EBC

      EBC launches new series of disease fact sheets!

      December 1, 2020

      EBC

      Present Your Business or Idea at the Brain Innovation Days Pitch Competition

      October 27, 2020

      EBC

      Save the date for the Brain Innovation Days launch!

      October 1, 2020

      EBC

      The EBC releases its 2019 Annual Report

      September 1, 2020

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      EFNA

      EFNA Advocacy Awards 2021 – ‘Action Against Stigma’

      October 1, 2020

      EFNA

      EFNA Annual Report 2019 Published

      August 1, 2020

      EFNA

      Results of EFNA’s Survey on Stigma and Neurological Disorder

      July 22, 2020

      News in general

      Alzheimer Europe launches new guide targeted at health and social care workers and a policy briefing on intercultural care and support

      January 1, 2021

      News in general

      Joint strategy sets direction for EMA and EU medicines regulatory agencies to 2025

      January 1, 2021

      News in general

      Societal Impact of Pain Stakeholder Forum

      December 1, 2020

      News in general

      EAN participation in EMA and COVID-19

      December 1, 2020

      Topic of the Month/Week

      Brain Awareness Week (BAW) is the global campaign to increase public awareness of the progress and benefits of brain research

      March 13, 2018

      Topic of the Month/Week

      Dystonia Europe celebrates 25 years

      March 13, 2018

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Surveys

      SURVEY: Driving with an intracranial tumor

      June 25, 2020

      Surveys

      EAN SURVEY: Neurological Symptoms in COVID-19 Patients

      April 10, 2020

      Surveys

      EMA communication: ICH Good Clinical Practice Guidelines (ICH E6) – Open Comment Opportunity – Deadline: 1 November 2019

      October 7, 2019

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Uncategorized

      Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform

      December 2, 2020

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (New Zealand)

      November 24, 2020

      Uncategorized

      Report from the annual Pain Forum meeting

      November 2, 2020

  • EAN
  • Congress 2020
  • Congress 2021
  • EAN pages
  • Eur J Neurol
  • Virtual Congress

eanpages

  • General interest
    • All COVID-19 Executive Page Country of the Month Paper of the Month EAN News EAN Congress news Interviews
      COVID-19

      Breaking News from EMA

      January 27, 2021

      General interest

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Breaking News from EMA

      January 27, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      COVID-19

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      COVID-19

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Executive Page

      Executive Page: Recap of 2020 from Secretary-General

      December 1, 2020

      Executive Page

      Executive Page: Dafin Muresanu reelected as Chair of Communication Committee

      November 1, 2020

      Country of the Month

      Country of the Month: Albania

      December 1, 2020

      Country of the Month

      Country of the Month: The Netherlands

      November 1, 2020

      Country of the Month

      Country of the Month: Serbia

      October 1, 2020

      Country of the Month

      Country of the Month: Kazakhstan

      September 1, 2020

      Paper of the Month

      COVID-19 Paper of the month: Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

      January 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial

      January 1, 2021

      Paper of the Month

      Covid-19 Papers of the month: ”COVID-19 case fatality and Parkinson’s disease” and ”Multiple sclerosis and COVID-19: how many are at risk?”

      December 1, 2020

      Paper of the Month

      Research Paper of the Month: The burden of neurological diseases in Europe: an analysis for the Global Burden of Disease Study 2017

      December 1, 2020

      EAN News

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      EAN News

      Welcome to new year by Editor-in-Chief

      January 1, 2021

      EAN News

      Congress Registration is open

      December 15, 2020

      EAN Congress news

      Congress Registration is open

      December 15, 2020

      EAN Congress news

      Abstract Submission is open

      December 15, 2020

      EAN Congress news

      EAN announces Virtual Congress in 2021

      December 1, 2020

      EAN Congress news

      Investigator Award Winners 2020

      September 14, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Interviews

      Interview of the Month with Marco Medina, President of PAFNS

      January 1, 2021

      Interviews

      External Interview – Asian Oceanian Association of Neurology

      November 1, 2020

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee, interviews Prof. Jean-Antoine Girault, President of FENS – Federation of European Neuroscience Societies

      October 1, 2020

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      COVID-19

      Breaking News from EMA

      January 27, 2021

      Academic/Scientific

      Neurology Update: Pain

      January 27, 2021

      Academic/Scientific

      Neurology Update: Dementia and Cognitive Disorders

      January 27, 2021

      Academic/Scientific

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      Breaking News from EMA

      January 27, 2021

      Breaking news

      Greater decline of acute stroke admissions compared with acute coronary syndromes during COVID‐19 outbreak in Greece: Cerebro/Cardiovascular implications amidst a second wave surge

      January 5, 2021

      Breaking news

      Neurology training and research in the COVID‐19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology

      January 5, 2021

      Breaking news

      Perceived stress and social support in a large population of people with multiple sclerosis recruited online through COVID 19 pandemic.

      January 5, 2021

      Neurology updates

      Neurology Update: Pain

      January 27, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      January 27, 2021

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Neurology updates

      Neurology Update: Epilepsy

      December 1, 2020

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

      Scientific Corner

      New Registrar’s Reading Lists from the Higher Cortical Functions Scientific Panel

      January 17, 2020

  • Educational
    • All E-Brain Grand Rounds Continuing medical education Resident and Research Fellows Fellowship reports Education corner
      General interest

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Educational

      Clinical Fellowship 2021 winners

      January 1, 2021

      Educational

      Clinical Fellowship Reports 2019 III

      December 21, 2020

      Educational

      Clinical Fellowship Reports 2019 II

      December 21, 2020

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Resident and Research Fellows

      EAN Virtual Congress: Round table Special Session: Unleash your potential with EAN!

      May 24, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019 III

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019 II

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019

      December 21, 2020

      Fellowship reports

      Clinical Fellowship Reports 2019

      November 2, 2020

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      Education corner

      EAN Spring School – Application Deadline is 31 January 2021

      December 21, 2020

      Education corner

      Research Fellowship winners 2021

      December 1, 2020

      Education corner

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

  • Miscellanea
    • All Holiday Calendar Grant opportunities News from EAN member societies EBC EFNA News in general Topic of the Month/Week Patients societies reports Surveys Forum Uncategorized
      COVID-19

      Breaking News from EMA

      January 27, 2021

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Miscellanea

      Alzheimer Europe launches new guide targeted at health and social care workers and a policy briefing on intercultural care and support

      January 1, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

      Holiday Calendar

      23.12. Last-minute gift idea

      December 23, 2018

      Holiday Calendar

      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      News from EAN member societies

      2020 – BioMed Alliance celebrates 10 years of existence

      January 1, 2021

      News from EAN member societies

      New BioMed Alliance Statement: Open Access Initiatives must not create inequality

      November 1, 2020

      News from EAN member societies

      Health partnership proposal paves the way for greater role for stakeholders

      October 1, 2020

      EBC

      EBC launches new series of disease fact sheets!

      December 1, 2020

      EBC

      Present Your Business or Idea at the Brain Innovation Days Pitch Competition

      October 27, 2020

      EBC

      Save the date for the Brain Innovation Days launch!

      October 1, 2020

      EBC

      The EBC releases its 2019 Annual Report

      September 1, 2020

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      EFNA

      EFNA Advocacy Awards 2021 – ‘Action Against Stigma’

      October 1, 2020

      EFNA

      EFNA Annual Report 2019 Published

      August 1, 2020

      EFNA

      Results of EFNA’s Survey on Stigma and Neurological Disorder

      July 22, 2020

      News in general

      Alzheimer Europe launches new guide targeted at health and social care workers and a policy briefing on intercultural care and support

      January 1, 2021

      News in general

      Joint strategy sets direction for EMA and EU medicines regulatory agencies to 2025

      January 1, 2021

      News in general

      Societal Impact of Pain Stakeholder Forum

      December 1, 2020

      News in general

      EAN participation in EMA and COVID-19

      December 1, 2020

      Topic of the Month/Week

      Brain Awareness Week (BAW) is the global campaign to increase public awareness of the progress and benefits of brain research

      March 13, 2018

      Topic of the Month/Week

      Dystonia Europe celebrates 25 years

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Grand Rounds

Case Report: Arnold-Chiari malformation presenting with recurrent syncope attacks

January 1, 2013

presented by Burcu Gökçe and Kemal Erdemoğlu

A 39-year-old, right-handed male presented to our outpatient clinic reporting daily occipital headache associated with recurrent syncope over a period of 2 years. His medical history was unremarkable and he took no medication on a regular basis. The patient had a normal neurological examination. His blood pressure was 120/70; his pulse rate was 70. Changes in both were physiologic when he went from supine to upright position. The patient was admitted for electroencephalogram (EEG), no epileptiform abnormalities were seen and his EEG remained normal in the later follow-ups (Figure 1). The cardiac evaluation included echocardiography, and a 24 hour Holter recording were both normal. A Doppler examination of extracranial and intracranial arteries, routine blood tests, thyroid function tests and vitamin B12 levels were also normal. Brain magnetic resonance imaging (MRI) showed a Chiari type I malformation with tonsillar herniation of 9mm below the plane of foramen magnum (Figures 2a and 2b). The patient was evaluated by neurosurgeons and decompression surgery was recommended.

Comment by the authors:

The Chiari type I malformation (CM1) is characterized by herniation of cerebellar tonsils to at least 3-5mm below the plane of foramen magnum. CM1 usually becomes symptomatic in adulthood and presents with some symptoms secondary to medullary distress, such as occipital headaches, sensorimotor abnormalities, and lower cranial nerve palsies (1). Rarely syncopal episodes have also been described (2).
Various pathophysiological mechanisms such as compression of the midbrain ascending reticular system, or vascular compromise (vertebrobasilar artery compression, hypotension secondary to cardiorespiratory center compression) have been proposed, although the exact cause of CM1 related syncope is still not well understood (3).
During a valsalva manoeuvre, intracranial pressure increases for a while and syncopes occur secondary to vertebrobasilar artery compression (4).
A certain similarity of symptoms such as dizziness, nausea, and fatigue is seen in patients with CM1, chronic fatigue syndrome, and orthostatic intolerance (OI), leading to a debate on their possible interrelation (4,5).
According to some authors orthostatic intolerance (OI) is a syndrome characterized by dizziness, nausea, and fatigue and associated with postural tachicardia (heart rate increases by at least 30 beats per minute, in upright posture) and high concentration of plasma norepinephrine concentrations (6,7).
The same condition, in the absence of specification of norepinephrine levels, is also referred to as postural orthostatic tachycardia syndrome (POTS) (5).
POTS has been defined as a rapid (within 10 minutes) increase in heart rate by more than 30 beats per minute, or to a heart rate that exceeds 120 beats per minute. People with POTS develop symptoms whenever they are in upright position (1). The pathophysiology of OI and POTS is still unknown. The blood pressure and heart rate in our patient was always within the normal range when he went from supine to upright position.
Hindbrain compression with or without CM1 can cause the symptoms of OI and it is resolved after surgical intervention but there are not many studies to prove this hypothesis (3).
Arnold-Chiari malformations should be considered in the differential diagnosis of recurrent syncope, especially if accompanied by headache, vertigo, or transient sensory or motor symptoms in arms or legs.

References
1. Prilipko O, Dehdashti AR, Zaim S, Seeck M. Orthostatic intolerance and syncope associated with Chiari type I malformation. J Neurol Neurosurg Psychiatry. 2005 Jul;76(7):1034-6.
2. Milhorat TH, Chou MW, Trinidad EM, et al. Chiari I malformation redefined:clinical and radiographic findings for 364 symptomatic patients.Neurosurgery 1999;44:1005–14.
3. Garland EM, Robertson D. Chiari I malformation as a cause of orthostatic intolerance symptoms: a media myth? Am J Med 2001;111:546–52.
4. Schondorf R, Freeman R. The importance of orthostatic intolerance in the chronic fatigue syndrome. Am J Med Sci 1999;317:117–23.
5. Jacob G, Biaggoni I. Idiopathic orthostatic intolerance and postural tachycardia syndromes. Am J Med Sci 1999;317:88–101.
6. Jacob G, Shannon JR, Black B, et al. Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia. Circulation 1997;96:575-80.
7. Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, Robertson D. Orthostatic intolerance and tachycardia associated with norepinephrine- transporter deficiency. N Engl J Med. 2000; 342: 541-9.

Burcu Gökçe and Kemal Erdemoğlu work at the Department of Neurology of Kirikkale University School of Medicine in Kirikkale, Turkey.

Comment by Pietro Cortelli

To the authors:
I agree with the short discussion that should be completed taking into account the following data:
1) A prospective study of 265 patients with Chiari malformation I (CM1) confirm that syncope is a rare phenomenon; given the definition of syncope it should be better to define these episodes as transient loss of consciousness since we are not sure that a global brain hypoperfusion is the cause (1).
2) Between the various pathophysiological mechanisms that have been proposed to explain the link between syncope and CM1 it should be underlined that the role of PoTS (postural tachycardia syndrome) as possible cause of orthostatic intolerance in CM1 (2) is only a speculation without strong supporting data.
3) A study reviewing MRI scans of the head or cervical spine from 24 female patients with orthostatic intolerance showed that the mean tonsillar depression for this group did not differ from published control values (3).
4) Please use PoTS (postural tachycardia syndrome) instead of POTS (postural and orthostatic are the same concept)

1. Mueller DM, Orò JJ. J Am Acad Nurse Pract 2005;16:134-8.
2. Prilipko O et at,. J Neurol Neuroseurg. Psychiatry 2005; 76: 1003-1036.
3. Benarroch EE. Mayo Clin Proc. 2012 Oct 31.

Comment:
The authors present an interesting case that has been rarely described in the literature, but the condition is probably often unrecognized.
Various pathophysiological mechanisms have been proposed to explain the link between syncope and CM1, but still none have been demonstrated.
A) Compression of the midbrain autonomic control systems: physiologic control of blood pressure regulation involves complex afferent signal processing by the central nervous system and subsequent efferent modulation of cardiac and vascular targets. Normal regulation of arterial pressure is controlled predominantly by stretch-activated (high-pressure) baroreceptors located in the aortic arch and carotid sinus. The afferent signals are transmitted from the aortic arch by the vagus nerve and from the carotid sinus by the glossopharyngeal nerve. Phasic distension of these vascular territories after cardiac systole results in phasic discharge of afferent nerves (IX and X), which converge on the nucleus tractus solitarius (NTS) in the brainstem. This is the first relay station for these cardiovascular (but also respiratory and gastrointestinal) afferents and it’s a critical component of a variety of medullary reflexes related to all other areas of the central autonomic network. Compression of the IX and X nerves at this level (between herniated tonsils and PICA or vertebral artery) could explain the reflex syncope (neurally mediated or vasovagal). Similarly compression or ischemia of the respiratory centre in the medulla oblongata and traction upon the lower cranial nerves (especially IX or X cranial) are considered cause of respiratory disturbance in Chiari I. Beyond NTS, also compression of the intermediate reticular formation of the medulla, particularly ventrolateral medulla that controls the sympathetic and respiratory motoneurones, is considered a potential trigger area causing reflex syncope.
B) PoTS (postural tachycardia syndrome): In support of this hypothesis, Millorath reported that more than 50% of the patients with CM1 refer palpitations and more than 60 % symptoms consistent with cerebral hypoperfusion, such as light-headedness, blurred vision and cognitive difficulties. Nevertheless, PoTS is a chronic condition with no clear pathologic substrate and multiple interacting pathophysiologic mechanisms (impaired sympathetic vasoconstriction leading to venous pooling, hypovolemia, deconditioning, and hyperadrenergic state) and there is an overlap between chronic fatigue syndrome and PoTS. An MRI study of 24 female patients with orthostatic intolerance evaluated that the mean tonsillar depression for this group did not differ from published control values.
Moreover, controversy exists regarding the relationship between CM1, syncope and the benefits of decompression surgery.
In conclusion the correlation between CM1 and syncope needs to be better studied with well-controlled studies based on a more standardized approach. In these cases it is mandatory to improve the quality of diagnosis that derives from the differential diagnosis of TLoC (transient loss of consciousness) and its mimics and to perform a complete evaluation of the autonomic control of the cardiovascular system.

Pietro Cortelli is Professor of Neurology at the IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy.

Case Report: Arnold-Chiari malformation presenting with recurrent syncope attacks was last modified: December 18th, 2012 by Editor
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1 comment

Mohammad Ali Arami February 1, 2013 at 8:21 pm

Ok, It is an intresting case. syncope is very common and has very different causes. It is very important that what was the result of surgery? did surgery stopped the syncop attacks? we have reported a case of Arnold-Chiari with sleep apnea and Ondine course that all symptoms were improved by surgery. Indications for type 1 Arnold-chiar surgery could be much more according to these case reports and sugeries results. We need more experiences with these cases.

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