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      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Executive Page

      Executive Page: Antonella Macerollo as Editor of EANpages

      April 1, 2021

      Executive Page

      Executive page: From Website editor to Co-Chair Communication Committee

      February 1, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Country of the Month

      Country of the Month: Lithuania

      March 1, 2021

      Country of the Month

      Country of the Month: Albania

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      Country of the Month: The Netherlands

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      October 1, 2020

      Paper of the Month

      Paper of the month: Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: A non-inflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

      March 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and Efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe Study)

      March 1, 2021

      EAN News

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EAN News

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      EAN News

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

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      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      EAN Congress news

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

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      December 15, 2020

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      December 15, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Cape Verde)

      March 3, 2021

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee interviews Prof. Raad Shakir, CBE

      March 1, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (South Africa)

      February 5, 2021

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      COVID-19

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

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      December 1, 2019

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      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      Breaking news

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      Breaking news

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Breaking news

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Neurology updates

      Neurology Update: Epilepsy

      March 19, 2021

      Neurology updates

      Neurology Update: Coordinating Panel on Rare Neurological Diseases

      March 12, 2021

      Neurology updates

      Neurology Update: Rare Diseases

      March 8, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      The Future of Brain Research: EU-Initiatives and Experts Together for a Shared European Brain Research Agenda

      March 1, 2021

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

  • Educational
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      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Educational

      Clinical Fellowship Reports 2020

      April 1, 2021

      Educational

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Educational

      Clinical Fellowship Reports 2020

      March 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Fellowship reports

      Clinical Fellowship Reports 2020

      April 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2020

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2019

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports III 2019

      February 1, 2021

      Education corner

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Education corner

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      Education corner

      New Scales & Scores on Dementia

      February 11, 2021

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

  • Miscellanea
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      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      General interest

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EBC

      The European Brain Council launches Brain Innovation Policy Roadmap on the occasion of Brain Awareness Week

      April 1, 2021

      Miscellanea

      Alzheimer Europe outlines state-of-play of dementia policy in Europe

      March 31, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

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      December 23, 2018

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      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      News from EMA: First oral treatment for spinal muscular atrophy (SMA) recommended for approval

      March 3, 2021

      News from EAN member societies

      EMA’s Webinar on ”COVID-19 vaccination – what you need to know as a health professional”

      February 5, 2021

      News from EAN member societies

      Personalized plans, blood biomarkers and early interventions: Think Brain Health conference highlights

      February 1, 2021

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

      January 18, 2021

      EBC

      The European Brain Council launches Brain Innovation Policy Roadmap on the occasion of Brain Awareness Week

      April 1, 2021

      EBC

      EBC launches statement on the impact of COVID-19 on brain health

      February 1, 2021

      EBC

      EBC launches new series of disease fact sheets!

      December 1, 2020

      EBC

      Present Your Business or Idea at the Brain Innovation Days Pitch Competition

      October 27, 2020

      EFNA

      EFNA launch eLearning Platform for neurology advocates

      February 1, 2021

      EFNA

      ‘Me and My Brain’ – Art Competition winners announced!

      February 1, 2021

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      EFNA

      EFNA Advocacy Awards 2021 – ‘Action Against Stigma’

      October 1, 2020

      News in general

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      News in general

      Alzheimer Europe outlines state-of-play of dementia policy in Europe

      March 31, 2021

      News in general

      EPA Forum 2021: Quality Indicators of Services and Care for Mental Health in Europe, from Clinician to Patient Perspective: A Paradigm Shift?

      March 31, 2021

      News in general

      ONE VOICE FOR NEUROLOGY

      March 31, 2021

      Topic of the Month/Week

      Brain Awareness Week (BAW) is the global campaign to increase public awareness of the progress and benefits of brain research

      March 13, 2018

      Topic of the Month/Week

      Dystonia Europe celebrates 25 years

      March 13, 2018

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Surveys

      SURVEY: Driving with an intracranial tumor

      June 25, 2020

      Surveys

      EAN SURVEY: Neurological Symptoms in COVID-19 Patients

      April 10, 2020

      Surveys

      EMA communication: ICH Good Clinical Practice Guidelines (ICH E6) – Open Comment Opportunity – Deadline: 1 November 2019

      October 7, 2019

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Saudi Arabia)

      January 12, 2021

      Uncategorized

      Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform

      December 2, 2020

      Uncategorized

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (New Zealand)

      November 24, 2020

      Uncategorized

      Report from the annual Pain Forum meeting

      November 2, 2020

  • EAN
  • Congress 2020
  • Congress 2021
  • EAN pages
  • Eur J Neurol
  • Virtual Congress

eanpages

  • General interest
    • All COVID-19 Executive Page Country of the Month Paper of the Month EAN News EAN Congress news Interviews
      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Executive Page

      Executive Page: Antonella Macerollo as Editor of EANpages

      April 1, 2021

      Executive Page

      Executive page: From Website editor to Co-Chair Communication Committee

      February 1, 2021

      Executive Page

      Severe COVID-19-related encephalitis can respond to immunotherapy

      January 5, 2021

      Executive Page

      Executive Page: Happy New Year 2021 from the EAN, the Home of Neurology

      January 4, 2021

      Country of the Month

      Country of the Month: Lithuania

      March 1, 2021

      Country of the Month

      Country of the Month: Albania

      December 1, 2020

      Country of the Month

      Country of the Month: The Netherlands

      November 1, 2020

      Country of the Month

      Country of the Month: Serbia

      October 1, 2020

      Paper of the Month

      Paper of the month: Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

      April 1, 2021

      Paper of the Month

      COVID-19 Paper of the month: A non-inflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

      March 1, 2021

      Paper of the Month

      Research Paper of the month: Safety and Efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe Study)

      March 1, 2021

      EAN News

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EAN News

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      EAN News

      European Academy of Neurology endorses the ALBA declaration on Equity and Inclusion

      January 25, 2021

      EAN News

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      EAN Congress news

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      EAN Congress news

      Congress Registration is open

      December 15, 2020

      EAN Congress news

      Abstract Submission is open

      December 15, 2020

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Kenya)

      April 9, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (Cape Verde)

      March 3, 2021

      Interviews

      Prof. Dafin Muresanu, Chair of the EAN Communication Committee interviews Prof. Raad Shakir, CBE

      March 1, 2021

      Interviews

      COVID-19 around the World: Clinician interviews on experience and impact of the virus (South Africa)

      February 5, 2021

  • Academic/Scientific
    • All Scientific committee reports Scientific panels reports Breaking news Neurology updates Eur J Neurol Top 10 Articles Scientific Corner
      COVID-19

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      COVID-19

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      COVID-19

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      COVID-19

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Breaking news

      The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

      April 6, 2021

      Breaking news

      Impact of the COVID‐19 pandemic on stroke teleconsultations in Germany in the first half of 2020

      April 1, 2021

      Breaking news

      Impact of the COVID‐19 pandemic and a national lockdown on hospitalisation for stroke and related 30‐day mortality in France: a nationwide observational study

      April 1, 2021

      Breaking news

      Outcomes and risk factors associated with SARS-CoV-2 infection in a north American registry of patients with multiple sclerosis

      April 1, 2021

      Neurology updates

      Neurology Update: Epilepsy

      March 19, 2021

      Neurology updates

      Neurology Update: Coordinating Panel on Rare Neurological Diseases

      March 12, 2021

      Neurology updates

      Neurology Update: Rare Diseases

      March 8, 2021

      Neurology updates

      Neurology Update: Dementia and Cognitive Disorders

      February 18, 2021

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Eur J Neurol

      EAN consensus statement for management of patients with neurological diseases during the COVID‐19 pandemic

      October 22, 2020

      Eur J Neurol

      BREAKING NEWS: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

      June 30, 2020

      Eur J Neurol

      EUROPEAN JOURNAL OF NEUROLOGY: CONTRIBUTIONS FROM SPANISH AUTHORS

      November 4, 2019

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      The Future of Brain Research: EU-Initiatives and Experts Together for a Shared European Brain Research Agenda

      March 1, 2021

      Scientific Corner

      New Scales & Scores on Sleep-wake disorders

      January 21, 2021

      Scientific Corner

      Registrar’s Reading List: Epilepsy Panel

      November 2, 2020

      Scientific Corner

      Registrar’s Reading List: Dementia

      September 22, 2020

  • Educational
    • All E-Brain Grand Rounds Continuing medical education Resident and Research Fellows Fellowship reports Education corner
      Educational

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Educational

      Clinical Fellowship Reports 2020

      April 1, 2021

      Educational

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Educational

      Clinical Fellowship Reports 2020

      March 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      E-Brain

      ebrain update: Changes in the ebrain team

      November 1, 2018

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Continuing medical education

      CME online – June 2019 

      June 3, 2019

      Continuing medical education

      Continuing Medical Education

      February 21, 2019

      Continuing medical education

      CME online – October 2018

      October 1, 2018

      Continuing medical education

      CME online – July 2018

      July 24, 2018

      Resident and Research Fellows

      RRFS special session in the upcoming virtual congress: Ph.D. and the Neurology residency: Why, when and how?”

      April 7, 2021

      Resident and Research Fellows

      EAN Spring School 2020 – Virtual – Webcasts

      November 20, 2020

      Resident and Research Fellows

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Resident and Research Fellows

      EAN VIRTUAL CONGRESS -Resident and Research Fellow Section General Assembly

      May 26, 2020

      Fellowship reports

      Clinical Fellowship Reports 2020

      April 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2020

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports 2019

      March 1, 2021

      Fellowship reports

      Clinical Fellowship Reports III 2019

      February 1, 2021

      Education corner

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Education corner

      First Virtual EAN Regional Teaching Course in Moscow, Russia

      March 1, 2021

      Education corner

      New Scales & Scores on Dementia

      February 11, 2021

      Education corner

      The First EAN Virtual Master Classes 2020 – Report

      January 1, 2021

  • Miscellanea
    • All Holiday Calendar Grant opportunities News from EAN member societies EBC EFNA News in general Topic of the Month/Week Patients societies reports Surveys Forum Uncategorized
      EAN Congress news

      EAN 2021 – Congress sessions recommended for undergraduate students

      April 14, 2021

      General interest

      International neurology groups unite to drive change for patients amid soaring figures

      April 1, 2021

      EBC

      The European Brain Council launches Brain Innovation Policy Roadmap on the occasion of Brain Awareness Week

      April 1, 2021

      Miscellanea

      Alzheimer Europe outlines state-of-play of dementia policy in Europe

      March 31, 2021

      Holiday Calendar

      EAN Calendar 2020 – Template For Printing

      December 12, 2019

      Holiday Calendar

      24.12. The last day

      December 24, 2018

      Holiday Calendar

      23.12. Last-minute gift idea

      December 23, 2018

      Holiday Calendar

      22.12. A chance to win…

      December 22, 2018

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      News from EMA: First oral treatment for spinal muscular atrophy (SMA) recommended for approval

      March 3, 2021

      News from EAN member societies

      EMA’s Webinar on ”COVID-19 vaccination – what you need to know as a health professional”

      February 5, 2021

      News from EAN member societies

      Personalized plans, blood biomarkers and early interventions: Think Brain Health conference highlights

      February 1, 2021

      News from EAN member societies

      New gene therapy to treat rare genetic disorder metachromatic leukodystrophy

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Grand Rounds

Case Report: Reversible unresponsiveness and complex movement disorder in an 84-year-old lady with cerebral amyloid and hypertensive angiopathy

January 1, 2013

presented by Ricardo Ginestal et al.

An 84-year-old woman, with chronic renal insufficiency due to hypertension and a restrictive and obstructive chronic respiratory condition was admitted to our internal medicine ward with pneumonia and hypoxia. Before admission, her general practitioner (GP) treated her with levofloxacin 500mg bid for 10 days because of dyspnoea, cough and fever. She did not improve and her GP switched to Amoxicilin/Clavulanic Acid 500/125 tid. After 3 days with this treatment scheme she was admitted to our hospital with hypoxia (PaO2 58mmHg, O2 saturation 81%). A full dose regimen of intravenous Cefepime was chosen at admission to treat the pneumonia. Oxygen therapy was also administered.
On day two after admission, she started to be progressively unresponsive. On day 3, left upper limb coreic and ballistic movements, together with lower limb ballistic movements and generalized myoclonias appeared (Video EFNS Grand Rounds 01 2013). The CT scan (Figure 1) showed an extensive chronic microangiopathic angiopathy. The CSF exam did not disclose any sign of infection or haemorrhage. The EEG (Figure 2) demonstrated diffuse 2-3Hz triphasic acute waves. This finding was consistent with a diffuse encephalopathy but non-specific regarding the cause of the symptoms. No signs of epileptic activity were disclosed. The abnormal movements presented by the patient did not alter the EEG record. Due to the predominance of the myoclonias above all other abnormal movements and taking into consideration the renal insufficiency, we started treatment with intravenous valproic acid. We added enteral tiapride in order to control all movement disorders. We also recommended adjusting the antibiotic dose regimen to the glomerular filtration rate. On the 4th day after admission, an MRI scan was performed (Figures 3-7) showing an extensive and severe microangiopathic angiopathy. Several haemosiderin deposits related with old microbleedings were seen both in supratentorial and infratentorial locations. There were no signs of acute haemorrhage or ischaemia. After 4 days with the new antibiotic scheme and under valproic acid and tiapride, the patient started to improve. First, all abnormal movements disappeared. Then, the level of consciousness progressively returned to normal. She was discharged 27 days after admission with no signs of neurological impairment.

Laboratory results:
– At admission: serum Creatinine level was 2.0mg/dl (0.7-1.2) and the glomerular filtration rate of 25ml/min/1.73m2. PaO2 58mmHg, O2 saturation 81%.
– Four days after the introduction of the full dose regimen of Cefepime, serum Creatinine level was 2.5mg/dl (0.7-1.2), glomerular filtration rate of 19ml/min/1.73m2. PaO2 89mmHg, O2 saturation 96% (blood gas levels were normal since day two after admission).
– At discharge, serum Creatinine level was 1.5mg/dl (0.7-1.2) with a glomerular filtration rate of 35ml/min/1.73m2.

Comments by the authors:

Cerebral amyloid angiopathy (CAA), also known as congophilic angiopathy, is increasingly recognized as a cause of lobar intracerebral haemorrhage among individuals over the age of 50. The diagnosis is suspected when the haemorrhage is “lobar” and not in the typical distribution of hypertensive haemorrhages. The Boston Criteria for Diagnosis of Cerebral Amyloid Angiopathy-related haemorrhages classifies as “probable CAA” the event that presents with clinical data of a lobar haemorrhage and a Magnetic Resonance Imaging (MRI) or Computed Tomography (CT) study demonstrating multiple haemorrhages restricted to lobar, cortical, or subcortical regions (cerebellar haemorrhage allowed) in individuals age ≥55 years old. Nevertheless, small haemorrhages can be seen on CT and MRI scans even in the absence of clinical symptoms.
Our patient, as shown in the CT and MRI figures, had both lobar and basal ganglia/ brainstem chronic haemorrhages. Taking into account her age and the clinical history of long-term hypertension, we could consider that she had imaging data fulfilling both cerebral amyloid and hypertensive angiopathy criteria.
The patient we present was admitted to our hospital with hypoxia (PaO2 58mmHg, O2 saturation 81%) and a glomerular filtration value of 25ml/min/1.73m2 (normal >60). A full dose regimen with intravenous cefepime was started. Oxygen therapy rapidly normalized blood gas levels but the renal function deteriorated until an adjustment of the antibiotic scheme to renal function was performed. The chronic vascular damage due to cerebral amyloid and hypertensive angiopathies remained unchanged during all admission time. No signs of acute haemorrhages or recent ischaemic strokes were detected by the imaging procedures. The CSF exam did not disclose signs of infection or bleeding inside the CNS. Therefore, other pathophysiological mechanisms, besides the chronic cerebrovascular disease, had to intervene in order to produce the drowsiness and abnormal movements beginning on day 2 after admission. We hypothesize that the responsible factors probably were a combination of fever and hypoxia due to the pneumonia on one hand and the non-corrected dose of cefepime to the glomerular filtration rate on the other.
Adjusting the cefepime regimen to the renal insufficiency led us to control the pneumonia not deteriorating the renal function.
Oxygen therapy normalized blood gas levels.
Intravenous valproic acid was used due to the predominant myoclonic movements. We preferred it to oral clonazepam because of the low level of consciousness.
Enteral tiapride was administered because there are reports of its utility in controlling movement disorders in cases of elderly patients with hypoxia. The benzamide derivative tiapride has a highly selective antagonistic effect on striatal adenylate cyclase-independent dopamine-2 receptors and the in vitro binding affinity is especially high for dopamine receptors which have been sensitized by pre-incubation with dopamine. The involvement of altered dopamine receptor sensitivity in several extrapyramidal dys- and hyperkinesia has been hypothesized. Clinical studies demonstrate its excellent efficacy in psychomotor agitation in geriatric patients and choreatic movement disorders. Tiapride is well tolerated in daily doses between 300 and 1200 mg. Adverse events are generally rare and mild.

A similar case was previously described by Mitsuoka and cols: A 75-year-old man with bilateral ballistic movements; He had suffered from pulmonary emphysema for about 35 years and was treated with oxygen therapy 3 years before. When he was 70 years old, involuntary movements appeared in bilateral limbs. His involuntary movements were ballistic, and gradually became worse. T2-weighted MRI after admission demonstrated high signal intensities in the bilateral pallidum, indicating multiple brain infarcts in the subcortical white matter. Laboratory studies revealed hypoxia. Medication with clonazepam and tiapride together with oxygen therapy normalized blood gas levels and improved his involuntary movements. But after discharge, he stopped oxygen therapy and involuntary movement became worse again, associated with hypoxia demonstrated by his blood gas analysis. These findings suggested that not only cerebrovascular disease but hypoxia might play an important role in the appearance and exacerbation of involuntary movements.
In this case Mitsuoka and cols, hypoxia appears to be the cause of the involuntary movements together with the chronic cerebrovascular disease in a 75-year-old man.

In our case, an 84-year-old woman with radiological signs of both chronic cerebral amyloid and hypertensive angiopathy, normalizing blood gas levels was not enough to control movement disorders. The worsening of the chronic renal insufficiency by the full dose regimen of cefepime seems to play a pathophysiological role in this clinical picture.

In conclusion, in the elderly patient who presents chronic cerebrovascular disease affecting basal ganglia and/or subcortical white matter, acute systemic disturbances such as hypoxia or renal insufficiency can initiate complex movement disorders. As the treatment with valproic acid, tiapride or other drugs is only symptomatic, metabolic and respiratory causes have to be detected and treated as soon as possible. If so, the prognosis seems to be excellent.

References:
Dose M, Lange HW. The benzamide tiapride: treatment of extrapyramidal motor and other clinical syndromes. Pharmacopsychiatry. 2000 Jan;33(1):19-27.
Mitsuoka T, Murata Y, Harada T, Ishizaki F, Nakamura S. An aged case of bilateral ballistic movement which was thought to be exacerbated by respiratory insufficiency. Nihon Ronen Igakkai Zasshi. 2000 Oct;37(10):823-7.

Ricardo C. Ginestal and his co-authors A. Herranz, P. Garcia-Ruiz, J. del Val, S. Bellido, M.A. Aranda, I. Navas, M.C. Alarcon-Morcillo, B. Gonzalez-Giraldez are working at the Neurology Department at Fundacion Jiménez Diaz Hospital in Madrid, Spain.

Case Report: Reversible unresponsiveness and complex movement disorder in an 84-year-old lady with cerebral amyloid and hypertensive angiopathy was last modified: December 18th, 2012 by Editor
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