The aim of this study is to compare COVID-19–related outcomes collected in an Italian cohort of patients with MS with the outcomes expected in the age- and sex-matched Italian population.
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Breaking newsCOVID-19
Impact of COVID-19 in Immunosuppressed Children With Neuroimmunologic Disorders
December 7, 2021The objective of this study was to investigate the impact of COVID-19 on children receiving immunosuppressive therapies for neuroimmunologic disorders. -
Breaking newsCOVID-19
Frequency of Neurologic Manifestations in COVID-19: A Systematic Review and Meta-analysis
December 7, 2021One year on from the onset of the COVID-19 pandemic, the authors aimed to summarise the frequency of neurological manifestations reported in COVID-19 patients and investigate the association of these manifestations with disease severity and mortality. -
Breaking newsCOVID-19
Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb
December 7, 2021In this article the authors have developed a postmortem bedside surgical procedure to harvest endoscopically samples of respiratory and olfactory mucosae and whole olfactory bulbs. -
Breaking newsCOVID-19
Inhaled and intranasal ciclesonide for the treatment of COVID-19 in adult outpatients: CONTAIN phase II randomised controlled trial
December 7, 2021The objective of this randomised, double blind, placebo controlled trial was to determine if inhaled and intranasal ciclesonide are superior to placebo at decreasing respiratory symptoms in adult outpatients with COVID-19. -
Breaking newsCOVID-19
Effectiveness of public health measures in reducing the incidence of COVID-19, SARS-CoV-2 transmission, and COVID-19 mortality: systematic review and meta-analysis
December 7, 2021The objective of this systematic review and meta-analysis was to review the evidence on the effectiveness of public health measures in reducing the incidence of COVID-19, SARS-CoV-2 transmission, and COVID-19 mortality. -
Breaking newsCOVID-19
Burdens of post-acute sequelae of COVID-19 by severity of acute infection, demographics and health status
December 7, 2021In this article the authors used the healthcare databases of the US to estimate that burden of PASC was 73.43 (72.10, 74.72) per 1000 persons at 6 months. -
Breaking newsCOVID-19
Organ-specific genome diversity of replication-competent SARS-CoV-2
December 7, 2021In this article the authors report an analysis of postmortem COVID-19 cases that provides proof of viremia and presence of replication-competent SARS-CoV-2 in extrapulmonary organs of immunocompromised patients, including heart, kidney, liver, and spleen. -
Breaking newsCOVID-19
Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor Antidepressants
December 3, 2021The objective of this study was to investigate the association of SSRIs with outcomes in patients with COVID-19 by analyzing electronic health records (EHRs). -
Breaking newsCOVID-19
Association of SARS-CoV-2 Infection With Psychological Distress, Psychotropic Prescribing, Fatigue, and Sleep Problems Among UK Primary Care Patients
December 3, 2021The objective of this study was to assess risk of incident or repeat psychiatric illness, fatigue, or sleep problems following SARS-CoV-2 infection and to analyze changes according to demographic subgroups. -
Breaking newsCOVID-19
Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study
December 3, 2021In this study the authors aimed to investigate transmission and viral load kinetics in vaccinated and unvaccinated individuals with mild delta variant infection in the community. -
Breaking newsCOVID-19
Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study
December 3, 2021In this article the authors aimed to use the data repositories of Israel's largest health-care organisation to evaluate the effectiveness of a third dose of the BNT162b2 mRNA vaccine for preventing severe COVID-19 outcomes. -
Breaking newsCOVID-19
Intravenous immunoglobulins in patients with COVID-19-associated moderate-to-severe acute respiratory distress syndrome (ICAR): multicentre, double-blind, placebo-controlled, phase 3 trial
December 3, 2021In this trial, done at 43 centres in France, the authors randomly assigned patients receiving invasive mechanical ventilation for up to 72 h with COVID-19 and associated moderate-to-severe ARDS to receive either IVIG or placebo. -
Breaking newsCOVID-19
Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial
December 3, 2021Adults in receipt of a single dose of ChAdOx1 or BNT162b2 were enrolled at 12 UK sites and randomly assigned to receive concomitant administration of either an age-appropriate influenza vaccine or placebo alongside their second dose of COVID-19 vaccine. -
Breaking newsCOVID-19
Subcutaneous Sarilumab in adults hospitalised with moderate-to-severe COVID-19 pneumonia (CORIMUNO-SARI-1): An open-label randomised controlled trial
December 3, 2021In this study the authors did a multicentric, open-label, Bayesian randomised, adaptive, phase 2/3 clinical trial, nested within the CORIMUNO-19 cohort, to test a superiority hypothesis.