eanpages
  • General interest
    • All Executive Page Paper of the Month EAN News EAN Congress news COVID-19 Interviews
      EAN Congress news

      Join us for the movement disorders programme at EAN 2022

      May 25, 2022

      EAN Congress news

      EMEAC-IFCN to hold several joint sessions on Clinical Neurophysiology at EAN 2022

      May 25, 2022

      Interviews

      Interview: Wolfgang Grisold, President of the World Federation of Neurology

      May 23, 2022

      EAN Congress news

      EAN Tournament Finals – Neurologists in training, on stage!

      May 20, 2022

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: Join the EAN Panels and reinforce our scientific backbone! (Plus ENERGY update, and our first Science School)

      May 1, 2022

      Executive Page

      Executive Page: National societies, our key partners on the path to progress

      April 6, 2022

      Executive Page

      EAN Statement in support of Ukraine

      March 18, 2022

      Executive Page

      Executive Page: supporting young neurologists in the European Year of Youth

      February 1, 2022

      Paper of the Month

      Research Paper of the Month: Prion protein monoclonal antibody (PRN100) therapy for Creutzfeldt-Jakob disease: evaluation of a first-in-human treatment programme

      May 1, 2022

      Paper of the Month

      Covid-19 Paper of the month: Clinical outcomes of COVID-19 infection among patients with Alzheimer’s disease or mild cognitive impairment

      May 1, 2022

      Paper of the Month

      Research Paper of the Month: Clonally expanded B cells in multiple sclerosis bind Epstein–Barr virus EBNA1 and GlialCAM

      April 1, 2022

      Paper of the Month

      Covid-19 Paper of the month: SARS-CoV-2 is associated with changes in brain structure in UK Biobank

      April 1, 2022

      EAN News

      Call for new Chairs for EAN Education Committee and EAN Programme Committee

      May 13, 2022

      EAN News

      EAN Seeks New Officers for Committees & Working Groups

      May 3, 2022

      EAN News

      EAN NeuroCOVID-19 Task Force position paper on COVID-19 vaccination hesitancy among people with chronic neurological disorders

      May 2, 2022

      EAN News

      TREAT AIE: First European networking conference focusing on Autoimmune Encephalitis

      April 27, 2022

      EAN Congress news

      Join us for the movement disorders programme at EAN 2022

      May 25, 2022

      EAN Congress news

      EMEAC-IFCN to hold several joint sessions on Clinical Neurophysiology at EAN 2022

      May 25, 2022

      EAN Congress news

      EAN Tournament Finals – Neurologists in training, on stage!

      May 20, 2022

      EAN Congress news

      ‘Getting evidence into practice’ – the overarching theme for EAN 2022

      May 3, 2022

      COVID-19

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – May 2022

      May 4, 2022

      COVID-19

      COVID-19 Breaking News: Observational studies – prospective longitudinal cohort – May 2022

      May 4, 2022

      COVID-19

      COVID-19 Breaking News: Meta-analyses/systematic reviews – May 2022

      May 4, 2022

      COVID-19

      EAN NeuroCOVID-19 Task Force position paper on COVID-19 vaccination hesitancy among people with chronic neurological disorders

      May 2, 2022

      Interviews

      Interview: Wolfgang Grisold, President of the World Federation of Neurology

      May 23, 2022

      Interviews

      Interview: Prof. Jean-Philippe Azulay, President of the French Society of Neurology

      April 27, 2022

      Interviews Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Interview: Prof. Thomas Berger, President of the Austrian Society of Neurology

      March 22, 2022

      Interviews

      One hot topic, one expert, three questions: Johann Sellner

      February 7, 2022

  • Academic/Scientific
    • All Breaking news Neurology updates Scientific committee reports Scientific panels reports Eur J Neurol Top 10 Articles Scientific Corner
      Scientific Corner

      Join the EAN Guideline Workshop on 24 June!

      May 13, 2022

      Breaking news

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – May 2022

      May 4, 2022

      Breaking news

      COVID-19 Breaking News: Observational studies – prospective longitudinal cohort – May 2022

      May 4, 2022

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – May 2022

      May 4, 2022

      Breaking news

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – May 2022

      May 4, 2022

      Breaking news

      COVID-19 Breaking News: Observational studies – prospective longitudinal cohort – May 2022

      May 4, 2022

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – May 2022

      May 4, 2022

      Breaking news

      Breaking News – May 2022

      May 2, 2022

      Neurology updates

      Neurology Update: Palliative care

      July 6, 2021

      Neurology updates

      Neurology Update: Clinical Neurophysiology

      June 2, 2021

      Neurology updates Hannover Medical School

      Progressive multifocal leukoencephalopathy – promising therapeutic approach with allogeneic BK virus-specific T cells

      May 17, 2021

      Neurology updates

      Neurology Update: Neuroimmunology

      May 12, 2021

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Scientific panels reports

      Scentific Panel of the Month: Higher Cortical Functions

      March 2, 2020

      Eur J Neurol

      EAN NeuroCOVID-19 Task Force position paper on COVID-19 vaccination hesitancy among people with chronic neurological disorders

      May 2, 2022

      Eur J Neurol

      European Journal of Neurology welcomes new associate editors

      December 13, 2021

      Eur J Neurol

      New European guideline and expert statements on the management of narcolepsy in adults and children

      June 30, 2021

      Eur J Neurol

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      Join the EAN Guideline Workshop on 24 June!

      May 13, 2022

      Scientific Corner

      First EAN Science School proves a hit in Salzburg

      April 1, 2022

      Scientific Corner

      Invitation to the EAN-EBRAINS Joint Workshop on ‘The Future of Medical Data Sharing in Clinical Neurosciences’

      July 2, 2021

      Scientific Corner

      1st EAN Science School, 26-29 March 2022: “Pathophysiology of disorders of the nervous system”

      June 18, 2021

  • Educational
    • All eLearning Student Corner E-Brain Grand Rounds Resident and Research Fellows Fellowship reports Education corner
      Education corner

      EAN Virtual Master Classes – A Series of Success!

      May 25, 2022

      Student Corner

      Students’ Corner: A day in the life of a medical student in your country

      May 20, 2022

      Education corner

      Organise an EAN-Day or EAN Regional Teaching Course in your Country!

      May 17, 2022

      Student Corner

      Student Teaser Fellowship winners 2022

      May 11, 2022

      eLearning

      Meet our new eLearning Associate Editors

      August 12, 2021

      eLearning

      Welcoming the new EAN eLearning Editors-in-Chief Prof. Barbara Tettenborn and Prof. Christian Müller

      April 1, 2021

      Student Corner

      Students’ Corner: A day in the life of a medical student in your country

      May 20, 2022

      Student Corner

      Student Teaser Fellowship winners 2022

      May 11, 2022

      Student Corner

      ‘Why Neurology?’ student essay competition: win a travel grant for a future EAN Congress!

      March 14, 2022

      Student Corner

      Apply for the Student Teaser Fellowship 2022 by March 31!

      March 10, 2022

      E-Brain

      ebrain May update: new website and podcast series

      May 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Resident and Research Fellows

      Mentor/mentee pairs matched in second round of EAN Mentorship Programme

      April 25, 2022

      Resident and Research Fellows

      RRFS – National Representatives Network Virtual Meeting

      April 12, 2022

      Resident and Research Fellows

      EAN Autumn School application open until 1 June

      April 1, 2022

      Resident and Research Fellows

      Nicosia, Cyprus, hosts first in-person Regional Teaching Course since start of pandemic

      March 31, 2022

      Fellowship reports

      Clinical Fellowship Reports 2021

      May 9, 2022

      Fellowship reports

      Clinical Fellowship Reports 2021

      April 12, 2022

      Fellowship reports

      Research Fellowship Report 2020

      April 12, 2022

      Fellowship reports

      Research Fellowship Report 2020

      March 21, 2022

      Education corner

      EAN Virtual Master Classes – A Series of Success!

      May 25, 2022

      Education corner

      Organise an EAN-Day or EAN Regional Teaching Course in your Country!

      May 17, 2022

      Education corner

      Student Teaser Fellowship winners 2022

      May 11, 2022

      Education corner

      Mentor/mentee pairs matched in second round of EAN Mentorship Programme

      April 25, 2022

  • Other News
    • All EAN Staff Grant opportunities News from EAN member societies EBC EFNA News in general Patients societies reports Surveys Forum
      News in general

      EAN lecture at the International Neuro-Urology Society annual congress 2022

      May 25, 2022

      News in general

      EPA-EAN Joint Symposium: ‘Etiology and Treatment of the Long Covid-19 Syndrome’ and other highlights at the 30th European Congress of Psychiatry

      May 25, 2022

      Education corner

      Organise an EAN-Day or EAN Regional Teaching Course in your Country!

      May 17, 2022

      News from EAN member societies

      Alzheimer Europe publishes new reports on ‘sex, gender and sexuality in the context of dementia’, and ‘dementia-inclusive initiatives and communities’

      April 5, 2022

      EAN Staff

      EAN Head Office Profiles: Julia & Maria

      April 4, 2022

      EAN Staff

      EAN Head Office Profiles: Elisabeth & Magdalena

      January 28, 2022

      EAN Staff

      EAN Head Office Profiles: Lucia & Anja

      January 3, 2022

      EAN Staff

      EAN Head Office Profiles: Florian & Helene

      December 2, 2021

      Grant opportunities

      1st EAN Science School, 26-29 March 2022: “Pathophysiology of disorders of the nervous system”

      June 18, 2021

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      Alzheimer Europe publishes new reports on ‘sex, gender and sexuality in the context of dementia’, and ‘dementia-inclusive initiatives and communities’

      April 5, 2022

      News from EAN member societies

      Look back at scientific highlights of ECTRIMS 2021

      February 9, 2022

      News from EAN member societies

      Austrian Society of Neurology meeting in-person in March 2022

      November 30, 2021

      News from EAN member societies

      Alzheimer Europe co-authors paper on dementia risk communication

      November 29, 2021

      EBC

      Value of Treatment project releases results and calls to action

      March 29, 2022

      EBC

      Best practices for patient safety: An EU-wide view on the use of medicines off-label

      December 31, 2021

      EBC

      Creating synergies and showcasing innovation: Brain Innovation Days 2021

      November 30, 2021

      EBC

      Best practices for patient safety: Register now!

      October 28, 2021

      EFNA

      OneNeurology European Summit underlines urgent need to prioritise neurology and drive change

      December 31, 2021

      EFNA

      EFNA launch eLearning Platform for neurology advocates

      February 1, 2021

      EFNA

      ‘Me and My Brain’ – Art Competition winners announced!

      February 1, 2021

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      News in general

      EAN lecture at the International Neuro-Urology Society annual congress 2022

      May 25, 2022

      News in general

      EPA-EAN Joint Symposium: ‘Etiology and Treatment of the Long Covid-19 Syndrome’ and other highlights at the 30th European Congress of Psychiatry

      May 25, 2022

      News in general

      Organise an EAN-Day or EAN Regional Teaching Course in your Country!

      May 17, 2022

      News in general

      Value of Treatment project releases results and calls to action

      March 29, 2022

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      Survey: management of covert brain infarction

      October 29, 2021

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Surveys

      SURVEY: Driving with an intracranial tumor

      June 25, 2020

      Surveys

      EAN SURVEY: Neurological Symptoms in COVID-19 Patients

      April 10, 2020

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

  • EAN
  • Congress 2022
  • EAN pages
  • Eur J Neurol
  • Virtual Congress

eanpages

  • General interest
    • All Executive Page Paper of the Month EAN News EAN Congress news COVID-19 Interviews
      EAN Congress news

      Join us for the movement disorders programme at EAN 2022

      May 25, 2022

      EAN Congress news

      EMEAC-IFCN to hold several joint sessions on Clinical Neurophysiology at EAN 2022

      May 25, 2022

      Interviews

      Interview: Wolfgang Grisold, President of the World Federation of Neurology

      May 23, 2022

      EAN Congress news

      EAN Tournament Finals – Neurologists in training, on stage!

      May 20, 2022

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: Join the EAN Panels and reinforce our scientific backbone! (Plus ENERGY update, and our first Science School)

      May 1, 2022

      Executive Page

      Executive Page: National societies, our key partners on the path to progress

      April 6, 2022

      Executive Page

      EAN Statement in support of Ukraine

      March 18, 2022

      Executive Page

      Executive Page: supporting young neurologists in the European Year of Youth

      February 1, 2022

      Paper of the Month

      Research Paper of the Month: Prion protein monoclonal antibody (PRN100) therapy for Creutzfeldt-Jakob disease: evaluation of a first-in-human treatment programme

      May 1, 2022

      Paper of the Month

      Covid-19 Paper of the month: Clinical outcomes of COVID-19 infection among patients with Alzheimer’s disease or mild cognitive impairment

      May 1, 2022

      Paper of the Month

      Research Paper of the Month: Clonally expanded B cells in multiple sclerosis bind Epstein–Barr virus EBNA1 and GlialCAM

      April 1, 2022

      Paper of the Month

      Covid-19 Paper of the month: SARS-CoV-2 is associated with changes in brain structure in UK Biobank

      April 1, 2022

      EAN News

      Call for new Chairs for EAN Education Committee and EAN Programme Committee

      May 13, 2022

      EAN News

      EAN Seeks New Officers for Committees & Working Groups

      May 3, 2022

      EAN News

      EAN NeuroCOVID-19 Task Force position paper on COVID-19 vaccination hesitancy among people with chronic neurological disorders

      May 2, 2022

      EAN News

      TREAT AIE: First European networking conference focusing on Autoimmune Encephalitis

      April 27, 2022

      EAN Congress news

      Join us for the movement disorders programme at EAN 2022

      May 25, 2022

      EAN Congress news

      EMEAC-IFCN to hold several joint sessions on Clinical Neurophysiology at EAN 2022

      May 25, 2022

      EAN Congress news

      EAN Tournament Finals – Neurologists in training, on stage!

      May 20, 2022

      EAN Congress news

      ‘Getting evidence into practice’ – the overarching theme for EAN 2022

      May 3, 2022

      COVID-19

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – May 2022

      May 4, 2022

      COVID-19

      COVID-19 Breaking News: Observational studies – prospective longitudinal cohort – May 2022

      May 4, 2022

      COVID-19

      COVID-19 Breaking News: Meta-analyses/systematic reviews – May 2022

      May 4, 2022

      COVID-19

      EAN NeuroCOVID-19 Task Force position paper on COVID-19 vaccination hesitancy among people with chronic neurological disorders

      May 2, 2022

      Interviews

      Interview: Wolfgang Grisold, President of the World Federation of Neurology

      May 23, 2022

      Interviews

      Interview: Prof. Jean-Philippe Azulay, President of the French Society of Neurology

      April 27, 2022

      Interviews Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Interview: Prof. Thomas Berger, President of the Austrian Society of Neurology

      March 22, 2022

      Interviews

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      February 7, 2022

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Paper of the Month

Paper of the month: Efficacy and safety of andexanet to reverse factor Xa inhibitors activity.

February 1, 2016

Elena Moro by Elena Moro

For February 2016 we have selected: Siegal DM, Curnutte JT, Connolly SJ, et al. Andexanet alfa for the reversal of factor Xa inhibitor activity. N Engl J Med 2015;33:2413-2424.

There is an increased use of direct factor Xa inhibitors (like apixaban, rivaroxaban, and edoxaban) to prevent stroke in patients with nonvalvular atrial fibrillation since these medications have several advantages compared to vitamin K antagonists. However, there has been no specific antidote able to reverse their anticoagulant effects, for example in case of major bleeding or emergency surgery. Recently, andexanet alfa has shown the ability to bind and sequestrate factor Xa inhibitors in the vascular space, thus reestablishing the activity of endogenous factor Xa and decreasing the levels of anticoagulant activity. This anticoagulant reversal capability can be assessed by measuring thrombin generation and anti-factor Xa activity.

A randomized, dual-center, double-blind, placebo-controlled study was conducted to assess the efficacy and safety of andexanet to reverse the anticoagulant effects of apixaban (ANNEXA-A trial) and rivaroxaban (ANNEXA-R trial) in healthy subjects (50-75 years old). Subjects were randomized to receive intravenously andexanet as a bolus, or the bolus followed by a 2-hour intravenous andexanet infusion. Subjects were housed at the study site for 8 days, with safety outcomes assessed 15, 36 and 43 days after drug administration. In the ANNEXA-A group, 5 mg of apixaban were given twice a day for 4 days before being randomized to 400-mg intravenous bolus of andexanet (or placebo), or to the same bolus followed by a continuous infusion of 4-mg andexanet (or placebo) per minute for 120 minutes (480 mg in total). In the ANNEXA-R group, subjects received 20 mg of rivaroxaban once a day for 4 days, and then randomized to an 800-mg intravenous bolus of andexanet (or placebo), or to the same bolus followed by a continuous infusion of 8-mg andexanet (or placebo) per minute for 120 minutes (960 mg in total). Main outcome was the percent change in anti-factor Xa activity, measured with validated chromogenic assay of factor Xa enzymatic activity before and after andexanet or placebo (2-5 minutes after the bolus, and 5 minutes after the continuous infusion). As secondary outcomes, the proportion of participants with 80% reduction in anti-factor Xa activity, the changes in unbound (active) inhibitor plasma concentration and in thrombin generation, and the occurrence of an endogenous thrombin potential above the lower limits were also assessed.

A total of 101 subjects received andexanet, whereas 44 subjects had placebo. After the bolus, andexanet was able to quickly (within 2 to 5 minutes) reduce anti-factor Xa activity by 94% (vs. 21% placebo, 9 subjects; P<0.001) and by 92% (vs. 18% placebo, 14 subjects; P<0.001) in the 24 ANNEXA-A subjects and in the 27 ANNEXA-R subjects, respectively. Similar results were found within subjects who received andexanet bolus followed by continuous infusion. The reversal effects lasted for about 2 hours after both the bolus and the bolus followed by infusion. Andexanet induced at least 80% reversal of anti-factor Xa activity in the participants and normalized thrombin generation within 10 minutes after the bolus. The mean concentrations of unbound apixaban and rivaroxaban were significantly reduced within 2 to 5 minutes after andexanet administration vs. placebo (by 9.3 ng/ml vs. 1.9 ng/ml, P<0.001, and by 23.4 ng/ml vs. 4.2 ng/ml, P<0.001, respectively). Transient elevation of D-Dimer and prothrombin fragments 1 and 2 were observed.

“This study shows that andexanet is effective in reversing the apixaban and rivaroxaban anticoagulant action,” says Prof L. Jaap Kappelle, Division of Neurology, University Medical Centre Utrecht, The Netherlands. “The andexanet reversal ability reached its maximal effect within few minutes after the bolus and remained constant during the continuous infusion. Any biomarker of anticoagulation resumed placebo levels between 1 and 3 hours after andexanet administration. These results are very important due to the real need of a specific antidote for factor Xa inhibitors. Moreover, no major adverse events due to andexanet (in particular, thrombotic events) were reported.”
“Although these results come only from healthy subjects, andexanet seems to be a flexible, potent and rapid drug to quickly restore hemostasis in patients taking factor Xa inhibitors”, says Prof. Thierry Moulin, Department of Neurology, CHU of Besancon, France. “We are impatiently waiting for further clinical trials results, such as the ongoing ANNEXA-4 phase 3b-4 trial (ClinicalTrials.gov identifier: NCT02329327) which is evaluating the efficacy and safety of andexanet in patients with factor Xa inhibitor–associated acute major bleedings, and from those which will evaluate its use in the real stroke world.”

The other nominees for the FEBRUARY paper of the month are:

Strupp R, Taillibert S, Kanner AA, et al. Maintenance therapy with tumor-treating fields plus temozolomide vs temozolomide alone for glioblastoma: a randomized clinical trial. JAMA 2015;314:2535-2543. In this multicenter, open-label trial, the interim analysis showed that combined treatment with tumor-treating fields (locoregionally delivered continuously) combined with temozolomide (150-200 mg/m2/d) was significantly superior to temozolomide alone in improving survival in 325 patients with glioblastoma.

Arya R, Kothari H, Zhang Z, Han B, Horn PS, Glauser TA. Efficacy of nonvenous medications for acute convulsive seizures: a network meta-analysis. Neurology 2015; 85:1859-1868. Results coming from this network meta-analysis about non venous drugs used to treat convulsive seizures and convulsive status epilepticus show that intramuscular midazolam was superior to other drugs concerning time to seizure termination. Intranasal midazolam was the most effective to terminate seizure with 10 minutes of administration.

Franz DN, Agricola K, Mays M, et al. Everolimus for subependymal giant cell astrocytoma: 5-year final analysis. Ann Neurol 2015; 78:929-938. 2015. This paper presents data coming from an open-label phase II study in patients with subependymal giant cell astrocytoma associated with tuberous sclerosis complex treated with everolimus for 5 years. Most patients had both tumor volume and daily seizures reduction. No safety concerns were reported.

Fitzgerald KC, Munger AL, Kochert K, et al. Association of vitamin D levels with multiple sclerosis activity and progression in patients receiving interferon beta-1b. JAMA Neurol 2015;72:1458-1465. Results from 1482 patients with multiple sclerosis undertaking interferon beta-1b (BEYOND study) and prospectively followed for 2 years showed that low serum 25-hydroxyvitamin D levels were associated with higher rates of disease activity observed on brain MRI.

Paper of the month: Efficacy and safety of andexanet to reverse factor Xa inhibitors activity. was last modified: November 13th, 2018 by Editor
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