eanpages
  • General interest
    • All Executive Page Paper of the Month EAN News EAN Congress news COVID-19 Interviews
      EAN News

      Become a Certified Leader of European Neurology with the new EAN Leadership Programme

      January 24, 2023

      EAN News

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      Executive Page

      Executive Page: Submit, register, and join us for EAN 2023

      December 5, 2022

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: New guideline prioritisation process begins setting path for next two years

      November 1, 2022

      Executive Page EAN Secretary General, 2022. Tony Marson, Liverpool UK.

      Executive Page: More reasons than ever to renew your EAN membership

      October 11, 2022

      Executive Page Head and shoulders portrait photo of Irena Rektorova, in colourful dress

      Executive Page: Challenge of maintaining high standards is a privilege says incoming Education Committee Chair

      September 1, 2022

      Paper of the Month

      Research Paper of the Month: Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT)

      January 1, 2023

      Paper of the Month

      COVID-19 Paper of the Month: The decline in stroke hospitalization due to COVID-19 is unrelated to COVID-19 intensity

      January 1, 2023

      Paper of the Month

      Research Paper of the Month: Lecanemab in Early Alzheimer’s Disease

      December 5, 2022

      Paper of the Month

      Covid-19 Paper of the Month: Incidence of Epilepsy and Seizures Over the First 6 Months After a COVID-19 Diagnosis

      December 5, 2022

      EAN News

      Become a Certified Leader of European Neurology with the new EAN Leadership Programme

      January 24, 2023

      EAN News

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      EAN Congress news

      EAN launches new ‘Congress Spin-Off with Masterclasses’ event, with first edition in March

      January 10, 2023

      EAN Congress news

      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

      EAN Congress news

      EAN 2023 – Join us in Budapest on July 1-4

      September 1, 2022

      EAN Congress news

      Special EAN issue of BrainMag features reports on EAN 2022 and more

      August 30, 2022

      COVID-19

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      COVID-19

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      COVID-19

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      COVID-19

      COVID-19 Paper of the Month: The decline in stroke hospitalization due to COVID-19 is unrelated to COVID-19 intensity

      January 1, 2023

      Interviews

      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

      Interviews

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajediene

      July 28, 2022

      Interviews

      Video: EAN supports World Brain Day

      July 19, 2022

      Interviews

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

  • Academic/Scientific
    • All Breaking news Neurology updates Scientific committee reports Scientific panels reports Eur J Neurol Top 10 Articles Scientific Corner
      EAN News

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      EAN News

      Impact of Burnout on Neurology Residents and Research Fellows in Europe

      December 23, 2022

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Miscellaneous – November 2022

      November 7, 2022

      Breaking news

      COVID-19 Breaking News: Observational Studies – Prospective Longitudinal Cohort – November 2022

      November 7, 2022

      Neurology updates

      Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome – A MAGNIMS Study

      September 26, 2022

      Neurology updates

      Relapse-independent disability worsening plays a relevant role in every disease phase of MS

      September 26, 2022

      Neurology updates

      Epstein-Barr virus infection is a major risk factor for the development of multiple sclerosis

      September 26, 2022

      Neurology updates

      Glymphatic system impairment may contribute to multiple sclerosis pathology

      September 23, 2022

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Highlights from the World Muscle Society annual meeting, chosen by the Scientific Panel on Muscle and NMJ Disorders

      November 2, 2022

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Eur J Neurol

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

      Eur J Neurol

      EAN NeuroCOVID-19 Task Force position paper on COVID-19 vaccination hesitancy among people with chronic neurological disorders

      May 2, 2022

      Eur J Neurol

      European Journal of Neurology welcomes new associate editors

      December 13, 2021

      Eur J Neurol

      New European guideline and expert statements on the management of narcolepsy in adults and children

      June 30, 2021

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      Join the EAN Guideline Workshop on 24 June!

      May 13, 2022

      Scientific Corner

      First EAN Science School proves a hit in Salzburg

      April 1, 2022

      Scientific Corner

      Invitation to the EAN-EBRAINS Joint Workshop on ‘The Future of Medical Data Sharing in Clinical Neurosciences’

      July 2, 2021

      Scientific Corner

      1st EAN Science School, 26-29 March 2022: “Pathophysiology of disorders of the nervous system”

      June 18, 2021

  • Educational
    • All eLearning Student Corner E-Brain Grand Rounds Resident and Research Fellows Fellowship reports Education corner
      Student Corner

      Application for the Student Teaser Fellowship 2023 NOW OPEN

      February 1, 2023

      EAN News

      Become a Certified Leader of European Neurology with the new EAN Leadership Programme

      January 24, 2023

      Fellowship reports

      Clinical Fellowship Reports 2022: Stockholm & Erlangen

      January 18, 2023

      Student Corner Illustration of a vertical pencil point on a blue background, with a yellow light bulb above it

      Students’ Corner: What neurology taught me in 2022

      January 17, 2023

      eLearning Illustration of two people holding an award between them and jumping in the air in a celebratory pose

      Learn with the eanCampus and win free EAN congress registration!

      January 12, 2023

      eLearning

      Kick off 2023 with highlights on the eanCampus

      January 10, 2023

      eLearning

      December Highlights on the eanCampus!

      December 5, 2022

      eLearning

      November Highlights on the eanCampus!

      November 4, 2022

      Student Corner

      Application for the Student Teaser Fellowship 2023 NOW OPEN

      February 1, 2023

      Student Corner Illustration of a vertical pencil point on a blue background, with a yellow light bulb above it

      Students’ Corner: What neurology taught me in 2022

      January 17, 2023

      Student Corner

      Student Teaser Fellowship reports 2022 – Karlsbad, Zagreb & Salzburg

      January 10, 2023

      Student Corner

      Student Teaser Fellowship reports 2022 – Salzburg, Ramat Gan, & Rostock

      December 30, 2022

      E-Brain

      ebrain May update: new website and podcast series

      May 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Resident and Research Fellows

      Become a Certified Leader of European Neurology with the new EAN Leadership Programme

      January 24, 2023

      Resident and Research Fellows

      13th Regional Teaching Course in Sub-Saharan Africa – Report

      January 12, 2023

      Resident and Research Fellows Close up photo of a Black graduation cap and yellow tassel

      European Board Examination in Neurology – Reasons to take it and how to contribute

      January 12, 2023

      Resident and Research Fellows

      Third round of pairs matched in EAN Mentorship Programme

      January 12, 2023

      Fellowship reports

      Clinical Fellowship Reports 2022: Stockholm & Erlangen

      January 18, 2023

      Fellowship reports

      Student Teaser Fellowship reports 2022 – Karlsbad, Zagreb & Salzburg

      January 10, 2023

      Fellowship reports

      Clinical Fellowship Reports 2022: Bern & Prague

      December 30, 2022

      Fellowship reports

      Student Teaser Fellowship reports 2022 – Salzburg, Ramat Gan, & Rostock

      December 30, 2022

      Education corner

      Application for the Student Teaser Fellowship 2023 NOW OPEN

      February 1, 2023

      Education corner

      Become a Certified Leader of European Neurology with the new EAN Leadership Programme

      January 24, 2023

      Education corner

      Clinical Fellowship Reports 2022: Stockholm & Erlangen

      January 18, 2023

      Education corner

      13th Regional Teaching Course in Sub-Saharan Africa – Report

      January 12, 2023

  • Other News
    • All EAN Staff Grant opportunities News from EAN member societies EBC EFNA News in general Patients societies reports Surveys Forum
      EAN Staff Composite image consisting of two chest-height portraits ide-by-side

      EAN Head Office Profiles: Katina & Robertina

      February 2, 2023

      Other News Portrait photo of Dr Ralph Sacco, former president of the American Academy of Neurology, in his office, wearing a white lab coat

      In Memoriam: Dr Ralph Sacco, former president of the American Academy of Neurology

      January 19, 2023

      EAN Staff

      EAN Head Office Profiles: Magda & Mira

      December 29, 2022

      News in general

      Registration now open for the launch event of the RETHINKING Alzheimer’s disease White Paper

      December 24, 2022

      EAN Staff Composite image consisting of two chest-height portraits ide-by-side

      EAN Head Office Profiles: Katina & Robertina

      February 2, 2023

      EAN Staff

      EAN Head Office Profiles: Magda & Mira

      December 29, 2022

      EAN Staff

      EAN Head Office Profiles: Peter & Nadine

      November 24, 2022

      EAN Staff

      EAN Head Office Profiles: Katharina & Rena

      October 31, 2022

      Grant opportunities

      1st EAN Science School, 26-29 March 2022: “Pathophysiology of disorders of the nervous system”

      June 18, 2021

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      14 June: Special publication celebrates 10 years of the European Working Group of People with Dementia

      August 2, 2022

      News from EAN member societies

      14 June: Alzheimer Europe hosts European Parliament Lunch Debate examining EU and WHO policies on neurological conditions

      August 2, 2022

      News from EAN member societies

      22 June: Alzheimer Europe invites applications for its new Anti-Stigma Award

      August 2, 2022

      News from EAN member societies

      Alzheimer Europe publishes new reports on ‘sex, gender and sexuality in the context of dementia’, and ‘dementia-inclusive initiatives and communities’

      April 5, 2022

      EBC

      Connecting brains for the future: Brain Innovation Days 2022

      November 23, 2022

      EBC

      Final programme available for Brain Innovation Days – Register now!

      September 22, 2022

      EBC

      EPICLUSTER Final Meeting – shaping the future of epilepsy research in Europe

      August 26, 2022

      EBC

      Registration open for Brain Innovation Days 2022

      August 19, 2022

      EFNA

      OneNeurology European Summit underlines urgent need to prioritise neurology and drive change

      December 31, 2021

      EFNA

      EFNA launch eLearning Platform for neurology advocates

      February 1, 2021

      EFNA

      ‘Me and My Brain’ – Art Competition winners announced!

      February 1, 2021

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      News in general

      Registration now open for the launch event of the RETHINKING Alzheimer’s disease White Paper

      December 24, 2022

      News in general

      EAN lecture at the International Neuro-Urology Society annual congress 2022

      May 25, 2022

      News in general

      EPA-EAN Joint Symposium: ‘Etiology and Treatment of the Long Covid-19 Syndrome’ and other highlights at the 30th European Congress of Psychiatry

      May 25, 2022

      News in general

      Organise an EAN-Day or EAN Regional Teaching Course in your Country!

      May 17, 2022

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      Help EAN contribute towards the development of a European Pain Research strategy

      December 5, 2022

      Surveys

      Survey: management of covert brain infarction

      October 29, 2021

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Surveys

      SURVEY: Driving with an intracranial tumor

      June 25, 2020

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

  • EAN
  • Congress 2023
  • EANpages
  • EAN Campus
  • Eur J Neurol
  • Virtual Congress

eanpages

  • General interest
    • All Executive Page Paper of the Month EAN News EAN Congress news COVID-19 Interviews
      EAN News

      Become a Certified Leader of European Neurology with the new EAN Leadership Programme

      January 24, 2023

      EAN News

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      Executive Page

      Executive Page: Submit, register, and join us for EAN 2023

      December 5, 2022

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: New guideline prioritisation process begins setting path for next two years

      November 1, 2022

      Executive Page EAN Secretary General, 2022. Tony Marson, Liverpool UK.

      Executive Page: More reasons than ever to renew your EAN membership

      October 11, 2022

      Executive Page Head and shoulders portrait photo of Irena Rektorova, in colourful dress

      Executive Page: Challenge of maintaining high standards is a privilege says incoming Education Committee Chair

      September 1, 2022

      Paper of the Month

      Research Paper of the Month: Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT)

      January 1, 2023

      Paper of the Month

      COVID-19 Paper of the Month: The decline in stroke hospitalization due to COVID-19 is unrelated to COVID-19 intensity

      January 1, 2023

      Paper of the Month

      Research Paper of the Month: Lecanemab in Early Alzheimer’s Disease

      December 5, 2022

      Paper of the Month

      Covid-19 Paper of the Month: Incidence of Epilepsy and Seizures Over the First 6 Months After a COVID-19 Diagnosis

      December 5, 2022

      EAN News

      Become a Certified Leader of European Neurology with the new EAN Leadership Programme

      January 24, 2023

      EAN News

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      EAN Congress news

      EAN launches new ‘Congress Spin-Off with Masterclasses’ event, with first edition in March

      January 10, 2023

      EAN Congress news

      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

      EAN Congress news

      EAN 2023 – Join us in Budapest on July 1-4

      September 1, 2022

      EAN Congress news

      Special EAN issue of BrainMag features reports on EAN 2022 and more

      August 30, 2022

      COVID-19

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      COVID-19

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      COVID-19

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      COVID-19

      COVID-19 Paper of the Month: The decline in stroke hospitalization due to COVID-19 is unrelated to COVID-19 intensity

      January 1, 2023

      Interviews

      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

      Interviews

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajediene

      July 28, 2022

      Interviews

      Video: EAN supports World Brain Day

      July 19, 2022

      Interviews

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

  • Academic/Scientific
    • All Breaking news Neurology updates Scientific committee reports Scientific panels reports Eur J Neurol Top 10 Articles Scientific Corner
      EAN News

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      EAN News

      Impact of Burnout on Neurology Residents and Research Fellows in Europe

      December 23, 2022

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Miscellaneous – November 2022

      November 7, 2022

      Breaking news

      COVID-19 Breaking News: Observational Studies – Prospective Longitudinal Cohort – November 2022

      November 7, 2022

      Neurology updates

      Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome – A MAGNIMS Study

      September 26, 2022

      Neurology updates

      Relapse-independent disability worsening plays a relevant role in every disease phase of MS

      September 26, 2022

      Neurology updates

      Epstein-Barr virus infection is a major risk factor for the development of multiple sclerosis

      September 26, 2022

      Neurology updates

      Glymphatic system impairment may contribute to multiple sclerosis pathology

      September 23, 2022

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Highlights from the World Muscle Society annual meeting, chosen by the Scientific Panel on Muscle and NMJ Disorders

      November 2, 2022

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Eur J Neurol

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

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Case report: A young woman with subacute onset of right hand numbness, diplopia and light headache

June 1, 2012

by Sandro Marini

We describe the case of a Caucasian 18-year-old woman self referred to the emergency department because of numbness in her right hand and dyplopia. Approximately one week earlier, the patient gradually began to feel as if her right hand was wrapped tightly in bandages. Two days after she complained of double vision, especially in her left side gaze. The following day a light generalized headache began.
The medical history of the patient includes a laparoscopic appendicectomy at the age of twelve years and some episodes of purulent tonsillitis at the age of sixteen, completely resolved with antibiotics therapy. The patient had been well until two months earlier when she was treated with ranitidine and some homeopathic medicines (“Bittersweet” and “Ignatia”) for epigastric pain. She has been a light smoker since two years before. A cousin of her mother is affected by multiple sclerosis.
In the emergency department, the patient reported a mild headache without any other symptoms. The vital signs were normal. The electrocardiogram was normal. Results of routine laboratory studies were normal including measurements of serum electrolytes, magnesium, calcium, phosphorus and tests of renal and liver function. The ophthalmologist confirmed left sixth cranial nerve palsy. A Computed tomography (CT) of the head did not show any abnormality. The patient was admitted to our Neurological ward.
On examination the blood pressure was 100/60 mmHg, the pulse was 65 beats per minute, the respiratory rate was 24 breaths per minute, the temperature was 36.1°C and the oxygen saturation was 98% while she was breathing ambient air. Neurological examination showed the presence of paraesthesia and hyperalgesia in the right hand and a mild palsy of the left lateral rectus muscle. The remainder of the neurological and physical examination was normal. Magnetic resonance imaging (MRI) with and without contrast showed T2-weighted hyperintense lesions in left paramedian region of Pons with no evidence of contrast enhancement and no abnormality in the intracranial vascolarisation, or restricted water diffusion (figure 1-2). No MRI signal alterations of the spinal cord were demonstrated. Visual evoked potentials (VEP) were normal. A lumbar puncture was performed and results of cerebrospinal fluid analysis are shown in Table 1.
In the hypothesis of an inflammatory demyelinating disease of the Central Nervous System, five days of high doses of Methylprednisolone were administrated. The next day, a diffuse headache began and became more severe with nausea and vomiting on the following days. The blood pressure was increasingly mild to moderate compared to that registered during the last days, but still in the normal reference interval. Two generalized tonic–clonic seizures occurred, with loss of consciousness for 10 minutes. Body temperature was normal. Sinus tachycardia was seen in the electrocardiogram. The hemochrome was normal as well as levels of serum electrolytes, glucose, tests of renal function and coagulation. An electroencephalography (EEG), registered some hours after the attacks, showed dispersed symmetric slowness especially in the occipital regions. The administration of levetiracetam (500 mg three times a day) and valproic acid (500 mg twice daily) was begun. No other seizures appeared but the patient became drowsier and less contactable without any other neurological deficits except the ones described at the admission.
A CT scan of the head demonstrated multiple hypodensities of the parieto-temporal subcortical white matter. MRI showed altered signal in the subcortical white matter of both parietal and occipital lobes (Figures 3-8). Findings on diffusion-weighted images suggested that these abnormalities were areas of vasogenic edema. There was no evidence of restricted water diffusion and magnetic resonance angiography (MRA) clearly visualized the dural venous sinuses. Diagnosis of Posterior reversible encephalopathy syndrome (PRES) was made. Therapy with mannitol was begun. For two days the patient was drowsy with poor awareness. Another EEG was similar to the former. Pregnancy test was negative. Results of erythrocyte sedimentation rate, vitamin B12, folic acid, C-reactive protein and serum protein electrophoresis were normal. Hypercoagulability screening was normal. Testing was negative for: antineutrophil cytoplasmic antibodies, antinuclear antibodies, antibodies against double-stranded DNA, Ro antigen and La antigen, as well as rheumatoid factor. Antibodies for the human immunodeficiency virus (HIV), hepatitis B and C viruses, syphilis, Borrelia burgdorferi, Varicella Zoster and Herpes simplex 2 were negative. Immunoglobulins G (IgG) were low positive for Herpes simplex 1 and Human Herpes virus 6 (HHV 6), but IgM were negative for both. Also neuromyelitis optica (NMO) antibodies were negative. An echography of the abdomen showed a septated cyst of the left adnexa with normal findings about the other organs including kidneys and liver. A transvaginal echography characterized that mass as a corpus luteum. Alpha-fetoprotein (AFP), cancer antigen 125 (CA-125) and Inhibin B were normal.
On the fourth day after the appearance of the seizures the consciousness gradually improved to the level of admission. Diuretic therapy was slowly reduced and no other epileptic attacks occurred. Also, ocular motility recovered completely. A second MRI (figures 9-11) was performed with demonstration of much less edema of the white matter and no contrast enhancement without evidence of any lesions in the left paramedian region of Pons.

Discussion

Clinical and radiological findings in our patient are almost typical for Posterior reversible encephalopathy syndrome. Headache, altered consciousness and tonic–clonic seizures represent clinical symptoms usually characteristic of this syndrome. Furthermore focal regions of symmetric hemispheric edema, distribution in the parietal and occipital lobes and the vasogenic etiology of the edema as established by MR diffusion-weighted imaging (DWI) are all typical of this syndrome (Fugate JE et al. 2010).
Some elements, however, are still controversial. Even if an acute setting is quite common in this disease, the first symptom that appeared was not a clinical feature of Neurotoxicity with PRES. Even if visual disturbance is often observed, this is usually represented by visual blurring or hemianopsia and not by cranial nerve palsy. Moreover the finding of the T2-weighted hyperintense lesion in the left paramedian region of Pons is not usually associated with PRES. Still unsolved is the etiology of this Brain steam lesion in our patient.
Many conditions have been associated with PRES, including preeclampsia/eclampsia, hypercalcemia, renal disease, systemic infections, rheumatologic diseases and immunosuppressive agents alone or in association with bone marrow or solid organ transplantation (G Leroux et al. 2008); but all of these conditions have been ruled out by clinical and instrumental investigations in this case. So apparently no cause of this neurotoxic state was found.
Furthermore PRES is also commonly seen in the setting of hypertension. The upper limits of autoregulation are not typically reached, but moderate-to-severe hypertension is seen in approximately 75% of patients with PRES (W.S. Bartynskia 2008). The blood pressure in our patient was always within the normal range.
Finally, even if corticosteroids have an immunosuppressive effect, PRES could develop only after chemotherapy drugs and, to our knowledge, no posterior reversible encephalopathy syndrome is described in association with cortisone. In fact it is even used as the main therapy in same PRES associated with rheumatologic disease. (Chen et al 2010)

References:

Fugate JE et al. Posterior reversible encephalopathy syndrome: associated clinical and radiologic findings. Mayo Clin Proc. 2010 May;85(5):427-32
G Leroux et al. Posterior reversible encephalopathy syndrome during systemic lupus erythematosus: four new cases and review of the literature, Lupus (2008) 17, 139–147
W.S. Bartynskia, Posterior Reversible Encephalopathy Syndrome, Part 1: Fundamental Imaging and Clinical Features, AJNR June 2008 29: 1036-1042.
Chen HA, et al. Systemic lupus erythematosus complicated with posterior reversible encephalopathy syndrome and intracranial vasculopathy. Int J Rheum Dis. 2010 Oct;13(4):e79-82.
Hinchey J, Chaves C, Appignani B, Breen J, Pao L, Wang A, Pessin MS, Lamy C, Mas JL, Caplan LR. A reversible posterior leukoencephalopathy syndrome. N Engl J Med. 1996 Feb 22;334(8):494-500.

 

S. Marini, G. Lucidi and S. Sorbi are working at the Department of Neurological and Psychiatric Sciences at the University of Florence, Italy

Comment by Jean-Claude Baron

In my opinion this is not a case of PRES. The authors themselves raise two main reasons why this diagnosis is very unlikely: the normal blood pressure, and the initial very focal brain-stem lesion. I would add two additional points: i) she had only mild headaches initially; and ii) the brainstem lesion seems to be in the tegmentum, i.e., affecting gray matter. Furthermore, the imaging is also not suggestive of PRES, as the lesions do not affect the usual white matter areas but are exclusively immediately sub-cortical, affecting the U-fibres.

I am not sure what the diagnosis is but I feel these are inflammatory lesions. We are lacking information on other MRI sequences such as diffusion. I would raise ADEM as first line diagnosis in this young lady.

The written description of the imaging is inadequate (e.g. the authors use the term “edema” for focal T2-weighted lesions).

Jean-Claude Baron is working at the Department of Clincial Neurosciences, Addenbrooke’s Hospital, London, UK

 

 

Case report: A young woman with subacute onset of right hand numbness, diplopia and light headache was last modified: May 20th, 2012 by Editor
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3 comments

Melita Rotar June 1, 2012 at 10:15 am

In my opinion the diagnosis of PRES is questionable for several reasons (normal to low blood pressure, cranial nerve palsy…) as the authors already implied.
The condition that should be excluded in a young adult with seizures, headache, and subcortical MRI lesions is MELAS (mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes). There are several indicators of possibility of this condition:

(a) the first episode is usually in childhood or early adulthood (the patient is 18 years old),
(b) she presented with headache, sixth cranial nerve palsy, and seizures
(c) the MRI lesions are typically subcortical, but there is a possibility of other lesions (the patient has a lesion in pons)
(d) after corticosteroid treatment there is an improvement
(e) there are reports that the MRI lesions in MELAS disappeared after corticosteroid treatment (the same was true in this patient)

In order to diagnose this condition serum and CSF lactic acid and pyruvate should be obtained.

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Domingo Escudero Rubi June 2, 2012 at 8:03 pm

Could be reversible vasoconstriction syndrome.

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Mohammad Ali Arami June 2, 2012 at 9:49 pm

This case may be a self limited postinfectious disease that we could diagnose it as a mild form of ADEM. We have seen many such self limited cases in our clinical experience. I had some cases like your patient that have been SLE which you have rejected.

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