eanpages
  • General interest
    • All Executive Page Paper of the Month EAN News EAN Congress news COVID-19 Interviews
      EAN News

      New EAN Regional Teaching initiative – host an EAN session at your national society’s meeting

      March 30, 2023

      EAN News

      Sign up now for the European Brain Health Summit 2023 – live online on May 9!

      March 28, 2023

      Academic/Scientific

      COVID-19 Research Round-Up: Literature reviews – March 2023

      March 16, 2023

      Academic/Scientific

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – March 2023

      March 16, 2023

      Executive Page Head and shoulders portrait photo of Irena Rektorova, in colourful dress

      Executive Page: Leadership, mentorship and many more EAN educational opportunities

      March 13, 2023

      Executive Page

      Executive Page: Key EAN events and new projects to strengthen neurology on many levels

      February 14, 2023

      Executive Page

      Executive Page: Submit, register, and join us for EAN 2023

      December 5, 2022

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: New guideline prioritisation process begins setting path for next two years

      November 1, 2022

      Paper of the Month One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – March 2023

      March 14, 2023

      Paper of the Month

      Research Paper of the Month: Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease

      March 13, 2023

      Paper of the Month

      Research Paper of the Month: Headache attributed to SARS-CoV-2 infection, vaccination and the impact on primary headache disorders of the COVID-19 pandemic

      February 9, 2023

      Paper of the Month

      COVID-19 Paper of the Month: Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study

      February 9, 2023

      EAN News

      New EAN Regional Teaching initiative – host an EAN session at your national society’s meeting

      March 30, 2023

      EAN News

      Sign up now for the European Brain Health Summit 2023 – live online on May 9!

      March 28, 2023

      EAN News Mapy of the world made from pills of various sizes, shapes and colours

      EAN endorses MSIF and the WHO Collaborating Centre Bologna’s application to add MS treatments on WHO’s Essential Medicines List

      March 14, 2023

      EAN News Head and shoulders portrait photo of Irena Rektorova, in colourful dress

      Executive Page: Leadership, mentorship and many more EAN educational opportunities

      March 13, 2023

      EAN Congress news

      EAN 2023 Congress Quiz – your chance to win free registration!

      March 14, 2023

      EAN Congress news Photo of a sheet of paper, pencil and crumpled paper on a desk.

      Win a travel grant for a future EAN congress with our ‘Why Neurology?’ student essay competition!

      March 10, 2023

      EAN Congress news

      New ‘Start-Up Corner’ introduced for EAN 2023 industrial exhibition

      February 13, 2023

      EAN Congress news EAN 2023 congress logo top left; running stick figure centre with Register Now in large type; EAN 2023 hashtag, bottom right

      Register Now for EAN 2023 in Budapest, 1-4 July

      February 10, 2023

      COVID-19

      COVID-19 Research Round-Up: Literature reviews – March 2023

      March 16, 2023

      COVID-19

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – March 2023

      March 16, 2023

      COVID-19

      COVID-19 Research Round-Up: Case Series/Case Reports – March 2023

      March 16, 2023

      COVID-19

      COVID-19 Research Round-Up: Meta-analyses/systematic reviews – March 2023

      March 16, 2023

      Interviews

      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

      Interviews

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajediene

      July 28, 2022

      Interviews

      Video: EAN supports World Brain Day

      July 19, 2022

      Interviews

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

  • Academic/Scientific
    • All Breaking news Neurology updates Scientific committee reports Scientific panels reports Eur J Neurol Top 10 Articles Scientific Corner
      Academic/Scientific

      COVID-19 Research Round-Up: Literature reviews – March 2023

      March 16, 2023

      Academic/Scientific

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – March 2023

      March 16, 2023

      Academic/Scientific

      COVID-19 Research Round-Up: Case Series/Case Reports – March 2023

      March 16, 2023

      Academic/Scientific

      COVID-19 Research Round-Up: Meta-analyses/systematic reviews – March 2023

      March 16, 2023

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Miscellaneous – November 2022

      November 7, 2022

      Breaking news

      COVID-19 Breaking News: Observational Studies – Prospective Longitudinal Cohort – November 2022

      November 7, 2022

      Neurology updates

      Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome – A MAGNIMS Study

      September 26, 2022

      Neurology updates

      Relapse-independent disability worsening plays a relevant role in every disease phase of MS

      September 26, 2022

      Neurology updates

      Epstein-Barr virus infection is a major risk factor for the development of multiple sclerosis

      September 26, 2022

      Neurology updates

      Glymphatic system impairment may contribute to multiple sclerosis pathology

      September 23, 2022

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Highlights from the World Muscle Society annual meeting, chosen by the Scientific Panel on Muscle and NMJ Disorders

      November 2, 2022

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Eur J Neurol

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

      Eur J Neurol

      EAN NeuroCOVID-19 Task Force position paper on COVID-19 vaccination hesitancy among people with chronic neurological disorders

      May 2, 2022

      Eur J Neurol

      European Journal of Neurology welcomes new associate editors

      December 13, 2021

      Eur J Neurol

      New European guideline and expert statements on the management of narcolepsy in adults and children

      June 30, 2021

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner graphic of a block staircase with text announcing the application deadline to the EAN's new Cost-Conscious Healthcare (CoCoCare) programme

      Training for the Future of European Guidelines: Cost-Conscious Healthcare 2023

      March 2, 2023

      Scientific Corner

      Join the EAN Guideline Workshop on 24 June!

      May 13, 2022

      Scientific Corner

      First EAN Science School proves a hit in Salzburg

      April 1, 2022

      Scientific Corner

      Invitation to the EAN-EBRAINS Joint Workshop on ‘The Future of Medical Data Sharing in Clinical Neurosciences’

      July 2, 2021

  • Educational
    • All eLearning Student Corner E-Brain Grand Rounds Resident and Research Fellows Fellowship reports Education corner
      EAN News

      New EAN Regional Teaching initiative – host an EAN session at your national society’s meeting

      March 30, 2023

      Resident and Research Fellows

      Report on the 3rd RRFS National Representative Network meeting in Berlin

      March 22, 2023

      Resident and Research Fellows

      Clinical Fellowship Reports 2022: Brno, Liège & Heeze

      March 21, 2023

      Resident and Research Fellows

      Clinical Fellowship Reports 2022: Grenoble, Prague & London

      March 17, 2023

      eLearning

      Keep your mind sharp with free content on Brain Health through the eanCampus!

      March 13, 2023

      eLearning Illustration of two people holding an award between them and jumping in the air in a celebratory pose

      Learn with the eanCampus and win free EAN congress registration!

      January 12, 2023

      eLearning

      Kick off 2023 with highlights on the eanCampus

      January 10, 2023

      eLearning

      December Highlights on the eanCampus!

      December 5, 2022

      Student Corner Photo of a sheet of paper, pencil and crumpled paper on a desk.

      Win a travel grant for a future EAN congress with our ‘Why Neurology?’ student essay competition!

      March 10, 2023

      Student Corner Illustration of a vertical pencil point on a blue background, with a yellow light bulb above it

      Students’ Corner: What is it like to be a student on a neurology placement?

      March 10, 2023

      Student Corner

      Application for the Student Teaser Fellowship 2023 NOW OPEN

      February 1, 2023

      Student Corner Illustration of a vertical pencil point on a blue background, with a yellow light bulb above it

      Students’ Corner: What neurology taught me in 2022

      January 17, 2023

      E-Brain

      ebrain May update: new website and podcast series

      May 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Resident and Research Fellows

      Report on the 3rd RRFS National Representative Network meeting in Berlin

      March 22, 2023

      Resident and Research Fellows

      Clinical Fellowship Reports 2022: Brno, Liège & Heeze

      March 21, 2023

      Resident and Research Fellows

      Clinical Fellowship Reports 2022: Grenoble, Prague & London

      March 17, 2023

      Resident and Research Fellows

      Research Fellowship Report 2021 – Pain Research Institute, University of Liverpool

      March 17, 2023

      Fellowship reports

      Clinical Fellowship Reports 2022: Brno, Liège & Heeze

      March 21, 2023

      Fellowship reports

      Clinical Fellowship Reports 2022: Grenoble, Prague & London

      March 17, 2023

      Fellowship reports

      Research Fellowship Report 2021 – Pain Research Institute, University of Liverpool

      March 17, 2023

      Fellowship reports

      Research Fellowship Report 2021 – Neurogenetics Laboratory at UCL, UK

      March 17, 2023

      Education corner

      New EAN Regional Teaching initiative – host an EAN session at your national society’s meeting

      March 30, 2023

      Education corner

      Clinical Fellowship Reports 2022: Brno, Liège & Heeze

      March 21, 2023

      Education corner

      Clinical Fellowship Reports 2022: Grenoble, Prague & London

      March 17, 2023

      Education corner

      Research Fellowship Report 2021 – Pain Research Institute, University of Liverpool

      March 17, 2023

  • Other News
    • All EAN Staff Grant opportunities News from EAN member societies EBC EFNA News in general Patients societies reports Surveys Forum
      Other News

      In Memoriam: Prof. Johan Aarli, former president of the World Federation of Neurology

      March 28, 2023

      EBC

      EBC & EFPIA launch RETHINKING Alzheimer’s disease White Paper

      March 22, 2023

      EBC

      Registration and call for abstracts launched for 2023 Brain Innovation Days

      March 21, 2023

      EAN Staff Chest-height portrait photo of a woman,

      Never say never – or my 8,752 days with neurologists

      March 20, 2023

      EAN Staff Chest-height portrait photo of a woman,

      Never say never – or my 8,752 days with neurologists

      March 20, 2023

      EAN Staff Composite image consisting of two chest-height portraits side-by-side

      EAN Head Office Profiles: Abigail & Bernadette

      March 15, 2023

      EAN Staff Composite image consisting of two chest-height portraits side-by-side

      EAN Head Office Profiles: Katina & Robertina

      February 2, 2023

      EAN Staff

      EAN Head Office Profiles: Magda & Mira

      December 29, 2022

      Grant opportunities

      1st EAN Science School, 26-29 March 2022: “Pathophysiology of disorders of the nervous system”

      June 18, 2021

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies Black image titled "In Memoriam" in remembrance of the neurologists lost in the earthquake on 6 February 2023.

      Earthquake in Türkiye and Syria: Statement from President of Turkish Neurological Society

      February 20, 2023

      News from EAN member societies

      14 June: Special publication celebrates 10 years of the European Working Group of People with Dementia

      August 2, 2022

      News from EAN member societies

      14 June: Alzheimer Europe hosts European Parliament Lunch Debate examining EU and WHO policies on neurological conditions

      August 2, 2022

      News from EAN member societies

      22 June: Alzheimer Europe invites applications for its new Anti-Stigma Award

      August 2, 2022

      EBC

      EBC & EFPIA launch RETHINKING Alzheimer’s disease White Paper

      March 22, 2023

      EBC

      Registration and call for abstracts launched for 2023 Brain Innovation Days

      March 21, 2023

      EBC

      Connecting brains for the future: Brain Innovation Days 2022

      November 23, 2022

      EBC

      Final programme available for Brain Innovation Days – Register now!

      September 22, 2022

      EFNA

      OneNeurology European Summit underlines urgent need to prioritise neurology and drive change

      December 31, 2021

      EFNA

      EFNA launch eLearning Platform for neurology advocates

      February 1, 2021

      EFNA

      ‘Me and My Brain’ – Art Competition winners announced!

      February 1, 2021

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      News in general

      Registration now open for the launch event of the RETHINKING Alzheimer’s disease White Paper

      December 24, 2022

      News in general

      EAN lecture at the International Neuro-Urology Society annual congress 2022

      May 25, 2022

      News in general

      EPA-EAN Joint Symposium: ‘Etiology and Treatment of the Long Covid-19 Syndrome’ and other highlights at the 30th European Congress of Psychiatry

      May 25, 2022

      News in general

      Organise an EAN-Day or EAN Regional Teaching Course in your Country!

      May 17, 2022

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      COVID-19 and neurology: a survey of previous and continued restrictions on clinical practice, professional education and neuroeconomics

      March 3, 2023

      Surveys

      Help EAN contribute towards the development of a European Pain Research strategy

      December 5, 2022

      Surveys

      Survey: management of covert brain infarction

      October 29, 2021

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

  • EAN
  • Congress 2023
  • EANpages
  • EAN Campus
  • Eur J Neurol
  • Virtual Congress

eanpages

  • General interest
    • All Executive Page Paper of the Month EAN News EAN Congress news COVID-19 Interviews
      EAN News

      New EAN Regional Teaching initiative – host an EAN session at your national society’s meeting

      March 30, 2023

      EAN News

      Sign up now for the European Brain Health Summit 2023 – live online on May 9!

      March 28, 2023

      Academic/Scientific

      COVID-19 Research Round-Up: Literature reviews – March 2023

      March 16, 2023

      Academic/Scientific

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – March 2023

      March 16, 2023

      Executive Page Head and shoulders portrait photo of Irena Rektorova, in colourful dress

      Executive Page: Leadership, mentorship and many more EAN educational opportunities

      March 13, 2023

      Executive Page

      Executive Page: Key EAN events and new projects to strengthen neurology on many levels

      February 14, 2023

      Executive Page

      Executive Page: Submit, register, and join us for EAN 2023

      December 5, 2022

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: New guideline prioritisation process begins setting path for next two years

      November 1, 2022

      Paper of the Month One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – March 2023

      March 14, 2023

      Paper of the Month

      Research Paper of the Month: Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease

      March 13, 2023

      Paper of the Month

      Research Paper of the Month: Headache attributed to SARS-CoV-2 infection, vaccination and the impact on primary headache disorders of the COVID-19 pandemic

      February 9, 2023

      Paper of the Month

      COVID-19 Paper of the Month: Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study

      February 9, 2023

      EAN News

      New EAN Regional Teaching initiative – host an EAN session at your national society’s meeting

      March 30, 2023

      EAN News

      Sign up now for the European Brain Health Summit 2023 – live online on May 9!

      March 28, 2023

      EAN News Mapy of the world made from pills of various sizes, shapes and colours

      EAN endorses MSIF and the WHO Collaborating Centre Bologna’s application to add MS treatments on WHO’s Essential Medicines List

      March 14, 2023

      EAN News Head and shoulders portrait photo of Irena Rektorova, in colourful dress

      Executive Page: Leadership, mentorship and many more EAN educational opportunities

      March 13, 2023

      EAN Congress news

      EAN 2023 Congress Quiz – your chance to win free registration!

      March 14, 2023

      EAN Congress news Photo of a sheet of paper, pencil and crumpled paper on a desk.

      Win a travel grant for a future EAN congress with our ‘Why Neurology?’ student essay competition!

      March 10, 2023

      EAN Congress news

      New ‘Start-Up Corner’ introduced for EAN 2023 industrial exhibition

      February 13, 2023

      EAN Congress news EAN 2023 congress logo top left; running stick figure centre with Register Now in large type; EAN 2023 hashtag, bottom right

      Register Now for EAN 2023 in Budapest, 1-4 July

      February 10, 2023

      COVID-19

      COVID-19 Research Round-Up: Literature reviews – March 2023

      March 16, 2023

      COVID-19

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – March 2023

      March 16, 2023

      COVID-19

      COVID-19 Research Round-Up: Case Series/Case Reports – March 2023

      March 16, 2023

      COVID-19

      COVID-19 Research Round-Up: Meta-analyses/systematic reviews – March 2023

      March 16, 2023

      Interviews

      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

      Interviews

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajediene

      July 28, 2022

      Interviews

      Video: EAN supports World Brain Day

      July 19, 2022

      Interviews

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

  • Academic/Scientific
    • All Breaking news Neurology updates Scientific committee reports Scientific panels reports Eur J Neurol Top 10 Articles Scientific Corner
      Academic/Scientific

      COVID-19 Research Round-Up: Literature reviews – March 2023

      March 16, 2023

      Academic/Scientific

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – March 2023

      March 16, 2023

      Academic/Scientific

      COVID-19 Research Round-Up: Case Series/Case Reports – March 2023

      March 16, 2023

      Academic/Scientific

      COVID-19 Research Round-Up: Meta-analyses/systematic reviews – March 2023

      March 16, 2023

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Miscellaneous – November 2022

      November 7, 2022

      Breaking news

      COVID-19 Breaking News: Observational Studies – Prospective Longitudinal Cohort – November 2022

      November 7, 2022

      Neurology updates

      Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome – A MAGNIMS Study

      September 26, 2022

      Neurology updates

      Relapse-independent disability worsening plays a relevant role in every disease phase of MS

      September 26, 2022

      Neurology updates

      Epstein-Barr virus infection is a major risk factor for the development of multiple sclerosis

      September 26, 2022

      Neurology updates

      Glymphatic system impairment may contribute to multiple sclerosis pathology

      September 23, 2022

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

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Paper of the MonthGeneral interestFeatured Slider

Paper of the month: No benefit from hypothermia after severe traumatic brain injury

February 1, 2019

 

 

 

by Elena Moro

 

 

 

 

 

For February 2019, we have selected: Cooper DJ, Nichol AD, Balley M, et al. for the POLAR Trial Investigators and the ANZICS Clinical Trial Group. Effect of early sustained prophylactic hypothermia on neurologic outcomes among patients with severe traumatic brain injury. JAMA 2018;320:2211-2220.

Over the last years, findings concerning the use of prophylactic hypothermia to improve clinical outcomes after traumatic brain injury have been conflicting. A few meta-analyses have concluded for some beneficial effects from hypothermia, including decreased mortality, whereas four randomized clinical trials did not report any benefit.

In this multinational randomized clinical trial (POLAR-RCT), the authors assessed the effects of early prophylactic hypothermia (33°C – 35°C) applied for at least 72 hours and compared it with normothermia in patients with severe traumatic brain injury. The trial was planned to include 510 patients in six countries, and spanned from December 2010 to November 2017. Patients were screened in five out-of-hospital or paramedic agencies and in 14 emergency departments. To be included, patients had to be between 18 and 60 years old, had a Glasgow Coma Scale Score (GCSS) <9, and actual or imminent endotracheal intubation. Out-of-hospital exclusion criteria were significant bleedings with systolic hypotension and tachycardia, suspected pregnancy, GCSS =3, and unreactive pupils. Patients were randomized to prophylactic hypothermia versus controlled normothermia, with unblinded treating physician. In the hypothermia group, hypothermia (33°C ± 0.5°C) was kept for at least 72 hours using a Gaymar Meditherm 3 console with surface-cooling wraps. If hemodynamic instability presumed to bleeding, patients could be rewarmed. After 72 hours, if intracranial pressure <20 mmHg, a gradual controlled rewarming was applied up to normothermia (37°C ± 0.5°C). The maximum period of hypothermia was 7 days after randomization.

The primary outcome of this study was the percentage of favorable Glasgow-Outcome-Scale-Extended (GOS-E) score (5 to 8) from blinded raters at 6 months after injury. Secondary outcomes included mortality, proportion of patients with adverse events within 10 days of randomization, duration of mechanical ventilation, and hospital length of stay. Of the 511 patients randomized, 240 patients of the hypothermia group and 226 of the normothemia group were available for the primary outcome analyses, respectively. Overall, the mean GCSS was of 6. Around 33% of patients in the hypothermia group received <48 hours of hypothermia, whereas 27% never reached the final target of 33°C.  Hypothermia was started quickly after injury (a median of 1.8 hours) and rewarming occurred slowly (a median of 22.5 hours).

At 6 months, there was no difference in the favorable outcome between groups, i.e., 117 patients (48.8%) in the hypothermia group and 111 patients (49.1%) in the normothermia group (absolute risk difference, -0.4%, 95% CI, -9.4-8.7; relative risk with hypothermia, 0.99, 95% CI, 0.82-1.19, P=0.94). There were no significant differences between groups regarding to any secondary outcome. Pneumonia and intracranial bleeding occurred in 55% and 18.1% of hypothermia patients, and in 51.3% and 15.4% of normothermia patients, respectively. However, the per-protocol analysis found increased risk of pneumonia in the hypothermia group (P=0.003).

“This is a large randomized study that further supports previous clinical findings coming from other four randomized trials conducted with different methodology”, says Prof. Maxwell Simon Damian, Department of Neurology, University of Cambridge, UK. ”These findings go against a large amount of pre-clinical evidence, and recent meta-analysis that sustained the use of hypothermia after brain traumatic injury. This trial definitely clarifies the futility of this treatment.”

“There are some limitation in this study, including the long recruitment time (seven years), the lack of blind treating physician, and of targeted hypothermia temperature (33°C) in several patients”, says Prof. Stefan Schwab, Department of Neurology, University of Erlangen, Germany. ”Nevertheless, the study was well-designed, and delivers conclusions that should be integrated in clinical practice and international guidelines.”

 

The other nominees for the February 2019 paper of the month are:

  • GBD 2016 Parkinson’s Disease Collaborators. Global, regional, and national burden of Parkinson’s disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2018;17;939-953. In this paper, the authors investigated the global burden of Parkinson’s disease between 1990 and 2016 using a systemic analysis of epidemiological studies. Compared to the estimation of 2.5 million of people with Parkinson’s disease worldwide in 1990, they found an increase up to 6.1 million in 2016. This increase was not solely explained by the parallel increase of older people. Disability-adjusted life-years and death ratios also increased, but not in southern Latin America, eastern Europe and Oceania.
  • FOCUS Trail Collaboration. Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomized, controlled trial. Lancet Neurol December 5, 2018. doi: 10.1016/S0140-6736(18)32823-X. The authors conducted a large multicenter, double-blinded, randomized, placebo-control trial in 3,127 UK patients with acute stroke (between 2 and 15 days after onset) with the aim to assess the effects of 20 mg fluoxetine at 6 months. Although patients with fluoxetine developed less depression compared to placebo, they had more bone fractures.
  • Prasad K, Siemieniuk R, Hao Q, et al. Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke: a clinical practice guideline. BMJ 2018;363:k5130 doi: 10.1136/bmj.k5130. In this experts’ opinion paper, the authors review the evidence and provide recommendation about the use of dual antiplatelet therapy (aspirin and clopidogrel) soon after TIA and minor ischaemic stroke.

 

 

Prof. Elena Moro is Editor in Chief of EAN Pages and treasurer of EAN as well as Director of the Movement Disorders Center at the Centre Hospital Universitaire (CHU) of Grenoble, France and the Associate Director of the CHU Department of Psychiatry, Neurology and Rehabilitation.

 

 

Paper of the month: No benefit from hypothermia after severe traumatic brain injury was last modified: February 7th, 2019 by Editor
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