Meta-analysis Systematic Review (Red)
Parkinson’s disease (PD), possibly due to associated factors. This study aimed to systematically review the factors associated with COVID-19 in people with PD. The search was carried out in PubMed, Scopus, and Web of Science until November 2020 (updated until April 1, 2021). Observational studies that analyzed factors associated with COVID-19 in people with PD were selected and revised.
The authors included six studies (4 case-controlled studies and 2 cross-sectional studies) in the qualitative and quantitative syntheses. Authors found that the following factors were associated with COVID-19 in people with PD: obesity (OR: 1.79, 95% CI: 1.07 to 2.99, I2: 0%), any pulmonary disease (OR: 1.92, 95% CI: 1.17 to 3.15, I2: 0%), COVID-19 contact (OR: 41.77, 95% CI: 4.77 – 365.56, I2: 0%), vitamin D supplementation (OR: 0.50, 95% CI: 0.30 to 0.83, I2: 0%), hospitalization (OR: 11.78, 95% CI: 6.27 to 22.12, I2: 0%), and death (OR: 11.23, 95% CI: 3.92 to 32.18, I2: 0%). Authors did not find significant association between COVID-19 and hypertension, diabetes, cardiopathy, cancer, any cognitive problem, dementia, chronic obstructive pulmonary disease, renal or hepatic disease, smoking, and tremor. The authors concluded that meta-analyses were limited by the number of events and some methodological limitations. Despite that, the authors assessed available evidence, and the results may be useful in future health policies.
Chambergo-Michilot D, Barros-Sevillano S, Rivera-Torrejón O, De la Cruz-Ku GA, Custodio N. Factors associated with COVID-19 in people with Parkinson’s disease: a systematic review and meta-analysis. Eur J Neurol. 2021 May 13. doi: 10.1111/ene.14912.