Research

by Lucia Cernicka   Guidelines International Network or G-I-N is a community with a mission to lead, strengthen and support collaboration in guideline production. To enhance its networking role, the G-I-N organises conferences on a regular basis, once a year,… Continue Reading

  Vienna, 12-13 October 2018: First recommendation meeting of the EAN ALS guideline panel. ALS is a disease with a very high unmet medical need. There are only limited options for disease-modifying pharmacotherapy. The cornerstone of the management remains multidisciplinary… Continue Reading

For November 2018, we have selected: Oh KW, Noh MY, Kwon NS, et al. Repeated intrathecal stem cells for amyotrophic lateral sclerosis. Ann Neurol 2018;84:361-373. Stem cell research is a hot topic in motor neuron disease/amyotrophic lateral sclerosis (MND/ALS) both for clinicians and patients. Whilst recognized as an important area of promise for developing future therapeutics in neurodegenerative disease, it has been much hyped in the media, and dissecting the scientific research on the subject from the many unproven approaches advertised to patients by commercially motivated companies can be challenging.

The November issue of the European Journal of Neurology is online!

Please find below articles from Turkish authors and co-authors that were published in the European Journal of Neurology

EAN and Wiley want to know how neurology is making a difference, and how it has inspired you.
Tell us and you could win an iPad Pro!   All you need to do is post your tweets, photos, videos and… Continue Reading

For September 2018, we have selected:  Katzenschlager R, Poewe W, Rascol O, et al. Apomorphine subcutaneous infusion in patients with Parkinson’s disease with persisten motor fluctuations (TOLEDO): a multicenter, double-blind, randomized, placebo-controlled trial. Lancet Neurol July 25, 2018. doi:10.1016/S1474-4422(18)30284-4. Subcutaneous infusion of apomorphine, a potent dopamine receptor agonist, is widely used in patients with Parkinson’s disease (PD) with motor fluctuations not optimally controlled with oral medication, but the previous evidence base to support this approach was weak, derived from open label studies.

Please find below articles from German authors and co-authors that were published in the European Journal of Neurology

For August 2018, we have selected: Corvol JC, Artaud F, Cornier-Dequaire F, et al., for the DIGPD Study Group. Longitudinal analysis of impulse control disorders in Parkinson disease. Neurology 2018. doi:10.1212/WNL.0000000000005816. Impulse control disorders (ICDs) are frequent in Parkinson’s disease (PD) patients, and can have relevant consequences on social life. Whereas the association between treatment with dopamine agonists (DA) and the onset of ICDs is well known, there is controversy about the relationship with dose and duration of DA therapy.

Despite its large use, recommendations for the use of brain F-18 FDG-PET in clinical practice were still lacking. The European Academy of Neurology (EAN) and the European Association of Nuclear Medicine (EANM) promoted a concerted action with 7 specialists from the two Societies and a group of facilitators in order to make the point on this issue. Extensive literature review and analysis of available data led, together with expert opinion (Delphi consensus), to deliver these recommendations that cover practically all the main brain neurodegenerative conditions causing cognitive impairment.

Please find below articles from Polish authors and co-authors that were published in the European Journal of Neurology

For July 2018, we have selected: Thomalla G, Simonsen CZ, Boutitie G, et al., for the WAKE-UP Investigators. MRI-guided thrombolysis for stroke with unknown time of onset. NEJM May 16, 2018. doi:10.1056/NEJMoa1804355. Thrombolysis is currently performed in patients with acute ischemic stroke within a window of 4.5 hours since the symptoms’ onset. In about one third of the patients, the exact time of stroke onset is unknown, like in patients who wake up from sleeping.

Please find below articles from Portuguese authors and co-authors that were published in the European Journal of Neurology