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      Regional Teaching Session in Antalya, Türkiye – 15 December 2025

      July 18, 2025

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      EAN 2025 Career development Session on AI: Is artificial intelligence coming to steal your job?

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      EAN Mentorship Workshop 2025: a mentee’s perspective

      July 11, 2025

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      July 10, 2025

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      Call for Applications: eanCampus Associate Editors

      July 1, 2025

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      June 10, 2025

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      Empowering the HD Community: The Launch of the Huntington Academy

      July 10, 2025

      Advocacy

      EAN TV | National Brain Plans and the Path Toward EU Coordination: Insights from Finland and Europe

      June 21, 2025

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      June 21, 2025

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      Yaoundé Declaration on the brain economy officially launched

      May 12, 2025

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      Celebrating 20 Years of Excellence: Anja Sander, EAN’s Executive Director!

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      June 21, 2025

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      EBC Composite image containing various photos from European Brain Council events, plus the EBC logo

      EBC launches 2024 annual report

      April 25, 2025

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      Brain Innovation Days announces theme and subtheme for 2025 edition!

      March 29, 2025

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      New paper offers insight into patient involvement in neurological research 

      January 31, 2025

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      January 31, 2025

      News in general

      The Brain Prize 2024: Pioneering work in computational and theoretical neuroscience is awarded the world’s largest brain research prize

      March 5, 2024

      News in general

      WHO’s Intersectoral Global Action Plan on epilepsy and other neurological disorders (IGAP) published in all six UN languages

      August 3, 2023

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      Public Consultation – European Charter for the Responsible Development of Neurotechnologies

      November 25, 2024

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      A survey on connectomics: key insights from EAN neurologists

      July 25, 2024

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      Survey: Mapping European Neurological Programs in Solid Organ Transplant Centers

      May 31, 2024

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      Neurorehabilitation Across Europe after Ischemic and Traumatic Brain Injuries: a survey to increase knowledge on brain-injury-specific neurorehabilitation

      July 14, 2023

Breaking newsCOVID-19

Altered mental status predicts length of stay but not death in a community-based cohort of hospitalized COVID-19 patients

November 8, 2021

Case series/case reports (Indigo)

Altered Mental Status (AMS) is a common neurological complication in patients hospitalized with the diagnosis of COVID-19. Studies show that AMS is associated with death and prolonged hospital stay. In addition to respiratory insufficiency, COVID-19 causes multi-organ failure and multiple metabolic derangements, which can cause AMS, and the multi-system involvement could account for the prolonged hospital stay and increased mortality. In this study, the authors built on their previous publication (Chachkhiani et al., 2020) using a new, larger cohort to investigate whether they could reproduce their previous findings while addressing some of the prior study’s limitations. Most notably, they sought to determine whether AMS still predicted prolonged hospital stay and increased mortality after controlling for systemic complications such as sepsis, liver failure, kidney failure, and electrolyte abnormalities. The primary purpose was to document the frequency of AMS in patients with COVID-19 at the time of presentation to the emergency room. Secondary aims were to determine: 1) if AMS at presentation was associated with worse outcomes as measured by prolonged hospitalization and death; and 2) if AMS remained a predictor of worse outcome after adjusting for concomitant organ failure and metabolic derangements. Out of 367 patients, 95 (26%) had AMS as a main or one of the presenting symptoms. The sample has a higher representation of African Americans (53%) than the US average and a high frequency of comorbidities, such as obesity (average BMI 29.1), hypertension (53%), and diabetes (30%). AMS was the most frequent neurological chief complaint. At their admission, out of 95 patients with AMS, 83 (88%) had organ failure or one of the systemic problems that could have caused AMS. However, a similar proportion (86%) of patients without AMS had one or more of these same problems. Age, race, and ethnicity were the main demographic predictors. African Americans had shorter hospital stay [HR1.3(1.0,1.7),p = 0.02] than Caucasians. Hispanics also had shorter hospital stay than non-Hispanics [HR1.6(1.2,2.1), p = 0.001]. Hypoxia, liver failure, hypernatremia, and kidney failure were also predictors of prolonged hospital stay. In the multivariate model, hypoxia, liver failure, and acute kidney injury were the remaining predictors of longer hospital stay, as well as people with AMS at baseline [HR0.7(0.6,0.9), p < 0.02] after adjusting for the demographic characteristics and clinical predictors. AMS at baseline predicted death, but not after adjusting for demographics and clinical variables in the multivariate model. Hypoxia and hyperglycemia at baseline were the strongest predictors of death. The authors concluded that altered mental status is an independent predictor of prolonged hospital stay, but not death. Further studies are needed to evaluate the causes of AMS in patients with COVID-19.

Chachkhiani D, Isakadze M, Villemarette-Pittman NR, Devier DJ, Lovera JF. Altered mental status predicts length of stay but not death in a community-based cohort of hospitalized COVID-19 patients. Clin Neurol Neurosurg. 2021 Oct 7;210:106977. doi: 10.1016/j.clineuro.2021.106977.

Altered mental status predicts length of stay but not death in a community-based cohort of hospitalized COVID-19 patients was last modified: November 8th, 2021 by Simon Lee
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