In a large nested case-control study, Bjornevik et al. (https://pubmed.ncbi.nlm.nih.gov/35025605/) assessed the association between Epstein-Barr virus (EBV) infection and multiple sclerosis (MS). The Authors showed that EBV seroconversion is associated with a 32-time higher risk of developing the disease compared with people who remained EBV-negative. This study provides strong epidemiological evidence that EBV represents the major known risk factor for MS development
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