COVID-19

The objective of this multicenter randomized clinical trial was to assess whether helmet noninvasive ventilation can increase the days free of respiratory support in patients with COVID-19 compared with high-flow nasal oxygen alone.

The objective of this study was to assess acute ischemic stroke in adults 50 years or younger in the convalescent phase of asymptomatic COVID-19 infection.

The objective of this randomized clinical trial was to determine whether hydroxychloroquine or lopinavir-ritonavir reduces hospitalization among high-risk patients with early symptomatic COVID-19 in an outpatient setting.

A new variant of SARS-CoV-2, B.1.1.7, emerged as the dominant cause of COVID-19 disease in the UK from November, 2020. In this article the authors report a post-hoc analysis of the efficacy of the adenoviral vector vaccine, ChAdOx1 nCoV-19 (AZD1222), against this variant.

The comparative performance of different clinical sampling methods for diagnosis of SARS-CoV-2 infection by RT-PCR among populations with suspected infection remains unclear. In this systematic review and meta-analysis, the authors aimed to systematically compare the diagnostic performance of different clinical specimen collection methods.

The COVID-19 pandemic is having profound mental health consequences for many people. Concerns have been expressed that, at their most extreme, these consequences could manifest as increased suicide rates. In this article the authors aimed to assess the early effect of the COVID-19 pandemic on suicide rates around the world.

In this phase 1, double-blind, placebo-controlled, block-randomised trial the authors aimed to assess the safety and immunogenicity of an MF59-adjuvanted subunit vaccine for COVID-19 based on recombinant SARS-CoV-2 spike glycoprotein stabilised in a pre-fusion conformation by a novel molecular clamp.

CoV2 preS dTM is a stabilised pre-fusion spike protein vaccine produced in a baculovirus expression system being developed against SARS-CoV-2. In this phase 1–2, randomised, double-blind study the authors present interim safety and immunogenicity results of the first-in-human study of the CoV2 preS dTM vaccine with two different adjuvant formulations.

In this article the authors examined vaccine effectiveness among health care workers at the Hadassah Hebrew University Medical Center (HHUMC), a two-campus medical center in Jerusalem that employs 6680 people.

Since the start of the vaccination campaign, the development of COVID-19 has been reported in persons who have received one or both doses of mRNA-1273 (Moderna) or BNT162b2 (Pfizer) vaccine.

Authors describe mRNA1273-elicited binding and neutralizing antibodies in 33 healthy adults in an ongoing phase 1 trial, 180 days after the second dose of 100 μg (day 209).

Whether or not people who have been infected SARS-CoV-2 should be vaccinated is unclear. This observational cohort study, the authors enrolled 100 health care workers, including 38 with a documented history of SARS-CoV-2 infection.

In this article, the authors report findings in five patients who presented with venous thrombosis and thrombocytopenia 7 to 10 days after receiving the first dose of the ChAdOx1nCoV-19 adenoviral vector vaccine against COVID-19.

In this article, the authors report findings in 23 patients who presented with thrombosis and thrombocytopenia 6 to 24 days after receiving the first dose of the ChAdOx1 nCoV-19 vaccine (AstraZeneca).

In this article the authors assessed the clinical and laboratory features of 11 patients in Germany and Austria in whom thrombosis or thrombocytopenia had developed after vaccination with ChAdOx1 nCov-19.