Paper of the Month

Results of the CREST-2 study, comparing carotid artery stenting or carotid endarterectomy plus intensive medical therapy with intensive medical therapy alone in patients aged 35+ with asymptomatic high-grade carotid artery stenosis.

This study assessed cognitively unimpaired older adults using pedometer-measured physical activity, longitudinal Aβ and tau PET imaging, and annual cognitive evaluations over 14 years.

This study reports the results of a trial involving patients with iNPH who were selected for ventriculoperitoneal shunt surgery on the basis of gait-velocity improvement following temporary CSF drainage.

This study used a probabilistic factor analysis hidden Markov model, combining MRI and clinical measures to identify patterns of disease expression and transition between different disease states.

This recent study examined the role of lithium in AD pathogenesis, using coupled plasma mass spectrometry to measure metal levels in the prefrontal cortex and cerebellum.

This study investigated the association between educational attainment and tau accumulation in Alzheimer's disease, with participants drawn from three independent cohorts.

This study presents the findings of a systematic review and a collaborative individual patient data meta-analysis of clinical trials involving patients with acute ischaemic stroke and atrial fibrillation, who were treated with either early or delayed initiation of DOACs at approved dosages.

Our papers of the month for June are two studies that suggest that transplantation of dopaminergic progenitor cells into the striatum may confer meaningful clinical benefits for patients with Parkinson’s disease.

Our papers of the month for May are two papers present findings from recent trials evaluating the efficacy and safety of tolebrutinib in patients with multiple sclerosis.

Our Paper of the Month is a prospective cohort study conducted in the US, including participants from the Nurses’ Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS).

EAN Website Editor, Letizia Leocani, talks to Raphael Wurm, lead author of the eanNews Paper of the Month for January 2025, 'Mood Alterations in the Prodromal Phase of Sporadic Creutzfeldt-Jakob Disease'

Our paper of the month for March is a phase 3 multicentre, double-blind, randomised trial investigating whether treatment with exenatide can slow the progression of Parkinson’s disease.

For February we have selected two co-papers of the month, each of which examines the safety and efficacy of a specific drug in the treatment of patients with generalised myasthenia gravis.

Our paper of the month compares drug prescription prior to the clinical onset of sporadic Creutzfeldt-Jakob disease in patients versus matched controls aiming to uncover potential risk or protective factors.

Our paper of the month highlights the findings of the stage 2 interim analysis from the first cycle of MND SMART, a phase 3, multi-arm, randomised, adaptive platform trial conducted across 20 centres in the UK.