Paper of the Month

Study analysing data of 38,816 study participants of the UK Biobank, an ongoing study investigating associations between sleep duration, a validated machine-learning-derived MRI signature of AD-related atrophy, and three cognitive test scores.

This month’s selected paper collected European-ancestry data from several large consortia and cohorts for a major consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementias.

Results from the TRIDENT trial, testing a daily pill combining three low-dose blood-pressure medicines for people who have had an intracerebral haemorrhage.

Prospective, multicentre cohort study examining how the effectiveness of DAPT varies with time from symptom onset to hospital arrival and to estimate when the benefit of DAPT attenuates.

Results of the EMPHASIS study, evaluating the efficacy and safety of minocycline in addition to routine treatment in patients with acute ischaemic stroke.

Large prospective analysis examining association of long-term coffee and tea intake with incident dementia, and with subjective and objective cognitive outcomes.

Results of a multicentre, placebo-controlled trial evaluating the efficacy and safety of fremanezumab in children and adolescents aged 6–17 years with episodic migraine.

Results of the CREST-2 study, comparing carotid artery stenting or carotid endarterectomy plus intensive medical therapy with intensive medical therapy alone in patients aged 35+ with asymptomatic high-grade carotid artery stenosis.

This study assessed cognitively unimpaired older adults using pedometer-measured physical activity, longitudinal Aβ and tau PET imaging, and annual cognitive evaluations over 14 years.

This study reports the results of a trial involving patients with iNPH who were selected for ventriculoperitoneal shunt surgery on the basis of gait-velocity improvement following temporary CSF drainage.

This study used a probabilistic factor analysis hidden Markov model, combining MRI and clinical measures to identify patterns of disease expression and transition between different disease states.

This recent study examined the role of lithium in AD pathogenesis, using coupled plasma mass spectrometry to measure metal levels in the prefrontal cortex and cerebellum.

This study investigated the association between educational attainment and tau accumulation in Alzheimer's disease, with participants drawn from three independent cohorts.

This study presents the findings of a systematic review and a collaborative individual patient data meta-analysis of clinical trials involving patients with acute ischaemic stroke and atrial fibrillation, who were treated with either early or delayed initiation of DOACs at approved dosages.

Our papers of the month for June are two studies that suggest that transplantation of dopaminergic progenitor cells into the striatum may confer meaningful clinical benefits for patients with Parkinson’s disease.