Paper of the Month

Our paper of the month is an observational cohort study exploring the link between sleep measures and AD pathology in 319 participants (mean ± SD age: 61.5 ± 5.4 years; 47% female) from the Rotterdam Study, a prospective population-based study conducted in the Netherlands.

Our paper of the month reports the result of a trial investigating the safety and the potential efficacy of intravenous treatment with acyl-ghrelin in improving neurological outcome in patients in a coma after cardiac arrest.

In our Paper of the Month for May, researchers traced the trajectory of Alzheimers biomarkers, for the first time employing a longitudinal design, with impressive, groundbreaking results.

Our paper of the month for April is the latest work by the Global Burden of Diseases Collaborator Network, which has found that neurological conditions are the leading cause of ill health and disability worldwide, with over 3.4 billion people worldwide are affected.

Our Paper of the month for March is a retrospective longitudinal study emphasizing the important role of cortical myelin dynamics in determining neurodegeneration and clinical progression in MS.

Our paper of the month for February is an open-label extension study to assess the long-term efficacy and safety of cerliponase in padiatric patients with CLN2 disease.

A retrospective, multicentre, cross-sectional study aiming to evaluate the performance of cortical lesions and the central vein sign in differentiating multiple sclerosis from other conditions with brain white matter lesions.

This study presents the results of a clinical trial investigating whether apixaban, compared to aspirin, would be associated with reduced risk of stroke or systemic embolism, with a tolerably low risk of major bleeding.

Our Paper of the Month for November is a meta-analysis investigating the safety and efficacy of oral anticoagulation for prevention of major cardiovascular events in patients with atrial fibrillation and previous spontaneous intracranial haemorrhage.

Our Paper of the Month for October 2023 is a multicentre, prospective, randomised clinical trial investigating whether transdermal nicotine may have a disease-modifying effect in early, therapy-naïve Parkinson's disease.

Our paper of the month presents the results of a randomised trial assessing AXER-204, a soluble decoy fragment of NgR1 able to block the action of three inhibitors of the axonal growth in individuals with chronic traumatic cervical SCI.

Our paper of the month is a phase 3, double-blind, multicentre, trial investigating the efficacy and the safety of vorasidenib, a dual inhibitor of the IDH1 and IHD2 enzymes, in patients with residual or recurrent IDH mutant grade 2 gliomas.

Each month the EANpages editorial team reviews the scientific press for recently published papers of outstanding interest to neurologists. Here we present our selection for July 2023.

This month we have selected two papers of the month, reporting the results of two randomised, double-blind, placebo-controlled, phase III trials investigating potential therapies for generalised Myasthenia Gravis.

Co-Chair of the EAN Scientific Panel on Dementia and Cognitive Disorders answers three key questions about a groundbreaking Alzheimer study.