eanpages
  • General interest
    • All Executive Page Paper of the Month EAN News EAN Congress news COVID-19 Interviews
      Executive Page

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      Paper of the Month

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      Paper of the Month One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      EAN News

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      Executive Page

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: EAN’s scientific activities provide opportunities to both learn and contribute

      May 1, 2023

      Executive Page

      Executive Page: EAN on a Mission to advocate for brain health & neurology in 2023

      April 11, 2023

      Executive Page Head and shoulders portrait photo of Irena Rektorova, in colourful dress

      Executive Page: Leadership, mentorship and many more EAN educational opportunities

      March 13, 2023

      Paper of the Month

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      Paper of the Month One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      Paper of the Month

      One hot topic, one expert, three questions: Kristian Steen Frederiksen on our May 2023 Paper of the Month

      May 16, 2023

      Paper of the Month

      Research Paper of the Month: Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease

      May 1, 2023

      EAN News

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      EAN News

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      EAN News One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      EAN News

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      EAN Congress news

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      EAN Congress news

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      EAN Congress news

      On sex and gender: the exciting new world of gender neurology at EAN 2023

      May 25, 2023

      EAN Congress news

      Join us for the movement disorders programme at EAN 2023

      May 24, 2023

      COVID-19

      COVID-19 Research Round-Up: Literature reviews – April 2023

      April 26, 2023

      COVID-19

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – April 2023

      April 26, 2023

      COVID-19

      COVID-19 Research Round-Up: Case Series/Case Reports – April 2023

      April 26, 2023

      COVID-19

      COVID-19 Research Round-Up: Literature reviews – March 2023

      March 16, 2023

      Interviews

      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

      Interviews

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajediene

      July 28, 2022

      Interviews

      Video: EAN supports World Brain Day

      July 19, 2022

      Interviews

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

  • Academic/Scientific
    • All Breaking news Neurology updates Scientific committee reports Scientific panels reports Eur J Neurol Top 10 Articles Scientific Corner
      Paper of the Month

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      Paper of the Month One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      EAN News

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      Paper of the Month

      One hot topic, one expert, three questions: Kristian Steen Frederiksen on our May 2023 Paper of the Month

      May 16, 2023

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Miscellaneous – November 2022

      November 7, 2022

      Breaking news

      COVID-19 Breaking News: Observational Studies – Prospective Longitudinal Cohort – November 2022

      November 7, 2022

      Neurology updates

      Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome – A MAGNIMS Study

      September 26, 2022

      Neurology updates

      Relapse-independent disability worsening plays a relevant role in every disease phase of MS

      September 26, 2022

      Neurology updates

      Epstein-Barr virus infection is a major risk factor for the development of multiple sclerosis

      September 26, 2022

      Neurology updates

      Glymphatic system impairment may contribute to multiple sclerosis pathology

      September 23, 2022

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Highlights from the World Muscle Society annual meeting, chosen by the Scientific Panel on Muscle and NMJ Disorders

      November 2, 2022

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Eur J Neurol

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

      Eur J Neurol

      EAN NeuroCOVID-19 Task Force position paper on COVID-19 vaccination hesitancy among people with chronic neurological disorders

      May 2, 2022

      Eur J Neurol

      European Journal of Neurology welcomes new associate editors

      December 13, 2021

      Eur J Neurol

      New European guideline and expert statements on the management of narcolepsy in adults and children

      June 30, 2021

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner graphic of a block staircase with text announcing the application deadline to the EAN's new Cost-Conscious Healthcare (CoCoCare) programme

      Training for the Future of European Guidelines: Cost-Conscious Healthcare 2023

      March 2, 2023

      Scientific Corner

      Join the EAN Guideline Workshop on 24 June!

      May 13, 2022

      Scientific Corner

      First EAN Science School proves a hit in Salzburg

      April 1, 2022

      Scientific Corner

      Invitation to the EAN-EBRAINS Joint Workshop on ‘The Future of Medical Data Sharing in Clinical Neurosciences’

      July 2, 2021

  • Educational
    • All eLearning Student Corner E-Brain Grand Rounds Resident and Research Fellows Fellowship reports Education corner
      Resident and Research Fellows

      24th EAN Spring School

      June 7, 2023

      Resident and Research Fellows

      Clinical Fellowship Reports 2022: London & Brussels

      June 5, 2023

      Student Corner Photo of a sheet of paper, pencil and crumpled paper on a desk.

      EAN 2023 ‘Why Neurology?’ essay contest winners

      May 24, 2023

      Resident and Research Fellows

      Activities for RRFS Members at EAN 2023

      May 4, 2023

      eLearning

      Brush up on your neuroimaging knowledge on the eanCampus!

      April 13, 2023

      eLearning

      Keep your mind sharp with free content on Brain Health through the eanCampus!

      March 13, 2023

      eLearning Illustration of two people holding an award between them and jumping in the air in a celebratory pose

      Learn with the eanCampus and win free EAN congress registration!

      January 12, 2023

      eLearning

      Kick off 2023 with highlights on the eanCampus

      January 10, 2023

      Student Corner Photo of a sheet of paper, pencil and crumpled paper on a desk.

      EAN 2023 ‘Why Neurology?’ essay contest winners

      May 24, 2023

      Student Corner Photo of a sheet of paper, pencil and crumpled paper on a desk.

      Win a travel grant for a future EAN congress with our ‘Why Neurology?’ student essay competition!

      March 10, 2023

      Student Corner Illustration of a vertical pencil point on a blue background, with a yellow light bulb above it

      Students’ Corner: What is it like to be a student on a neurology placement?

      March 10, 2023

      Student Corner

      Application for the Student Teaser Fellowship 2023 NOW OPEN

      February 1, 2023

      E-Brain

      ebrain May update: new website and podcast series

      May 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Resident and Research Fellows

      24th EAN Spring School

      June 7, 2023

      Resident and Research Fellows

      Clinical Fellowship Reports 2022: London & Brussels

      June 5, 2023

      Resident and Research Fellows

      Activities for RRFS Members at EAN 2023

      May 4, 2023

      Resident and Research Fellows

      Clinical Fellowship Reports 2022: Copenhagen & Dresden

      May 4, 2023

      Fellowship reports

      Clinical Fellowship Reports 2022: London & Brussels

      June 5, 2023

      Fellowship reports

      Clinical Fellowship Reports 2022: Copenhagen & Dresden

      May 4, 2023

      Fellowship reports

      Research Fellowship Report 2022 – Centre Hospitalier Universitaire de Lyon, France

      May 4, 2023

      Fellowship reports

      Research Fellowship Report 2022 – Department of Neuropathology, Amsterdam UMC

      May 4, 2023

      Education corner

      24th EAN Spring School

      June 7, 2023

      Education corner

      Clinical Fellowship Reports 2022: London & Brussels

      June 5, 2023

      Education corner

      Clinical Fellowship Reports 2022: Copenhagen & Dresden

      May 4, 2023

      Education corner

      Research Fellowship Report 2022 – Centre Hospitalier Universitaire de Lyon, France

      May 4, 2023

  • Other News
    • All EAN Staff Grant opportunities News from EAN member societies EBC EFNA News in general Patients societies reports Surveys Forum
      EAN Staff

      EAN Head Office Profiles: Dauren & Benita

      June 5, 2023

      EAN Staff

      EAN Head Office Profiles: Kristián & Anna

      May 2, 2023

      EAN Staff

      EAN Head Office Profiles: Antonia & Farah

      April 12, 2023

      Other News

      Alzheimer Europe supports the rights and dignity of people with dementia with three new publications

      April 10, 2023

      EAN Staff

      EAN Head Office Profiles: Dauren & Benita

      June 5, 2023

      EAN Staff

      EAN Head Office Profiles: Kristián & Anna

      May 2, 2023

      EAN Staff

      EAN Head Office Profiles: Antonia & Farah

      April 12, 2023

      EAN Staff Chest-height portrait photo of a woman,

      Never say never – or my 8,752 days with neurologists

      March 20, 2023

      Grant opportunities

      1st EAN Science School, 26-29 March 2022: “Pathophysiology of disorders of the nervous system”

      June 18, 2021

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies Black image titled "In Memoriam" in remembrance of the neurologists lost in the earthquake on 6 February 2023.

      Earthquake in Türkiye and Syria: Statement from President of Turkish Neurological Society

      February 20, 2023

      News from EAN member societies

      14 June: Special publication celebrates 10 years of the European Working Group of People with Dementia

      August 2, 2022

      News from EAN member societies

      14 June: Alzheimer Europe hosts European Parliament Lunch Debate examining EU and WHO policies on neurological conditions

      August 2, 2022

      News from EAN member societies

      22 June: Alzheimer Europe invites applications for its new Anti-Stigma Award

      August 2, 2022

      EBC

      EBC & EFPIA launch RETHINKING Alzheimer’s disease White Paper

      March 22, 2023

      EBC

      Registration and call for abstracts launched for 2023 Brain Innovation Days

      March 21, 2023

      EBC

      Connecting brains for the future: Brain Innovation Days 2022

      November 23, 2022

      EBC

      Final programme available for Brain Innovation Days – Register now!

      September 22, 2022

      EFNA

      OneNeurology European Summit underlines urgent need to prioritise neurology and drive change

      December 31, 2021

      EFNA

      EFNA launch eLearning Platform for neurology advocates

      February 1, 2021

      EFNA

      ‘Me and My Brain’ – Art Competition winners announced!

      February 1, 2021

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      News in general

      Registration now open for the launch event of the RETHINKING Alzheimer’s disease White Paper

      December 24, 2022

      News in general

      EAN lecture at the International Neuro-Urology Society annual congress 2022

      May 25, 2022

      News in general

      EPA-EAN Joint Symposium: ‘Etiology and Treatment of the Long Covid-19 Syndrome’ and other highlights at the 30th European Congress of Psychiatry

      May 25, 2022

      News in general

      Organise an EAN-Day or EAN Regional Teaching Course in your Country!

      May 17, 2022

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      COVID-19 and neurology: a survey of previous and continued restrictions on clinical practice, professional education and neuroeconomics

      March 3, 2023

      Surveys

      Help EAN contribute towards the development of a European Pain Research strategy

      December 5, 2022

      Surveys

      Survey: management of covert brain infarction

      October 29, 2021

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

  • EAN
  • Congress 2023
  • EANpages
  • EAN Campus
  • Eur J Neurol
  • Virtual Congress

eanpages

  • General interest
    • All Executive Page Paper of the Month EAN News EAN Congress news COVID-19 Interviews
      Executive Page

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      Paper of the Month

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      Paper of the Month One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      EAN News

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      Executive Page

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: EAN’s scientific activities provide opportunities to both learn and contribute

      May 1, 2023

      Executive Page

      Executive Page: EAN on a Mission to advocate for brain health & neurology in 2023

      April 11, 2023

      Executive Page Head and shoulders portrait photo of Irena Rektorova, in colourful dress

      Executive Page: Leadership, mentorship and many more EAN educational opportunities

      March 13, 2023

      Paper of the Month

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      Paper of the Month One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      Paper of the Month

      One hot topic, one expert, three questions: Kristian Steen Frederiksen on our May 2023 Paper of the Month

      May 16, 2023

      Paper of the Month

      Research Paper of the Month: Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease

      May 1, 2023

      EAN News

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      EAN News

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      EAN News One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      EAN News

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      EAN Congress news

      Executive Page: Get ready for EAN 2023 in Budapest!

      June 1, 2023

      EAN Congress news

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      EAN Congress news

      On sex and gender: the exciting new world of gender neurology at EAN 2023

      May 25, 2023

      EAN Congress news

      Join us for the movement disorders programme at EAN 2023

      May 24, 2023

      COVID-19

      COVID-19 Research Round-Up: Literature reviews – April 2023

      April 26, 2023

      COVID-19

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – April 2023

      April 26, 2023

      COVID-19

      COVID-19 Research Round-Up: Case Series/Case Reports – April 2023

      April 26, 2023

      COVID-19

      COVID-19 Research Round-Up: Literature reviews – March 2023

      March 16, 2023

      Interviews

      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

      Interviews

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajediene

      July 28, 2022

      Interviews

      Video: EAN supports World Brain Day

      July 19, 2022

      Interviews

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

  • Academic/Scientific
    • All Breaking news Neurology updates Scientific committee reports Scientific panels reports Eur J Neurol Top 10 Articles Scientific Corner
      Paper of the Month

      Research Papers of the Month: Safety and efficacy of rozanolixizumab/zilucoplan in patients with generalised myasthenia gravis (MycarinG and RAISE)

      June 1, 2023

      Paper of the Month One glowing light bulb that stands out from unlit or dim lamps on a blue background

      Research Highlights of the Month – June 2023

      June 1, 2023

      EAN News

      Take our EAN Survey on General Neurology for a chance to win free registration and accommodation for EAN 2024!

      May 25, 2023

      Paper of the Month

      One hot topic, one expert, three questions: Kristian Steen Frederiksen on our May 2023 Paper of the Month

      May 16, 2023

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Miscellaneous – November 2022

      November 7, 2022

      Breaking news

      COVID-19 Breaking News: Observational Studies – Prospective Longitudinal Cohort – November 2022

      November 7, 2022

      Neurology updates

      Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome – A MAGNIMS Study

      September 26, 2022

      Neurology updates

      Relapse-independent disability worsening plays a relevant role in every disease phase of MS

      September 26, 2022

      Neurology updates

      Epstein-Barr virus infection is a major risk factor for the development of multiple sclerosis

      September 26, 2022

      Neurology updates

      Glymphatic system impairment may contribute to multiple sclerosis pathology

      September 23, 2022

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

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Case report: A 29-year-old man with rapid onset tetraplegia and respiratory insufficiency

May 1, 2012

by Svein Ivar Bekkelund

A 29-year-old man with a history of moderate autism and diabetes mellitus treated with insulin presented with a 2-week history of malaise, progressive pareses in both legs and slight weakness in both arms. The last two days before admission in the ward, he was unable to walk. Clinical neurological examination revealed grade 3 weakness in both arms and almost complete paralysis in the legs. The sensory findings were normal. The tendon reflexes were hypoactive but the plantar response was extensor bilaterally. He had urine retention, but there were no clinical signs of encephalopathy. MRI showed multiple hyperintense lesions in the brain, both supra- and infratentorial (Figs 1 and 2) and a significant lesion at the C1 level of the spinal cord (Fig. 3). Most lesions were slightly to moderately gadolinium enhancing but none were expansive. Examination of the cerebrospinal fluid (CSF) showed 7 x 106/l mononuclear leucocytes, normal total protein (291 mg/l) level and 10 oligoclonal bands on isoelectric focusing. Computer tomography of the chest, abdomen and pelvis were normal. Additional blood samples including search for HIV, malignancy, borrelia, syphilis and autoimmune disorders were negative. Neuronal and aquaporine-4 antibodies were also negative.
Initially, he was treated with intravenous methylprednisolone 1g per day for 5 days, but he still deteriorated. He developed complete tetraplegia, loss of sensation to pinprick and vibration. Mentally he seemed unaffected and electroencephalogram (EEG) was normal. The tendon reflexes were still hypoactive.
Suspecting acute disseminated encephalomyelitis (ADEM), he was treated with five courses of plasmapheresis. During the treatment, he developed left-sided ptosis, diplopia and dysphagia. He also needed respiratory support.
A follow-up MRI showed reduced sizes of the previous lesions, but some new periventricular lesions appeared. A new spinal tap with CSF analysis did not reveal further information. Treatment with intravenous immunoglobulin, 2g/kg body weight over 5 days, resulted in no clinical improvement. The patient now was in need of a mobile respirator.
Treatment with mitoxantrone, 12mg per m2 body surface per month during 3 months follow-up was initiated and during the treatment, the clinical progression ceased but he remained tetraplegic, had dysphagia and was unable to breathe independently.
A new MRI showed regression of both intracerebral and intraspinal hyperintensities (Figs. 4-6). Tetraplegia with extensor plantar responses persisted; there was no spasticity.
Nerve conduction studies (NCV) and electromyography (EMG) were performed 12 weeks after admission. An axonal sensorimotor polyneuropathy was found and interpreted as indicating critical illness neuropathy.

Svein Ivar Bekkelund is Head of the Department of Neurology at the University Hospital of North-Norway, Tomasjord, Norway

Comment by the Editor – Gian Luigi Lenzi

I have tried to get comments on this case from eminent experts – without success. Therefore, I – as a Senior Neurologist in charge of a neurological ward – am now trying to comment on this patient.

At my department, I would have asked for the same examinations and tests and would have performed the same therapies in the same sequence. In conclusion, my theoretical patient would have become tetraplegic and unable to breath independently – Rankin Scale 4.

Who may suggest something different?
Competition is open!

We would be glad, if the authors could give us an update on this patient.

Comment by Bernard Decard and Ralf Gold

 In this challenging case report Bekkelund present a 29 year-old man with subacute onset of progressive neurological motor symptoms up to complete tetraplegia, severe sensory symptoms, and concomitant brain stem symptoms including respiratory insufficiency and dysphagia. Interestingly, while bilateral plantar responses were detectable, tendon reflexes were hypoactive on admission and encephalopathic symptoms were absent throughout. The MRI revealed new large T2 lesions, many of them contrast enhancing with affection of the brainstem and upper spinal cord. CSF showed inflammatory changes with evidence of oligoclonal bands (OCB) and mild (7/µl) increase of mononuclear leucocytes paired with normal protein levels. The diagnosis of ADEM was made and the patient received escalating immunotherapies with methylprednisolone, plasmapheresis, IVIg, and mitoxantrone.
Given the patient’s age, the absence of encephalopathic symptoms, appearance of new periventricular lesions in the follow-up MRI, evidence for OCBs and the poor clinical response to methylprednisolone and other immunosupressive therapies, we suggest to reconsider the working hypothesis of ADEM.

The following questions remain open:
1) Did the CSF analysis include cell cytology and search for malignant cells? Although a CNS lymphoma would probably have responded to steroids and protein/glucose levels would typically be abnormal, it cannot be excluded.
2) Were there any anti-myelin antibodies detectable in the patient’s serum? Especially in childhood this shows a higher link with ADEM.
3) Did the physicians consider a stereotactic biopsy of a non-eloquent cerebral lesion?
4) Were infectious causes like listeriosis or tropheryma Whipplei excluded?
There might be some counterarguments regarding the diagnosis of ADEM in this case: Typically ADEM manifests during childhood or adolescence, whereas ADEM is rare among adults. CSF analysis of ADEM patients detected OCBs in about only 12.5% of cases and they often disappeared after treatment with methylprednisolone. As hypoactive reflexes were detectable on admission, one might speculate that the PNS was already affected prior to the intensive care treatment. In very rare cases there can also be an inflammatory process of the CNS and PNS like isolated vasculitis of the nervous system. Furthermore, there are individual cases described in the literature where Marburg variants of MS display severe demyelinating and axonal destruction of the CNS. Marburg variants typically also show serious or fatal disease courses with poor response to immunosuppressive therapies.
In cases of atypical presentation of inflammatory CNS diseases with acute or subacute onset and rapid deterioration of neurological symptoms even under immunosuppressive therapies, we would recommend (if possible) a stereotactic biopsy in order to clarify the histopathological nature of the CNS lesions and allow a possible therapeutic re-adjustment.

Bernhard Decard and Ralf Gold are working at the  Department of Neurology at St. Josef Hospital, Ruhr-University Bochum, Germany

Comment by Saša Šega Jazbec

Dr. Bekkelund presents an interesting case of a 29-years old autistic diabetic (treated with insulin) with subacute onset tetraplegia, respiratory insufficiency and brainstem signs (diplopia, ptosis and dysphagia). He believes that the patient has ADEM.
Onset and clinical course of the disease together with MRI findings (multiple enhancing hyperintense lesions supra- and infratentorial and a large one in spinal cord) are compatible with the diagnosis of ADEM; no response to corticosteroids, IVIG and plasmapharesis is, however, somewhat unusual for ADEM. In most cases of ADEM such treatment improves the clinical picture or at least stops the progression of the disease. Unusual for ADEM with such a malignant course is also the only slightly abnormal CSF with normal proteins, I would expect more cells (with some neutrophils), and elevated proteins.
OB are positive only in 10% of patients with ADEM.
I agree with dr. Decard that encephalopathy is common in ADEM, however its absence in this case does not exclude possible ADEM.
Regarding therapy all recommended and usually effective treatments in ADEM have been tried; I would only argue if mitoxantrone was really indicated.
Dr. Bekkelund claims that all autoimmune diseases have been excluded. I would like to ask if also antiphospholipid syndrome (APS) was excluded? Sometimes neurological manifestations and MRI findings in APS can be indistinguishable from ADEM and MS and these cases anticoagulant treatment can be effective.
I also agree with Dr. Decard that lymphoma could look alike, and in case of lymphoma lesions could decrease in size after coticosteroid treatment as in this case. Most probably biopsy of one of the lesions could clarify this interesting case.

Dr. Saša Šega Jazbec, dr. sc., is associate Professor of neurology at the MS Center, Department of Neurological Diseases, Division of Neurology, University Clinical Center

Ljubljana, Slovenia

 

Case report: A 29-year-old man with rapid onset tetraplegia and respiratory insufficiency was last modified: May 11th, 2012 by Editor
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4 comments

Mohammed A.G. EL-Sherif May 11, 2012 at 11:58 am

The differentail diagnosis for this case:
1-Acute disseminated encephalomyelitis (ADEM).
2-CNS Lymphoma.
3-CNS vasculitis.
4-Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS).
5-Others
*Paraneoplastic disease
*Histiocytosis X
*Bickerstaff brainstem encephalitis

Futher imvestigations needed if possible
Brain Biopsy
Brain MRA
Neural autoantibody
Paraneoplastic markers

Regarding the treatment
I agree with what Dr.Bekkelund had done.
May I suggest also Rituxmab.

Dr.Mohammed ELSherif, Mansoura University,Egypt

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AHMED EL MUGTABA May 22, 2012 at 12:29 am

probability of guillian barrie sydrome i agree is very strong in this case as stated by the authour

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Helen Patience January 18, 2014 at 7:06 pm

Possibility It may be from a virus in the ear. So virus encephalitis. The initial ear symptoms (no ear ache) can very subtle, almost unnoticeable sometimes for some people. Ear symptoms may only last a short time. Antivirus treatment would be needed with the steroids. Might be why symptoms progressed if no antivirus given with steroids. Clinical signs of encephalopathy, this can also be discrete to medical staff. Weakness in both arms, diplopia, periventricular lesions – this could possibly go with this theory.

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Helen Patience January 18, 2014 at 7:49 pm

Also some spinal symptoms with spinal lesion including bladder, numbness is lower extremities, PNS symptoms, mild breathing and occasional dysphagia could go with this theory. I understand in the patients case it was much more extreme.

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