eanNews
  • EAN News
    • All Executive Page President’s Corner EAN News EAN Congress news Interviews
      EAN Congress news

      Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

      September 10, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Executive Page

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      President’s Corner

      President’s Corner – September 2025

      September 4, 2025

      Executive Page

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      Executive Page

      Executive Page: the RRFS is here to support you – and help shape the future of European neurology

      August 12, 2025

      Executive Page

      Executive Page: thank you for making the EAN Congress 2025 a great success!

      July 16, 2025

      Executive Page

      Executive Page: Get ready for EAN 2025 in Helsinki!

      June 3, 2025

      President’s Corner

      President’s Corner – September 2025

      September 4, 2025

      President’s Corner

      President’s Corner – August 2025

      August 12, 2025

      President’s Corner

      President’s Corner – July 2025

      July 16, 2025

      President’s Corner

      President’s Corner – June 2025

      June 3, 2025

      EAN News

      Research Highlights of the Month – September 2025

      September 10, 2025

      EAN News

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      EAN News

      President’s Corner – September 2025

      September 4, 2025

      EAN News

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      EAN Congress news

      Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

      September 10, 2025

      EAN Congress news

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      EAN Congress news

      A Congress Highlight in Helsinki: Brain Health and Sustainability Booth

      August 28, 2025

      EAN Congress news

      Revisit the Highlights of EAN 2025 in Our Congress Review eBook

      July 24, 2025

      Interviews

      Video Interview: Mood Alterations in the Prodromal Phase of Sporadic Creutzfeldt-Jakob Disease, with Raphael Wurm

      March 14, 2025

      Interviews

      Video Interview: EMA approval of lecanemab, with Sebastiaan Engelborghs, EAN Dementia Panel Co-Chair

      January 15, 2025

      Interviews

      Video interview: Claudia Sommer, incoming Editor-in-Chief of the European Journal of Neurology

      January 3, 2025

      Interviews

      Video interviews: meet some of the EAN’s national neurological society partners!

      November 20, 2024

  • Research
    • All Paper of the Month Research Highlights Research Funding
      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Paper of the Month

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      Research

      EMA Neurology News – August 2025

      August 20, 2025

      Research Highlights

      Research Highlights of the Month – August 2025

      August 12, 2025

      Paper of the Month

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      Paper of the Month

      Research Paper of the Month: Higher Educational Attainment and Accelerated Tau Accumulation in Alzheimer Disease

      August 12, 2025

      Paper of the Month

      Research Paper of the Month: Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation (CATALYST)

      July 16, 2025

      Paper of the Month

      Research Papers of the Month: Phase I trial of hES cell-derived dopaminergic neurons for Parkinson’s disease / Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease

      June 2, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Research Highlights

      Research Highlights of the Month – August 2025

      August 12, 2025

      Research Highlights

      Research Highlights of the Month – July 2025

      July 16, 2025

      Research Highlights

      Research Highlights of the Month – June 2025

      June 11, 2025

      Research Funding

      Draft Innovative Health Initiative (IHI) Funding Call topics related to the brain

      May 2, 2025

      Research Funding 'Horizon Europe' in large 3D text, surrounded by illustrations of people undertaking various activities

      Upcoming Horizon Europe Funding Opportunities for Neurology Researchers (Draft Calls)

      May 2, 2025

  • Education
    • All eLearning Mid-Career Resident and Research Fellows Student Corner Fellowship reports
      eLearning

      Join us for all-new Webinars in September!

      September 2, 2025

      EAN Congress news

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      EAN News

      Shape the Future of EAN Panels – Apply to Join a Panel Management Group!

      September 1, 2025

      eLearning

      Join our Webinar on New challenges in Myasthenia Gravis in the Era of Innovative Treatments

      August 28, 2025

      eLearning

      Join us for all-new Webinars in September!

      September 2, 2025

      eLearning

      Join our Webinar on New challenges in Myasthenia Gravis in the Era of Innovative Treatments

      August 28, 2025

      eLearning

      Join our Webinar on Multidisciplinary Perspectives on aTTR Amyloidosis: From Nerves to Heart

      August 21, 2025

      eLearning

      Call for Applications: eanCampus Associate Editors

      July 1, 2025

      Mid-Career

      Certificate of Advanced Studies (CAS) in Brain Health starts second round in January 2026

      August 25, 2025

      Mid-Career

      First 20 EAN Leadership Programme participants graduate, as second group gets underway

      July 10, 2025

      Mid-Career

      Empowering growth: my journey through the EAN Leadership Programme

      March 14, 2025

      Mid-Career

      Join the EAN Congress Masterclass in Vienna!

      January 20, 2025

      Resident and Research Fellows

      Shape the Future of EAN Panels – Apply to Join a Panel Management Group!

      September 1, 2025

      Resident and Research Fellows

      Sign up for the 5th EAN Science School, 13-17 March, 2026

      August 20, 2025

      Resident and Research Fellows

      EAN Regional Teaching Day in Riga, Latvia – 6 November 2025

      August 13, 2025

      Resident and Research Fellows

      Executive Page: the RRFS is here to support you – and help shape the future of European neurology

      August 12, 2025

      Student Corner

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      Student Corner

      Student Teaser Fellowships winners 2025

      June 6, 2025

      Student Corner Photo of a sheet of paper, pencil and crumpled paper on a desk.

      Why Neurology? Read some compelling answers from our EAN 2025 essay contest winners!

      May 12, 2025

      Student Corner

      Student Teaser Fellowship reports 2023 – Paris & Basel

      March 12, 2025

      Fellowship reports

      Research Fellowship Reports 2023: Lyon, Berlin, & London

      March 31, 2025

      Fellowship reports

      Student Teaser Fellowship reports 2023 – Paris & Basel

      March 12, 2025

      Fellowship reports

      Clinical Fellowship Reports 2023: Utrecht, Dianalund, & London

      February 20, 2025

      Fellowship reports

      Research Fellowship Reports 2023: London & Vienna/Paris

      October 8, 2024

  • Other News
    • All EAN Staff EBC News in general Surveys
      Advocacy

      Why do Placebo and Nocebo Effects Matter? – Improving the Education of Healthcare Professionals | 5 November 2025

      August 21, 2025

      Other News

      EAN Panel Management Group Member Discusses Palliative Care on OneNeurology Podcast Marking World Brain Day

      August 8, 2025

      Other News

      Empowering the HD Community: The Launch of the Huntington Academy

      July 10, 2025

      Advocacy

      EAN TV | National Brain Plans and the Path Toward EU Coordination: Insights from Finland and Europe

      June 21, 2025

      EAN Staff

      EAN Head Office Profiles: Ulla & Piyapat

      December 1, 2023

      EAN Staff

      EAN Head Office Profiles: Kathrin & Sasha

      August 28, 2023

      EAN Staff Anja Sander receiving flowers at the end of EAN Congress 2023

      Celebrating 20 Years of Excellence: Anja Sander, EAN’s Executive Director!

      August 3, 2023

      EAN Staff

      EAN Head Office Profiles: Dauren & Benita

      June 5, 2023

      EBC

      EAN TV | National Brain Plans and the Path Toward EU Coordination: Insights from Finland and Europe

      June 21, 2025

      EBC

      EAN TV | European Brain Council: Paving the Way for a European Brain Health Partnership

      June 21, 2025

      EBC Composite image containing various photos from European Brain Council events, plus the EBC logo

      EBC launches 2024 annual report

      April 25, 2025

      EBC

      Brain Innovation Days announces theme and subtheme for 2025 edition!

      March 29, 2025

      News in general

      New paper offers insight into patient involvement in neurological research 

      January 31, 2025

      News in general

      Join the European Brain Council’s ‘Towards a Rare Brain Disease Ecosystem’ event in Brussels on 20 February!

      January 31, 2025

      News in general

      The Brain Prize 2024: Pioneering work in computational and theoretical neuroscience is awarded the world’s largest brain research prize

      March 5, 2024

      News in general

      WHO’s Intersectoral Global Action Plan on epilepsy and other neurological disorders (IGAP) published in all six UN languages

      August 3, 2023

      Surveys

      Public Consultation – European Charter for the Responsible Development of Neurotechnologies

      November 25, 2024

      Surveys

      A survey on connectomics: key insights from EAN neurologists

      July 25, 2024

      Surveys

      Survey: Mapping European Neurological Programs in Solid Organ Transplant Centers

      May 31, 2024

      Surveys

      Neurorehabilitation Across Europe after Ischemic and Traumatic Brain Injuries: a survey to increase knowledge on brain-injury-specific neurorehabilitation

      July 14, 2023

  • EAN
  • Congress 2026
  • eanNews
  • eanCampus
  • Eur J Neurol
  • Brain Health Mission

eanNews

  • EAN News
    • All Executive Page President’s Corner EAN News EAN Congress news Interviews
      EAN Congress news

      Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

      September 10, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Executive Page

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      President’s Corner

      President’s Corner – September 2025

      September 4, 2025

      Executive Page

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      Executive Page

      Executive Page: the RRFS is here to support you – and help shape the future of European neurology

      August 12, 2025

      Executive Page

      Executive Page: thank you for making the EAN Congress 2025 a great success!

      July 16, 2025

      Executive Page

      Executive Page: Get ready for EAN 2025 in Helsinki!

      June 3, 2025

      President’s Corner

      President’s Corner – September 2025

      September 4, 2025

      President’s Corner

      President’s Corner – August 2025

      August 12, 2025

      President’s Corner

      President’s Corner – July 2025

      July 16, 2025

      President’s Corner

      President’s Corner – June 2025

      June 3, 2025

      EAN News

      Research Highlights of the Month – September 2025

      September 10, 2025

      EAN News

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      EAN News

      President’s Corner – September 2025

      September 4, 2025

      EAN News

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      EAN Congress news

      Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

      September 10, 2025

      EAN Congress news

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      EAN Congress news

      A Congress Highlight in Helsinki: Brain Health and Sustainability Booth

      August 28, 2025

      EAN Congress news

      Revisit the Highlights of EAN 2025 in Our Congress Review eBook

      July 24, 2025

      Interviews

      Video Interview: Mood Alterations in the Prodromal Phase of Sporadic Creutzfeldt-Jakob Disease, with Raphael Wurm

      March 14, 2025

      Interviews

      Video Interview: EMA approval of lecanemab, with Sebastiaan Engelborghs, EAN Dementia Panel Co-Chair

      January 15, 2025

      Interviews

      Video interview: Claudia Sommer, incoming Editor-in-Chief of the European Journal of Neurology

      January 3, 2025

      Interviews

      Video interviews: meet some of the EAN’s national neurological society partners!

      November 20, 2024

  • Research
    • All Paper of the Month Research Highlights Research Funding
      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Paper of the Month

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      Research

      EMA Neurology News – August 2025

      August 20, 2025

      Research Highlights

      Research Highlights of the Month – August 2025

      August 12, 2025

      Paper of the Month

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      Paper of the Month

      Research Paper of the Month: Higher Educational Attainment and Accelerated Tau Accumulation in Alzheimer Disease

      August 12, 2025

      Paper of the Month

      Research Paper of the Month: Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation (CATALYST)

      July 16, 2025

      Paper of the Month

      Research Papers of the Month: Phase I trial of hES cell-derived dopaminergic neurons for Parkinson’s disease / Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease

      June 2, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Research Highlights

      Research Highlights of the Month – August 2025

      August 12, 2025

      Research Highlights

      Research Highlights of the Month – July 2025

      July 16, 2025

      Research Highlights

      Research Highlights of the Month – June 2025

      June 11, 2025

      Research Funding

      Draft Innovative Health Initiative (IHI) Funding Call topics related to the brain

      May 2, 2025

      Research Funding 'Horizon Europe' in large 3D text, surrounded by illustrations of people undertaking various activities

      Upcoming Horizon Europe Funding Opportunities for Neurology Researchers (Draft Calls)

      May 2, 2025

  • Education
    • All eLearning Mid-Career Resident and Research Fellows Student Corner Fellowship reports
      eLearning

      Join us for all-new Webinars in September!

      September 2, 2025

      EAN Congress news

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      EAN News

      Shape the Future of EAN Panels – Apply to Join a Panel Management Group!

      September 1, 2025

      eLearning

      Join our Webinar on New challenges in Myasthenia Gravis in the Era of Innovative Treatments

      August 28, 2025

      eLearning

      Join us for all-new Webinars in September!

      September 2, 2025

      eLearning

      Join our Webinar on New challenges in Myasthenia Gravis in the Era of Innovative Treatments

      August 28, 2025

      eLearning

      Join our Webinar on Multidisciplinary Perspectives on aTTR Amyloidosis: From Nerves to Heart

      August 21, 2025

      eLearning

      Call for Applications: eanCampus Associate Editors

      July 1, 2025

      Mid-Career

      Certificate of Advanced Studies (CAS) in Brain Health starts second round in January 2026

      August 25, 2025

      Mid-Career

      First 20 EAN Leadership Programme participants graduate, as second group gets underway

      July 10, 2025

      Mid-Career

      Empowering growth: my journey through the EAN Leadership Programme

      March 14, 2025

      Mid-Career

      Join the EAN Congress Masterclass in Vienna!

      January 20, 2025

      Resident and Research Fellows

      Shape the Future of EAN Panels – Apply to Join a Panel Management Group!

      September 1, 2025

      Resident and Research Fellows

      Sign up for the 5th EAN Science School, 13-17 March, 2026

      August 20, 2025

      Resident and Research Fellows

      EAN Regional Teaching Day in Riga, Latvia – 6 November 2025

      August 13, 2025

      Resident and Research Fellows

      Executive Page: the RRFS is here to support you – and help shape the future of European neurology

      August 12, 2025

      Student Corner

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      Student Corner

      Student Teaser Fellowships winners 2025

      June 6, 2025

      Student Corner Photo of a sheet of paper, pencil and crumpled paper on a desk.

      Why Neurology? Read some compelling answers from our EAN 2025 essay contest winners!

      May 12, 2025

      Student Corner

      Student Teaser Fellowship reports 2023 – Paris & Basel

      March 12, 2025

      Fellowship reports

      Research Fellowship Reports 2023: Lyon, Berlin, & London

      March 31, 2025

      Fellowship reports

      Student Teaser Fellowship reports 2023 – Paris & Basel

      March 12, 2025

      Fellowship reports

      Clinical Fellowship Reports 2023: Utrecht, Dianalund, & London

      February 20, 2025

      Fellowship reports

      Research Fellowship Reports 2023: London & Vienna/Paris

      October 8, 2024

  • Other News
    • All EAN Staff EBC News in general Surveys
      Advocacy

      Why do Placebo and Nocebo Effects Matter? – Improving the Education of Healthcare Professionals | 5 November 2025

      August 21, 2025

      Other News

      EAN Panel Management Group Member Discusses Palliative Care on OneNeurology Podcast Marking World Brain Day

      August 8, 2025

      Other News

      Empowering the HD Community: The Launch of the Huntington Academy

      July 10, 2025

      Advocacy

      EAN TV | National Brain Plans and the Path Toward EU Coordination: Insights from Finland and Europe

      June 21, 2025

      EAN Staff

      EAN Head Office Profiles: Ulla & Piyapat

      December 1, 2023

      EAN Staff

      EAN Head Office Profiles: Kathrin & Sasha

      August 28, 2023

      EAN Staff Anja Sander receiving flowers at the end of EAN Congress 2023

      Celebrating 20 Years of Excellence: Anja Sander, EAN’s Executive Director!

      August 3, 2023

      EAN Staff

      EAN Head Office Profiles: Dauren & Benita

      June 5, 2023

      EBC

      EAN TV | National Brain Plans and the Path Toward EU Coordination: Insights from Finland and Europe

      June 21, 2025

      EBC

      EAN TV | European Brain Council: Paving the Way for a European Brain Health Partnership

      June 21, 2025

      EBC Composite image containing various photos from European Brain Council events, plus the EBC logo

      EBC launches 2024 annual report

      April 25, 2025

      EBC

      Brain Innovation Days announces theme and subtheme for 2025 edition!

      March 29, 2025

      News in general

      New paper offers insight into patient involvement in neurological research 

      January 31, 2025

      News in general

      Join the European Brain Council’s ‘Towards a Rare Brain Disease Ecosystem’ event in Brussels on 20 February!

      January 31, 2025

      News in general

      The Brain Prize 2024: Pioneering work in computational and theoretical neuroscience is awarded the world’s largest brain research prize

      March 5, 2024

      News in general

      WHO’s Intersectoral Global Action Plan on epilepsy and other neurological disorders (IGAP) published in all six UN languages

      August 3, 2023

      Surveys

      Public Consultation – European Charter for the Responsible Development of Neurotechnologies

      November 25, 2024

      Surveys

      A survey on connectomics: key insights from EAN neurologists

      July 25, 2024

      Surveys

      Survey: Mapping European Neurological Programs in Solid Organ Transplant Centers

      May 31, 2024

      Surveys

      Neurorehabilitation Across Europe after Ischemic and Traumatic Brain Injuries: a survey to increase knowledge on brain-injury-specific neurorehabilitation

      July 14, 2023

Paper of the MonthEAN NewsFeatured Slider

Paper of the month: Waking up with a stroke: should we do thrombolysis?

July 1, 2018

 

 

 

 

 

by Elena Moro

 

 

 

For July 2018, we have selected: Thomalla G, Simonsen CZ, Boutitie G, et al., for the WAKE-UP Investigators. MRI-guided thrombolysis for stroke with unknown time of onset. NEJM May 16, 2018. doi:10.1056/NEJMoa1804355.

Thrombolysis is currently performed in patients with acute ischemic stroke within a window of 4.5 hours since the symptoms’ onset. In about one third of the patients, the exact time of stroke onset is unknown, like in patients who wake up from sleeping. In such patients, intravenous thrombolysis is not currently recommended. To improve access to iv thrombolysis, the mismatch between some brain MRI sequences has been used. The absence of hyperintense signal in FLAIR sequences together with the evidence of diffusion-weighted imaging lesions in the same brain region suggest that the stroke may have occurred within the last few hours. Alternatively, it may suggest that some brain parenchyma can still be saved (the penumbra area).

In this multicenter, investigator-initiated, randomized, double-blind, placebo controlled trial, the authors assessed the outcomes of thrombolysis intervention in stroke patients with unknown time of stroke onset. The trial was supported by the European Union Seventh Framework Program. Patients otherwise eligible for thrombolysis (with alteplase, 0.9 mg/kg IV) were screened according to the presence of brain MRI mismatch. Patients with intracranial hemorrhage or ischemic lesions involving more than one third of the middle cerebral artery territory, or NIHSS >25, were not included. Primary outcome was defined as a score of 0 or 1 on the modified Rankin scale at 90-day time point after randomization. Secondary outcomes included the infarct volume on MRI between 22 and 36 hours, and ordinal scores on the modified Rankin scale, a global outcome score, the Beck Depression Inventory score, and two EuroQol-5 dimension scales scores at 90 days. Primary and secondary safety end points were also established, being death and a composite outcome of death or dependence, and the incidence of intracranial bleeding, respectively.

An intention-to-treat approach was used. Unconditional logistic-regression model was used for analyzing the primary outcome. About 800 patients were estimated to be needed to have 80% power to show the expected treatment effect.

Patients were enrolled between September 2012 and June 2017 at 61 centers in eight European countries. The study was stopped in June 2017 due to lack of funding. Of the 503 patients included, 254 were randomized towards alteplase and 249 towards placebo. Clinical characteristics were similar between the two groups. The median NIHSS score at baseline was 6, whereas the median time between symptoms’ recognition and treatment was 3.1-3.2 hours.

There was a significant more favorable outcome in 55.3% (131/246) of the patients with alteplace compared to 41.8% (102/244) of those with placebo at 3months (adjusted OR 1.61, 95% CI, 1.09-2.36, p=0.02). Median score of the modified Rankin scale was 1 in the alteplase group and 2 in the placebo group (common OR 1.63, 95% CI, 1.17-2.23, p=0.003). Quality of life measures overall favored the alteplase group compared to placebo. There was no significant difference between group concerning death or inability to live independently at 90 days (adjusted OR 0.68, 95% CI, 0.92-12.52, p=17). Parenchymal hemorrhage was more frequent in the alteplase group (adjusted OR 10.46, 95% CI, 1.32-82.77, p=0.03).

“This study supports the use of thrombolysis in patients with unknown stroke onset. It also stresses the importance of the mismatch MRI criteria to select patients to the treatment.”, says Prof. Charlotte Cordonnier, Division of Neurology, University of Lille, France. “Two recent clinical trials have also supported the use of thrombectomy in patients with uncertain stroke time onset. The conventional clock will be less important in the near future of stroke therapies. MRI data and other biomarkers will contribute to define the concept of tissular clock that will guide our reperfusion strategies.”

“It is unfortunate that the study could not enroll the goal number of patients. This would have allowed further analysis,” says Prof. Catarina Fonseca, Department of Neurosciences, University of Lisbon, Portugal. “There were more intracranial hemorrhages in the alteplase groups and numerically more deaths. These findings are in keeping with previous published trials but they could have been better analyzed with a larger sample size.”

The other nominees for the July 2018 Paper of the month are:

  • Wilson D, Ambler G, Shakeshft C, et al., on behalf of the CROMIS-2 collaborators. Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after stroke or transient ischaemic attack (CROMIS-2): a multicenter observational study. Lancet Neurol 2018; 17:539-547. This multicenter observational study involved 1,490 patients with atrial fibrillation and recent ischemic stroke or transient ischemic attack treated with oral anticoagulants and followed prospectively up to 2 years. The presence of cerebral microbleeds was found to be independently associated with a significant higher risk to have intracerebral bleedings.
  • Johston AC, Easton JD, Farrant M, et al., for the Clinical Research Collaboration, Neurological Emergencies Treatment Trials Network, and the POINT Investigators. Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA. NEJM 2018 May 16. doi: 10.1056/NEJMoa1800410. The risk of a recurrent stroke at 3 months was assessed in 4,881 patients who were randomized to receive either clopidogrek plus aspirin or the same range of aspirin alone after a minor ischemic stroke or TIA. The combination of clopidogrel and aspirin was associated with lower risk of stroke and higher risk of bleeding compared to aspirin alone.
  • Sprigg N, Flaherty K, Appleton JP, et al., for the TICH-2 Investigators. Tranexamic acid for hyperacute primary intracerebral haemorrhage (TICH-2): an international randomized, placebo-controlled, phase 3 superiority trial. Lancet Neurol 2018 May 16. 10.1016/S0140-6736(18)31033-X. Around 2,325 patients with intracranial hemorrhage were randomized to receive 1 g intravenous tranexamic acid bolus followed by an 8 h infusion of 1 g tranexamic acid or a matching placebo, within 8 h of symptom onset. At 3-month follow-up there was no significant difference in the functional status between the tranexamic acid group and the placebo group.
  • Hart RG, Sharma M, Mundl H, et al., for the NAVIGATE ESUS Investigators. Rivaroxaban for stroke prevention after embolic stroke of undetermined source. N Eng J Med May 16, 2018; doi:10.1056/NEJMoa1802686. In this multicenter trial, efficacy and safety of 15 mg rivaroxaban, an oral factor Xa inhibitor, was compared with 100 mg aspirin in preventing recurrent stroke in 7,213 patients with recent ischemic stroke presumed from cerebral embolism. No differences were found between the two medication in stroke prevention, but rivaroxaban was associated with higher risk of bleeding.

 

Paper of the month: Waking up with a stroke: should we do thrombolysis? was last modified: November 13th, 2018 by Editor
Share this...
Share on facebook
Facebook
Share on twitter
Twitter
Share on linkedin
Linkedin
FLAIR sequencesstrokeMRIthrombolysis
previous post
Country of the month – Poland
next post
Executive Page: Neurology on the move

You may also like

Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

September 10, 2025

Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

September 4, 2025

President’s Corner – September 2025

September 4, 2025

Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

September 4, 2025

A Congress Highlight in Helsinki: Brain Health and Sustainability Booth

August 28, 2025

Executive Page: the RRFS is here to support you – and help shape the future of European neurology

August 12, 2025

President’s Corner – August 2025

August 12, 2025

Research Paper of the Month: Higher Educational Attainment and Accelerated Tau Accumulation in Alzheimer Disease

August 12, 2025

Executive Page: thank you for making the EAN Congress 2025 a great success!

July 16, 2025

President’s Corner – July 2025

July 16, 2025

Leave a Comment Cancel Reply

You need to be logged in to comment. Please login to MyEAN on top.

Upcoming Events

Sep
9
Tue
all-day 17th World Congress of Biologica...
17th World Congress of Biologica...
Sep 9 – Sep 12 all-day
17th World Congress of Biological Psychiatry
  Join leading researchers, clinicians, and professionals from around the globe for the 17th World Congress of Biological Psychiatry, hosted by the World Federation of Societies of Biological Psychiatry (WFSBP).…
Sep
10
Wed
all-day International Headache Congress ...
International Headache Congress ...
Sep 10 – Sep 13 all-day
International Headache Congress 2025
  IHC 2025 will bring together international colleagues in the headache field to share knowledge and learn about the latest advances in headache diagnosis and treatment. We are delighted to hold…
Sep
15
Mon
all-day The XXIII Nordic Stroke Society ...
The XXIII Nordic Stroke Society ...
Sep 15 – Sep 17 all-day
The XXIII Nordic Stroke Society Congress
  23rd Nordic Congress on Cerebrovascular Diseases is held in Tartu, Estonia on September 15-17, 2025. Participants and abstracts are welcome from all countries and specialities to continue the valuable…
6:00 pm EAN Webinar: Multidisciplinary P...
EAN Webinar: Multidisciplinary P...
Sep 15 @ 6:00 pm – 7:30 pm
  This EAN webinar will explore the neurological and cardiac perspectives of aTTR amyloidosis, offering insights into diagnosis, clinical challenges, and emerging therapies. We invite you to be part of…
Sep
24
Wed
all-day 41st Congress of the European Co...
41st Congress of the European Co...
Sep 24 – Sep 26 all-day
41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)
  41-th Congress of ECTRIMS will be held from 24-26 September, in Barcelona at the CCIB Barcelona International Convention Center. This year’s programme offers top-tier scientific sessions, education, networking, and…
View Calendar

Keep in touch

Facebook Instagram Linkedin
EAN Pages is a members service of the European Academy of Neurology https://www.ean.org

All content from January 2012 - June 2013 was published by EFNS; content from July 2013 - June 2014 by EFNS and ENS.

ISSN 2310-2934

Keep in touch

Facebook Instagram Linkedin

Archives

Pages

  • Privacy Policy
  • About us
  • Help

Back To Top