eanNews
  • EAN News
    • All Executive Page President’s Corner EAN News EAN Congress news Interviews
      Advocacy Panel of five speakers sitting on chairs on a stage

      Brains, Bytes, and Budgets: EAN Hosts Strategic Session on the Future of Brain Health at EHFG

      October 14, 2025

      EAN News panel of four people sitting on chairs

      EAN President Takes Part in Brain Days During UNGA80 in New York

      October 14, 2025

      Executive Page

      Executive Page: New Congress Co-Hosting Plan, Upcoming Elections, and Membership Renewal   

      October 9, 2025

      President’s Corner

      President’s Corner – October 2025

      October 8, 2025

      Executive Page

      Executive Page: New Congress Co-Hosting Plan, Upcoming Elections, and Membership Renewal   

      October 9, 2025

      Executive Page

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      Executive Page

      Executive Page: the RRFS is here to support you – and help shape the future of European neurology

      August 12, 2025

      Executive Page

      Executive Page: thank you for making the EAN Congress 2025 a great success!

      July 16, 2025

      President’s Corner

      President’s Corner – October 2025

      October 8, 2025

      President’s Corner

      President’s Corner – September 2025

      September 4, 2025

      President’s Corner

      President’s Corner – August 2025

      August 12, 2025

      President’s Corner

      President’s Corner – July 2025

      July 16, 2025

      EAN News Panel of five speakers sitting on chairs on a stage

      Brains, Bytes, and Budgets: EAN Hosts Strategic Session on the Future of Brain Health at EHFG

      October 14, 2025

      EAN News panel of four people sitting on chairs

      EAN President Takes Part in Brain Days During UNGA80 in New York

      October 14, 2025

      EAN News

      Executive Page: New Congress Co-Hosting Plan, Upcoming Elections, and Membership Renewal   

      October 9, 2025

      EAN News

      President’s Corner – October 2025

      October 8, 2025

      EAN Congress news

      EAN Associate Members Get Access to EAN Congress 2025 Content for October!

      September 26, 2025

      EAN Congress news

      Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

      September 10, 2025

      EAN Congress news

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      EAN Congress news

      A Congress Highlight in Helsinki: Brain Health and Sustainability Booth

      August 28, 2025

      Interviews

      Video Interview: Mood Alterations in the Prodromal Phase of Sporadic Creutzfeldt-Jakob Disease, with Raphael Wurm

      March 14, 2025

      Interviews

      Video Interview: EMA approval of lecanemab, with Sebastiaan Engelborghs, EAN Dementia Panel Co-Chair

      January 15, 2025

      Interviews

      Video interview: Claudia Sommer, incoming Editor-in-Chief of the European Journal of Neurology

      January 3, 2025

      Interviews

      Video interviews: meet some of the EAN’s national neurological society partners!

      November 20, 2024

  • Research
    • All Paper of the Month Research Highlights Research Funding
      Research

      EMA Neurology News – September 2025

      October 8, 2025

      Research Highlights

      Research Highlights of the Month – October 2025

      October 7, 2025

      Paper of the Month

      Research Paper of the Month: AI-driven reclassification of multiple sclerosis progression

      October 6, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Paper of the Month

      Research Paper of the Month: AI-driven reclassification of multiple sclerosis progression

      October 6, 2025

      Paper of the Month

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      Paper of the Month

      Research Paper of the Month: Higher Educational Attainment and Accelerated Tau Accumulation in Alzheimer Disease

      August 12, 2025

      Paper of the Month

      Research Paper of the Month: Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation (CATALYST)

      July 16, 2025

      Research Highlights

      Research Highlights of the Month – October 2025

      October 7, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Research Highlights

      Research Highlights of the Month – August 2025

      August 12, 2025

      Research Highlights

      Research Highlights of the Month – July 2025

      July 16, 2025

      Research Funding

      Draft Innovative Health Initiative (IHI) Funding Call topics related to the brain

      May 2, 2025

      Research Funding 'Horizon Europe' in large 3D text, surrounded by illustrations of people undertaking various activities

      Upcoming Horizon Europe Funding Opportunities for Neurology Researchers (Draft Calls)

      May 2, 2025

  • Education
    • All eLearning Mid-Career Resident and Research Fellows Student Corner Fellowship reports
      Fellowship reports

      Student Teaser Fellowship Reports 2024: Brussels, Paris, & Zurich

      October 10, 2025

      Resident and Research Fellows

      Clinical Fellowship Reports 2024: Göttingen, London, & Salzburg

      October 10, 2025

      Resident and Research Fellows

      Research Fellowship Reports 2023/2024: Basel, Edinburgh, & Barcelona

      October 10, 2025

      eLearning

      More Webinars and Brand-New Episodes of eanCast: Weekly Neurology in October!

      October 7, 2025

      eLearning

      More Webinars and Brand-New Episodes of eanCast: Weekly Neurology in October!

      October 7, 2025

      eLearning

      Join us for all-new Webinars in September!

      September 2, 2025

      eLearning

      Join our Webinar on New challenges in Myasthenia Gravis in the Era of Innovative Treatments

      August 28, 2025

      eLearning

      Join our Webinar on Multidisciplinary Perspectives on aTTR Amyloidosis: From Nerves to Heart

      August 21, 2025

      Mid-Career

      Certificate of Advanced Studies (CAS) in Brain Health starts second round in January 2026

      August 25, 2025

      Mid-Career

      First 20 EAN Leadership Programme participants graduate, as second group gets underway

      July 10, 2025

      Mid-Career

      Empowering growth: my journey through the EAN Leadership Programme

      March 14, 2025

      Mid-Career

      Join the EAN Congress Masterclass in Vienna!

      January 20, 2025

      Resident and Research Fellows

      Clinical Fellowship Reports 2024: Göttingen, London, & Salzburg

      October 10, 2025

      Resident and Research Fellows

      Research Fellowship Reports 2023/2024: Basel, Edinburgh, & Barcelona

      October 10, 2025

      Resident and Research Fellows

      Shape the Future of EAN Panels – Apply to Join a Panel Management Group!

      September 1, 2025

      Resident and Research Fellows

      Sign up for the 5th EAN Science School, 13-17 March, 2026

      August 20, 2025

      Student Corner

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      Student Corner

      Student Teaser Fellowships winners 2025

      June 6, 2025

      Student Corner Photo of a sheet of paper, pencil and crumpled paper on a desk.

      Why Neurology? Read some compelling answers from our EAN 2025 essay contest winners!

      May 12, 2025

      Student Corner

      Student Teaser Fellowship reports 2023 – Paris & Basel

      March 12, 2025

      Fellowship reports

      Student Teaser Fellowship Reports 2024: Brussels, Paris, & Zurich

      October 10, 2025

      Fellowship reports

      Clinical Fellowship Reports 2024: Göttingen, London, & Salzburg

      October 10, 2025

      Fellowship reports

      Research Fellowship Reports 2023/2024: Basel, Edinburgh, & Barcelona

      October 10, 2025

      Fellowship reports

      Research Fellowship Reports 2023: Lyon, Berlin, & London

      March 31, 2025

  • Other News
    • All EAN Staff EBC News in general Surveys
      EAN News panel of four people sitting on chairs

      EAN President Takes Part in Brain Days During UNGA80 in New York

      October 14, 2025

      Surveys

      Share Your Experience with EMA: Participate in the Patient Experience Data (PED) Survey

      October 13, 2025

      Advocacy

      Why do Placebo and Nocebo Effects Matter? – Improving the Education of Healthcare Professionals | 5 November 2025

      August 21, 2025

      Other News

      EAN Panel Management Group Member Discusses Palliative Care on OneNeurology Podcast Marking World Brain Day

      August 8, 2025

      EAN Staff

      EAN Head Office Profiles: Ulla & Piyapat

      December 1, 2023

      EAN Staff

      EAN Head Office Profiles: Kathrin & Sasha

      August 28, 2023

      EAN Staff Anja Sander receiving flowers at the end of EAN Congress 2023

      Celebrating 20 Years of Excellence: Anja Sander, EAN’s Executive Director!

      August 3, 2023

      EAN Staff

      EAN Head Office Profiles: Dauren & Benita

      June 5, 2023

      EBC panel of four people sitting on chairs

      EAN President Takes Part in Brain Days During UNGA80 in New York

      October 14, 2025

      EBC

      EAN TV | National Brain Plans and the Path Toward EU Coordination: Insights from Finland and Europe

      June 21, 2025

      EBC

      EAN TV | European Brain Council: Paving the Way for a European Brain Health Partnership

      June 21, 2025

      EBC Composite image containing various photos from European Brain Council events, plus the EBC logo

      EBC launches 2024 annual report

      April 25, 2025

      News in general

      New paper offers insight into patient involvement in neurological research 

      January 31, 2025

      News in general

      Join the European Brain Council’s ‘Towards a Rare Brain Disease Ecosystem’ event in Brussels on 20 February!

      January 31, 2025

      News in general

      The Brain Prize 2024: Pioneering work in computational and theoretical neuroscience is awarded the world’s largest brain research prize

      March 5, 2024

      News in general

      WHO’s Intersectoral Global Action Plan on epilepsy and other neurological disorders (IGAP) published in all six UN languages

      August 3, 2023

      Surveys

      Share Your Experience with EMA: Participate in the Patient Experience Data (PED) Survey

      October 13, 2025

      Surveys

      Public Consultation – European Charter for the Responsible Development of Neurotechnologies

      November 25, 2024

      Surveys

      A survey on connectomics: key insights from EAN neurologists

      July 25, 2024

      Surveys

      Survey: Mapping European Neurological Programs in Solid Organ Transplant Centers

      May 31, 2024

  • EAN
  • Congress 2026
  • eanNews
  • eanCampus
  • Eur J Neurol
  • Brain Health Mission

eanNews

  • EAN News
    • All Executive Page President’s Corner EAN News EAN Congress news Interviews
      Advocacy Panel of five speakers sitting on chairs on a stage

      Brains, Bytes, and Budgets: EAN Hosts Strategic Session on the Future of Brain Health at EHFG

      October 14, 2025

      EAN News panel of four people sitting on chairs

      EAN President Takes Part in Brain Days During UNGA80 in New York

      October 14, 2025

      Executive Page

      Executive Page: New Congress Co-Hosting Plan, Upcoming Elections, and Membership Renewal   

      October 9, 2025

      President’s Corner

      President’s Corner – October 2025

      October 8, 2025

      Executive Page

      Executive Page: New Congress Co-Hosting Plan, Upcoming Elections, and Membership Renewal   

      October 9, 2025

      Executive Page

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      Executive Page

      Executive Page: the RRFS is here to support you – and help shape the future of European neurology

      August 12, 2025

      Executive Page

      Executive Page: thank you for making the EAN Congress 2025 a great success!

      July 16, 2025

      President’s Corner

      President’s Corner – October 2025

      October 8, 2025

      President’s Corner

      President’s Corner – September 2025

      September 4, 2025

      President’s Corner

      President’s Corner – August 2025

      August 12, 2025

      President’s Corner

      President’s Corner – July 2025

      July 16, 2025

      EAN News Panel of five speakers sitting on chairs on a stage

      Brains, Bytes, and Budgets: EAN Hosts Strategic Session on the Future of Brain Health at EHFG

      October 14, 2025

      EAN News panel of four people sitting on chairs

      EAN President Takes Part in Brain Days During UNGA80 in New York

      October 14, 2025

      EAN News

      Executive Page: New Congress Co-Hosting Plan, Upcoming Elections, and Membership Renewal   

      October 9, 2025

      EAN News

      President’s Corner – October 2025

      October 8, 2025

      EAN Congress news

      EAN Associate Members Get Access to EAN Congress 2025 Content for October!

      September 26, 2025

      EAN Congress news

      Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

      September 10, 2025

      EAN Congress news

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      EAN Congress news

      A Congress Highlight in Helsinki: Brain Health and Sustainability Booth

      August 28, 2025

      Interviews

      Video Interview: Mood Alterations in the Prodromal Phase of Sporadic Creutzfeldt-Jakob Disease, with Raphael Wurm

      March 14, 2025

      Interviews

      Video Interview: EMA approval of lecanemab, with Sebastiaan Engelborghs, EAN Dementia Panel Co-Chair

      January 15, 2025

      Interviews

      Video interview: Claudia Sommer, incoming Editor-in-Chief of the European Journal of Neurology

      January 3, 2025

      Interviews

      Video interviews: meet some of the EAN’s national neurological society partners!

      November 20, 2024

  • Research
    • All Paper of the Month Research Highlights Research Funding
      Research

      EMA Neurology News – September 2025

      October 8, 2025

      Research Highlights

      Research Highlights of the Month – October 2025

      October 7, 2025

      Paper of the Month

      Research Paper of the Month: AI-driven reclassification of multiple sclerosis progression

      October 6, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Paper of the Month

      Research Paper of the Month: AI-driven reclassification of multiple sclerosis progression

      October 6, 2025

      Paper of the Month

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      Paper of the Month

      Research Paper of the Month: Higher Educational Attainment and Accelerated Tau Accumulation in Alzheimer Disease

      August 12, 2025

      Paper of the Month

      Research Paper of the Month: Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation (CATALYST)

      July 16, 2025

      Research Highlights

      Research Highlights of the Month – October 2025

      October 7, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Research Highlights

      Research Highlights of the Month – August 2025

      August 12, 2025

      Research Highlights

      Research Highlights of the Month – July 2025

      July 16, 2025

      Research Funding

      Draft Innovative Health Initiative (IHI) Funding Call topics related to the brain

      May 2, 2025

      Research Funding 'Horizon Europe' in large 3D text, surrounded by illustrations of people undertaking various activities

      Upcoming Horizon Europe Funding Opportunities for Neurology Researchers (Draft Calls)

      May 2, 2025

  • Education
    • All eLearning Mid-Career Resident and Research Fellows Student Corner Fellowship reports
      Fellowship reports

      Student Teaser Fellowship Reports 2024: Brussels, Paris, & Zurich

      October 10, 2025

      Resident and Research Fellows

      Clinical Fellowship Reports 2024: Göttingen, London, & Salzburg

      October 10, 2025

      Resident and Research Fellows

      Research Fellowship Reports 2023/2024: Basel, Edinburgh, & Barcelona

      October 10, 2025

      eLearning

      More Webinars and Brand-New Episodes of eanCast: Weekly Neurology in October!

      October 7, 2025

      eLearning

      More Webinars and Brand-New Episodes of eanCast: Weekly Neurology in October!

      October 7, 2025

      eLearning

      Join us for all-new Webinars in September!

      September 2, 2025

      eLearning

      Join our Webinar on New challenges in Myasthenia Gravis in the Era of Innovative Treatments

      August 28, 2025

      eLearning

      Join our Webinar on Multidisciplinary Perspectives on aTTR Amyloidosis: From Nerves to Heart

      August 21, 2025

      Mid-Career

      Certificate of Advanced Studies (CAS) in Brain Health starts second round in January 2026

      August 25, 2025

      Mid-Career

      First 20 EAN Leadership Programme participants graduate, as second group gets underway

      July 10, 2025

      Mid-Career

      Empowering growth: my journey through the EAN Leadership Programme

      March 14, 2025

      Mid-Career

      Join the EAN Congress Masterclass in Vienna!

      January 20, 2025

      Resident and Research Fellows

      Clinical Fellowship Reports 2024: Göttingen, London, & Salzburg

      October 10, 2025

      Resident and Research Fellows

      Research Fellowship Reports 2023/2024: Basel, Edinburgh, & Barcelona

      October 10, 2025

      Resident and Research Fellows

      Shape the Future of EAN Panels – Apply to Join a Panel Management Group!

      September 1, 2025

      Resident and Research Fellows

      Sign up for the 5th EAN Science School, 13-17 March, 2026

      August 20, 2025

      Student Corner

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      Student Corner

      Student Teaser Fellowships winners 2025

      June 6, 2025

      Student Corner Photo of a sheet of paper, pencil and crumpled paper on a desk.

      Why Neurology? Read some compelling answers from our EAN 2025 essay contest winners!

      May 12, 2025

      Student Corner

      Student Teaser Fellowship reports 2023 – Paris & Basel

      March 12, 2025

      Fellowship reports

      Student Teaser Fellowship Reports 2024: Brussels, Paris, & Zurich

      October 10, 2025

      Fellowship reports

      Clinical Fellowship Reports 2024: Göttingen, London, & Salzburg

      October 10, 2025

      Fellowship reports

      Research Fellowship Reports 2023/2024: Basel, Edinburgh, & Barcelona

      October 10, 2025

      Fellowship reports

      Research Fellowship Reports 2023: Lyon, Berlin, & London

      March 31, 2025

  • Other News
    • All EAN Staff EBC News in general Surveys
      EAN News panel of four people sitting on chairs

      EAN President Takes Part in Brain Days During UNGA80 in New York

      October 14, 2025

      Surveys

      Share Your Experience with EMA: Participate in the Patient Experience Data (PED) Survey

      October 13, 2025

      Advocacy

      Why do Placebo and Nocebo Effects Matter? – Improving the Education of Healthcare Professionals | 5 November 2025

      August 21, 2025

      Other News

      EAN Panel Management Group Member Discusses Palliative Care on OneNeurology Podcast Marking World Brain Day

      August 8, 2025

      EAN Staff

      EAN Head Office Profiles: Ulla & Piyapat

      December 1, 2023

      EAN Staff

      EAN Head Office Profiles: Kathrin & Sasha

      August 28, 2023

      EAN Staff Anja Sander receiving flowers at the end of EAN Congress 2023

      Celebrating 20 Years of Excellence: Anja Sander, EAN’s Executive Director!

      August 3, 2023

      EAN Staff

      EAN Head Office Profiles: Dauren & Benita

      June 5, 2023

      EBC panel of four people sitting on chairs

      EAN President Takes Part in Brain Days During UNGA80 in New York

      October 14, 2025

      EBC

      EAN TV | National Brain Plans and the Path Toward EU Coordination: Insights from Finland and Europe

      June 21, 2025

      EBC

      EAN TV | European Brain Council: Paving the Way for a European Brain Health Partnership

      June 21, 2025

      EBC Composite image containing various photos from European Brain Council events, plus the EBC logo

      EBC launches 2024 annual report

      April 25, 2025

      News in general

      New paper offers insight into patient involvement in neurological research 

      January 31, 2025

      News in general

      Join the European Brain Council’s ‘Towards a Rare Brain Disease Ecosystem’ event in Brussels on 20 February!

      January 31, 2025

      News in general

      The Brain Prize 2024: Pioneering work in computational and theoretical neuroscience is awarded the world’s largest brain research prize

      March 5, 2024

      News in general

      WHO’s Intersectoral Global Action Plan on epilepsy and other neurological disorders (IGAP) published in all six UN languages

      August 3, 2023

      Surveys

      Share Your Experience with EMA: Participate in the Patient Experience Data (PED) Survey

      October 13, 2025

      Surveys

      Public Consultation – European Charter for the Responsible Development of Neurotechnologies

      November 25, 2024

      Surveys

      A survey on connectomics: key insights from EAN neurologists

      July 25, 2024

      Surveys

      Survey: Mapping European Neurological Programs in Solid Organ Transplant Centers

      May 31, 2024

Paper of the MonthEAN NewsFeatured Slider

Paper of the month: Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

October 1, 2019

 

 

 

by Thomas Jenkins

 

 

 

 

For October 2019, we have selected: Nelson et al., Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report Brain 2019; 142: 1503-27.

This month’s selected paper is a working group report that addresses a recently described disorder, limbic-predominant age-related TDP-43 encephalopathy (LATE), which is emerging as an important cause of cognitive impairment in the elderly. The group make recommendations for standardised neuropathological evaluation and identify research avenues to better understand this evolving new disease phenotype.

 

It is increasingly recognised that pathological findings in people with cognitive impairment often extend beyond Alzheimer-disease neuropathological change, multiple pathologies are common, and may help explain observed discordance between clinical and histological findings. The first report of hippocampal sclerosis in patients lacking typical Alzheimer changes, such as amyloid plaques, was in 1994, from a case series of 13 elderly patients with dementia. This was published prior to the discovery of phosphorylated TDP-43, which occurred in 2006, and was first identified in ubiquitinylated inclusions in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 is encoded by the TARDBP gene, and regulates aspects of both gene transcription and translation. In health, TDP-43 is expressed in most cell types, is predominantly non-phosphorylated and located within the cell nuclei. In disease states, TDP-43 is phosphorylated and mislocated to the cytoplasm. TDP-43 proteinopathy was subsequently identified in people older than 80 years who had no clinical features of ALS or FTD. These patients had hippocampal sclerosis, like those in the 1994 case series, and TDP-43 proteinopathy is now recognised to be associated with a progressive amnestic syndrome distinct from Alzheimer’s disease.

 

The pathological hallmark of LATE is mislocalised and phosphorylated TDP-43 within limbic structures, and changes have also been found in the olfactory bulb, neocortex, basal ganglia and occasionally the brainstem. Neuronal loss, astrogliosis and atrophy occur. Hippocampal sclerosis is unilateral in 40-50% of cases and is non-specific for disease aetiology; demonstration of TDP-43 pathology is necessary for histological diagnosis of LATE and is generally bilateral. In order to better understand this emerging phenotype, the authors recommend that TDP-43 immunohistochemistry is performed at autopsy in all older subjects and that, as a minimum, the amygdala, mid-level hippocampus and middle frontal gyrus are assessed (which tend to be involved sequentially in that order and form the basis of staging protocols).

 

Radiologically, hippocampal atrophy may appear more marked in LATE than Alzheimer’s disease. Atrophy in inferior frontal, anterior temporal and insular cortices has been observed. Clinically, the condition affects especially the very elderly. An amnestic cognitive syndrome is typical at onset, but can evolve into a multi-domain dementia. Delayed recall of word lists (a hippocampal-dependent neuropsychological function) with relatively preserved verbal fluency (cortically-dependent) is associated with LATE, and this pattern differs from Alzheimer’s disease and FTD. Behavioural features such as agitation and aggression have been reported. TDP-43 pathological change in the absence of clinical cognitive change is recognised.

 

Five genes have been found to confer risk of developing LATE pathological changes: granulin and TMEM106B (which are also associated with FTD), APOE (which is also associated with Alzheimer’s disease), ABCC9 and KCNMB2. These associations suggest some commonality of pathogenetic mechanisms in neurodegenerative disease.

 

LATE appears quite common, with pathological features identified in approximately 20% of people over the age of 80 in autopsy series. Comorbidity with Alzheimer’s disease is frequent and appears to be associated with a more rapidly progressive disease course. LATE is likely to represent a significant public health burden.

 

Therefore, further research is needed. Additional epidemiological, clinical, pathological, neuroimaging and genetic studies are required to better characterise phenotypes and public health impact. Animal models and basic science studies to help decipher disease mechanisms are necessary. No biomarkers currently exist in LATE and this is another important area-of-need

 

Prof Reinhold Schmidt, Medical University of Graz commented: “The working group has to be complimented for proposing a new terminology for a clinical-pathological entity that is long recognized and has initially been termed hippocampal sclerosis. It was known from many sources that hippocampal sclerosis most commonly relates to a TDP-43 proteinopathy and occurs often in dementia cases of the oldest-old. The merit of this paper is that the authors now provide a consensus-based nomenclature. The new name is limbic-predominant age-related TDP-43 encephalopathy (LATE) and guidance is provided for the autopsy evaluation and staging of LATE neuropathological change (LATE-NC). I am certain that this article will foster much needed research on this entity as diagnostic tools, such as biofluid or neuroimaging biomarkers, for ante-mortem detection are currently lacking.”

 

 

Paper of the month: Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report was last modified: May 8th, 2023 by Editor
Share this...
Share on facebook
Facebook
Share on twitter
Twitter
Share on linkedin
Linkedin
previous post
Country of the Month: Sweden
next post
Executive Page: update from President-Elect

You may also like

Executive Page: New Congress Co-Hosting Plan, Upcoming Elections, and Membership Renewal   

October 9, 2025

President’s Corner – October 2025

October 8, 2025

Research Paper of the Month: AI-driven reclassification of multiple sclerosis progression

October 6, 2025

Join Now for Bonus Months! Plus: October Renewal Discount and Special Benefit for Associate Members 

October 1, 2025

Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

September 10, 2025

Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

September 4, 2025

President’s Corner – September 2025

September 4, 2025

Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

September 4, 2025

A Congress Highlight in Helsinki: Brain Health and Sustainability Booth

August 28, 2025

Executive Page: the RRFS is here to support you – and help shape the future of European neurology

August 12, 2025

Leave a Comment Cancel Reply

You need to be logged in to comment. Please login to MyEAN on top.

Upcoming Events

Oct
2
Thu
all-day GNP Annual Conference 2025
GNP Annual Conference 2025
Oct 2 2025 – Oct 5 2026 all-day
GNP Annual Conference 2025
  The GNP Annual conference will take place in the Kursaal Bern, in the heart of the city with a view of the old town and the mountains. You can expect…
Oct
9
Thu
12:00 pm eSleep Europe 2025: Basic Human ...
eSleep Europe 2025: Basic Human ...
Oct 9 2025 @ 12:00 pm – Oct 9 2026 @ 5:00 pm
eSleep Europe 2025: Basic Human Track
  eSleep Europe 2025 is a year-long virtual congress by the European Sleep Research Society (ESRS), dedicated to advancing sleep research, medicine, and technology. Building on the success of its…
Oct
22
Wed
all-day 17th World Stroke Congress (WSC ...
17th World Stroke Congress (WSC ...
Oct 22 – Oct 24 all-day
17th World Stroke Congress (WSC 2025)
  The World Stroke Congress (WSC 2025) is set to take place on October 22-24, 2025, in the vibrant city of Barcelona. The event offers a unique opportunity to advance…
Oct
24
Fri
all-day 55th National Congress of the It...
55th National Congress of the It...
Oct 24 – Oct 28 all-day
55th National Congress of the Italian Society of Neurology (SIN)
  The 2025 edition of the Italian Society of Neurology Congress will gather leading neurologists, neuroscientists, and healthcare professionals from across the country and beyond to explore the latest breakthroughs…
Oct
28
Tue
all-day Scientific Symposium “European h...
Scientific Symposium “European h...
Oct 28 all-day
Scientific Symposium “European healthcare for RND patients”
  Scientific symposium “European healthcare for RND Patients” is part of the ERN-RND Annual Meeting Care-RND25 and it will be streamed online. The participation in the symposium is free of…
View Calendar

Keep in touch

Bluesky Facebook Instagram LinkedIn
eanNews is a members service of the European Academy of Neurology https://www.ean.org

All content from January 2012 - June 2013 was published by EFNS; content from July 2013 - June 2014 by EFNS and ENS.

ISSN 2310-2934

Keep in touch

Bluesky Facebook Instagram LinkedIn

Archives

Pages

  • Privacy Policy
  • About us
  • Help

Back To Top