Cross-sectional case-control studies (Blue)
Headache is an adverse event of coronavirus 2019 (COVID-19) vaccination. Whether patients with history of headache suffer more from vaccination-induced headaches is unknown. In this article the authors aimed to uncover if headache patients develop more headaches after COVID-19 mRNA vaccination than healthy controls. They performed a questionnaire survey for nursing staff in their hospital from April to May 2021. Based on baseline characteristics, they divided the participants into migraine, non-migrainous headache, and healthy control, and examined the occurrence and features of headache after COVID-19 vaccinations. 171 participants were included (15.2% migraine and 24.6% non-migrainous headache). Headache incidence after vaccinations was significantly higher in the migraine (69.2%) and non-migrainous headache (71.4%) groups than in the healthy control (37.9%) group. The incidence of headaches was significantly higher after the second dose compared to the first (45.6% vs. 20.5%). The authors concluded that migraineurs and non-migrainous headache participants developed more headaches compared to the healthy controls after COVID-19 vaccination.
Sekiguchi K, Watanabe N, Miyazaki N, Ishizuchi K, Iba C, Tagashira Y, Uno S, Shibata M, Hasegawa N, Takemura R, Nakahara J, Takizawa T. Incidence of headache after COVID-19 vaccination in patients with history of headache: A cross-sectional study. Cephalalgia. 2021 Aug 18:3331024211038654. doi: 10.1177/03331024211038654.