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      Brain Health

      EAN Joins European Health Alliance on Alcohol, Co-Funded by EU/WHO Evidence into Action Alcohol

      September 16, 2025

      EAN Congress news

      Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

      September 10, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Executive Page

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      Executive Page

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      Executive Page

      Executive Page: the RRFS is here to support you – and help shape the future of European neurology

      August 12, 2025

      Executive Page

      Executive Page: thank you for making the EAN Congress 2025 a great success!

      July 16, 2025

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      Executive Page: Get ready for EAN 2025 in Helsinki!

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      EAN News

      EAN Joins European Health Alliance on Alcohol, Co-Funded by EU/WHO Evidence into Action Alcohol

      September 16, 2025

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      Research Highlights of the Month – September 2025

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      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

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      President’s Corner – September 2025

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      EAN Congress news

      Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

      September 10, 2025

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      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

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      A Congress Highlight in Helsinki: Brain Health and Sustainability Booth

      August 28, 2025

      EAN Congress news

      Revisit the Highlights of EAN 2025 in Our Congress Review eBook

      July 24, 2025

      Interviews

      Video Interview: Mood Alterations in the Prodromal Phase of Sporadic Creutzfeldt-Jakob Disease, with Raphael Wurm

      March 14, 2025

      Interviews

      Video Interview: EMA approval of lecanemab, with Sebastiaan Engelborghs, EAN Dementia Panel Co-Chair

      January 15, 2025

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      Video interview: Claudia Sommer, incoming Editor-in-Chief of the European Journal of Neurology

      January 3, 2025

      Interviews

      Video interviews: meet some of the EAN’s national neurological society partners!

      November 20, 2024

  • Research
    • All Paper of the Month Research Highlights Research Funding
      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Paper of the Month

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      Research

      EMA Neurology News – August 2025

      August 20, 2025

      Research Highlights

      Research Highlights of the Month – August 2025

      August 12, 2025

      Paper of the Month

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      Paper of the Month

      Research Paper of the Month: Higher Educational Attainment and Accelerated Tau Accumulation in Alzheimer Disease

      August 12, 2025

      Paper of the Month

      Research Paper of the Month: Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation (CATALYST)

      July 16, 2025

      Paper of the Month

      Research Papers of the Month: Phase I trial of hES cell-derived dopaminergic neurons for Parkinson’s disease / Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease

      June 2, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Research Highlights

      Research Highlights of the Month – August 2025

      August 12, 2025

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      Research Highlights of the Month – July 2025

      July 16, 2025

      Research Highlights

      Research Highlights of the Month – June 2025

      June 11, 2025

      Research Funding

      Draft Innovative Health Initiative (IHI) Funding Call topics related to the brain

      May 2, 2025

      Research Funding 'Horizon Europe' in large 3D text, surrounded by illustrations of people undertaking various activities

      Upcoming Horizon Europe Funding Opportunities for Neurology Researchers (Draft Calls)

      May 2, 2025

  • Education
    • All eLearning Mid-Career Resident and Research Fellows Student Corner Fellowship reports
      eLearning

      Join us for all-new Webinars in September!

      September 2, 2025

      EAN Congress news

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      EAN News

      Shape the Future of EAN Panels – Apply to Join a Panel Management Group!

      September 1, 2025

      eLearning

      Join our Webinar on New challenges in Myasthenia Gravis in the Era of Innovative Treatments

      August 28, 2025

      eLearning

      Join us for all-new Webinars in September!

      September 2, 2025

      eLearning

      Join our Webinar on New challenges in Myasthenia Gravis in the Era of Innovative Treatments

      August 28, 2025

      eLearning

      Join our Webinar on Multidisciplinary Perspectives on aTTR Amyloidosis: From Nerves to Heart

      August 21, 2025

      eLearning

      Call for Applications: eanCampus Associate Editors

      July 1, 2025

      Mid-Career

      Certificate of Advanced Studies (CAS) in Brain Health starts second round in January 2026

      August 25, 2025

      Mid-Career

      First 20 EAN Leadership Programme participants graduate, as second group gets underway

      July 10, 2025

      Mid-Career

      Empowering growth: my journey through the EAN Leadership Programme

      March 14, 2025

      Mid-Career

      Join the EAN Congress Masterclass in Vienna!

      January 20, 2025

      Resident and Research Fellows

      Shape the Future of EAN Panels – Apply to Join a Panel Management Group!

      September 1, 2025

      Resident and Research Fellows

      Sign up for the 5th EAN Science School, 13-17 March, 2026

      August 20, 2025

      Resident and Research Fellows

      EAN Regional Teaching Day in Riga, Latvia – 6 November 2025

      August 13, 2025

      Resident and Research Fellows

      Executive Page: the RRFS is here to support you – and help shape the future of European neurology

      August 12, 2025

      Student Corner

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      Student Corner

      Student Teaser Fellowships winners 2025

      June 6, 2025

      Student Corner Photo of a sheet of paper, pencil and crumpled paper on a desk.

      Why Neurology? Read some compelling answers from our EAN 2025 essay contest winners!

      May 12, 2025

      Student Corner

      Student Teaser Fellowship reports 2023 – Paris & Basel

      March 12, 2025

      Fellowship reports

      Research Fellowship Reports 2023: Lyon, Berlin, & London

      March 31, 2025

      Fellowship reports

      Student Teaser Fellowship reports 2023 – Paris & Basel

      March 12, 2025

      Fellowship reports

      Clinical Fellowship Reports 2023: Utrecht, Dianalund, & London

      February 20, 2025

      Fellowship reports

      Research Fellowship Reports 2023: London & Vienna/Paris

      October 8, 2024

  • Other News
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      Advocacy

      Why do Placebo and Nocebo Effects Matter? – Improving the Education of Healthcare Professionals | 5 November 2025

      August 21, 2025

      Other News

      EAN Panel Management Group Member Discusses Palliative Care on OneNeurology Podcast Marking World Brain Day

      August 8, 2025

      Other News

      Empowering the HD Community: The Launch of the Huntington Academy

      July 10, 2025

      Advocacy

      EAN TV | National Brain Plans and the Path Toward EU Coordination: Insights from Finland and Europe

      June 21, 2025

      EAN Staff

      EAN Head Office Profiles: Ulla & Piyapat

      December 1, 2023

      EAN Staff

      EAN Head Office Profiles: Kathrin & Sasha

      August 28, 2023

      EAN Staff Anja Sander receiving flowers at the end of EAN Congress 2023

      Celebrating 20 Years of Excellence: Anja Sander, EAN’s Executive Director!

      August 3, 2023

      EAN Staff

      EAN Head Office Profiles: Dauren & Benita

      June 5, 2023

      EBC

      EAN TV | National Brain Plans and the Path Toward EU Coordination: Insights from Finland and Europe

      June 21, 2025

      EBC

      EAN TV | European Brain Council: Paving the Way for a European Brain Health Partnership

      June 21, 2025

      EBC Composite image containing various photos from European Brain Council events, plus the EBC logo

      EBC launches 2024 annual report

      April 25, 2025

      EBC

      Brain Innovation Days announces theme and subtheme for 2025 edition!

      March 29, 2025

      News in general

      New paper offers insight into patient involvement in neurological research 

      January 31, 2025

      News in general

      Join the European Brain Council’s ‘Towards a Rare Brain Disease Ecosystem’ event in Brussels on 20 February!

      January 31, 2025

      News in general

      The Brain Prize 2024: Pioneering work in computational and theoretical neuroscience is awarded the world’s largest brain research prize

      March 5, 2024

      News in general

      WHO’s Intersectoral Global Action Plan on epilepsy and other neurological disorders (IGAP) published in all six UN languages

      August 3, 2023

      Surveys

      Public Consultation – European Charter for the Responsible Development of Neurotechnologies

      November 25, 2024

      Surveys

      A survey on connectomics: key insights from EAN neurologists

      July 25, 2024

      Surveys

      Survey: Mapping European Neurological Programs in Solid Organ Transplant Centers

      May 31, 2024

      Surveys

      Neurorehabilitation Across Europe after Ischemic and Traumatic Brain Injuries: a survey to increase knowledge on brain-injury-specific neurorehabilitation

      July 14, 2023

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eanNews

  • EAN News
    • All Executive Page President’s Corner EAN News EAN Congress news Interviews
      Brain Health

      EAN Joins European Health Alliance on Alcohol, Co-Funded by EU/WHO Evidence into Action Alcohol

      September 16, 2025

      EAN Congress news

      Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

      September 10, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Executive Page

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      Executive Page

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      Executive Page

      Executive Page: the RRFS is here to support you – and help shape the future of European neurology

      August 12, 2025

      Executive Page

      Executive Page: thank you for making the EAN Congress 2025 a great success!

      July 16, 2025

      Executive Page

      Executive Page: Get ready for EAN 2025 in Helsinki!

      June 3, 2025

      President’s Corner

      President’s Corner – September 2025

      September 4, 2025

      President’s Corner

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      August 12, 2025

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      July 16, 2025

      President’s Corner

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      June 3, 2025

      EAN News

      EAN Joins European Health Alliance on Alcohol, Co-Funded by EU/WHO Evidence into Action Alcohol

      September 16, 2025

      EAN News

      Research Highlights of the Month – September 2025

      September 10, 2025

      EAN News

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      EAN News

      President’s Corner – September 2025

      September 4, 2025

      EAN Congress news

      Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

      September 10, 2025

      EAN Congress news

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      EAN Congress news

      A Congress Highlight in Helsinki: Brain Health and Sustainability Booth

      August 28, 2025

      EAN Congress news

      Revisit the Highlights of EAN 2025 in Our Congress Review eBook

      July 24, 2025

      Interviews

      Video Interview: Mood Alterations in the Prodromal Phase of Sporadic Creutzfeldt-Jakob Disease, with Raphael Wurm

      March 14, 2025

      Interviews

      Video Interview: EMA approval of lecanemab, with Sebastiaan Engelborghs, EAN Dementia Panel Co-Chair

      January 15, 2025

      Interviews

      Video interview: Claudia Sommer, incoming Editor-in-Chief of the European Journal of Neurology

      January 3, 2025

      Interviews

      Video interviews: meet some of the EAN’s national neurological society partners!

      November 20, 2024

  • Research
    • All Paper of the Month Research Highlights Research Funding
      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Paper of the Month

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      Research

      EMA Neurology News – August 2025

      August 20, 2025

      Research Highlights

      Research Highlights of the Month – August 2025

      August 12, 2025

      Paper of the Month

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      Paper of the Month

      Research Paper of the Month: Higher Educational Attainment and Accelerated Tau Accumulation in Alzheimer Disease

      August 12, 2025

      Paper of the Month

      Research Paper of the Month: Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation (CATALYST)

      July 16, 2025

      Paper of the Month

      Research Papers of the Month: Phase I trial of hES cell-derived dopaminergic neurons for Parkinson’s disease / Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease

      June 2, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Research Highlights

      Research Highlights of the Month – August 2025

      August 12, 2025

      Research Highlights

      Research Highlights of the Month – July 2025

      July 16, 2025

      Research Highlights

      Research Highlights of the Month – June 2025

      June 11, 2025

      Research Funding

      Draft Innovative Health Initiative (IHI) Funding Call topics related to the brain

      May 2, 2025

      Research Funding 'Horizon Europe' in large 3D text, surrounded by illustrations of people undertaking various activities

      Upcoming Horizon Europe Funding Opportunities for Neurology Researchers (Draft Calls)

      May 2, 2025

  • Education
    • All eLearning Mid-Career Resident and Research Fellows Student Corner Fellowship reports
      eLearning

      Join us for all-new Webinars in September!

      September 2, 2025

      EAN Congress news

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      EAN News

      Shape the Future of EAN Panels – Apply to Join a Panel Management Group!

      September 1, 2025

      eLearning

      Join our Webinar on New challenges in Myasthenia Gravis in the Era of Innovative Treatments

      August 28, 2025

      eLearning

      Join us for all-new Webinars in September!

      September 2, 2025

      eLearning

      Join our Webinar on New challenges in Myasthenia Gravis in the Era of Innovative Treatments

      August 28, 2025

      eLearning

      Join our Webinar on Multidisciplinary Perspectives on aTTR Amyloidosis: From Nerves to Heart

      August 21, 2025

      eLearning

      Call for Applications: eanCampus Associate Editors

      July 1, 2025

      Mid-Career

      Certificate of Advanced Studies (CAS) in Brain Health starts second round in January 2026

      August 25, 2025

      Mid-Career

      First 20 EAN Leadership Programme participants graduate, as second group gets underway

      July 10, 2025

      Mid-Career

      Empowering growth: my journey through the EAN Leadership Programme

      March 14, 2025

      Mid-Career

      Join the EAN Congress Masterclass in Vienna!

      January 20, 2025

      Resident and Research Fellows

      Shape the Future of EAN Panels – Apply to Join a Panel Management Group!

      September 1, 2025

      Resident and Research Fellows

      Sign up for the 5th EAN Science School, 13-17 March, 2026

      August 20, 2025

      Resident and Research Fellows

      EAN Regional Teaching Day in Riga, Latvia – 6 November 2025

      August 13, 2025

      Resident and Research Fellows

      Executive Page: the RRFS is here to support you – and help shape the future of European neurology

      August 12, 2025

      Student Corner

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      Student Corner

      Student Teaser Fellowships winners 2025

      June 6, 2025

      Student Corner Photo of a sheet of paper, pencil and crumpled paper on a desk.

      Why Neurology? Read some compelling answers from our EAN 2025 essay contest winners!

      May 12, 2025

      Student Corner

      Student Teaser Fellowship reports 2023 – Paris & Basel

      March 12, 2025

      Fellowship reports

      Research Fellowship Reports 2023: Lyon, Berlin, & London

      March 31, 2025

      Fellowship reports

      Student Teaser Fellowship reports 2023 – Paris & Basel

      March 12, 2025

      Fellowship reports

      Clinical Fellowship Reports 2023: Utrecht, Dianalund, & London

      February 20, 2025

      Fellowship reports

      Research Fellowship Reports 2023: London & Vienna/Paris

      October 8, 2024

  • Other News
    • All EAN Staff EBC News in general Surveys
      Advocacy

      Why do Placebo and Nocebo Effects Matter? – Improving the Education of Healthcare Professionals | 5 November 2025

      August 21, 2025

      Other News

      EAN Panel Management Group Member Discusses Palliative Care on OneNeurology Podcast Marking World Brain Day

      August 8, 2025

      Other News

      Empowering the HD Community: The Launch of the Huntington Academy

      July 10, 2025

      Advocacy

      EAN TV | National Brain Plans and the Path Toward EU Coordination: Insights from Finland and Europe

      June 21, 2025

      EAN Staff

      EAN Head Office Profiles: Ulla & Piyapat

      December 1, 2023

      EAN Staff

      EAN Head Office Profiles: Kathrin & Sasha

      August 28, 2023

      EAN Staff Anja Sander receiving flowers at the end of EAN Congress 2023

      Celebrating 20 Years of Excellence: Anja Sander, EAN’s Executive Director!

      August 3, 2023

      EAN Staff

      EAN Head Office Profiles: Dauren & Benita

      June 5, 2023

      EBC

      EAN TV | National Brain Plans and the Path Toward EU Coordination: Insights from Finland and Europe

      June 21, 2025

      EBC

      EAN TV | European Brain Council: Paving the Way for a European Brain Health Partnership

      June 21, 2025

      EBC Composite image containing various photos from European Brain Council events, plus the EBC logo

      EBC launches 2024 annual report

      April 25, 2025

      EBC

      Brain Innovation Days announces theme and subtheme for 2025 edition!

      March 29, 2025

      News in general

      New paper offers insight into patient involvement in neurological research 

      January 31, 2025

      News in general

      Join the European Brain Council’s ‘Towards a Rare Brain Disease Ecosystem’ event in Brussels on 20 February!

      January 31, 2025

      News in general

      The Brain Prize 2024: Pioneering work in computational and theoretical neuroscience is awarded the world’s largest brain research prize

      March 5, 2024

      News in general

      WHO’s Intersectoral Global Action Plan on epilepsy and other neurological disorders (IGAP) published in all six UN languages

      August 3, 2023

      Surveys

      Public Consultation – European Charter for the Responsible Development of Neurotechnologies

      November 25, 2024

      Surveys

      A survey on connectomics: key insights from EAN neurologists

      July 25, 2024

      Surveys

      Survey: Mapping European Neurological Programs in Solid Organ Transplant Centers

      May 31, 2024

      Surveys

      Neurorehabilitation Across Europe after Ischemic and Traumatic Brain Injuries: a survey to increase knowledge on brain-injury-specific neurorehabilitation

      July 14, 2023

Breaking newsCOVID-19

COVID-19 Breaking News: Cross-Sectional Case Control Studies – April 2022

April 5, 2022

Cross-sectional case-control studies (Blue)

Read on for our highlighted selection of Covid-related cross-sectional case control studies from the scientific press for April 2022:

  • Short- and long-term outcome and predictors in an international cohort of patients with neuro-COVID-19
  • SARS-CoV-2 is associated with changes in brain structure in UK Biobank
  • Cellular and humoral immunity to SARS-CoV-2 infection in multiple sclerosis patients on ocrelizumab and other disease-modifying therapies: a multi-ethnic observational study
  • Trends in Mortality Rates Among Medicare Enrollees With Alzheimer Disease and Related Dementias Before and During the Early Phase of the COVID-19 Pandemic (Submitted by the EAN Scientific Panel on Dementia and Cognitive Disorders)

Short- and long-term outcome and predictors in an international cohort of patients with neuro-COVID-19
Despite the increasing number of reports on the spectrum of neurological manifestations of COVID-19 (neuro-COVID), few studies have assessed short- and long-term outcome of the disease. This cohort study enrolled adult patients with neuro-COVID seen in neurological consultation. Data were collected prospectively or retrospectively in the European Academy of Neurology NEuro-covid ReGistrY ((ENERGY). The outcome at discharge was measured using the modified Rankin Scale and defined as ‘stable/improved’ if the modified Rankin Scale score was equal to or lower than the pre-morbid score, ‘worse’ if the score was higher than the pre-morbid score. Status at 6 months was also recorded. Demographic and clinical variables were assessed as predictors of outcome at discharge and 6 months. From July 2020 to March 2021, 971 patients from 19 countries were included. 810 (83.4%) were hospitalized. 432 (53.3%) were discharged with worse functional status. Older age, stupor/coma, stroke and intensive care unit (ICU) admission were predictors of worse outcome at discharge. 132 (16.3%) died in hospital. Older age, cancer, cardiovascular complications, refractory shock, stupor/coma and ICU admission were associated with death. 262 were followed for 6 months. Acute stroke or ataxia, ICU admission and degree of functional impairment at discharge were predictors of worse outcome. 65/221 hospitalized patients (29.4%) and 10/32 non-hospitalized patients (24.4%) experienced persisting neurological symptoms/signs. 10/262 patients (3.8%) developed new neurological complaints during the 6 months of follow-up. The authors concluded that neuro-COVID is a severe disease associated with worse functional status at discharge, particularly in older subjects and those with comorbidities and acute complications of infection.
Beghi E, Helbok R, Ozturk S, Karadas O, Lisnic V, Grosu O, Kovács T, Dobronyi L, Bereczki D, Cotelli MS, Turla M, Davidescu EI, Popescu BO, Valzania F, Cavallieri F, Ulmer H, Maia LF, Amodt AH, Armon C, Brola W, Victoria G, Riahi A, Krehan I, von Oertzen T, Azab MA, Crean M, Lolich M, Lima MJ, Sellner J, Perneczky J, Jenkins T, Meoni S, Bianchi E, Moro E, Bassetti CLA; ENERGY Study Group. Short- and long-term outcome and predictors in an international cohort of patients with neuro-COVID-19. Eur J Neurol. 2022 Feb 23. doi: 10.1111/ene.15293.


SARS-CoV-2 is associated with changes in brain structure in UK Biobank
There is strong evidence for brain-related abnormalities in COVID-19. It remains unknown however whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing to brain pathology. In this article the authors investigated brain changes in 785 UK Biobank participants (aged 51–81) imaged twice, including 401 cases who tested positive for infection with SARS-CoV-2 between their two scans, with 141 days on average separating their diagnosis and second scan, and 384 controls. The availability of pre-infection imaging data reduces the likelihood of pre-existing risk factors being misinterpreted as disease effects. The authors identified significant longitudinal effects when comparing the two groups, including: (i) greater reduction in grey matter thickness and tissue-contrast in the orbitofrontal cortex and parahippocampal gyrus, (ii) greater changes in markers of tissue damage in regions functionally-connected to the primary olfactory cortex, and (iii) greater reduction in global brain size. The infected participants also showed on average larger cognitive decline between the two timepoints. Importantly, these imaging and cognitive longitudinal effects were still seen after excluding the 15 cases who had been hospitalised. These mainly limbic brain imaging results may be the in vivo hallmarks of a degenerative spread of the disease via olfactory pathways, of neuroinflammatory events, or of the loss of sensory input due to anosmia. Whether this deleterious impact can be partially reversed, or whether these effects will persist in the long term, remains to be investigated with additional follow up.
Douaud, G., Lee, S., Alfaro-Almagro, F. et al. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature (2022). https://doi.org/10.1038/s41586-022-04569-5.


Cellular and humoral immunity to SARS-CoV-2 infection in multiple sclerosis patients on ocrelizumab and other disease-modifying therapies: a multi-ethnic observational study
To determine the impact of MS disease-modifying therapies (DMTs) on the development of cellular and humoral immunity to SARS-CoV-2 infection.
MS patients aged 18-60 were evaluated for anti-nucleocapsid and anti-Spike RBD antibody with electro-chemiluminescence immunoassay; antibody responses to Spike protein, RBD, N-terminal domain with multiepitope bead-based immunoassays (MBI); live virus immunofluorescence-based microneutralization assay; T-cell responses to SARS-CoV-2 Spike using TruCulture ELISA; and IL-2 and IFNγ ELISpot assays. Assay results were compared by DMT class. Spearman correlation and multivariate analyses were performed to examine associations between immunologic responses and infection severity. Between 1/6/2021 and 7/21/2021, 389 MS patients were recruited (mean age 40.3 years; 74% female; 62% non-White). Most common DMTs were ocrelizumab (OCR) – 40%; natalizumab – 17%, Sphingosine 1-phosphate receptor (S1P) modulators -12%; and 15% untreated. 177 patients (46%) had laboratory evidence of SARS-CoV-2 infection; 130 had symptomatic infection, 47 – asymptomatic. Antibody responses were markedly attenuated in OCR compared to other groups (p≤0.0001). T-cell responses (IFNγ) were decreased in S1P (p=0.03), increased in natalizumab (p<0.001), and similar in other DMTs, including OCR. Cellular and humoral responses were moderately correlated in both OCR (r=0.45, p=0.0002) and non-OCR (r=0.64, p<0.0001). Immune responses did not differ by race/ethnicity. COVID-19 clinical course was mostly non-severe and similar across DMTs; 7% (9/130) were hospitalized. The authors concluded that DMTs had differential effects on humoral and cellular immune responses to SARS-CoV-2 infection. Immune responses did not correlate with COVID-19 clinical severity in this relatively young and non-disabled group of MS patients.
Ilya Kister, Yury Patskovsky, Ryan Curtin, Jinglan Pei, Katherine Perdomo, Zoe Rimler, Iryna Voloshyna, Marie I. Samanovic, Amber R. Cornelius, Yogambigai Velmurugu, Samantha Nyovanie, Joseph Kim, Ethan Tardio, Tamar E. Bacon, Lana Zhovtis Ryerson, Pranil Raut, Pedotti Rosetta, Kathleen Hawker, Catarina Raposo, Jessica Priest, Mark Cabatingan, Ryan C. Winger, Mark J. Mulligan, Michelle Krogsgaard, Gregg J. Silverman. Cellular and humoral immunity to SARS-CoV-2 infection in multiple sclerosis patients on ocrelizumab and other disease-modifying therapies: a multi-ethnic observational study. Annals of Neurology. First published: 15 March 2022 https://doi.org/10.1002/ana.26346.


Trends in Mortality Rates Among Medicare Enrollees With Alzheimer Disease and Related Dementias Before and During the Early Phase of the COVID-19 Pandemic
The authors compared mortality rates in 2020 (March-December) with rates in 2019 for the same period among 53 640 888 Medicare enrollees > 65-year-old, categorized into 4 prespecified cohorts: enrollees with or without Alzheimer’s Disease and related Dementias (ADRD), and enrollees with or without ADRD residing in nursing homes. Estimates were age and sex-adjusted, and by using largely overlapping populations during 2019 and 2020 within each of the 306 hospital referral regions analysed, underlying initial health conditions and other potential confounders were considered as being implicitly accounted for. Compared with 2019, mortality in 2020 was 12.4% higher among enrollees without ADRD and 25.7% higher among enrollees with ADRD. Higher rates in 2020 were seen in Asian (36.0%), Black (36.7%), and Hispanic (40.1%) populations with ADRD, with similar rates seen also in subjects without ADRD. Among nursing home residents without ADRD mortality was 24.2% higher, and among nursing home residents with ADRD mortality was 33.4% higher. In areas with low COVID-19 prevalence (lowest quintile for COVID-19 infections in 2020), there was no excess mortality among enrollees without ADRD, but 8.8% higher mortality among community-dwelling enrollees with ADRD and 14.2% higher mortality among enrollees with ADRD living in nursing homes.
Gilstrap L, Zhou W, Alsan M, Nanda A, Skinner JS. Trends in Mortality Rates Among Medicare Enrollees With Alzheimer Disease and Related Dementias Before and During the Early Phase of the COVID-19 Pandemic. JAMA Neurol. Published online February 28, 2022. doi:10.1001/jamaneurol.2022.0010.



COVID-19 Breaking News: Cross-Sectional Case Control Studies – April 2022 was last modified: May 4th, 2022 by Simon Lee
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