PML

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After more than a decade from the natalizumab approval, most MS specialists consider this biological therapy as one of the most efficient drugs that we have nowadays to treat relapsing-remitting MS patients. However, the problem we have to face when we start to use natalizumab is the risk of the occurrence of progressive multifocal leukoencephalopathy (PML) in some patients.

Abstract Background: Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection that develops in immunosuppressed patients with HIV infection. Paradoxically, some of these patients may develop PML during combined antiretroviral therapy in the setting of immune reconstitution. We describe the types… Continue Reading