eanNews
  • EAN News
    • All Executive Page President’s Corner EAN News EAN Congress news Interviews
      Brain Health

      EAN Joins European Health Alliance on Alcohol, Co-Funded by EU/WHO Evidence into Action Alcohol

      September 16, 2025

      EAN Congress news

      Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

      September 10, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Executive Page

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      Executive Page

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      Executive Page

      Executive Page: the RRFS is here to support you – and help shape the future of European neurology

      August 12, 2025

      Executive Page

      Executive Page: thank you for making the EAN Congress 2025 a great success!

      July 16, 2025

      Executive Page

      Executive Page: Get ready for EAN 2025 in Helsinki!

      June 3, 2025

      President’s Corner

      President’s Corner – September 2025

      September 4, 2025

      President’s Corner

      President’s Corner – August 2025

      August 12, 2025

      President’s Corner

      President’s Corner – July 2025

      July 16, 2025

      President’s Corner

      President’s Corner – June 2025

      June 3, 2025

      EAN News

      EAN Joins European Health Alliance on Alcohol, Co-Funded by EU/WHO Evidence into Action Alcohol

      September 16, 2025

      EAN News

      Research Highlights of the Month – September 2025

      September 10, 2025

      EAN News

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      EAN News

      President’s Corner – September 2025

      September 4, 2025

      EAN Congress news

      Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

      September 10, 2025

      EAN Congress news

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      EAN Congress news

      A Congress Highlight in Helsinki: Brain Health and Sustainability Booth

      August 28, 2025

      EAN Congress news

      Revisit the Highlights of EAN 2025 in Our Congress Review eBook

      July 24, 2025

      Interviews

      Video Interview: Mood Alterations in the Prodromal Phase of Sporadic Creutzfeldt-Jakob Disease, with Raphael Wurm

      March 14, 2025

      Interviews

      Video Interview: EMA approval of lecanemab, with Sebastiaan Engelborghs, EAN Dementia Panel Co-Chair

      January 15, 2025

      Interviews

      Video interview: Claudia Sommer, incoming Editor-in-Chief of the European Journal of Neurology

      January 3, 2025

      Interviews

      Video interviews: meet some of the EAN’s national neurological society partners!

      November 20, 2024

  • Research
    • All Paper of the Month Research Highlights Research Funding
      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Paper of the Month

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      Research

      EMA Neurology News – August 2025

      August 20, 2025

      Research Highlights

      Research Highlights of the Month – August 2025

      August 12, 2025

      Paper of the Month

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      Paper of the Month

      Research Paper of the Month: Higher Educational Attainment and Accelerated Tau Accumulation in Alzheimer Disease

      August 12, 2025

      Paper of the Month

      Research Paper of the Month: Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation (CATALYST)

      July 16, 2025

      Paper of the Month

      Research Papers of the Month: Phase I trial of hES cell-derived dopaminergic neurons for Parkinson’s disease / Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease

      June 2, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Research Highlights

      Research Highlights of the Month – August 2025

      August 12, 2025

      Research Highlights

      Research Highlights of the Month – July 2025

      July 16, 2025

      Research Highlights

      Research Highlights of the Month – June 2025

      June 11, 2025

      Research Funding

      Draft Innovative Health Initiative (IHI) Funding Call topics related to the brain

      May 2, 2025

      Research Funding 'Horizon Europe' in large 3D text, surrounded by illustrations of people undertaking various activities

      Upcoming Horizon Europe Funding Opportunities for Neurology Researchers (Draft Calls)

      May 2, 2025

  • Education
    • All eLearning Mid-Career Resident and Research Fellows Student Corner Fellowship reports
      eLearning

      Join us for all-new Webinars in September!

      September 2, 2025

      EAN Congress news

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      EAN News

      Shape the Future of EAN Panels – Apply to Join a Panel Management Group!

      September 1, 2025

      eLearning

      Join our Webinar on New challenges in Myasthenia Gravis in the Era of Innovative Treatments

      August 28, 2025

      eLearning

      Join us for all-new Webinars in September!

      September 2, 2025

      eLearning

      Join our Webinar on New challenges in Myasthenia Gravis in the Era of Innovative Treatments

      August 28, 2025

      eLearning

      Join our Webinar on Multidisciplinary Perspectives on aTTR Amyloidosis: From Nerves to Heart

      August 21, 2025

      eLearning

      Call for Applications: eanCampus Associate Editors

      July 1, 2025

      Mid-Career

      Certificate of Advanced Studies (CAS) in Brain Health starts second round in January 2026

      August 25, 2025

      Mid-Career

      First 20 EAN Leadership Programme participants graduate, as second group gets underway

      July 10, 2025

      Mid-Career

      Empowering growth: my journey through the EAN Leadership Programme

      March 14, 2025

      Mid-Career

      Join the EAN Congress Masterclass in Vienna!

      January 20, 2025

      Resident and Research Fellows

      Shape the Future of EAN Panels – Apply to Join a Panel Management Group!

      September 1, 2025

      Resident and Research Fellows

      Sign up for the 5th EAN Science School, 13-17 March, 2026

      August 20, 2025

      Resident and Research Fellows

      EAN Regional Teaching Day in Riga, Latvia – 6 November 2025

      August 13, 2025

      Resident and Research Fellows

      Executive Page: the RRFS is here to support you – and help shape the future of European neurology

      August 12, 2025

      Student Corner

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      Student Corner

      Student Teaser Fellowships winners 2025

      June 6, 2025

      Student Corner Photo of a sheet of paper, pencil and crumpled paper on a desk.

      Why Neurology? Read some compelling answers from our EAN 2025 essay contest winners!

      May 12, 2025

      Student Corner

      Student Teaser Fellowship reports 2023 – Paris & Basel

      March 12, 2025

      Fellowship reports

      Research Fellowship Reports 2023: Lyon, Berlin, & London

      March 31, 2025

      Fellowship reports

      Student Teaser Fellowship reports 2023 – Paris & Basel

      March 12, 2025

      Fellowship reports

      Clinical Fellowship Reports 2023: Utrecht, Dianalund, & London

      February 20, 2025

      Fellowship reports

      Research Fellowship Reports 2023: London & Vienna/Paris

      October 8, 2024

  • Other News
    • All EAN Staff EBC News in general Surveys
      Advocacy

      Why do Placebo and Nocebo Effects Matter? – Improving the Education of Healthcare Professionals | 5 November 2025

      August 21, 2025

      Other News

      EAN Panel Management Group Member Discusses Palliative Care on OneNeurology Podcast Marking World Brain Day

      August 8, 2025

      Other News

      Empowering the HD Community: The Launch of the Huntington Academy

      July 10, 2025

      Advocacy

      EAN TV | National Brain Plans and the Path Toward EU Coordination: Insights from Finland and Europe

      June 21, 2025

      EAN Staff

      EAN Head Office Profiles: Ulla & Piyapat

      December 1, 2023

      EAN Staff

      EAN Head Office Profiles: Kathrin & Sasha

      August 28, 2023

      EAN Staff Anja Sander receiving flowers at the end of EAN Congress 2023

      Celebrating 20 Years of Excellence: Anja Sander, EAN’s Executive Director!

      August 3, 2023

      EAN Staff

      EAN Head Office Profiles: Dauren & Benita

      June 5, 2023

      EBC

      EAN TV | National Brain Plans and the Path Toward EU Coordination: Insights from Finland and Europe

      June 21, 2025

      EBC

      EAN TV | European Brain Council: Paving the Way for a European Brain Health Partnership

      June 21, 2025

      EBC Composite image containing various photos from European Brain Council events, plus the EBC logo

      EBC launches 2024 annual report

      April 25, 2025

      EBC

      Brain Innovation Days announces theme and subtheme for 2025 edition!

      March 29, 2025

      News in general

      New paper offers insight into patient involvement in neurological research 

      January 31, 2025

      News in general

      Join the European Brain Council’s ‘Towards a Rare Brain Disease Ecosystem’ event in Brussels on 20 February!

      January 31, 2025

      News in general

      The Brain Prize 2024: Pioneering work in computational and theoretical neuroscience is awarded the world’s largest brain research prize

      March 5, 2024

      News in general

      WHO’s Intersectoral Global Action Plan on epilepsy and other neurological disorders (IGAP) published in all six UN languages

      August 3, 2023

      Surveys

      Public Consultation – European Charter for the Responsible Development of Neurotechnologies

      November 25, 2024

      Surveys

      A survey on connectomics: key insights from EAN neurologists

      July 25, 2024

      Surveys

      Survey: Mapping European Neurological Programs in Solid Organ Transplant Centers

      May 31, 2024

      Surveys

      Neurorehabilitation Across Europe after Ischemic and Traumatic Brain Injuries: a survey to increase knowledge on brain-injury-specific neurorehabilitation

      July 14, 2023

  • EAN
  • Congress 2026
  • eanNews
  • eanCampus
  • Eur J Neurol
  • Brain Health Mission

eanNews

  • EAN News
    • All Executive Page President’s Corner EAN News EAN Congress news Interviews
      Brain Health

      EAN Joins European Health Alliance on Alcohol, Co-Funded by EU/WHO Evidence into Action Alcohol

      September 16, 2025

      EAN Congress news

      Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

      September 10, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Executive Page

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      Executive Page

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      Executive Page

      Executive Page: the RRFS is here to support you – and help shape the future of European neurology

      August 12, 2025

      Executive Page

      Executive Page: thank you for making the EAN Congress 2025 a great success!

      July 16, 2025

      Executive Page

      Executive Page: Get ready for EAN 2025 in Helsinki!

      June 3, 2025

      President’s Corner

      President’s Corner – September 2025

      September 4, 2025

      President’s Corner

      President’s Corner – August 2025

      August 12, 2025

      President’s Corner

      President’s Corner – July 2025

      July 16, 2025

      President’s Corner

      President’s Corner – June 2025

      June 3, 2025

      EAN News

      EAN Joins European Health Alliance on Alcohol, Co-Funded by EU/WHO Evidence into Action Alcohol

      September 16, 2025

      EAN News

      Research Highlights of the Month – September 2025

      September 10, 2025

      EAN News

      Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

      September 4, 2025

      EAN News

      President’s Corner – September 2025

      September 4, 2025

      EAN Congress news

      Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

      September 10, 2025

      EAN Congress news

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      EAN Congress news

      A Congress Highlight in Helsinki: Brain Health and Sustainability Booth

      August 28, 2025

      EAN Congress news

      Revisit the Highlights of EAN 2025 in Our Congress Review eBook

      July 24, 2025

      Interviews

      Video Interview: Mood Alterations in the Prodromal Phase of Sporadic Creutzfeldt-Jakob Disease, with Raphael Wurm

      March 14, 2025

      Interviews

      Video Interview: EMA approval of lecanemab, with Sebastiaan Engelborghs, EAN Dementia Panel Co-Chair

      January 15, 2025

      Interviews

      Video interview: Claudia Sommer, incoming Editor-in-Chief of the European Journal of Neurology

      January 3, 2025

      Interviews

      Video interviews: meet some of the EAN’s national neurological society partners!

      November 20, 2024

  • Research
    • All Paper of the Month Research Highlights Research Funding
      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Paper of the Month

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      Research

      EMA Neurology News – August 2025

      August 20, 2025

      Research Highlights

      Research Highlights of the Month – August 2025

      August 12, 2025

      Paper of the Month

      Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

      September 4, 2025

      Paper of the Month

      Research Paper of the Month: Higher Educational Attainment and Accelerated Tau Accumulation in Alzheimer Disease

      August 12, 2025

      Paper of the Month

      Research Paper of the Month: Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation (CATALYST)

      July 16, 2025

      Paper of the Month

      Research Papers of the Month: Phase I trial of hES cell-derived dopaminergic neurons for Parkinson’s disease / Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease

      June 2, 2025

      Research Highlights

      Research Highlights of the Month – September 2025

      September 10, 2025

      Research Highlights

      Research Highlights of the Month – August 2025

      August 12, 2025

      Research Highlights

      Research Highlights of the Month – July 2025

      July 16, 2025

      Research Highlights

      Research Highlights of the Month – June 2025

      June 11, 2025

      Research Funding

      Draft Innovative Health Initiative (IHI) Funding Call topics related to the brain

      May 2, 2025

      Research Funding 'Horizon Europe' in large 3D text, surrounded by illustrations of people undertaking various activities

      Upcoming Horizon Europe Funding Opportunities for Neurology Researchers (Draft Calls)

      May 2, 2025

  • Education
    • All eLearning Mid-Career Resident and Research Fellows Student Corner Fellowship reports
      eLearning

      Join us for all-new Webinars in September!

      September 2, 2025

      EAN Congress news

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      EAN News

      Shape the Future of EAN Panels – Apply to Join a Panel Management Group!

      September 1, 2025

      eLearning

      Join our Webinar on New challenges in Myasthenia Gravis in the Era of Innovative Treatments

      August 28, 2025

      eLearning

      Join us for all-new Webinars in September!

      September 2, 2025

      eLearning

      Join our Webinar on New challenges in Myasthenia Gravis in the Era of Innovative Treatments

      August 28, 2025

      eLearning

      Join our Webinar on Multidisciplinary Perspectives on aTTR Amyloidosis: From Nerves to Heart

      August 21, 2025

      eLearning

      Call for Applications: eanCampus Associate Editors

      July 1, 2025

      Mid-Career

      Certificate of Advanced Studies (CAS) in Brain Health starts second round in January 2026

      August 25, 2025

      Mid-Career

      First 20 EAN Leadership Programme participants graduate, as second group gets underway

      July 10, 2025

      Mid-Career

      Empowering growth: my journey through the EAN Leadership Programme

      March 14, 2025

      Mid-Career

      Join the EAN Congress Masterclass in Vienna!

      January 20, 2025

      Resident and Research Fellows

      Shape the Future of EAN Panels – Apply to Join a Panel Management Group!

      September 1, 2025

      Resident and Research Fellows

      Sign up for the 5th EAN Science School, 13-17 March, 2026

      August 20, 2025

      Resident and Research Fellows

      EAN Regional Teaching Day in Riga, Latvia – 6 November 2025

      August 13, 2025

      Resident and Research Fellows

      Executive Page: the RRFS is here to support you – and help shape the future of European neurology

      August 12, 2025

      Student Corner

      An EAN Student Member’s experience at the EAN Congress – Helsinki 2025

      September 1, 2025

      Student Corner

      Student Teaser Fellowships winners 2025

      June 6, 2025

      Student Corner Photo of a sheet of paper, pencil and crumpled paper on a desk.

      Why Neurology? Read some compelling answers from our EAN 2025 essay contest winners!

      May 12, 2025

      Student Corner

      Student Teaser Fellowship reports 2023 – Paris & Basel

      March 12, 2025

      Fellowship reports

      Research Fellowship Reports 2023: Lyon, Berlin, & London

      March 31, 2025

      Fellowship reports

      Student Teaser Fellowship reports 2023 – Paris & Basel

      March 12, 2025

      Fellowship reports

      Clinical Fellowship Reports 2023: Utrecht, Dianalund, & London

      February 20, 2025

      Fellowship reports

      Research Fellowship Reports 2023: London & Vienna/Paris

      October 8, 2024

  • Other News
    • All EAN Staff EBC News in general Surveys
      Advocacy

      Why do Placebo and Nocebo Effects Matter? – Improving the Education of Healthcare Professionals | 5 November 2025

      August 21, 2025

      Other News

      EAN Panel Management Group Member Discusses Palliative Care on OneNeurology Podcast Marking World Brain Day

      August 8, 2025

      Other News

      Empowering the HD Community: The Launch of the Huntington Academy

      July 10, 2025

      Advocacy

      EAN TV | National Brain Plans and the Path Toward EU Coordination: Insights from Finland and Europe

      June 21, 2025

      EAN Staff

      EAN Head Office Profiles: Ulla & Piyapat

      December 1, 2023

      EAN Staff

      EAN Head Office Profiles: Kathrin & Sasha

      August 28, 2023

      EAN Staff Anja Sander receiving flowers at the end of EAN Congress 2023

      Celebrating 20 Years of Excellence: Anja Sander, EAN’s Executive Director!

      August 3, 2023

      EAN Staff

      EAN Head Office Profiles: Dauren & Benita

      June 5, 2023

      EBC

      EAN TV | National Brain Plans and the Path Toward EU Coordination: Insights from Finland and Europe

      June 21, 2025

      EBC

      EAN TV | European Brain Council: Paving the Way for a European Brain Health Partnership

      June 21, 2025

      EBC Composite image containing various photos from European Brain Council events, plus the EBC logo

      EBC launches 2024 annual report

      April 25, 2025

      EBC

      Brain Innovation Days announces theme and subtheme for 2025 edition!

      March 29, 2025

      News in general

      New paper offers insight into patient involvement in neurological research 

      January 31, 2025

      News in general

      Join the European Brain Council’s ‘Towards a Rare Brain Disease Ecosystem’ event in Brussels on 20 February!

      January 31, 2025

      News in general

      The Brain Prize 2024: Pioneering work in computational and theoretical neuroscience is awarded the world’s largest brain research prize

      March 5, 2024

      News in general

      WHO’s Intersectoral Global Action Plan on epilepsy and other neurological disorders (IGAP) published in all six UN languages

      August 3, 2023

      Surveys

      Public Consultation – European Charter for the Responsible Development of Neurotechnologies

      November 25, 2024

      Surveys

      A survey on connectomics: key insights from EAN neurologists

      July 25, 2024

      Surveys

      Survey: Mapping European Neurological Programs in Solid Organ Transplant Centers

      May 31, 2024

      Surveys

      Neurorehabilitation Across Europe after Ischemic and Traumatic Brain Injuries: a survey to increase knowledge on brain-injury-specific neurorehabilitation

      July 14, 2023

Paper of the MonthEAN NewsFeatured Slider

Paper of the month: No benefit from hypothermia after severe traumatic brain injury

February 1, 2019

 

 

 

by Elena Moro

 

 

 

 

 

For February 2019, we have selected: Cooper DJ, Nichol AD, Balley M, et al. for the POLAR Trial Investigators and the ANZICS Clinical Trial Group. Effect of early sustained prophylactic hypothermia on neurologic outcomes among patients with severe traumatic brain injury. JAMA 2018;320:2211-2220.

Over the last years, findings concerning the use of prophylactic hypothermia to improve clinical outcomes after traumatic brain injury have been conflicting. A few meta-analyses have concluded for some beneficial effects from hypothermia, including decreased mortality, whereas four randomized clinical trials did not report any benefit.

In this multinational randomized clinical trial (POLAR-RCT), the authors assessed the effects of early prophylactic hypothermia (33°C – 35°C) applied for at least 72 hours and compared it with normothermia in patients with severe traumatic brain injury. The trial was planned to include 510 patients in six countries, and spanned from December 2010 to November 2017. Patients were screened in five out-of-hospital or paramedic agencies and in 14 emergency departments. To be included, patients had to be between 18 and 60 years old, had a Glasgow Coma Scale Score (GCSS) <9, and actual or imminent endotracheal intubation. Out-of-hospital exclusion criteria were significant bleedings with systolic hypotension and tachycardia, suspected pregnancy, GCSS =3, and unreactive pupils. Patients were randomized to prophylactic hypothermia versus controlled normothermia, with unblinded treating physician. In the hypothermia group, hypothermia (33°C ± 0.5°C) was kept for at least 72 hours using a Gaymar Meditherm 3 console with surface-cooling wraps. If hemodynamic instability presumed to bleeding, patients could be rewarmed. After 72 hours, if intracranial pressure <20 mmHg, a gradual controlled rewarming was applied up to normothermia (37°C ± 0.5°C). The maximum period of hypothermia was 7 days after randomization.

The primary outcome of this study was the percentage of favorable Glasgow-Outcome-Scale-Extended (GOS-E) score (5 to 8) from blinded raters at 6 months after injury. Secondary outcomes included mortality, proportion of patients with adverse events within 10 days of randomization, duration of mechanical ventilation, and hospital length of stay. Of the 511 patients randomized, 240 patients of the hypothermia group and 226 of the normothemia group were available for the primary outcome analyses, respectively. Overall, the mean GCSS was of 6. Around 33% of patients in the hypothermia group received <48 hours of hypothermia, whereas 27% never reached the final target of 33°C.  Hypothermia was started quickly after injury (a median of 1.8 hours) and rewarming occurred slowly (a median of 22.5 hours).

At 6 months, there was no difference in the favorable outcome between groups, i.e., 117 patients (48.8%) in the hypothermia group and 111 patients (49.1%) in the normothermia group (absolute risk difference, -0.4%, 95% CI, -9.4-8.7; relative risk with hypothermia, 0.99, 95% CI, 0.82-1.19, P=0.94). There were no significant differences between groups regarding to any secondary outcome. Pneumonia and intracranial bleeding occurred in 55% and 18.1% of hypothermia patients, and in 51.3% and 15.4% of normothermia patients, respectively. However, the per-protocol analysis found increased risk of pneumonia in the hypothermia group (P=0.003).

“This is a large randomized study that further supports previous clinical findings coming from other four randomized trials conducted with different methodology”, says Prof. Maxwell Simon Damian, Department of Neurology, University of Cambridge, UK. ”These findings go against a large amount of pre-clinical evidence, and recent meta-analysis that sustained the use of hypothermia after brain traumatic injury. This trial definitely clarifies the futility of this treatment.”

“There are some limitation in this study, including the long recruitment time (seven years), the lack of blind treating physician, and of targeted hypothermia temperature (33°C) in several patients”, says Prof. Stefan Schwab, Department of Neurology, University of Erlangen, Germany. ”Nevertheless, the study was well-designed, and delivers conclusions that should be integrated in clinical practice and international guidelines.”

 

The other nominees for the February 2019 paper of the month are:

  • GBD 2016 Parkinson’s Disease Collaborators. Global, regional, and national burden of Parkinson’s disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2018;17;939-953. In this paper, the authors investigated the global burden of Parkinson’s disease between 1990 and 2016 using a systemic analysis of epidemiological studies. Compared to the estimation of 2.5 million of people with Parkinson’s disease worldwide in 1990, they found an increase up to 6.1 million in 2016. This increase was not solely explained by the parallel increase of older people. Disability-adjusted life-years and death ratios also increased, but not in southern Latin America, eastern Europe and Oceania.
  • FOCUS Trail Collaboration. Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomized, controlled trial. Lancet Neurol December 5, 2018. doi: 10.1016/S0140-6736(18)32823-X. The authors conducted a large multicenter, double-blinded, randomized, placebo-control trial in 3,127 UK patients with acute stroke (between 2 and 15 days after onset) with the aim to assess the effects of 20 mg fluoxetine at 6 months. Although patients with fluoxetine developed less depression compared to placebo, they had more bone fractures.
  • Prasad K, Siemieniuk R, Hao Q, et al. Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke: a clinical practice guideline. BMJ 2018;363:k5130 doi: 10.1136/bmj.k5130. In this experts’ opinion paper, the authors review the evidence and provide recommendation about the use of dual antiplatelet therapy (aspirin and clopidogrel) soon after TIA and minor ischaemic stroke.

 

 

Prof. Elena Moro is Editor in Chief of EAN Pages and treasurer of EAN as well as Director of the Movement Disorders Center at the Centre Hospital Universitaire (CHU) of Grenoble, France and the Associate Director of the CHU Department of Psychiatry, Neurology and Rehabilitation.

 

 

Paper of the month: No benefit from hypothermia after severe traumatic brain injury was last modified: February 7th, 2019 by Editor
Share this...
Share on facebook
Facebook
Share on twitter
Twitter
Share on linkedin
Linkedin
traumatic brain injuryhypothermiaprophylactic hypothermia
previous post
News from EBC – EBRA
next post
Executive Page: the EAN Communication Committee – our visions and goals

You may also like

Save the Dates: EAN Congress 2026 in Geneva, Switzerland, 27-30 June

September 10, 2025

Executive Page: New Opportunities and Resources to Strengthen EAN’s Scientific Community in 2025–2026

September 4, 2025

President’s Corner – September 2025

September 4, 2025

Research Paper of the Month: Lithium deficiency and the onset of Alzheimer’s disease

September 4, 2025

A Congress Highlight in Helsinki: Brain Health and Sustainability Booth

August 28, 2025

Executive Page: the RRFS is here to support you – and help shape the future of European neurology

August 12, 2025

President’s Corner – August 2025

August 12, 2025

Research Paper of the Month: Higher Educational Attainment and Accelerated Tau Accumulation in Alzheimer Disease

August 12, 2025

Executive Page: thank you for making the EAN Congress 2025 a great success!

July 16, 2025

President’s Corner – July 2025

July 16, 2025

Leave a Comment Cancel Reply

You need to be logged in to comment. Please login to MyEAN on top.

Upcoming Events

Sep
24
Wed
all-day 41st Congress of the European Co...
41st Congress of the European Co...
Sep 24 – Sep 26 all-day
41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)
  41-th Congress of ECTRIMS will be held from 24-26 September, in Barcelona at the CCIB Barcelona International Convention Center. This year’s programme offers top-tier scientific sessions, education, networking, and…
all-day The 21st EuGMS Congress
The 21st EuGMS Congress
Sep 24 – Sep 26 all-day
The 21st EuGMS Congress
    The 21st EuGMS Congress is coming to Reykjavik, Iceland 🇮🇸, on September 24-26, 2025! Under the theme “New landscapes in geriatric medicine”, this congress will bring together experts…
Sep
25
Thu
all-day European Huntington’s Associatio... @ Ramada Plaza by Wyndham Bucharest Convention Center,
European Huntington’s Associatio... @ Ramada Plaza by Wyndham Bucharest Convention Center,
Sep 25 – Sep 28 all-day
European Huntington's Association 5th Biennal Conference - Bucharest, Romania @ Ramada Plaza by Wyndham Bucharest Convention Center,
The European Huntington Association is thrilled to announce its 5th Biennial Conference, taking place in Bucharest, Romania, from 25–28 September 2025. Under the theme “Shaping our Future Together, We are the Change!”, the…
all-day 26th Congress of the European Fe...
26th Congress of the European Fe...
Sep 25 – Sep 27 all-day
  The 26th Congress of the European Federation of Autonomic Societies will be held in Toulouse, France, from 25 to 27 September 2025. The congress will be hosted by CESNA,…
6:00 pm EAN – EJoN Webinar: Functional N...
EAN – EJoN Webinar: Functional N...
Sep 25 @ 6:00 pm – 7:00 pm
  Join us this September for an EAN/European Journal of Neurology webinar on Functional Neurological Disorders, where leading experts will discuss advances in diagnosis, management, and service development for these…
View Calendar

Keep in touch

Facebook Instagram Linkedin
EAN Pages is a members service of the European Academy of Neurology https://www.ean.org

All content from January 2012 - June 2013 was published by EFNS; content from July 2013 - June 2014 by EFNS and ENS.

ISSN 2310-2934

Keep in touch

Facebook Instagram Linkedin

Archives

Pages

  • Privacy Policy
  • About us
  • Help

Back To Top