eanpages
  • General interest
    • All Executive Page Paper of the Month EAN News EAN Congress news COVID-19 Interviews
      EAN News

      Become a Certified Leader of European Neurology with the new EAN Leadership Programme

      January 24, 2023

      EAN News

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      Executive Page

      Executive Page: Submit, register, and join us for EAN 2023

      December 5, 2022

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: New guideline prioritisation process begins setting path for next two years

      November 1, 2022

      Executive Page EAN Secretary General, 2022. Tony Marson, Liverpool UK.

      Executive Page: More reasons than ever to renew your EAN membership

      October 11, 2022

      Executive Page Head and shoulders portrait photo of Irena Rektorova, in colourful dress

      Executive Page: Challenge of maintaining high standards is a privilege says incoming Education Committee Chair

      September 1, 2022

      Paper of the Month

      Research Paper of the Month: Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT)

      January 1, 2023

      Paper of the Month

      COVID-19 Paper of the Month: The decline in stroke hospitalization due to COVID-19 is unrelated to COVID-19 intensity

      January 1, 2023

      Paper of the Month

      Research Paper of the Month: Lecanemab in Early Alzheimer’s Disease

      December 5, 2022

      Paper of the Month

      Covid-19 Paper of the Month: Incidence of Epilepsy and Seizures Over the First 6 Months After a COVID-19 Diagnosis

      December 5, 2022

      EAN News

      Become a Certified Leader of European Neurology with the new EAN Leadership Programme

      January 24, 2023

      EAN News

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      EAN Congress news

      EAN launches new ‘Congress Spin-Off with Masterclasses’ event, with first edition in March

      January 10, 2023

      EAN Congress news

      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

      EAN Congress news

      EAN 2023 – Join us in Budapest on July 1-4

      September 1, 2022

      EAN Congress news

      Special EAN issue of BrainMag features reports on EAN 2022 and more

      August 30, 2022

      COVID-19

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      COVID-19

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      COVID-19

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      COVID-19

      COVID-19 Paper of the Month: The decline in stroke hospitalization due to COVID-19 is unrelated to COVID-19 intensity

      January 1, 2023

      Interviews

      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

      Interviews

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajediene

      July 28, 2022

      Interviews

      Video: EAN supports World Brain Day

      July 19, 2022

      Interviews

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

  • Academic/Scientific
    • All Breaking news Neurology updates Scientific committee reports Scientific panels reports Eur J Neurol Top 10 Articles Scientific Corner
      EAN News

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      EAN News

      Impact of Burnout on Neurology Residents and Research Fellows in Europe

      December 23, 2022

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Miscellaneous – November 2022

      November 7, 2022

      Breaking news

      COVID-19 Breaking News: Observational Studies – Prospective Longitudinal Cohort – November 2022

      November 7, 2022

      Neurology updates

      Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome – A MAGNIMS Study

      September 26, 2022

      Neurology updates

      Relapse-independent disability worsening plays a relevant role in every disease phase of MS

      September 26, 2022

      Neurology updates

      Epstein-Barr virus infection is a major risk factor for the development of multiple sclerosis

      September 26, 2022

      Neurology updates

      Glymphatic system impairment may contribute to multiple sclerosis pathology

      September 23, 2022

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Highlights from the World Muscle Society annual meeting, chosen by the Scientific Panel on Muscle and NMJ Disorders

      November 2, 2022

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Eur J Neurol

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

      Eur J Neurol

      EAN NeuroCOVID-19 Task Force position paper on COVID-19 vaccination hesitancy among people with chronic neurological disorders

      May 2, 2022

      Eur J Neurol

      European Journal of Neurology welcomes new associate editors

      December 13, 2021

      Eur J Neurol

      New European guideline and expert statements on the management of narcolepsy in adults and children

      June 30, 2021

      Top 10 Articles

      EAN is proud to announce the 2020 Virtual Master Classes Christmas Special

      November 13, 2020

      Top 10 Articles

      EUROPEAN JOURNAL OF NEUROLOGY – TOP 15 ARTICLES 2018

      February 1, 2019

      Top 10 Articles

      Interview with Prof. Patrick Cras – UEMS Section of Neurology (SN)

      February 3, 2018

      Top 10 Articles

      Interview with Mr. Bertrand Daval and Mrs. Nathalie Paulus

      February 3, 2018

      Scientific Corner

      Join the EAN Guideline Workshop on 24 June!

      May 13, 2022

      Scientific Corner

      First EAN Science School proves a hit in Salzburg

      April 1, 2022

      Scientific Corner

      Invitation to the EAN-EBRAINS Joint Workshop on ‘The Future of Medical Data Sharing in Clinical Neurosciences’

      July 2, 2021

      Scientific Corner

      1st EAN Science School, 26-29 March 2022: “Pathophysiology of disorders of the nervous system”

      June 18, 2021

  • Educational
    • All eLearning Student Corner E-Brain Grand Rounds Resident and Research Fellows Fellowship reports Education corner
      Student Corner

      Application for the Student Teaser Fellowship 2023 NOW OPEN

      February 1, 2023

      EAN News

      Become a Certified Leader of European Neurology with the new EAN Leadership Programme

      January 24, 2023

      Fellowship reports

      Clinical Fellowship Reports 2022: Stockholm & Erlangen

      January 18, 2023

      Student Corner Illustration of a vertical pencil point on a blue background, with a yellow light bulb above it

      Students’ Corner: What neurology taught me in 2022

      January 17, 2023

      eLearning Illustration of two people holding an award between them and jumping in the air in a celebratory pose

      Learn with the eanCampus and win free EAN congress registration!

      January 12, 2023

      eLearning

      Kick off 2023 with highlights on the eanCampus

      January 10, 2023

      eLearning

      December Highlights on the eanCampus!

      December 5, 2022

      eLearning

      November Highlights on the eanCampus!

      November 4, 2022

      Student Corner

      Application for the Student Teaser Fellowship 2023 NOW OPEN

      February 1, 2023

      Student Corner Illustration of a vertical pencil point on a blue background, with a yellow light bulb above it

      Students’ Corner: What neurology taught me in 2022

      January 17, 2023

      Student Corner

      Student Teaser Fellowship reports 2022 – Karlsbad, Zagreb & Salzburg

      January 10, 2023

      Student Corner

      Student Teaser Fellowship reports 2022 – Salzburg, Ramat Gan, & Rostock

      December 30, 2022

      E-Brain

      ebrain May update: new website and podcast series

      May 1, 2021

      E-Brain

      EBRA launches 3rd call for clusters

      May 1, 2020

      E-Brain

      News from ebrain

      February 28, 2020

      E-Brain

      ebrain to host the 2019 Neurology Formative Test Questions, from 15 April to 26 May

      April 1, 2019

      Grand Rounds

      eBrain: virtual case report from Belgium

      October 2, 2017

      Grand Rounds

      Free access to Ebrain for EAN members

      July 1, 2016

      Grand Rounds

      Ebrain granted Royal College of Physicians (UK) CPD/CME accreditation

      July 1, 2016

      Grand Rounds

      ebrain session of the month: neuromuscular junction

      February 1, 2016

      Resident and Research Fellows

      Become a Certified Leader of European Neurology with the new EAN Leadership Programme

      January 24, 2023

      Resident and Research Fellows

      13th Regional Teaching Course in Sub-Saharan Africa – Report

      January 12, 2023

      Resident and Research Fellows Close up photo of a Black graduation cap and yellow tassel

      European Board Examination in Neurology – Reasons to take it and how to contribute

      January 12, 2023

      Resident and Research Fellows

      Third round of pairs matched in EAN Mentorship Programme

      January 12, 2023

      Fellowship reports

      Clinical Fellowship Reports 2022: Stockholm & Erlangen

      January 18, 2023

      Fellowship reports

      Student Teaser Fellowship reports 2022 – Karlsbad, Zagreb & Salzburg

      January 10, 2023

      Fellowship reports

      Clinical Fellowship Reports 2022: Bern & Prague

      December 30, 2022

      Fellowship reports

      Student Teaser Fellowship reports 2022 – Salzburg, Ramat Gan, & Rostock

      December 30, 2022

      Education corner

      Application for the Student Teaser Fellowship 2023 NOW OPEN

      February 1, 2023

      Education corner

      Become a Certified Leader of European Neurology with the new EAN Leadership Programme

      January 24, 2023

      Education corner

      Clinical Fellowship Reports 2022: Stockholm & Erlangen

      January 18, 2023

      Education corner

      13th Regional Teaching Course in Sub-Saharan Africa – Report

      January 12, 2023

  • Other News
    • All EAN Staff Grant opportunities News from EAN member societies EBC EFNA News in general Patients societies reports Surveys Forum
      EAN Staff Composite image consisting of two chest-height portraits ide-by-side

      EAN Head Office Profiles: Katina & Robertina

      February 2, 2023

      Other News Portrait photo of Dr Ralph Sacco, former president of the American Academy of Neurology, in his office, wearing a white lab coat

      In Memoriam: Dr Ralph Sacco, former president of the American Academy of Neurology

      January 19, 2023

      EAN Staff

      EAN Head Office Profiles: Magda & Mira

      December 29, 2022

      News in general

      Registration now open for the launch event of the RETHINKING Alzheimer’s disease White Paper

      December 24, 2022

      EAN Staff Composite image consisting of two chest-height portraits ide-by-side

      EAN Head Office Profiles: Katina & Robertina

      February 2, 2023

      EAN Staff

      EAN Head Office Profiles: Magda & Mira

      December 29, 2022

      EAN Staff

      EAN Head Office Profiles: Peter & Nadine

      November 24, 2022

      EAN Staff

      EAN Head Office Profiles: Katharina & Rena

      October 31, 2022

      Grant opportunities

      1st EAN Science School, 26-29 March 2022: “Pathophysiology of disorders of the nervous system”

      June 18, 2021

      Grant opportunities

      European Commission: Innovation and novelty in medical devices and in vitro diagnostic devices; towards common concepts of innovation-related risk assessments

      November 1, 2019

      Grant opportunities

      GBS|CIDP Foundation International 2020 Research Grant Opportunity

      October 29, 2019

      Grant opportunities

      The Clinical Fellowship application deadline is approaching

      October 1, 2019

      News from EAN member societies

      14 June: Special publication celebrates 10 years of the European Working Group of People with Dementia

      August 2, 2022

      News from EAN member societies

      14 June: Alzheimer Europe hosts European Parliament Lunch Debate examining EU and WHO policies on neurological conditions

      August 2, 2022

      News from EAN member societies

      22 June: Alzheimer Europe invites applications for its new Anti-Stigma Award

      August 2, 2022

      News from EAN member societies

      Alzheimer Europe publishes new reports on ‘sex, gender and sexuality in the context of dementia’, and ‘dementia-inclusive initiatives and communities’

      April 5, 2022

      EBC

      Connecting brains for the future: Brain Innovation Days 2022

      November 23, 2022

      EBC

      Final programme available for Brain Innovation Days – Register now!

      September 22, 2022

      EBC

      EPICLUSTER Final Meeting – shaping the future of epilepsy research in Europe

      August 26, 2022

      EBC

      Registration open for Brain Innovation Days 2022

      August 19, 2022

      EFNA

      OneNeurology European Summit underlines urgent need to prioritise neurology and drive change

      December 31, 2021

      EFNA

      EFNA launch eLearning Platform for neurology advocates

      February 1, 2021

      EFNA

      ‘Me and My Brain’ – Art Competition winners announced!

      February 1, 2021

      EFNA

      Survey on the impact of COVID-19 on neurology service delivery

      November 1, 2020

      News in general

      Registration now open for the launch event of the RETHINKING Alzheimer’s disease White Paper

      December 24, 2022

      News in general

      EAN lecture at the International Neuro-Urology Society annual congress 2022

      May 25, 2022

      News in general

      EPA-EAN Joint Symposium: ‘Etiology and Treatment of the Long Covid-19 Syndrome’ and other highlights at the 30th European Congress of Psychiatry

      May 25, 2022

      News in general

      Organise an EAN-Day or EAN Regional Teaching Course in your Country!

      May 17, 2022

      Patients societies reports

      News from Alzheimer Europe

      March 2, 2020

      Patients societies reports

      News from the WHO

      January 9, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 3, 2020

      Patients societies reports

      News from EFIC and the European Pain Forum

      January 2, 2020

      Surveys

      Help EAN contribute towards the development of a European Pain Research strategy

      December 5, 2022

      Surveys

      Survey: management of covert brain infarction

      October 29, 2021

      Surveys

      Driving with an intracranial tumor

      July 13, 2020

      Surveys

      SURVEY: Driving with an intracranial tumor

      June 25, 2020

      Forum

      Call for Applications: e-Learning Platform Editor-in-Chief

      August 4, 2020

      Forum

      Neurological News from Denmark VI – the land of the 2nd EAN congress 2016: Pain Research in Denmark from a neurological perspective

      April 1, 2016

      Forum

      Neurological News from Denmark V – the land of the 2nd EAN congress 2016: Clinical Dementia Research in Denmark

      March 1, 2016

      Forum

      Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri – Comment to EMA recommendation

      March 1, 2016

  • EAN
  • Congress 2023
  • EANpages
  • EAN Campus
  • Eur J Neurol
  • Virtual Congress

eanpages

  • General interest
    • All Executive Page Paper of the Month EAN News EAN Congress news COVID-19 Interviews
      EAN News

      Become a Certified Leader of European Neurology with the new EAN Leadership Programme

      January 24, 2023

      EAN News

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      Executive Page

      Executive Page: Submit, register, and join us for EAN 2023

      December 5, 2022

      Executive Page Dear EAN members, dear friends, It is my pleasure to give you an update on behalf of the EAN Scientific Committee following a busy year since my appointment as chair. It has been a privilege to be so deeply involved in the scientific activities of the EAN and to work closely with an amazing community of people who are so dedicated to the advancement of neurology. One of the strongest threads within that community is the EAN’s group of Scientific Panels, which are often referred to as the organisation’s ‘scientific backbone’. The panels have a hand in everything the EAN does from a scientific point of view, including coordinating clinical research, disseminating good practice, assisting in planning the EAN annual congress, supporting the EAN’s educational efforts, and producing guidelines that assist neurologists in daily practice. All of this work requires a considerable amount of oversight, and this is why each panel is run by its own Management Group, elected by the panel members. Being a part of one of these Management Groups (PDF) is an opportunity to play a direct part in determining the direction of scientific progress within Europe, and I am excited to say that the call for applications to stand for election will be announced in September. All panel members and EAN individual members are eligible to apply to be candidates, with the vote being held among the existing panel members in autumn. I would like to urge every neurologist with a passion for the scientific future of their special area of interest to consider standing for election to the relevant Management Group and to look out for the call for applications later this month. I can tell you from personal experience that fulfilling a role such as this within the structure of the EAN is a fascinating and extremely rewarding experience. The chance to take on such a unique leadership position should not be missed! The most satisfying aspect of being involved in the EAN’s organisational structure is surely seeing all the hard work and planning come to fruition when a small idea evolves into a newly launched project. One such example is the 1st EAN Science School, taking place in Salzburg next March. The idea of the Science School is to offer early career neurologists with an interest in translational research a new avenue for learning about basic pathomechanisms of neurological disorders. Application for this very first edition, on ‘Pathophysiology of disorders of the nervous system’, closed last week and we have been delighted with the level of interest. It was a pleasure to be part of the task force in charge of planning this new project and I look forward to seeing it officially transferred to the hands of the Scientific Committee after a successful event and evaluation in spring. Of our ongoing activities, one of the most significant is the EAN Neuro-covid Registry, which aims to collate epidemiological data on neurological manifestations in patients with COVID-19 infection reported by neurologists in outpatient services, emergency rooms, and hospital departments. We currently have 1,542 patients entered in the database, from 35 centres across 23 countries. So far, 29 patients have been followed for 12 months and 387 have completed the 6-months follow up. This is a decent start, but I would like to strongly encourage EAN members and their institutions to get involved and contribute cases to what will become an invaluable resource for neurologists and clinicians to improve care for Covid-19 patients. Finally, I would like share a word on a forthcoming collaboration between EAN and the Human Brain Project in December, that I think will interest a lot of EAN members. The EAN-EBRAINS joint workshop on ‘The future of medical data sharing in clinical neurosciences’ will be a three-day virtual event that aims to discuss issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. The whole workshop is completely free of charge and registration is open until 25 November, so please check out the details and sign up! I wish you all a healthy and pleasant autumn and I look forward to updating you again. Best wishes Thomas Berger Chair of the EAN Scientific Committee

      Executive Page: New guideline prioritisation process begins setting path for next two years

      November 1, 2022

      Executive Page EAN Secretary General, 2022. Tony Marson, Liverpool UK.

      Executive Page: More reasons than ever to renew your EAN membership

      October 11, 2022

      Executive Page Head and shoulders portrait photo of Irena Rektorova, in colourful dress

      Executive Page: Challenge of maintaining high standards is a privilege says incoming Education Committee Chair

      September 1, 2022

      Paper of the Month

      Research Paper of the Month: Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT)

      January 1, 2023

      Paper of the Month

      COVID-19 Paper of the Month: The decline in stroke hospitalization due to COVID-19 is unrelated to COVID-19 intensity

      January 1, 2023

      Paper of the Month

      Research Paper of the Month: Lecanemab in Early Alzheimer’s Disease

      December 5, 2022

      Paper of the Month

      Covid-19 Paper of the Month: Incidence of Epilepsy and Seizures Over the First 6 Months After a COVID-19 Diagnosis

      December 5, 2022

      EAN News

      Become a Certified Leader of European Neurology with the new EAN Leadership Programme

      January 24, 2023

      EAN News

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      EAN Congress news

      EAN launches new ‘Congress Spin-Off with Masterclasses’ event, with first edition in March

      January 10, 2023

      EAN Congress news

      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

      EAN Congress news

      EAN 2023 – Join us in Budapest on July 1-4

      September 1, 2022

      EAN Congress news

      Special EAN issue of BrainMag features reports on EAN 2022 and more

      August 30, 2022

      COVID-19

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      COVID-19

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      COVID-19

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      COVID-19

      COVID-19 Paper of the Month: The decline in stroke hospitalization due to COVID-19 is unrelated to COVID-19 intensity

      January 1, 2023

      Interviews

      Video Interview: Dementia & Cognitive Disorders Panel Co-Chairs

      September 8, 2022

      Interviews

      Video Interview: Sleep-Wake Panel Co-Chair, Dr. Evelina Pajediene

      July 28, 2022

      Interviews

      Video: EAN supports World Brain Day

      July 19, 2022

      Interviews

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

      July 18, 2022

  • Academic/Scientific
    • All Breaking news Neurology updates Scientific committee reports Scientific panels reports Eur J Neurol Top 10 Articles Scientific Corner
      EAN News

      COVID-19 Research Round-Up: Literature reviews – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Case Series/Case Reports – January 2023

      January 17, 2023

      EAN News

      COVID-19 Research Round-Up: Cross-Sectional Case Control Studies – January 2023

      January 17, 2023

      EAN News

      Impact of Burnout on Neurology Residents and Research Fellows in Europe

      December 23, 2022

      Breaking news

      COVID-19 Breaking News: Meta-analyses/systematic reviews – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Cross-Sectional Case Control Studies – November 2022

      November 8, 2022

      Breaking news

      COVID-19 Breaking News: Miscellaneous – November 2022

      November 7, 2022

      Breaking news

      COVID-19 Breaking News: Observational Studies – Prospective Longitudinal Cohort – November 2022

      November 7, 2022

      Neurology updates

      Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome – A MAGNIMS Study

      September 26, 2022

      Neurology updates

      Relapse-independent disability worsening plays a relevant role in every disease phase of MS

      September 26, 2022

      Neurology updates

      Epstein-Barr virus infection is a major risk factor for the development of multiple sclerosis

      September 26, 2022

      Neurology updates

      Glymphatic system impairment may contribute to multiple sclerosis pathology

      September 23, 2022

      Scientific committee reports

      Scientific Committee Snapshot: Didier Leys

      April 1, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Rigmor Hojland

      February 26, 2020

      Scientific committee reports

      Scientific Committee Snapshot: Christian Enzinger

      December 1, 2019

      Scientific committee reports

      Scientific Committee Snapshot: Maurizio Leone

      November 1, 2019

      Scientific panels reports

      Highlights from the World Muscle Society annual meeting, chosen by the Scientific Panel on Muscle and NMJ Disorders

      November 2, 2022

      Scientific panels reports

      Coma and DOC Panel Update (May-June): news from the EAN Virtual Congress, personalized pain assessment, NIRS-EEG and machine learning to predict outcomes, prevalence of swallowing disorders and new multimodal predictive algorithms.

      August 11, 2020

      Scientific panels reports

      Statement of the EAN Sleep-Wake-Panel

      June 3, 2020

      Scientific panels reports

      Rare Neurological Diseases in the COVID-19 era: Suggestions for information to patients and caregivers

      May 13, 2020

      Eur J Neurol

      Video Interview: European Journal of Neurology Award winner, Dr. Jonathan Coutinho

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Paper of the MonthGeneral interestFeatured Slider

Paper of the month: Intrathecal stem cells for amyotrophic lateral sclerosis

November 1, 2018

 

 

 

 

by Elena Moro

 

 

 

 

For November 2018, we have selected: Oh KW, Noh MY, Kwon NS, et al. Repeated intrathecal stem cells for amyotrophic lateral sclerosis. Ann Neurol 2018;84:361-373.

Stem cell research is a hot topic in motor neuron disease/amyotrophic lateral sclerosis (MND/ALS) both for clinicians and patients. Whilst recognized as an important area of promise for developing future therapeutics in neurodegenerative disease, it has been much hyped in the media, and dissecting the scientific research on the subject from the many unproven approaches advertised to patients by commercially motivated companies can be challenging. Our paper of the month is a randomized controlled trial that makes a genuine contribution to the literature on stem cell approaches in ALS.

 

The Korean authors of this paper performed a phase 2 randomized controlled trial of autologous mesenchymal stem cells derived from bone marrow and delivered intrathecally to 33 patients, compared to 31 disease controls, treated with riluzole alone. Patients were recruited from a single centre in Seoul. Inclusion criteria were age 25-75 years, clinically probable or definite ALS by revised El Escorial criteria, an ALSFRS-R (patient-reported disability rating) score of 31-46, stable riluzole therapy at standard doses for at least 3 months, and disease duration of less than 5 years from symptom onset. Exclusions were involvement in other trials within 12 months, forced vital capacity of <40%, any comorbidity that might confound outcomes, tracheostomy or non-invasive ventilation, haemorrhagic tendency or any drug that could affect bone marrow.

 

The trial design included a 3-month lead-in period. Patients were genotyped. Bone marrow was extracted from patients randomly assigned to stem cell treatment after 2 and 3 months lead-in, the last extraction 2 days before day zero when the first treatment was given. A second treatment was given one month later, allowing 28 days between each bone marrow extraction and subsequent treatment, to give time to expand the stem cells for intrathecal delivery. One day before each delivery, a lumbar puncture was performed and 20-30mls of cerebrospinal fluid was extracted to analyze cytokine profiles and suspend the cultured stem cells. A million cells per kg body weight were delivered at each treatment. There was no sham procedure in controls, so the trial was effectively open-label. Outcomes of safety and efficacy were assessed. Patients were followed up with physical, neurological examination and ALSFRS-R at monthly intervals for 6 months and monitored at intervals for any clinical, haematological or biochemical adverse events, the latter including assessment of full blood count, renal and liver function and urinalysis. The primary efficacy outcome measure was change in ALSFRS-R between baseline and 4 months. Additional clinical assessments including Appel clinical status scores, forced vital capacity and the SF-36 quality-of-life measure were secondary outcomes. Changes in cytokine profiles were assessed from CSF derived just before each of the two treatments i.e. just before first treatment and after a month of therapy. Survival was censored approximately 5 years after the last patient follow-up visit. T-tests were used to compare differences between groups to assess primary and secondary outcomes.

 

There were no systematic clinical or demographic differences between treated and untreated groups at baseline. No patient had an identified gene mutation. Fifty-six of the 64 patients completed 6 months follow-up. There were 20/33 adverse events in the stem cell group and 22/31 in controls. The most common events in the stem cell group were a flu-like illness, back and musculoskeletal pain. There were 3 serious adverse events in the stem cell group, including 1 death from ALS, none of which were judged treatment-related, and 6 serious adverse events in the control group (3 deaths). Mean change in ALSFRS-R was 3.0 points slower in the stem cell group than the control group at 4 months (p<0.001) and 3.4 points at 6 months (p=0.003). Change in Appel scores was also significantly reduced, but there was no difference in forced vital capacity, quality of life or survival. Following treatment, changes were demonstrated in a number of cytokines, including an increase in IL-6 and IL-10 and a decrease in TNF-alpha.  Changes in the levels of monocyte chemoattractant protein (MCP-1) and transforming growth factor (TGF Beta 1) were highlighted as potential biomarkers of treatment response.

The authors concluded that the treatment was safe and that the differences observed in ALSFRS-R merit a larger, phase 3 trial. The main limitation of the study was the lack of a sham control in the context of a patient-reported primary outcome measure, meaning that the trial was prone to bias due to placebo effect. The reason given was that the relatively invasive nature of bone marrow harvest and lumbar punctures made sham control group unethical, illustrating the difficulties in studying such cell-based treatments.

 

“This study is a welcome addition to the scientific literature on the application of stem cell-based therapies in ALS”, said Prof Pamela Shaw, Department of Neurology, Sheffield Institute for Translational Neuroscience (SITraN) University of Sheffield, UK. “Whilst the trial has some important limitations, the study has demonstrated safety, which is important, and the efficacy data are encouraging, but must be treated with caution, because a sham control was not used. It should be emphasized to patients that this work is different from the many companies across the world offering commercial stem cell treatments of dubious origin and unproven efficacy to patients with ALS, who are understandably desperate for more effective treatments than are currently available. It is also important to note that this study did not observe a difference in survival. However, given the safety observed and the indications of benefit, further work in this area should be pursued”

 

“A larger phase 3 trial is now warranted,” said Prof Vincenzo Silani, Department of Neurology, IRCCS Istituto Auxologico Italiano, University of Milan Medical School, Italy. “It is a challenge for the scientific community to reconcile the development of effective trial designs to reduce bias, whilst balancing the ethics of sham control procedures in trials of stem cell therapy that require relatively invasive harvest and delivery methods. Engagement with patient groups will be important to achieve consensus on the right way to proceed to evaluate these therapies in the most objective way possible. The search for more effective treatments for ALS continues.”

 

The other nominees for the November 201* paper of the month are:

 

  • Chitnis T, Arnold DL, Banwell B, et al., for the PARADIGMS Study Group. Trial of fingolimod versus interferon beta-1a in pediatric multiple sclerosis. N Engl J Med 2018;379:1017-27. In 215 patients between 10 and 17 years of age with relapsing remitting multiple sclerosis, the effects of oral fingolimod versus intramuscular interferon beta-1a were assed over a 2-year period. The adjusted annualized relapse rate was 0.12 with fingolimod and 0.67 with interferon beta-1a (absolute difference, 0.55 relapses; relative difference, 82%; P<0.001). Moreover, fingolimod had less accumulation of brain MRI lesion. However, fingolimod had higher rate of serious adverse events.

 

  • Bassez G, Audureau E, Hogrel J-Y, et al. Improved mobility with metformin in patients with myotonic dystrophy type 1; a randomized controlled trial. Brain 2018;141:2855-2865. In this randomized, placebo-controlled trial, oral metformin or placebo were administered TID up to 3 g/day in 40 patients with myotonic dystrophy type 1. Twenty-three patients completed the study at 1 year. The nine treated patients showed significantly better 6-minute walk test compared to the 14 patients with placebo. Adverse events were more common in the treated group, mainly gastrointestinal dysfunction.

 

  • Kasner SE, Swaminathan B, Lavados P, et al., on behalf of the NAVIGATE ESUS Investigators. Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial. Lancet Neurol, September 2018. org/10.1016/ S1474-4422(18)30319-3. In the NAVIGATE ESUS trial, efficacy and safety of rivaroxaban (an oral factor Xa inhibitor) versus aspirin were assessed for secondary stroke prevention in patients with embolic stroke of undetermined source (ESUS). In this paper, the authors made a prespecified subgroup analysis considering the presence or absence of patent foramen ovale and assessing time to recurrent ischemic stroke between groups. Patients with PFO assigned to receive aspirin had a recurrent ischemic stroke rate of 4·8 events per 100 person-years compared with 2·6 events per 100 person-years in those treated with rivaroxaban The risks of major bleeding with rivaroxaban versus aspirin were similar in patients with PFO detected and in those without PFO detected.

 

 

 

Paper of the month: Intrathecal stem cells for amyotrophic lateral sclerosis was last modified: November 13th, 2018 by Editor
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